Upcoming Events

Qunwei Zhang, MD, MPH, PhD

Qunwei Zhang ImageEpidemiology & Population Health


Office: Room108F, MDR Building, 511 South Floyd St., Louisville, Kentucky 40202

Lab: Room 205 & 206, MDR Building, 511 South Floyd St., Louisville, Kentucky 40202

Phone: 502-852-7200 (Office); 502-852-2439 (Lab); Fax: 502-852-7246;

Email: qunwei.zhang@louisville.edu



Qunwei Zhang, MD, MPH, PhD, is a Professor of the Department Environmental and Occupational Health Sciences at the University of Louisville School of Public Health and Information Sciences. Dr. Zhang received his MD degree from Fujiang Medical University and his MPH degree from the School of Public Health at Zhejiang University, China. After three years of experimental and clinical studies on the treatment of pneumoconiosis by whole lung lavage, he entered a graduate program in the University of Fukui School of Medicine, Japan, and was got his PhD degree in 2000 for study of the mechanism of pulmonary effects of metals nano-particles. His subsequent post-doctoral training was in Dr. Max Costa's (Professor and Chairman) laboratory at New York University School of Medicine where he studied the molecular mechanisms of metal toxicity and carcinogenesis. He was then recruited to the Institute for Environmental Medicine at the University of Pennsylvania Medical Center as a Research Associate and Institute Associate Investigator under the mentorship of Dr. Aron Fisher (Professor and Director), where he studied on the mechanism of oxidative injury in lung ischemia-reperfusion. Dr. Zhang joined University of Louisville in 2005 as an assistant professor, and was promoted to associate professor in 2011 and professor in 2016. He has published over 90 scientific articles and book chapters, and more than 92 abstracts presented in the national or international conference.

Support Staff: Barbara Parker (502-852-3290)

Research Interests
Nanotoxicology and pulmonary toxicology;
Metals toxicology, genotoxicology and carcinogenesis;
Lung ischemia and ion channel;
Free radicals and pulmonary diseases;
Gene expression and function;
Shear stress and NADPH oxidase;
Signal transduction involved in tumor promotion, prevention and cellular function.

Current and Past Projects

1.Mechanisms underlying metal nanoparticle-induced lung injury and fibrosis. NHLBI (HL147856). Principal Investigator. June 1, 2019-May 31, 2023

2. Mechanisms of carcinogenic effects of nickel nanoparticles. NIEHS (ES028911). Principal Investigator, Dec.15, 2017-Nov. 30, 2021

3. Mechanisms underlying ambient particulate matter-induced lung cancer. Kentucky Lung Cancer Research Program. Principal Investigator, June.1, 2017-May 30, 2020

4. The role of microRNA miR21 in nickel nanoparticles-induced MMPs production. NIEHS (ES023693). Principal Investigator. Sept. 17, 2014-June 30, 2019

5. Mechanisms underlying ambient particulate matter-induced DNA damage and cell transformation. KSEF-148-502-16-381. Principal Investigator, July 1, 2016-June 30, 2018

6. Develop and evaluate the degradable polymerpoly(troloxester) nanoparticles for  medial application. The Clinical and Translational Science Grant Program at UofL.Principal Investigator, June 1, 2010-May, 31, 2011.

7. Activation of Endothelial cell and gene expression in lungs following exposure to ultrafine particles. Health Effects Institute, Walter A. Rosenblith New Investigator Award (4751-RFA-05-2/06-12).Principal Investigator, Mar.1, 2007-December 31, 2011.

8. KSEF-1686-RED-11.  Oxidative stress and endothelial dysfunction in aminal exposure to ultrafine particles and cigarette smoke. KSEF, Principal Investigator, July 1, 2008-June 30, 2010 (no cost-extension until June 30, 2011).

9. Mechanisms Underlying the Susceptibility of Diabetics to Ultrafine Particles. American Heart Association Great Rivers Affiliate, Principal Investigator, July 1, 2008-June 30, 2010 (no cost-extension until June 30, 2011).

