Pol-Destruction of Select Agents

policy Destruction Select Agents modified Wed Oct 05 2022 10:32:43 GMT-0400 (Eastern Daylight Time)

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University of Louisville



Destruction of Select Agents


March 11, 2003


This policy applies to the University Community (administrators, faculty, staff, and students) and any individual, including a principal investigator, researcher, instructor, laboratory, or clinical manager that wishes to dispose of any Select Agent(s).


When laboratory staff no longer need a Select Agent they possess, the Agent(s) should be destroyed appropriately and in a timely fashion and the destruction documented. The process must be witnessed and documented by a representative of the Department of Environmental Health and Safety (DEHS). Investigators are advised that possession of a Select Agent is permissible only if the DEHS approves the possession of the Select Agent.

Failure to comply with this policy may result in sanctions.


Select Agent: Any biological agent or toxin that is designated by the Centers for Disease Control or United States Department of Agriculture as a Select Agent because it could pose a threat to human, animal or plant health and safety. The Centers for Disease Control reviews the list of Select Agents at least biennially and may revise the list of agents periodically. The current list can be found at http://louisville.edu/dehs/biological-safety.


Department of Environmental Health and Safety (DEHS)

Witness and assist in the destruction of the Select Agent. DEHS will also execute and maintain documentation of the destruction of the Select Agent and provide a copy of this documentation to the department chair. If required, the designated Responsible Official (RO) for UofL, DEHS Director, will submit official notification to the Centers for Disease Control for Select Agents that are consumed or destroyed via a CDC Form EA-101.

Deans, Directors and Department Heads

Ensure that all principal investigators, researchers, instructors, laboratory or clinical managers or other applicable individuals are aware of and follow the procedures outlined in this policy.

Principal Investigator, Researcher, Instructor,  Laboratory or Clinical Manager or Other Applicable Individual 

Notify the University’s Environmental Manager of the intention to destroy Select Agents by calling 502-852-6670.  Prior to destruction, the principal investigator, researcher, instructor, laboratory or clinical manager or other applicable individual must call the Environmental Manager at 502-852-6670 and make arrangements for a DEHS representative to witness the destruction. Until DEHS arrives, the Select Agent must remain securely stored in the laboratory and shall not be moved or transferred without DEHS approval.

Department Chair/ Unit Head

The department chair or unit head is responsible for any Select Agent that is left abandoned by a principal investigator, researcher, instructor, laboratory or clinical manager or other applicable individual. The department/unit is responsible for implementing this policy if the Select Agent is abandoned.  The department is also responsible for securely storing the Select Agent and maintaining a copy of the documentation of destruction.


Senior Associate Vice President for Operations


Environmental Health and Safety
University of Louisville
Louisville, KY 40292


Revision Date(s):

Reviewed Date(s):

The University Policy and Procedure Library is updated regularly. In order to ensure a printed copy of this document is current, please access it online at http://louisville.edu/policies.