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Dongfeng Wu, PhD

 

Dongfeng WuBioinformatics and Biostatistics

Associate Professor
Room No. 122, 485 E. Gray St.
Louisville, KY 40202
Phone: 502-852-1888
Fax: 502-852-3294
dongfeng.wu@louisville.edu

Education:
B.S. in Probability and Statistics, Peking University, P.R. China. 1986-1990.
M.S. in Probability and Statistics, Peking University, P.R. China. 1990-1993.
M.S. in Computer Science, University of California, Santa Barbara. 1997-1999.
Ph.D. in Statistics, University of California, Santa Barbara. 1995-1999.

Positions and Employment:
01/2000-08/2001. Research Associate, Department of Biostat., Univ. of Texas, M.D. Anderson
Cancer Center. Houston, TX.

08/2001-08/2007. Assistant Professor, Department of Math. & Stat., Mississippi State Univ.
Tenured and promoted to associate professor in 05/2007.

09/2007-Present. Associate Professor, Dept. of Bioinformatics and Biostatistics, School of
Public Health and Information Sciences, Univ. of Louisville. Tenured 2014.

Teaching at University of Louisville (2007-Present):
2015-2016:
Fall: PHST683-Survival Analysis; PHST680-Biostat. Method I (joint w/ Dr. Rai);
Spring: PHST662-Math. Stat;
Summer:PHST671-Special Topics in Biostat: Probability Model and Stat. Inference in Cancer
Screening.


2014-2015:
Fall: PHST683-Survival Analysis; PHST680-Biostat. Method I (joint w/ Dr. Rai);
Spring: PHST724-Advanced Clinical Trials (joint with Dr. Rai); PHST662-Math. Stat.

2013-2014:
Fall: PHST683-Survival Analysis;
Spring: PHST662-Math. Stat;
Summer: PHST671-Special Topics in Biostat: Probability Model and Stat. Inference in Cancer
Screening.

2012-2013:
Fall: PHST661-Probability;
Spring: PHST691-Bayesian Inference; PHST662-Math. Stat;
Summer: PHST671-Special Topics in Biostat: Probability Model and Stat. Inference in Cancer
Screening.

2011-2012:
PHST661-Probability; PHST691-Bayesian Inference.

2010-2011:
PHST661-Probability; PHST662-Math. Stat; PHST780-Nonparametric Stat.

2009-2010:
PHST661-Probability; PHST662-Math. Stat.

2008-2009:
PHST661-Probability; PHST691-Bayesian Inference; PHST662-Math. Stat.

2007-2008:
PHST661-Probability; PHST 691-Bayesian Inference.

Students Mentored/Mentoring at University of Louisville (2007-Present):
Ruiqi Liu, PhD candidacy. Cancer screening modeling and methods. Expected 2017.

Jiying Ling, MS. Evaluating nutrition and physical activity trend in middle school students at four
underserved regions in Kentucky. May 2013.

Sarah K Kendrick, MS. Simulation study for the lead time in cancer screening when human
lifetime is a competing risk. May 2013.

Vikranth Shetty, MS. (w/ Dr. Rai). Statistical methods to find miRNA related to aging in mice.
August 2012.

Dianhong Luo, MS. The trend and disparities in the diagnosis of breast cancer by mobile
mammography at a comprehensive cancer center. August 2012.

Xinyuan Duan, MS. Evaluating Fiberoptic Intubation Simulator Training in Reaching Proficiency
of Skills. December 2010.

Chengxin Li, MS. The statistical effects on measuring myocyte with different image zoom rates.
August 2010.

Yinlu Chen, MS. Breast Cancer Screening Model – Application to the Canadian Study. August
2009.

Research:
My main research area is in probability modeling and statistical inferences in periodic cancer
screening. Besides that, I am interested in Bayesian inference, statistical decision theory, time
series, smoothing spline, wavelet regression and all kinds of statistical problems in medical
research.

Selected Publications:
Kim S, Jang H, Wu D, Abrams J. (2015) A Bayesian Nonlinear Mixed-effects Disease
Progression Model. Journal of Biometrics and Biostatistics. 6:271. doi:10.4172/2155-
6180.1000271.

Kendrick SK, Rai SN and Wu D. (2015). Simulation study for the sensitivity and mean sojourn
time specific lead time in cancer screening when human lifetime is a competing risk. Journal of
Biometrics and Biostatistics. 6:247. DOI:10.4172/2155-6180.1000247.