10. Partial-thickness wound healing via topical ATP delivery. NIH/NIAMSD SBIR (2R44AR052984-02). Co-investigator (Dr. Chien, Principal Investigator), Sept.12, 2007-Aug. 31, 2010.

11. Carcinogenesis of nickel nanoparticles. Pilot project from the NIESH Center for Environmental Genomics and Integrative Biology (CEGIB) at the University of Louisville,  Principal Investigator, April 1, 2008-March 31, 2009

12. Center for Environmental Genomics and Integrative Biology (1P30ES01443-01A1). NIH/NIESH. Dr. Ramos (Principal Investigator), Dr. Zhang is a Career Development Program recipient, April 1, 2007-March 31, 2008

13. Endothelial generation of reactive oxygen species in lung exposure to ultrafine particles. National American Lung Association (RG-872-N), Principal Investigator. July 2004-Dec 2006.

14. Genotoxic effects of transition metal nanoparticles. University of Louisville Intramural Research Incentive Grant,    Principal Investigator,      June 1, 2006-May 31, 2007

Honors and Awards

2008 Winner, Scientific Importance, Research!Louisville

2006 Walter A. Rosenblith New Investigator Award, Health Effects Institute

2006 First Place of the Scientific Importance, Research!Louisville

2004-2006 National American Lung Association research grant award (Independent Investigator Award)

2002 Mechanism of Toxicity Gordon Research Conference travel grant award

2000-2002 Japan Society for the Promotion of Science (JSPS) post-doc fellowship for foreign researcher (about $100,000.00) - returned fellowship due to accepting the research associate scientist position in New York University, USA.

1998 Third British Epidemiology and Public Health Course travel grant award

1997 9th International Conference on Occupational Respiratory Diseases travel grant award

1995-2000 Japanese Ministry of Education, Sciences and Culture scholarship award (Japanese Government Scholarship)

1995 25th International Congress on Occupational Health travel grant award

Post-doc Fellow Received Awards Under the Mentor of Dr. Zhang

2018    First Place:  Basic Research in Public Health, Research! Louisville (Awardee: Dr. Yiqun Mo)

2017    First Place:  Basic Research in Public Health, Research! Louisville (Awardee: Dr. Yiqun Mo)

2015    First Place:  Basic Research in Public Health, Research! Louisville (Awardee: Dr. Yiqun Mo

2010   The post-doc award, Nanotoxicology Specialty Section, 49 th Annual Meeting of Society of Toxicology at Salt Lake City, March 7-11, 2010. (Awardee: Dr. Rong Wan)

2009   Best Abstract by a post-doc, Inhalation and Respiratory Specialty Section, Annual Meeting of Society of Toxicology at Baltimore, March 15-19, 2009. (Awardee:Dr. Yiqun Mo)

2009  Travel Award for Trainees, Wound Biotechnology Foundation,   Wound Healing Society, 19 th Annual Meeting and Exhibition, Dallas, Texas,  April 26-29, 2009. (Awardee:Dr. Yiqun Mo)



1.    Qunwei Zhang (Editor). Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular  Biology,                  Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). DOI: 10.1007/978-1-4939-8916-4; Hardcover ISBN: 978-1-4939-8915-7; eBook ISBN: 978-1-4939-8916-4.   https://www.springer.com/us/book/9781493989157

