The goal of the Center is to evaluate the health impact of volatile organic chemicals (VOCs; e.g. benzene, toluene, trichloroethylene, vinyl chloride, 1,3 butadiene, acrolein etc.) that are present in the environment and to understand how exposure to chemicals could contribute to the risk and development of obesity, diabetes, and heart disease, which despite recent medical advances, remain the leading causes of death worldwide. Center investigators will conduct mode-of-action research to unravel critical pathways of toxicity and to identify toxicological end-points (cardiometabolic changes) of chemicals (VOCs) found at Superfund and related sites. In addition, Center investigators will create new technologies for detecting VOCs at low environmental levels to enable future exposure assessment activities. Senior Center members will educate and train junior investigators, graduate students, and post-doctoral Fellows in the field of environmental science. They will promote relevant community awareness and participation to enhance mutual bidirectional understanding of exposure risk and the health effects of exposure. The findings and discoveries of the Center will be transferred to affected communities, end users in public and private sectors, and other stakeholders.