Current News and Events

Two new publications by UofL SRC Investigators:

Pre-clinical studies show that chronic benzene inhalation induces endothelial injury and augments platelet activation in mice, as assessed by a panel of blood endothelial cell and platelet microparticles and platelet-leukocyte adduct formations: 

  • Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko IN, Uchida S, Sutaria SA, Nantz MH, Bhatnagar A, Conklin DJ, O’Toole TE and Srivastava S. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice.   Toxicol. Appl. Pharmacol.   (in press).  DOI: 10.1016/j.taap.2021.115742
ULSRC investigators demonstrate that chronic inhaled benzene exposure exacerbates pressure overload (by transverse aortic constriction, TAC)-induced cardiac dysfunction in mice.  The TAC/Benzene-induced cardiac dysfunction is accompanied by endothelial activation and enhanced recruitment of granulocytes in the heart and differential regulation of genes involved in neutrophil degranulation, inflammatory signaling, and stress response:

  • Zelko IN, Dassanayaka S, Malovichko MV, Howard CM, Garrett LF, Uchida S, Brittian KR, Conklin DJ, Jones SP and Srivastava S. Chronic benzene exposure aggravates pressure overload-induced cardiac dysfunction.  Toxicol Sci. (in press) DOI: 10.1101/2021.08.31.458367


 

UofL Superfund Project 3 develops portable GC/MS to monitor VOCs in indoor and outdoor air

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