Book Chapters

  1. Mo Y, Zhang Y, Zhang Q. Evaluation of Pulmonary Toxicity of Nanoparticles by Bronchoalveolar Lavage Method. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:313-322. doi: 10.1007/978-1-4939-8916-4_18. PMID:30547469
  2. Zhang Y, Wan R, Zhang Q, Mo Y. Application of gelatin zymography in nanotoxicity research. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:133-143. doi: 10.1007/978-1-4939-8916-4_8. PMID:30547459
  3. Wan R, Mo Y, Tong R, Gao M, Zhang Q. Determination of Phosphorylated Histone H2AX in Nanoparticle-Induced Genotoxic Studies. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:145-159. doi: 10.1007/978-1-4939-8916-4_9. PMID:30547460
  4. Long G, Mo Y, Zhang Q, Jiang M. Analysis of Nanomaterial Toxicity by Western Blot.. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:161-169. doi: 10.1007/978-1-4939-8916-4_10. PMID:30547461
  5. Mo Y, Gu A, Tollerud DJ, Zhang Q. Nanoparticle toxicity and environmental impact. Oxidative stress and biomaterial. Editors: Thomas Dziubla and D. Allan Butterfield. Elsevier Ltd. (2016). ISBN: 978-0-12-803269-5, page 117-143.
  6. Mo Y, Wan R, Tollerud DJ, Zhang Q. Nanomaterials.  Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspect. Editors: Yusuke Hiraku, Shosuke Kawanishi, Hiroshi Ohshima. John Wiley & Sons, Inc. (2014).  ISBN: 978-1-118-16030-5, page 235-249.
  7. Mo Y, Wan R, Zhang Q.  Application of reverse transcription-PCR and real-time PCR in nanotoxicity research. Nanotoxicity: Method and Protocols. In the series: Methods in Molecular Biology (Vol. 926). Editor: Reineke, Joshua. Springer Protocols (www.SpringerProtocols.com).  Humana Press (2012) Methods Mol. Biol. 2012; 926: 99-112.  PMID: 22975959.
  8. Fisher AB, Zhang Q.  NADPH and NADPH oxidase. Encyclopedia of Respiratory Medicine. Editors: Geoffrey J. Laurent and Steven D. Shapiro. C2006 Elsevier Ltd, ISBN: 0-12 438360-2, 2006; Vol 3: 77-83.
  9. Zhang Q, Kusaka Y, Sato K, Donaldson K.  Differences in the inflammogenicity of standard and ultrafine metals: the role of nitric oxide. Advances in the Prevention of Occupational Respiratory Diseases. Editors: Chiyotani K, Hosoda Y, Aizawa Y. Elsevier Sciences B.V. 1998: 866-872.
  10. Zhang Z, Zhang Q, Yang D, Ding X, Luo J, He L Zhong H, Chen F. Luo J, Hong C.  The therapeutic effect of whole lung lavage with polyvinypyridine-N-Oxide solution in pneumoconiosis patients.  Advances in the Prevention of Occupational Respiratory Diseases. Editors: Chiyotani K, Hosoda Y, Aizawa Y. Elsevier Sciences B.V. 1998: 838-844.
  11. Kusaka Y, Zhang Q, Sato K, Kyono H, Kohyama N.  Which is more immunotoxic to the respiratory system, ionic or metallic cobalt? Metal Ions in Biology Medicine. Editors: Collery PH, Corbella J, Domingo JL, Etienne JC, Liobet JM. John Liibbey Eurotext, Pairs, 1996, Vol 4: 661-613.
  12. Sato K, Kusaka Y, Zhang Q, Okada K, Nakakuki K, Muraoka R.  Effect of cadmium on citrate uptake by isolated rats renal brush border membrane vesicles. Metal Ions in Biology Medicine. Editors: Collery PH, Corbella J, Domingo JL, Etienne JC, Liobet JM.  John Liibbey Eurotext, Pairs, 1996, Vol 4: 238-240.

