UofL Superfund Research Center Publications


Dang AJ, Kreisberg NM, Cargill TL, Chen JH, Hornitschek S, Hutheesing R, Turner JR, Williams BJ. Development of a Multichannel Organics In situ enviRonmental Analyzer (MOIRA) for mobile measurements of volatile organic compounds. Atmospheric Measurement Techniques, in press.

Hart JL, Shuck B, Owen J, Walker KL, Keith RJ. Biological Sex as a Moderator of Work Determinants of Health: Implications for Work and Stress. Healthcare (Basel, Switzerland). 2024 January 8;12(2). PubMed PMID: 38255024; PMCID: PMC10815146; DOI: 10.3390/healthcare12020135

Xie Z, Sutaria SR, Chen JY, Gao H, Conklin DJ, Keith RJ, Srivastava S, Lorkiewicz P, Bhatnagar A. Evaluation of urinary limonene metabolites as biomarkers of exposure to greenness. Environmental research. 2024 March 15;245:117991. PMID: 38141921; PMCID: PMC10922478; DOI: 10.1016/j.envres.2023.117991

Hopkins CD, Wessel C, Chen O, El-Kersh K, Cathey D, Cave MC, Cai L, Huang J. A hypothesis: Potential contributions of metals to the pathogenesis of pulmonary artery hypertension. Life sciences. 2024 January 1;336:122289. PMID: 38007143; PMCID: PMC10872724; DOI: 10.1016/j.lfs.2023.122289


Chaudhari M, Zelko I, Lorkiewicz P, Hoetker D, Doelling B, Brittian K, Bhatnagar A, Srivastava S, Baba SP. Metabolic Pathways for Removing Reactive Aldehydes are Diminished in Atrophic Muscle During Heart Failure. Research square. 2023 November 21. PMID: 38045249; PMCID: PMC10690332; DOI: 10.21203/rs.3.rs-3621159/v1

McGraw KE, Schilling K, Glabonjat RA, Galvez-Fernandez M, Domingo-Relloso A, Martinez-Morata I, Jones MR, Post WS, Kaufman J, Tellez-Plaza M, Valeri L, Brown ER, Kronmal RA, Barr GR, Shea S, Navas-Acien A, Sanchez TR. Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA). medRxiv : the preprint server for health sciences. 2023 November 1.PMID: 37961623; PMCID: PMC10635251; DOI: 10.1101/2023.10.31.23297878

Luo J, Watson WH, Gripshover TC, Qaissi Z, Wahlang B. Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 October;180:114024. PMID: 37666290; PMCID: PMC10617492; DOI: 10.1016/j.fct.2023.114024

Petri BJ, Piell KM, Wahlang B, Head KZ, Rouchka EC, Park JW, Hwang JY, Banerjee M, Cave MC, Klinge CM. Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease. Environmental toxicology and pharmacology. 2023 October;103:104260. PMID: 37683712; PMCID: PMC10591945; DOI: 10.1016/j.etap.2023.104260

Petri BJ, Cave MC, Klinge CM. Changes in m6A in Steatotic Liver Disease. Genes (Basel). 2023 Aug 19;14(8):1653. PMID: 37628704; PMCID: PMC10454815. DOI: 10.3390/genes14081653

Groswald AM, Gripshover TC, Watson WH, Wahlang B, Luo J, Jophlin LL, Cave MC. Investigating the Acute Metabolic Effects of the N-Methyl Carbamate Insecticide, Methomyl, on Mouse Liver. Metabolites. 2023 Aug 1;13(8):901. PMID: 37623845; PMCID: PMC10456691. DOI: 10.3390/metabo13080901

Anderson LB, Kanneganti D, Houk MB, Holm RH, Smith T. Generative AI as a Tool for Environmental Health Research Translation. Geohealth. 2023 Jul 26;7(7):e2023GH000875. PMID: 37502196; PMCID: PMC10369501. DOI: 10.1029/2023GH000875

Head KZ, Bolatimi OE, Gripshover TC, Tan M, Li Y, Audam TN, Jones SP, Klinge CM, Cave MC, Wahlang B. Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model. Front Gastroenterol (Lausanne). 2023;2:1180712. Epub 2023 May 12. PMID: 37426695; PMCID: PMC10327714. DOI: 10.3389/fgstr.2023.1180712

Walls KM, Hong KU, Hein DW. Induction of glucose production by heterocyclic amines is dependent on N-acetyltransferase 2 genetic polymorphism in cryopreserved human hepatocytes. Toxicol Lett. 2023 Jul 1;383:192-195. Epub 2023 Jul 7. PMID: 37423373; PMCID: PMC10528954. DOI: 10.1016/j.toxlet.2023.07.002

