UofL Superfund Research Center Publications

2022

In Press

Richardson A, Krivokhizhina T, Lorkiewicz P, D’Souza S, Bhatnagar A, Srivastava S, Conklin DJ.  Effects of Electronic Cigarette Flavorants on Human Platelet Aggregation Ex Vivo.  Toxicol Reports. 2022.  In press DOI:10.1016/j.toxrep.2022.04.003


2021

Riggs DW, Malovichko MV, Gao H, McGraw KE, Taylor BS, Krivokhizhina T, Rai SN, Keith RJ, Bhatnagar A, Srivastava S. Environmental exposure to volatile organic compounds is associated with endothelial injury. Toxicol Appl Pharmacol. 2022 Feb 15;437:115877. DOI: 10.1016/j.taap.2022.115877. Epub 2022 Jan 16. PMID: 35045333.

Zelko IN, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol. 2022 Feb;37(2):245-255. DOI: 10.1002/tox.23394. Epub 2021 Oct 30. PMID: 34717031; PMCID: PMC8724461.

Zelko IN, Dassanayaka S, Malovichko MV, Howard CM, Garrett LF, Uchida S, Brittian KR, Conklin DJ, Jones SP, Srivastava S. Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction. Toxicol Sci. 2021 Dec 28;185(1):64-76. DOI: 10.1093/toxsci/kfab125. PMID: 34718823; PMCID: PMC8714365.

Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko IN, Uchida S, Hill BG, Sutaria SR, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol. 2021 Nov 15;431:115742. DOI: 10.1016/j.taap.2021.115742. Epub 2021 Oct 5. PMID: 34624356; PMCID: PMC8647905.

Wahlang B, Gripshover TC, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. Associations Between Residential Exposure to Volatile Organic Compounds and Liver Injury Markers. Toxicol Sci. 2021 Dec 28;185(1):50-63.  DOI: 10.1093/toxsci/kfab119. PMID: 34668566; PMCID: PMC8714366.

McGraw KE, Riggs DW, Rai S, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy S, Taylor KC, Conklin DJ, DeFilippis AP, Srivastava S, Bhatnagar A. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 2021;196:110903. DOI: 10.1016/j.envres.2021.110903.

Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin DJ. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicol Appl Pharmacol 2021;426:115647. DOI: 10.1016/j.taap.2021.115647.

SR Sutaria and MH Nantz.  A Convenient Preparation of Muconaldehyde Using a One-Pot Acid-to-Aldehyde Reduction Protocol.  Organic Preparations and Procedures International 2021, 53In PressDOI:10.1080/00304948.2021.1953889.

Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant M, Shi H, Jin J, Cave MC. Effect of Epidermal Growth Factor Treatment and Polychlorinated Biphenyl Exposure in a Dietary-Exposure Mouse Model of Steatohepatitis. Environ Health Perspect 2021;129(3):37010. DOI: 10.1289/EHP8222.

Haberzettl P, Jin L, Riggs DW, Zhao J, O'Toole TE, Conklin DJ. Fine particulate matter air pollution and aortic perivascular adipose tissue: Oxidative stress, leptin, and vascular dysfunction. Physiol Rep 2021;9(15):e14980. DOI: 10.14814/phy2.14980.

Jin L, Lynch J, Richardson A, Lorkiewicz P, Srivastava S, Theis W, Shirk G, Hand A, Bhatnagar A, Srivastava S, Conklin DJ. Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: role of acetaldehyde and formaldehyde. Am J Physiol Heart Circ Physiol 2021;320(4):H1510-H1525. DOI: 10.1152/ajpheart.00878.2020.

Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis AP, Rai SN, Bhatnagar A. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol 2021;320(3):H1102-h1111. (In eng). DOI: 10.1152/ajpheart.00689.2020.