Journal Articles

  1. Mo Y, Zhang Y, Zhang YB, Yuan J, Mo L, Zhang Q. Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway. Journal of Nanobiotechnology. 2021 Nov 17;19(1):370. https://doi.org/10.1186/s12951-021-01117-7. PMID: 34789290

  2. Yuan J, Li P, Pan H, Xu Q, Xu T, Li Y, Wei D, Mo Y, Zhang Q, Chen J, Ni C. miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1. Ecotoxicology and Environmental Safety. 2021; 20:112375 https://doi.org/10.1016/j.ecoenv.2021.112372 PMID: 34082245
  3. Sarojini H, Bajorek A, Wan R, Wang J, Zhang Q, Billeter AT, Chien S. Enhanced Skin Incisional Wound Healing with Intracellular ATP Delivery via Macrophage Proliferation and Direct Collagen Production. Front Pharmacology. 2021; 12:594586. https://doi.org/10.3389/fphar.2021.594586
  4.  Yuan J, Zhang Y, Zhang Y, Mo Y, Zhang Q. Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes. Particle and Fibre Toxicology. 2021 Mar 19;18(1):13.  https://doi.org/10.1186/s12989-021-00405-2  PMID:33740985 
  5. Mo Y, Zhang Y, Wan R, Jiang M, Xu Y, Zhang Q. miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis. Nanotoxicology. 2020; 14(9): 1175–1197. DOI: 10.1080/17435390.2020.1808727  PMID: 32924694
  6. Mo Y, Zhang Y, Mo L, Wan R, Jiang M, Zhang Q. The role of miR-21 in nickel nanoparticle-induced MMP-2 and MMP-9 production in mouse primary monocytes: in vitro and in vivo studies. Environmental Pollution. 2020 Dec;267:115597. DOI: 10.1016/j.envpol.2020.115597 PMID: 33254626.
  7. Feng S, Zhang Z, Mo Y, Tong R, Zhang Z, Chen Z. He D, Wan R, Gao M, Mo Y. Zhang Q, Huang Y. Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: the role of oxidative stress. Toxicology in Vitro. 2020; 69: 10496769. PMID: 32805375
  8. Zhang X, He Y, Lin Q, Hung L, Zhang Q, Xu Y. Adverse effects of sub-chronic exposure to cooking oil fumes on the gonads and the GPR30-mediated signaling pathway in female rats. Molecular and Cellular Toxicology, 2020; 16(1): 13-24.
  9. Mo Y, Sarojini H, Wan R, Zhang Q, Wang J, Eichenberger SE, Kotwal G,  Chien S. Intracellular ATP delivery causes rapid tissue regeneration via upregulation of cytokines, chemokines, and stem cells.  Front Pharmacol. 2020 Jan 16;10:1502. doi: 10.3389/fphar.2019.01502. eCollection 2019. PMID: 32009945
  10. Huang Y, Zhu J, Li H, Wang W, Li Y, Yang X, Zheng N, Liu Q, Zhang Q, Zhang W, Liu J. Cadmium exposure during prenatal development causes testosterone disruption in multigeneration via SF-1 signaling in rats. Food and Chemical Toxicology. 2020; 135:110897 (https://doi.org/10.1016/j.fct.2019.110897). PMID: 31654709
  11. Cai Z, Zheng F, Ding Y, Zhan Y, Gong R, Li J, Aschner M, Zhang Q, Wu S, Li H. Nrf2-regulated miR-380-3p blocks the translation of Sp3 protein and its mediation of paraquat-induced toxicity in mouse neuroblastoma N2a cells. Toxicology Sciences. 2019; 171(2): 515–529. PMID: 31368498
  12. Zheng F,  Luo Z,  Zheng C,  Li J,  Zeng J, Yang H,  Chen J,  Jin Y, Aschnere M,  Wu S, Zhang Q,  Li H. Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in wistar rats. Toxicology and Applied Pharmacology. 2019; 369: 90-99. PMID: 30849457
  13. Mo Y, Jiang M, Zhang Y, Wan R, Li J, Zhong CJ, Li H, Tang S, Zhang Q. Comparative mouse lung injury by nickel nanoparticles with differential surface modification. Journal of Nanobiotechnology. 2019; 17:2. PMID:30616599    https://doi.org/10.1186/s12951-018-0436-0