Hong KU, Hein DW. N -acetyltransferase 2 haplotype modifies risks for both dyslipidemia and urinary bladder cancer. Pharmacogenet Genomics. 2023 Aug 1;33(6):136-137. Epub 2023 May 29. PMID: 37306342; PMCID: PMC10524719. DOI: 10.1097/FPC.0000000000000500

McLeish AC, Walker KL, Keith RJ, Hart JL. The Role of Perceived Neighborhood Cohesion in the Association between Depressive Symptoms and Cigarette Smoking. Subst Use Misuse. 2023;58(10):1295-1301. Epub 2023 May 26. PMID: 37232382; PMCID: PMC10413331. DOI: 10.1080/10826084.2023.2215331

Yeager R, Browning MHEM, Breyer E, Ossola A, Larson LR, Riggs DW, Rigolon A, Chandler C, Fleischer D, Keith R, Walker K, Hart JL, Smith T, Bhatnagar A. Greenness and equity: Complex connections between intra-neighborhood contexts and residential tree planting implementation. Environ Int. 2023 Jun;176:107955. Epub 2023 May 12. PMID: 37196566; PMCID: PMC10367429. DOI: 10.1016/j.envint.2023.107955

Habil MR, Salazar-González RA, Doll MA, Hein DW. Effect of N-acetyltransferase 2 genetic polymorphism on 4,4'-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress. Arch Toxicol. 2023 Jun;97(6):1773-1781. Epub 2023 May 4. PMID: 37142755; PMCID: PMC10259506. DOI: 10.1007/s00204-023-03508-1

Piell KM, Petri BJ, Head KZ, Wahlang B, Xu R, Zhang X, Pan J, Rai SN, de Silva K, Chariker JH, Rouchka EC, Tan M, Li Y, Cave MC, Klinge CM. Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure. Environ Toxicol Pharmacol. 2023 Jun;100:104138. 104138. Epub 2023 May 1. PMID: 37137421; PMCID: PMC10330322. DOI: 10.1016/j.etap.2023.104138

Wahlang B. RISING STARS: Sex differences in toxicant-associated fatty liver disease. J Endocrinol. 2023 Jun 16;258(1):e220247. PMID: 37074385; PMCID: PMC10330380. DOI: 10.1530/JOE-22-0247

Liu S, He L, Bannister OB, Li J, Schnegelberger RD, Vanderpuye CM, Althouse AD, Schopfer FJ, Wahlang B, Cave MC, Monga SP, Zhang X, Arteel GE, Beier JI. Western diet unmasks transient low-level vinyl chloride-induced tumorigenesis; potential role of the (epi-)transcriptome. Toxicol Appl Pharmacol. 2023 Jun 1;468:116514.116514. Epub 2023 Apr 14. PMID: 37061008; PMCID: PMC10164119. DOI: 10.1016/j.taap.2023.116514

Ge Y, Bruno M, Nash MS, Coates NH, Chorley BN, Cave MC, Beier JI. Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction. Toxicol Sci. 2023 May 12;193(1):103-114. PMID: 36892438; PMCID: PMC10176240. DOI: 10.1093/toxsci/kfad024

Rai SN, Das S, Pan J, Mishra DC, Fu XA. Multigroup prediction in lung cancer patients and comparative controls using signature of volatile organic compounds in breath samples. PLoS One. 2022 Nov 30;17(11):e0277431. PMID: 36449484; PMCID: PMC9710764. DOI: 10.1371/journal.pone.0277431

Xie Z, Chen JY, Gao H, Keith RJ, Bhatnagar A, Lorkiewicz P, Srivastava S. Global Profiling of Urinary Mercapturic Acids Using Integrated Library-Guided Analysis. Environ Sci Technol. 2023 Jul 25;57(29):10563-10573. Epub 2023 Jul 11. PMID: 37432892. DOI: 10.1021/acs.est.2c09554

McGraw KE, Konkle SL, Riggs DW, Rai SN, DeJarnett N, Xie Z, Keith RJ, Oshunbade A, Hall ME, Shimbo D, Bhatnagar A. Exposure to Volatile Organic Compounds Is Associated with Hypertension in Black Adults: The Jackson Heart Study. Environ Res. 2023 Apr 15;223:115384. Epub 2023 Feb 14. PMID: 36796615; PMCID: PMC10134439. DOI: 10.1016/j.envres.2023.115384

Wahlang B, Gao H, Rai SN, Keith RJ, McClain CJ, Srivastava S, Cave MC, Bhatnagar A. Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race. Environ Res. 2023 Mar 15;221:115228.115228. Epub 2023 Jan 4.PMID: 36610539; PMCID: PMC9957966. DOI: 10.1016/j.envres.2023.115228

