Dr. Sufan Chien

Tissue Ischemia and Energy Metabololism  laboratory, Director

The laboratory research of Dr. Sufan Chien focuses on tissue ischemia and reperfusion and direct infusion of high energy phosphates such as adenosine triphosphate to improve tissue protection during ischemia in many models, including ischemia of the heart, kidney, liver, and various forms of shock. While many of these changes are poorly understood, several important inter-related event; are involved, including the decline of high energy phosphates, the accumulation of metabolic intermediates, cell swelling, intracellular acidosis, the accumulation of oxygen-free radicals and structural changes.

This laboratory has developed a new ATP encapsulation technique to deliver high energy phosphate directly into the cytosol of normal and ischemic cells to provide a new therapeutic approach to various clinical ischemic conditions, such as shock, stroke, heart attack, coronary arteries, spinal cord injury, cardiopulmonary bypass surgery, organ transplantation and severe trauma.