  14. Wang L, Yang H, Wang Q, Zhang Q, Wang Z, Zhang Q, Wu S, Li H. Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2. Toxicology Letter. 2018; 291:11-28. PMID: 29627306
  15. Wang Q, Zhan Y, Ren N, Wang Z, Zhang Q, Wu S, Li H. Paraquat and MPTP alter microRNA expression profiles, and down-regulated expression of miR-17-5p contributes to PQ-induced dopaminergic neurodegeneration. Journal Applied Toxicology, 2018; 38(5): 665-667. PMID: 29250806
  16. Guo Z, Zhang Z, Wang Q, Wang L. Zhang J, Zhang Q, Li H, Wu S. Manganese chloride induces histone acetylation changes in neuronal cells: its role in manganese-induced damage.  Neurotoxicology, 2018; 65: 255–263. PMID: 29155171
  17. Wang Q, Ren N, Cai Z, Lin Q, Wang Z, Zhang Q, Wu S, Li H. Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2.  NPJ Parkinson’s Dis, 2017 Oct 20;3:31. doi: 10.1038/s41531-017-0033-1. eCollection 2017. PMID: 29071302
  18. Wan R*, Mo Y*, Zhang Z*, Jiang M, Tang S, Zhang Q. Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice. Part Fibre Toxicol. 2017 Sep 18;14(1):38. doi: 10.1186/s12989-017-0219-z. (*co-first author)
  19. Liu Q, Xu C, Ji G, Liu H, Mo Y, Tollerud DJ, Gu A, Zhang Q. Sublethal effects of zinc oxide nanoparticles on male reproductive cells. Toxicology in Vitro, 2016; 35: 131-138.  PMID: 27247145
  20. Zhang Y, Mo Y, Gu A, Wan R, Zhang Q, Tollerud DJ. Effects of urban particulate matter with high glucose on human monocytes U937.  Journal of Applied Toxicology, 2016; 36: 586–595. PMID: 26179980
  21. Xu Y, Zhang X, Chen Y, Ren N, Lin W, Zhang Q. Health effects of electromagnetic fields on reproductive-age female operators of plastic welding machines in Fuzhou, China.  Journal of Occupational and Environmental Medicine, 2016; 58(2): 148-153. PMID: 26849258
  22. Zou H, Zhang Q, Xing M, Gao X, Zhou Li, Tollerud DJ, Tang S, Zhang M.  Evaluation of appropriate exposure metrics for nanoparticles in workplaces. Environmental Science: Processes & Impacts, 2015; 17(8):1470-1481. PMID: 26166442
  23. Xu C, Liu Q,  Liu H, Zhang Q,  Héroux P,  Jiang ZY, Gu A.  Low serum testosterone levels are associated with elevated urinary mandelic acid, tungsten, and strontium levels in adult men according to the US 2011-2012 National Health and Nutrition Examination Survey. PLoS One, 2015 May 21; 10(5): e0127451. PMID: 25996772
  24. Xu C, Liu Q, Zhang Q, Jiang Z, Gu A. Urinary enterolactone associated with liver enzyme levels in U.S. adults: NHANES survey. British Journal of Nutrition, 2015; 114:91-97. PMID: 25990984
  25. Yang X, Shao H, Liu W, Gu W, Shu X, Mo Y, Chen X, Zhang Q, Jiang M. Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity. Toxicology Letters, 2015; 234: 40-49. PMID: 25680694
  26. Xu C, Liu Q, Zhang Q, Jiang Z, Gu A. Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-2010. British Journal of Nutrition, 2015; 113: 683-690. PMID: 25634494
  27. Feng L, Zhang Y, Jiang M, Mo Y, Wan R, Jia Z, Tollerud DJ, Zhang X, Zhang Q.   Up-regulation of Gadd45a after exposure to metal nanoparticles: the role of hypoxia inducible factor 1a. Environmental Toxicology, 2015; 30 (4): 490-499. PMID: 24277352