Walls KM, Hong KU, Hein DW. Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes. Arch Toxicol. 2023 Jun;97(6):1613-1626. Epub 2023 Apr 2. PMID: 37005939; PMCID: PMC10192068. DOI: 10.1007/s00204-023-03488-2

Hart JL, Yeager RA, Riggs DW, Fleischer D, Owolabi U, Walker KL, Bhatnagar A, Keith RJ. The Relationship between Perceptions and Objective Measures of Greenness. Int J Environ Res Public Health. 2022 Dec 6;19(23):16317. PMID: 36498387; PMCID: PMC9736070. DOI: 10.3390/ijerph192316317

Halder S, Xie Z, Nantz MH, Fu XA. Integration of a micropreconcentrator with solid-phase microextraction for analysis of trace volatile organic compounds by gas chromatography-mass spectrometry. J Chromatogr A. 2022 Jun 21;1673:463083. Epub 2022 Apr 22. PMID: 35508097; PMCID: PMC10210751. DOI: 10.1016/j.chroma.2022.463083

Agbonlahor O, DeJarnett N, Hart JL, Bhatnagar A, McLeish AC, Walker KL. Racial/Ethnic Discrimination and Cardiometabolic Diseases: A Systematic Review. J Racial Ethn Health Disparities. 2023 Mar 28:1–25. Epub ahead of print. PMID: 36976513; PMCID:PMC10044132. DOI: 10.1007/s40615-023-01561-1

Habil MR, Hein DW. Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity. Arch Toxicol. 2023 Jun;97(6):1765-1772. Epub 2023 Apr 25. PMID:37097310; PMCID: PMC10192036. DOI: 10.1007/s00204-023-03497-1

Wise JTF, Yin X, Ma X, Zhang X, Hein DW. Stable Isotope Tracing Reveals an Altered Fate of Glucose in N-Acetyltransferase 1 Knockout Breast Cancer Cells. Genes (Basel). 2023 Mar 31;14(4):843. PMID: 37107601; PMCID: PMC10137864.  DOI: 10.3390/genes14040843.

Bolatimi OE, Head KZ, Luo J, Gripshover TC, Lin Q, Adiele NV, Watson WH, Wilkerson C, Cai L, Cave MC, Young JL. Can Zinc Supplementation Attenuate High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease? Int J Mol Sci. 2023 Jan16;24(2):1763. PMID: 36675277; PMCID: PMC9864360. DOI: 10.3390/ijms24021763

Basner M, Smith MG, Jones CW, Ecker AJ, Howard K, Schneller V, Cordoza M, Kaizi-Lutu M, Park-Chavar S, Stahn AC, Dinges DF, Shou H, Mitchell JA, Bhatnagar A, Smith T, Smith AE, Stopforth CK, Yeager R, Keith RJ. Associations of bedroom PM2.5, CO2, temperature, humidity, and noise with sleep: An observational actigraphy study. Sleep Health. 2023 Jun;9(3):253-263. Epub 2023 Apr 18. PMID: 37076419; PMCID: PMC10293115. DOI: 10.1016/j.sleh.2023.02.010 


Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Cave MC, Klinge CM. Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease. Environ Res. 2023 Jan 1;216(Pt 3):114686. Epub 2022 Oct 28. PMID: 36341798; PMCID: PMC10120843. DOI: 10.1016/j.envres.2022.114686

Conklin DJ. How Irritating! Electronic Cigarettes Not "95% Safer" Than Combustible Cigarettes: Recent Mechanistic Insights Into Endothelial Dysfunction. Arterioscler Thromb Vasc Biol. 2022 Nov;42(11):1351-1354. Epub 2022 Oct 26. Erratum in: Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):e65. PMID: 36288291; PMCID: PMC10038145. DOI: 10.1161/ATVBAHA.122.318468

Mattingly DT, Agbonlahor O, Rai J, Hart JL, McLeish AC, Walker KL. Harm perceptions of secondhand e-cigarette aerosol among youth in the United States. Addict Behav. 2023 Feb;137:107535. Epub 2022 Oct 29. PMID: 36351320; PMCID: PMC10106102. DOI: 10.1016/j.addbeh.2022.107535

Kuehl PJ, McDonald JD, Weber DT, Khlystov A, Nystoriak MA, Conklin DJ. Composition of aerosols from thermal degradation of flavors used in ENDS and tobacco products. Inhal Toxicol. 2022;34(11-12):319-328. Epub 2022 Aug 1. PMID: 35913821; PMCID:PMC9830633. DOI: 10.1080/08958378.2022.2103602

McLeish AC, Smith T, Riggs DW, Hart JL, Walker KL, Keith RJ, Anderson L, Sithu I, Pinilla-Baquero J, Srivastava S, Bhatnagar A. Community-Based Evaluation of the Associations Between Well-Being and Cardiovascular Disease Risk. J Am Heart Assoc. 2022 Nov 15;11(22):e027095. Epub 2022 Nov 12. PMID: 36370026; PMCID: PMC9750082. DOI: 10.1161/JAHA.122.027095