Pfeiffer JA, Hart JL, Wood LA, Bhatnagar A, Keith RJ, Yeager RA, Smith T, Tomlinson M, Gilkey D, Kerstiens S, Gao H, Srivastava S, Walker KL. The importance of urban planning: Views of greenness and open space is reversely associated with self-reported views and depressive symptoms. Popul Med 2021;3. DOI: 10.18332/popmed/139173.

Wood LA, Tomlinson MM, Pfeiffer JA, Walker KL, Keith RJ, Smith T, Yeager RA, Bhatnagar A, Kerstiens S, Gilkey D, Gao H, Srivastava S, Hart JL. Time spent outdoors and sleep normality: A preliminary investigation. Population Medicine 2021;3(March):1-6. (journal article). DOI: 10.18332/popmed/132119.

Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development. Int J Mol Sci 2021;22(10). DOI: 10.3390/ijms22105093.

Bhattacharyya A, Seth A, Srivast N, Imeokparia M, Rai S. Coronavirus (COVID-19): A Systematic Review and Meta-analysis to Evaluate the Significance of Demographics and Comorbidities. Res Sq 2021. DOI: 10.21203/rs.3.rs-144684/v1.

Leggett CS, Doll MA, States JC, Hein DW. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol 2021;95(1):311-319. DOI: 10.1007/s00204-020-02901-4.


2020

Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MHEM, Zafar N, Krishnasamy S, DeFilippis A, Turner J, Rai SN, Bhatnagar A. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 2020;707:135435. DOI: 10.1016/j.scitotenv.2019.135435.

Xie Z, Ramakrishnam Raju MV, Adhihetty PK, Fu XA, Nantz MH. Effect of Thiol Molecular Structure on the Sensitivity of Gold Nanoparticle-Based Chemiresistors toward Carbonyl Compounds. Sensors (Basel) 2020;20(24). DOI: 10.3390/s20247024.

Werder EJ, Beier JI, Sandler DP, Falkner KC, Gripshover T, Wahlang B, Engel LS, Cave MC. Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents. Food Chem Toxicol 2020;139:111242. DOI: 10.1016/j.fct.2020.111242.

Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner KC, Prough RA, Cave MC, Beier JI. Hepatic Injury Caused by the Environmental Toxicant Vinyl Chloride is Sex-Dependent in Mice. Toxicol Sci 2020;174(1):79-91. DOI: 10.1093/toxsci/kfz236.

Wahlang B, Appana S, Falkner KC, McClain CJ, Brock G, Cave MC. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004. Environ Sci Pollut Res Int 2020;27(6):6476-6487. DOI: 10.1007/s11356-019-07066-x.

Sibakoti TR, Jasinski JB, Nantz MH, Zamborini FP. Iodine activation: a general method for catalytic enhancement of thiolate monolayer-protected metal clusters. Nanoscale 2020;12(22):12027-12037. DOI: 10.1039/d0nr00844c.

Riggs DW, Zafar N, Krishnasamy S, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 2020;180:108890. (In eng). DOI: 10.1016/j.envres.2019.108890.

Rai SN, Qian C, Pan J, McClain M, Eichenberger MR, McClain CJ, Galandiuk S. Statistical Issues and Group Classification in Plasma MicroRNA Studies With Data Application. Evol Bioinform Online 2020;16:1176934320913338. (In eng). DOI: 10.1177/1176934320913338.

Mohamed TMA, Conklin DJ. Emerging technology and platforms for cardiotoxicity testing. Toxicol Appl Pharmacol 2020;408:115262. (In eng). DOI: 10.1016/j.taap.2020.115262.

Lynch J, Jin L, Richardson A, Conklin DJ. Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes? Curr Hypertens Rep 2020;22(9):73. (In eng). DOI: 10.1007/s11906-020-01085-7.

Konkle SL, Zierold KM, Taylor KC, Riggs DW, Bhatnagar A. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 2020;182:108991. (In eng). DOI: 10.1016/j.envres.2019.108991.

Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res 2020;22(2):264-272. (In eng). DOI: 10.1093/ntr/ntz021.

Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 2020;29:1247-1263. DOI: 10.1007/s00044-020-02581-w.

Hong KU, Doll MA, Lykoudi A, et al. Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2. Toxicol Rep 2020;7:1319-1330. (In eng). DOI: 10.1016/j.toxrep.2020.09.011.

Habil MR, Doll MA, Hein DW. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes. Pharmacogenet Genomics 2020;30(3):61-65. DOI: 10.1097/FPC.0000000000000394.

Donde H, Ghare S, Joshi-Barve S, et al. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol 2020;9(4):569-585. DOI: 10.1016/j.jcmgh.2019.10.005.

Cave MC. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology 2020;72(5):1518-1521. DOI: 10.1002/hep.31549.


2019

Wahlang BH, J.E.; Jin, J.; Falkner, K.C.; Cave, M.C. Polychlorinated biphenyls and nonalcoholic fatty liver disease. Current Opinion in Toxicology 2019;14(2019):21-28. DOI: 10.1016/j.cotox.2019.06.001.

Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 2019;129:64-76. DOI: 10.1016/j.fct.2019.04.007.

Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. Mechanisms of Environmental Contributions to Fatty Liver Disease. Curr Environ Health Rep 2019;6(3):80-94. DOI: 10.1007/s40572-019-00232-w.

Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol 2019;316(1):G115-g122. (In eng). DOI: 10.1152/ajpgi.00209.2018.

Srivastava S, Merchant M, Rai A, Rai SN. Interactive Web Tool for Standardizing Proteomics Workflow for Liquid Chromatography-Mass Spectrometry Data. J Proteomics Bioinform 2019;12(4):85-88. (In eng).https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059686/

Srivastava S, Merchant M, Rai A, Rai SN. Standardizing Proteomics Workflow for Liquid Chromatography-Mass Spectrometry: Technical and Statistical Considerations. J Proteomics Bioinform 2019;12(3):48-55. (In eng). DOI: 10.35248/0974-276x.19.12.496.

Sibakoti TR, Stinger CR, Adhihetty PK, Zamborini FP, Nantz MH. Tunable Aminooxy-Functionalized Monolayer-Protected Gold Clusters for Non-Polar or Aqueous Oximation Reactions. Part Part Syst Charact 2019;36(7). DOI: 10.1002/ppsc.201900093.

Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam SP, Chari ST, Cave MC. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 2019;363:22-33. (In eng). DOI: 10.1016/j.taap.2018.10.011.

Shi H, Hardesty JE, Jin J, Head KZ, Falkner KC, Cave MC, Prough RA. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica 2019;49(12):1414-1422. (In eng). DOI: 10.1080/00498254.2019.1566582.

Salazar-González RA, Zhang X, Doll MA, Lykoudi A, Hein DW. Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline. Arch Toxicol 2019;93(8):2237-2246. (In eng). DOI: 10.1007/s00204-019-02516-4.

Lorkiewicz P, Riggs DW, Keith RJ, Conklin DJ, Xie Z, Sutaria S, Lynch B, Srivastava S, Bhatnagar A. Comparison of Urinary Biomarkers of Exposure in Humans Using Electronic Cigarettes, Combustible Cigarettes, and Smokeless Tobacco. Nicotine Tob Res 2019;21(9):1228-1238. (In eng). DOI: 10.1093/ntr/nty089.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey DW, Merchant ML, Watson CT, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. J Proteome Res 2019;18(4):1582-1594. DOI: 10.1021/acs.jproteome.8b00886.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant M, Watson C, Prough RA, Cave MC. Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis. Cell Signal 2019;53:132-139. DOI: 10.1016/j.cellsig.2018.10.004.

Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol 2019;316(4):H801-H827. DOI: 10.1152/ajpheart.00591.2018.

Conklin DJ, Guo Y, Nystoriak MA, Jagatheesan G, Obal D, Kilfoil PJ, Hoetker JD, Guo L, Bolli R, Bhatnagar A. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2019;316(4):H889-H899. DOI: 10.1152/ajpheart.00106.2018.

Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res 2019;124(4):e6-e19. DOI: 10.1161/CIRCRESAHA.118.313028.

Bhattacharyya A, Rai SN. Adaptive Signature Design- review of the biomarker guided adaptive phase -III controlled design. Contemp Clin Trials Commun 2019;15:100378. DOI: 10.1016/j.conctc.2019.100378.

Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 2019;247:1055-1063. DOI: 10.1016/j.envpol.2019.01.064.

Abplanalp WT, Wickramasinghe NS, Sithu SD, Conklin DJ, Xie Z, Bhatnagar A, Srivastava S, O'Toole TE. Benzene Exposure Induces Insulin Resistance in Mice. Toxicol Sci 2019;167(2):426-437. DOI: 10.1093/toxsci/kfy252.


2018

Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. Association Between Residential Greenness and Cardiovascular Disease Risk. J Am Heart Assoc 2018;7(24):e009117. DOI: 10.1161/JAHA.118.009117.

Xie Z, Ramakrishnam Raju MV, Stewart AC, Nantz MH, Fu XA. Imparting sensitivity and selectivity to a gold nanoparticle chemiresistor through thiol monolayer functionalization for sensing acetone. RSC Adv 2018;8(62):35618-35624. DOI: 10.1039/c8ra06137h.

Xie Z, Lorkiewicz P, Riggs DW, Bhatnagar A, Srivastava S. Comprehensive, robust, and sensitive UPLC-MS/MS analysis of free biogenic monoamines and their metabolites in urine. J Chromatogr B Analyt Technol Biomed Life Sci 2018;1099:83-91. DOI: 10.1016/j.jchromb.2018.09.012.

Riggs DW, Yeager RA, Bhatnagar A. Defining the Human Envirome: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease. Circ Res 2018;122(9):1259-1275. (In eng). DOI: 10.1161/circresaha.117.311230.

Liang Y, Lang AL, Zhang J, Chen J, Wang K, Chen L, Beier JI, Qian Y, Cai L. Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling. Chem Res Toxicol 2018;31(6):482-493. (In eng). DOI: 10.1021/acs.chemrestox.8b00043.

Li M, Li Q, Nantz MH, Fu XA. Analysis of Carbonyl Compounds in Ambient Air by a Microreactor Approach. ACS Omega 2018;3(6):6764-6769. DOI: 10.1021/acsomega.8b00503.

Lang AL, Chen L, Poff GD, Ding WX, Barnett RA, Arteel GE, Beier JI. Vinyl chloride dysregulates metabolic homeostasis and enhances diet-induced liver injury in mice. Hepatol Commun 2018;2(3):270-284. (In eng). DOI: 10.1002/hep4.1151.

Lang AL, Beier JI. Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk. Biol Chem 2018;399(11):1237-1248. (In eng). DOI: 10.1515/hsz-2017-0324.

Hein DW, Zhang X, Doll MA. Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation. Toxicol Lett 2018;283:100-105. (In eng). DOI: 10.1016/j.toxlet.2017.11.028.

Hein DW, Fakis G, Boukouvala S. Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review. Pharmacogenet Genomics 2018;28(10):238-244. (In eng). DOI: 10.1097/fpc.0000000000000350.

Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals. Toxicol Sci 2018;162(2):622-634. DOI: 10.1093/toxsci/kfy004.

Conklin DJ, Ogunwale MA, Chen Y, Theis WS, Nantz MH, Fu XA, Chen LC, Riggs DW, Lorkiewicz P, Bhatnagar A, Srivastava S. Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Sci Technol 2018;52(11):1219-1232. DOI: 10.1080/02786826.2018.1500013.

Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. Liver Disease in a Residential Cohort With Elevated Polychlorinated Biphenyl Exposures. Toxicol Sci 2018;164(1):39-49. DOI: 10.1093/toxsci/kfy076.