  28. Skeete Z, Cheng H, Crew E,  Shan S, Zhao W,  Cronk H,  Luo J, Zhang Q,  Zhong CJ.  Design of functional nanoparticles and assemblies for theranostic applications.  ACS Applied Materials & Interfaces, 2014; 6 (24): 21752-21768. PMID: 25111087
  29. Wan R, Mo Y, Feng L, Chien S, Tollerud DJ, Zhang Q. DNA damage caused by metal nanoparticles: the involvement of oxidative stress and activation of ATM. Chemical Research in Toxicology, 2012; 25: 1402-1411. (Highlighting in this issue; 2012; 25(7):1283)PMID:22559321
  30. Mo Y, Wan R, Feng L, Chien S, Tollerud DJ, Zhang Q.  Combination effects of Cigarette smoke extract and ambient ultrafine particles on endothelial cells. Toxicology in Vitro, 2012; 26: 295-303. PMID: 22178768
  31. Wan R, Mo Y, Chien S, Li Y, Li Y, Tollerud DJ, and Zhang Q.  The role of hypoxia inducible factor-1α in MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. Nanotoxicology, 2011; 5(4): 568-582. PMID: 21401309
  32. Pushpakumar SB, Perez-Abadia G, Soni C, Wan R, Todnem N, Patibandla P, Fenster T, Zhang Q, Barker JH, Maldonado C. Enhancing complement control on endothelial barrier reduced renal post-ischemia dysfunction. Journal of Surgery Research, 2011, 170: e263-e270. PMID: 21816416
  33. Wang J, Wan R, Mo Y, Zhang Q, Sherwood L, Chien S.  Creating a long-term diabetic rabbit model. Experimental Diabetes Research, 2010, Article ID 289614, 10 pages, doi: 10.1155/2010/289614  PMID: 21234414
  34. Wang L, Zhang J, Zheng Y, Yang J, Zhang Q, Zhu X.  Bioeffects of CdTe quantum dots on human umbilical vein endothelial cells. Journal of Nanoscience Nanotechnology, 2010; 10: 8591-8596. PMID: 21121370
  35. Yu M, Mo Y, Wan R, Chien S, Zhang X, and Zhang Q.  Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles. Toxicology Letters, 2010; 195:82-89. PMID: 20171267
  36. Wang J, Wan R, Mo Y, Li M, Zhang Q, Chien S.  Intracellular delivery of ATP enhanced healing process in full thickness skin wounds in diabetic animals. The American Journal of Surgery, 2010; 199:823-832. PMID: 20609726
  37. Wattamwar PP, Mo Y, Wan R, Palli R, Zhang Q, Dziubla TD.  Antioxidant activity of degradable polymer poly(trolox) to suppress oxidative stress injury in cells. Advanced Functional Materials, 2010; 20:147-154.
  38. Mo Y, Wan R, Wang J, Chien S, Tollerud DJ, Zhang Q.  Diabetes is associated with increased sensitivity of alveolar macrophages to urban particulate matter exposure. Toxicology, 2009; 262:130-137. PMID: 19505525
  39. Mo Y, Wan R, Chien S, Tollerud, DJ, Zhang Q.  Activation of endothelial cells after exposure to ambient ultrafine particles: the role of NADPH oxidase. Toxicology and Applied Pharmacology, 2009; 236:183-193. PMID: 19371610
  40. Wang J, Zhang Q, Wan R, Mo Y, Li M, Tseng M, Chien S.  Intracellular ATP enhanced skin wound healing in rabbits.  Annals of Plastic Surgery, 2009; 64(2):180-186. PMID: 19158531
  41. Wan R, Mo Y, Zhang X, Chien S, Tollerud DJ, Zhang Q.  Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: the role of oxidative stress and protein tyrosine kinase activation. Toxicology and Applied Pharmacology, 2008; 233:276-285.  PMID: 18835569
  42. Mo Y, Zhu X, Hu X, Tollerud DJ, Zhang Q.  Cytokine and NO release from peripheral blood neutrophils after exposure to metal nanoparticles: in vitro and ex vivo studies. Nanotoxicology, 2008; 2(2):79-87.