Richardson A, Krivokhizhina T, Lorkiewicz P, D'Souza S, Bhatnagar A, Srivastava S, Conklin DJ. Effects of electronic cigarette flavorants on human platelet aggregation ex vivo. Toxicol Rep. 2022 Apr 8;9:814-820. PMID: 36518374; PMCID: PMC9742839.  DOI:10.1016/j.toxrep.2022.04.003

Gripshover TC, Wahlang B, Head KZ, Young JL, Luo J, Mustafa MT, Kirpich IA, Cave MC. The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease. Alcohol Clin Exp Res. 2023 Jan;47(1):60-75. Epub 2022 Dec 1. PMID: 36377258; PMCID: PMC9974797. DOI: 10.1111/acer.14976.

Shuck B, Hart JL, Walker KL, Rai J, Srivastava S, Srivastava S, Rai S, Bhatnagar A, Keith RJ. Workplace Culture and Biomarkers of Health Risk. Int J Environ Res Public Health. 2022 Sep 21;19(19):11920. DOI: 10.3390/ijerph191911920. PMID: 36231223; PMCID: PMC9565767.

Adhihetty P, Halder S, Jasinski J, Fu X, Nantz MH. 2022. Harnessing the cation-pi interactions of metalated gold monolayer-protected clusters to detect aromatic volatile organic compounds. Talanta. 253:123915. PMID:36155323; PMCID: PMC10210835. DOI: 10.1016/j.talanta.2022.123915.

Habil MR, Salazar-González RA, Doll MA, Hein DW. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes. Arch Toxicol. 2022 Dec;96(12):3257-3263. DOI: 10.1007/s00204-022-03381-4. Epub 2022 Sep 16. PMID: 36112171; PMCID: PMC9641657.

Habil MR, Salazar-González RA, Doll MA, Hein DW. Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. Arch Toxicol. 2022 Nov;96(11):2999-3012. DOI: 10.1007/s00204-022-03367-2. Epub 2022 Aug 30. PMID: 36040704.

Srivastava S. Effects of Environmental Polycyclic Aromatic Hydrocarbons Exposure and Pro-Inflammatory Activity on Type 2 Diabetes Mellitus in US Adults. Open J Air Pollut. 2022 Jun;11(2):29-46. DOI: 10.4236/ojap.2022.112003. Epub 2022 Jun 24. PMID: 35844632; PMCID: PMC9283753.

Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022 May;199:115015. DOI: 10.1016/j.bcp.2022.115015. Epub 2022 Apr 5. Erratum in: Biochem Pharmacol. 2022 Aug;202:115144. PMID: 35395240; PMCID: PMC9124454.

Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol. 2022 May;199:115012. DOI: 10.1016/j.bcp.2022.115012. Epub 2022 Apr 5. PMID:35393120; PMCID: PMC9050949.

Wise JTF, Salazar-González RA, Habil MR, Doll MA, Hein DW. Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells. Toxicol Appl Pharmacol. 2022 May 1;442:115993. DOI: 10.1016/j.taap.2022.115993. Epub 2022 Mar 27. PMID: 35353990; PMCID: PMC9112076.

Hein DW, Doll MA, Habil MR. Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens. Front Pharmacol. 2022 Feb 25;13:821133. DOI: 10.3389/fphar.2022.821133. PMID: 35281898; PMCID: PMC8914035.

Doll MA, Hein DW. 560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment. Front Pharmacol. 2022 Feb 22;13:820082. DOI: 10.3389/fphar.2022.820082. PMID: 35273499; PMCID: PMC8902414.

Lorkiewicz P, Keith R, Lynch J, Jin L, Theis W, Krivokhizhina T, Riggs D, Bhatnagar A, Srivastava S, Conklin DJ. Electronic Cigarette Solvents, JUUL E-Liquids, and Biomarkers of Exposure: In Vivo Evidence for Acrolein and Glycidol in E-Cig-Derived Aerosols. Chem Res Toxicol. 2022 Feb 21;35(2):283-292. DOI: 10.1021/acs.chemrestox.1c00328. Epub 2022 Jan 19. PMID: 35044764; PMCID: PMC8864610.

Young JL, Cave MC, Xu Q, Kong M, Xu J, Lin Q, Tan Y, Cai L. Whole life exposure to low dose cadmium alters diet-induced NAFLD. Toxicol Appl Pharmacol. 2022 Feb 1;436:115855. DOI: 10.1016/j.taap.2021.115855. Epub 2022 Jan 3. PMID: 34990729; PMCID: PMC8796138.

Cave MC, Pinkston CM, Rai SN, Wahlang B, Pavuk M, Head KZ, Carswell GK, Nelson GM, Klinge CM, Bell DA, Birnbaum LS, Chorley BN. Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey. Environ Health Perspect. 2022 Jan;130(1):17003. DOI: 10.1289/EHP9467. Epub 2022 Jan 6. PMID: 34989596; PMCID: PMC8734566.

Petriello MC, Mottaleb MA, Serio TC, Balyan B, Cave MC, Pavuk M, Birnbaum LS, Morris AJ. Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II). Environ Int. 2022 Jan;158:106907. DOI: 10.1016/j.envint.2021.106907. Epub 2021 Nov 8. PMID: 34763231; PMCID: PMC9131314.

Bhatnagar A. Cardiovascular Effects of Particulate Air Pollution. Annu Rev Med. 2022 Jan 27;73:393-406. DOI: 10.1146/annurev-med-042220-011549. Epub 2021 Oct 13. PMID: 34644154.

Wise JTF, Salazar-González RA, Walls KM, Doll MA, Habil MR, Hein DW. Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116095. DOI: 10.1016/j.taap.2022.116095. Epub 2022 Jun 2. PMID: 35662664; PMCID: PMC9382885.

Bhattacharyya A, Pal S, Mitra R, Rai S. Applications of Bayesian shrinkage prior models in clinical research with categorical responses. BMC Med Res Methodol. 2022 Apr 28;22(1):126. DOI: 10.1186/s12874-022-01560-6. PMID: 35484507; PMCID: PMC9046716.


Jin L, Conklin DJ. A novel evaluation of endothelial dysfunction ex vivo: "Teaching an Old Drug a New Trick". Physiol Rep. 2021 Nov;9(21):e15120. DOI: 10.14814/phy2.15120. PMID: 34755498; PMCID: PMC8579072.

Das S, Rai A, Merchant ML, Cave MC, Rai SN. A Comprehensive Survey of Statistical Approaches for Differential Expression Analysis in Single-Cell RNA Sequencing Studies. Genes (Basel). 2021 Dec 2;12(12):1947. DOI: 10.3390/genes12121947. PMID: 34946896; PMCID: PMC8701051.

Srivastava DK, George EO, Lu Z, Rai SN. Impact of unequal censoring and insufficient follow-up on comparing survival outcomes: Applications to clinical studies. Stat Methods Med Res. 2021 Sep;30(9):2057-2074. DOI: 10.1177/09622802211017592. Epub 2021 Jul 7. PMID: 34232837.

Linder MW, Egger ME, Van Meter T, Rai SN, Valdes R Jr, Hall MB, Wu X, Alghamdi N, Chesney JA. Longitudinal Relationship between Idylla Plasma ctBRAF V600 Mutation Detection and Tumor Burden in Patients with Metastatic Melanoma. Mol Diagn Ther. 2021 May;25(3):361-371. DOI: 10.1007/s40291-021-00528-4. Epub 2021 May 10. PMID: 33970440; PMCID: PMC8827645.

Tevis DS, Flores SR, Kenwood BM, Bhandari D, Jacob P 3rd, Liu J, Lorkiewicz PK, Conklin DJ, Hecht SS, Goniewicz ML, Blount BC, De Jesús VR. Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system. Int J Hyg Environ Health. 2021 Jun;235:113749. DOI: 10.1016/j.ijheh.2021.113749. Epub 2021 May 4. Erratum in: Int J Hyg Environ Health. 2022 Sep 7;:114030. PMID: 33962120; PMCID: PMC9019778.

Das S, Rai SN. SwarnSeq: An improved statistical approach for differential expression analysis of single-cell RNA-seq data. Genomics. 2021 May;113(3):1308-1324. DOI: 10.1016/j.ygeno.2021.02.014. Epub 2021 Mar 1. PMID: 33662531.

Riggs DW, Malovichko MV, Gao H, McGraw KE, Taylor BS, Krivokhizhina T, Rai SN, Keith RJ, Bhatnagar A, Srivastava S. Environmental exposure to volatile organic compounds is associated with endothelial injury. Toxicol Appl Pharmacol. 2022 Feb 15;437:115877. DOI: 10.1016/j.taap.2022.115877. Epub 2022 Jan 16. PMID: 35045333.

Zelko IN, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol. 2022 Feb;37(2):245-255. DOI: 10.1002/tox.23394. Epub 2021 Oct 30. PMID: 34717031; PMCID: PMC8724461.

Zelko IN, Dassanayaka S, Malovichko MV, Howard CM, Garrett LF, Uchida S, Brittian KR, Conklin DJ, Jones SP, Srivastava S. Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction. Toxicol Sci. 2021 Dec 28;185(1):64-76. DOI: 10.1093/toxsci/kfab125. PMID: 34718823; PMCID: PMC8714365.

Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko IN, Uchida S, Hill BG, Sutaria SR, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol. 2021 Nov 15;431:115742. DOI: 10.1016/j.taap.2021.115742. Epub 2021 Oct 5. PMID: 34624356; PMCID: PMC8647905.

Wahlang B, Gripshover TC, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. Associations Between Residential Exposure to Volatile Organic Compounds and Liver Injury Markers. Toxicol Sci. 2021 Dec 28;185(1):50-63.  DOI: 10.1093/toxsci/kfab119. PMID: 34668566; PMCID: PMC8714366.

McGraw KE, Riggs DW, Rai S, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy S, Taylor KC, Conklin DJ, DeFilippis AP, Srivastava S, Bhatnagar A. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 2021;196:110903. DOI: 10.1016/j.envres.2021.110903.

Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin DJ. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicol Appl Pharmacol 2021;426:115647. DOI: 10.1016/j.taap.2021.115647.

SR Sutaria and MH Nantz.  A Convenient Preparation of Muconaldehyde Using a One-Pot Acid-to-Aldehyde Reduction Protocol.  Organic Preparations and Procedures International 2021, 53In PressDOI:10.1080/00304948.2021.1953889.

Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant M, Shi H, Jin J, Cave MC. Effect of Epidermal Growth Factor Treatment and Polychlorinated Biphenyl Exposure in a Dietary-Exposure Mouse Model of Steatohepatitis. Environ Health Perspect 2021;129(3):37010. DOI: 10.1289/EHP8222.

Haberzettl P, Jin L, Riggs DW, Zhao J, O'Toole TE, Conklin DJ. Fine particulate matter air pollution and aortic perivascular adipose tissue: Oxidative stress, leptin, and vascular dysfunction. Physiol Rep 2021;9(15):e14980. DOI: 10.14814/phy2.14980.

Jin L, Lynch J, Richardson A, Lorkiewicz P, Srivastava S, Theis W, Shirk G, Hand A, Bhatnagar A, Srivastava S, Conklin DJ. Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: role of acetaldehyde and formaldehyde. Am J Physiol Heart Circ Physiol 2021;320(4):H1510-H1525. DOI: 10.1152/ajpheart.00878.2020.

Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis AP, Rai SN, Bhatnagar A. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol 2021;320(3):H1102-h1111. (In eng). DOI: 10.1152/ajpheart.00689.2020.

Pfeiffer JA, Hart JL, Wood LA, Bhatnagar A, Keith RJ, Yeager RA, Smith T, Tomlinson M, Gilkey D, Kerstiens S, Gao H, Srivastava S, Walker KL. The importance of urban planning: Views of greenness and open space is reversely associated with self-reported views and depressive symptoms. Popul Med 2021;3. DOI: 10.18332/popmed/139173.

Wood LA, Tomlinson MM, Pfeiffer JA, Walker KL, Keith RJ, Smith T, Yeager RA, Bhatnagar A, Kerstiens S, Gilkey D, Gao H, Srivastava S, Hart JL. Time spent outdoors and sleep normality: A preliminary investigation. Population Medicine 2021;3(March):1-6. (journal article). DOI: 10.18332/popmed/132119.

Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development. Int J Mol Sci 2021;22(10). DOI: 10.3390/ijms22105093.

Bhattacharyya A, Seth A, Srivast N, Imeokparia M, Rai S. Coronavirus (COVID-19): A Systematic Review and Meta-analysis to Evaluate the Significance of Demographics and Comorbidities. Res Sq 2021. DOI: 10.21203/rs.3.rs-144684/v1.

Leggett CS, Doll MA, States JC, Hein DW. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol 2021;95(1):311-319. DOI: 10.1007/s00204-020-02901-4.


Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MHEM, Zafar N, Krishnasamy S, DeFilippis A, Turner J, Rai SN, Bhatnagar A. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 2020;707:135435. DOI: 10.1016/j.scitotenv.2019.135435.

Xie Z, Ramakrishnam Raju MV, Adhihetty PK, Fu XA, Nantz MH. Effect of Thiol Molecular Structure on the Sensitivity of Gold Nanoparticle-Based Chemiresistors toward Carbonyl Compounds. Sensors (Basel) 2020;20(24). DOI: 10.3390/s20247024.

Werder EJ, Beier JI, Sandler DP, Falkner KC, Gripshover T, Wahlang B, Engel LS, Cave MC. Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents. Food Chem Toxicol 2020;139:111242. DOI: 10.1016/j.fct.2020.111242.

Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner KC, Prough RA, Cave MC, Beier JI. Hepatic Injury Caused by the Environmental Toxicant Vinyl Chloride is Sex-Dependent in Mice. Toxicol Sci 2020;174(1):79-91. DOI: 10.1093/toxsci/kfz236.