  43. Zhang Q, Chatterjee S, Wei Z, Liu W, Fisher AB.  Rac and PI3 kinase mediate endothelial cell reactive oxygen species generation during normoxic lung ischemia.  Antioxid Redox Signalling, 2008; 10(4):679-690 (Journal cover). PMID: 18162054
  44. Zhang Q, Matsuzaki I, Chatterjee S, Fisher AB.  Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent. American Journal Physiology Lung Cellular Molecular Physiology, 2005; 289:L954-L961. PMID: 16280460
  45. Matsuzaki I, Chatterjee S, Manevich Y, DeBolt K, Zhang Q, Fisher AB.  Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction. American Journal Physiology Heart Circulatory Physiology, 2005; 288:H336-343. PMID: 15331375
  46. Zhao J, Chen H, Davison T, Kluz T, Zhang Q, Costa M.  Nickel-induced 1,4-alpha-glucan branching enzyme 1 upregulation via the hypoxic signaling pathway. Toxicology and Applied Pharmacology, 2004; 196:404-409. PMID: 15094311
  47. Davidson T, Kluz T, Burns F, Rossman T, Zhang Q, Uddin A, Nadas A, Costa M.  Exposure to chromium (VI) in the drinking water increased susceptibility to UV-induced skin tumors in hairless mice. Toxicology and Applied Pharmacology, 2004; 196:431-437. PMID: 15094314
  48. Mo YFeinstein SI, Manevich Y, Zhang Q, Lu L, Ho YS, Fisher AB.  Mouse 1-Cys peroxiredoxin highly related intronless gene is an expressed pseudogene. FEBS Letter, 2003; 555(2):192-198.  PMID: 14644414
  49. Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. Inhibition and reversal of nickel-induced transformation by histone deacetylase inhibitor trichostatin A. Toxicology and Applied Pharmacology, 2003; 192:201-211. PMID: 14575637
  50. Salnikow K, Davision T, Zhang Q, Chen L, Su W, Costa M.  The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Research, 2003; 63:3524-3530. PMID: 12839937
  51. Zhang Q, Kusaka Y, Zhu X, Sato K, Mo Y, Kluz T, Donaldson K.  Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation. Journal of Occupational Health, 2003, 45:20-32. PMID: 14605425
  52. Costa M, Salnikow K, Sutherland JE, Broday L, Peng W, Zhang Q, Kluz T.  The role of oxidative stress in nickel and chromate genotoxicity. Molecular Cellular Biochemistry, 2002, 234/235:265-275.  PMID: 12162442
  53. Cangul H, Broday L, Salnikow K, Sutherland J, Peng W, Zhang Q, Poltaratsky V, Zoroddu MA.  Molecular mechanism of nickel carcinogenesis. Toxicology Letter, 2002, 127:69-75. PMID: 12052643
  54. Zhang Q, Kluz T, Salnikow K, Costa M.  Comparison of the cytotoxicity, cellular uptake and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell line derived from three different individuals. Biological Trace Element Research, 2002, 86:11-22. PMID: 12002656
  55. Sutherland JE, Peng W, Zhang Q, Costa M.  The histone acetylase inhibitor trichostatin A reduce nickel-induced gene silicening in yeast and mamalian cells. Mutation Research (Fundamental and Molecular mechanisms of Mutagenesis), 2001; 497:225-233. PMID: 11470494
  56. Huang C, Zhang Q, Li J, Ding M, Shi X, Castranova V, Ji G, Costa M, Dong  Z.  Involvement of Erks activation in cadmium-induced AP-1 transactivation in vivo and in vitroMolecular Cellular Biochemistry, 2001, 222:141-147. PMID: 11678596