Wahlang B, Appana S, Falkner KC, McClain CJ, Brock G, Cave MC. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004. Environ Sci Pollut Res Int 2020;27(6):6476-6487. DOI: 10.1007/s11356-019-07066-x.

Sibakoti TR, Jasinski JB, Nantz MH, Zamborini FP. Iodine activation: a general method for catalytic enhancement of thiolate monolayer-protected metal clusters. Nanoscale 2020;12(22):12027-12037. DOI: 10.1039/d0nr00844c.

Riggs DW, Zafar N, Krishnasamy S, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 2020;180:108890. (In eng). DOI: 10.1016/j.envres.2019.108890.

Rai SN, Qian C, Pan J, McClain M, Eichenberger MR, McClain CJ, Galandiuk S. Statistical Issues and Group Classification in Plasma MicroRNA Studies With Data Application. Evol Bioinform Online 2020;16:1176934320913338. (In eng). DOI: 10.1177/1176934320913338.

Mohamed TMA, Conklin DJ. Emerging technology and platforms for cardiotoxicity testing. Toxicol Appl Pharmacol 2020;408:115262. (In eng). DOI: 10.1016/j.taap.2020.115262.

Lynch J, Jin L, Richardson A, Conklin DJ. Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes? Curr Hypertens Rep 2020;22(9):73. (In eng). DOI: 10.1007/s11906-020-01085-7.

Konkle SL, Zierold KM, Taylor KC, Riggs DW, Bhatnagar A. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 2020;182:108991. (In eng). DOI: 10.1016/j.envres.2019.108991.

Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res 2020;22(2):264-272. (In eng). DOI: 10.1093/ntr/ntz021.

Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 2020;29:1247-1263. DOI: 10.1007/s00044-020-02581-w.

Hong KU, Doll MA, Lykoudi A, et al. Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2. Toxicol Rep 2020;7:1319-1330. (In eng). DOI: 10.1016/j.toxrep.2020.09.011.

Habil MR, Doll MA, Hein DW. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes. Pharmacogenet Genomics 2020;30(3):61-65. DOI: 10.1097/FPC.0000000000000394.

Donde H, Ghare S, Joshi-Barve S, et al. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol 2020;9(4):569-585. DOI: 10.1016/j.jcmgh.2019.10.005.

Cave MC. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology 2020;72(5):1518-1521. DOI: 10.1002/hep.31549.


Wahlang BH, J.E.; Jin, J.; Falkner, K.C.; Cave, M.C. Polychlorinated biphenyls and nonalcoholic fatty liver disease. Current Opinion in Toxicology 2019;14(2019):21-28. DOI: 10.1016/j.cotox.2019.06.001.

Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 2019;129:64-76. DOI: 10.1016/j.fct.2019.04.007.

Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. Mechanisms of Environmental Contributions to Fatty Liver Disease. Curr Environ Health Rep 2019;6(3):80-94. DOI: 10.1007/s40572-019-00232-w.

Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol 2019;316(1):G115-g122. (In eng). DOI: 10.1152/ajpgi.00209.2018.

Srivastava S, Merchant M, Rai A, Rai SN. Interactive Web Tool for Standardizing Proteomics Workflow for Liquid Chromatography-Mass Spectrometry Data. J Proteomics Bioinform 2019;12(4):85-88. (In eng).https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059686/

Srivastava S, Merchant M, Rai A, Rai SN. Standardizing Proteomics Workflow for Liquid Chromatography-Mass Spectrometry: Technical and Statistical Considerations. J Proteomics Bioinform 2019;12(3):48-55. (In eng). DOI: 10.35248/0974-276x.19.12.496.

Sibakoti TR, Stinger CR, Adhihetty PK, Zamborini FP, Nantz MH. Tunable Aminooxy-Functionalized Monolayer-Protected Gold Clusters for Non-Polar or Aqueous Oximation Reactions. Part Part Syst Charact 2019;36(7). DOI: 10.1002/ppsc.201900093.

Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam SP, Chari ST, Cave MC. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 2019;363:22-33. (In eng). DOI: 10.1016/j.taap.2018.10.011.

Shi H, Hardesty JE, Jin J, Head KZ, Falkner KC, Cave MC, Prough RA. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica 2019;49(12):1414-1422. (In eng). DOI: 10.1080/00498254.2019.1566582.

Salazar-González RA, Zhang X, Doll MA, Lykoudi A, Hein DW. Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline. Arch Toxicol 2019;93(8):2237-2246. (In eng). DOI: 10.1007/s00204-019-02516-4.

Lorkiewicz P, Riggs DW, Keith RJ, Conklin DJ, Xie Z, Sutaria S, Lynch B, Srivastava S, Bhatnagar A. Comparison of Urinary Biomarkers of Exposure in Humans Using Electronic Cigarettes, Combustible Cigarettes, and Smokeless Tobacco. Nicotine Tob Res 2019;21(9):1228-1238. (In eng). DOI: 10.1093/ntr/nty089.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey DW, Merchant ML, Watson CT, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. J Proteome Res 2019;18(4):1582-1594. DOI: 10.1021/acs.jproteome.8b00886.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant M, Watson C, Prough RA, Cave MC. Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis. Cell Signal 2019;53:132-139. DOI: 10.1016/j.cellsig.2018.10.004.

Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol 2019;316(4):H801-H827. DOI: 10.1152/ajpheart.00591.2018.

Conklin DJ, Guo Y, Nystoriak MA, Jagatheesan G, Obal D, Kilfoil PJ, Hoetker JD, Guo L, Bolli R, Bhatnagar A. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2019;316(4):H889-H899. DOI: 10.1152/ajpheart.00106.2018.

Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res 2019;124(4):e6-e19. DOI: 10.1161/CIRCRESAHA.118.313028.

Bhattacharyya A, Rai SN. Adaptive Signature Design- review of the biomarker guided adaptive phase -III controlled design. Contemp Clin Trials Commun 2019;15:100378. DOI: 10.1016/j.conctc.2019.100378.

Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 2019;247:1055-1063. DOI: 10.1016/j.envpol.2019.01.064.

Abplanalp WT, Wickramasinghe NS, Sithu SD, Conklin DJ, Xie Z, Bhatnagar A, Srivastava S, O'Toole TE. Benzene Exposure Induces Insulin Resistance in Mice. Toxicol Sci 2019;167(2):426-437. DOI: 10.1093/toxsci/kfy252.


Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. Association Between Residential Greenness and Cardiovascular Disease Risk. J Am Heart Assoc 2018;7(24):e009117. DOI: 10.1161/JAHA.118.009117.

Xie Z, Ramakrishnam Raju MV, Stewart AC, Nantz MH, Fu XA. Imparting sensitivity and selectivity to a gold nanoparticle chemiresistor through thiol monolayer functionalization for sensing acetone. RSC Adv 2018;8(62):35618-35624. DOI: 10.1039/c8ra06137h.

Xie Z, Lorkiewicz P, Riggs DW, Bhatnagar A, Srivastava S. Comprehensive, robust, and sensitive UPLC-MS/MS analysis of free biogenic monoamines and their metabolites in urine. J Chromatogr B Analyt Technol Biomed Life Sci 2018;1099:83-91. DOI: 10.1016/j.jchromb.2018.09.012.

Riggs DW, Yeager RA, Bhatnagar A. Defining the Human Envirome: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease. Circ Res 2018;122(9):1259-1275. (In eng). DOI: 10.1161/circresaha.117.311230.

Liang Y, Lang AL, Zhang J, Chen J, Wang K, Chen L, Beier JI, Qian Y, Cai L. Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling. Chem Res Toxicol 2018;31(6):482-493. (In eng). DOI: 10.1021/acs.chemrestox.8b00043.

Li M, Li Q, Nantz MH, Fu XA. Analysis of Carbonyl Compounds in Ambient Air by a Microreactor Approach. ACS Omega 2018;3(6):6764-6769. DOI: 10.1021/acsomega.8b00503.

Lang AL, Chen L, Poff GD, Ding WX, Barnett RA, Arteel GE, Beier JI. Vinyl chloride dysregulates metabolic homeostasis and enhances diet-induced liver injury in mice. Hepatol Commun 2018;2(3):270-284. (In eng). DOI: 10.1002/hep4.1151.

Lang AL, Beier JI. Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk. Biol Chem 2018;399(11):1237-1248. (In eng). DOI: 10.1515/hsz-2017-0324.

Hein DW, Zhang X, Doll MA. Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation. Toxicol Lett 2018;283:100-105. (In eng). DOI: 10.1016/j.toxlet.2017.11.028.

Hein DW, Fakis G, Boukouvala S. Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review. Pharmacogenet Genomics 2018;28(10):238-244. (In eng). DOI: 10.1097/fpc.0000000000000350.

Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals. Toxicol Sci 2018;162(2):622-634. DOI: 10.1093/toxsci/kfy004.

Conklin DJ, Ogunwale MA, Chen Y, Theis WS, Nantz MH, Fu XA, Chen LC, Riggs DW, Lorkiewicz P, Bhatnagar A, Srivastava S. Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Sci Technol 2018;52(11):1219-1232. DOI: 10.1080/02786826.2018.1500013.

Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures. Toxicol Sci 2018;164(1):39-49. DOI: 10.1093/toxsci/kfy076.