  57. Zhang Q, Mo Y, Lou J, Zhu X, He L, Zhong H.  Determination the platelet activating factor in silicotic patients and its effect on the fibroblast cells. Environmental Health and Preventive Medicine, 2001, 5(4):134-137. PMID: 21432401
  58. Sato K, Kusaka Y, Zhang Q, Zhu X, Okada K.  Effect of platinum complex (PtCx) on citrate uptake by rat renal brush border membrane vesicles (BBMV): direct effects of cisplatin.  Industrial Health, 2000; 38(3); 327-329. PMID: 10943082
  59. Zhang Q, Kusaka Y, Donaldson K.  Comparative rat pulmonary responses caused by exposure to standard cobalt and ultrafine cobalt. Journal Occupational Health, 2000; 42:179-184.
  60. Zhang Q, Kusaka Y, Donaldson K.  Comparative injurious and pro-inflammatory effects of three ultrafine metals in macrophages from young and old rats. Inhalation Toxicology, 2000; 12 (Suppl 3):267-273. PMID: 26368625.
  61. Wang D, Kato N, Inaba Y, Tango T, Yoshida Y, Kusaka Y, Deguchi Y, Tomita F and Zhang Q.  Physical and personality traits of preschool children in Fuzhou, China: only child vs. sibling. Child: Care, Health and Development, 2000; 26(1): 49-60.  PMID: 10696518
  62. Zhu X, Sato K, Kusaka Y, Zhang Q.  The endocrine disruptive effects of mercury.  Environmental Health and Preventive Medicine, 2000; 4: 174-183.  PMID: 21432482
  63. Zhang Q, Kusaka Y, Sato K, Wang D, Donaldson K.  Tumor necrosis factor-alpha release from rat pulmonary leukocytes exposed to ultrafine cobalt: in vivo and in vitro studies.  Environmental Health and Preventive Medicine, 1999; 4:87-91. PMID: 21432178
  64. Zhang Q, Kusaka Y, Sato K, Mo Y, Fukuda M, Donaldson K.  Toxicity of ultrafine nickel particle in lung after intratracheal instillation. Journal of Occupational Health, 1998; 40: 171-176.
  65. Zhang Q, Kusaka Y, Sato K, Nakakuki K, Koyama N, Donaldson K.  Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radical. Journal of Toxicology and Environmental Health, 1998; 53:423-438. PMID: 9537280
  66. Sato K, Kusaka Y, Zhang Q, Deguchi Y, Li B, Okada K, Nakakuki K, Muraoka R.  Direct effect of inorganic mercury on citrate uptake by isolated rat renal brush border membrane vesicles. Industrial Health, 1997; 35:456-460. PMID: 9348716
  67. Sato K, Kusaka Y, Zhang Q, Yanagihara M, Ueda K.  An epidemiological study on mercury sensitization. Allergy International, 1997; 46: 201-206.
  68. Sato K, Kusaka Y, Zhang Q, Deguchi Y, Li B, Okada K, Nakakuki K, Muraoka R.  Citrate uptake by isolated rat renal brush border membrane vesicles in cadmium-intoxicated rats. Industrial Health, 1997; 35: 388-393. PMID: 9104787
  69. Kusaka Y, Sato K, Zhang Q, Morita A, Kasahara T, Yanagihara Y.  Association of natural killer cell activity with serum Ig E. International Arch Allergy and Immunology, 1997; 112:331-335.  PMID: 9104787
  70. Zhang Q, Kusaka Y, Zhang QF, He L, Zhang Z, Sato K.  Dynamic changes of constituents in bronchoalveolar fluid in experimental silicotic rats. Industrial Health, 1996; 34:379-388. (Correspondence author).  PMID: 8908848
  71. Sato K, Kusaka Y, Zhang Q, Yanagihara M, Ueda K, Morihiro H and Ishii Y.  Investigation of the association between mercury sensitization and HLA-DR6. Contact Dermatitis (Environmental and Occupational Dermatitis), 1996; 34:295. PMID: 8730172



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