Wu D, Kafadar K, and Rosner GL. (2014). Inference of long term effects and over-diagnosis in
periodic cancer screening. Statistica Sinica. 2014; 24: 815-831.

Chen Y, Erwin D, and Wu D. (2014). Over-diagnosis in lung cancer screening using the MSKCLCSP
data. Journal of Biometrics and Biostatistics. 5:201. DOI: 10.4172/2155-6180.1000201.

Jang H, Kim S, and Wu D. (2013). Bayesian lead time calculation for the Johns Hopkins lung
project data. Journal of Epidemiology and Global Health. Vol. 3, 157-173.

Kim S, and Wu D. (2012). Estimation of sensitivity depending on sojourn time and time spent in
preclinical state. Statistical Methods in Medical Research. DOI: 10.1177/0962280212465499.

Kim S, Erwin D, and Wu D. (2012). Efficacy of dual lung cancer screening by chest x-ray and
sputum cytology using Johns Hopkins lung project data. Journal of Biometrics and Biostatistics.
3:139. doi:10.4172/2155-6180.1000139

Wu D, Kafadar, K, Rosner GL, Broemeling LD. (2012). The lead time distribution when lifetime
is subject to competing risks in cancer screening. The International Journal of Biostatistics.
Volume 8: Issue 1, Article 6, ISSN: 1557-4679, DOI:10.1515/1557-4679.1363, April 2012.

Luo D, Cambon AC, Wu D. (2012). Evaluating long term effect of FOBT in colon cancer
screening. Cancer Epidemiology. 36 (2012), e54-e60. DOI: 10.1016/j.canep.2011.09.011.

Wu D and Perez A. (2012). Chapter 24: Modeling and inference in screening: exemplification
with the faecal occult blood test. Colorectal Cancer-From Prevention to Patient Care, Editor:
Ettarh, R. (eds.) InTech Publisher. ISBN: 978-953-51-0028-7. February 2012.

Wu D, Erwin D, and Kim S. (2011). Projection of long-term outcomes using x-rays and pooled
cytology in lung cancer screening. Open Access Medical Statistics. 2011: 1 13-19.
DOI:10.2147/OAMS. S22987.

Wu D and Perez A. (2011). A limited review of over-diagnosis methods and long term effects in
breast cancer screening. Oncology Reviews (2011) 5:143-147.

Shows J and Wu D. (2011) Inferences for the lead time in breast cancer screening trials under a
stable disease model. Cancers. 2011, 3(2), 2131-2140; DOI:10.3390/cancers3022131.

Wu D, Erwin D. and Rosner GL. (2011). Sojourn time and lead time projection in lung cancer
screening. Lung Cancer. 72 (2011) 322-326.

Wu D and Rosner GL. (2010). Chapter 10: Probability modeling and statistical inference in
periodic cancer screening. Frontiers in Computational and System Biology, Editors: J. Feng et al
(eds.) Computational Biology 15. Springer-Verlag London, 2010. ISBN: 978-1-84996-195-0.
June 2010.

Chen Y, Brock G, and Wu, D. (2010). Estimating key parameters in periodic breast cancer
screening - application to the Canadian National Breast Screening Study data. Cancer
Epidemiology. 34, 429-433. DOI:10.1016/j.canep.2010.04.001.

Wu D, Erwin D, and Rosner GL. (2009). A projection of benefits due to fecal occult blood test for
colorectal cancer. Cancer Epidemiology. 33, 212-215. DOI: 10.1016/j.canep.2009.08.001.

Wu D, Erwin D. and Rosner GL. (2009) Estimating key parameters in FOBT screening for
colorectal cancer. Cancer Causes and Control (2009) 20: 41-46.

Wu D, Carino RL, and Wu X. (2008). When sensitivity is a function of age and time spent in the
preclinical state in periodic cancer screening. Journal of Modern Applied Statistical Methods.
Vol. 7, No. 1, 297-303.

Wu D, Rosner GL, and Broemeling LD. (2007). Bayesian inference for the lead time in periodic
cancer screening. Biometrics. Vol. 63, No. 3, 873–880.

Wu D, Rosner GL, and Broemeling LD. (2005). MLE and Bayesian inference of age-dependent
sensitivity and transition probability in periodic screening. Biometrics. Vol.61, No.4, 1056-1063.

Shen, Y., Wu, D., and Zelen, M.(2001). Testing the independence of two diagnostic tests.
Biometrics. Vol. 57, 1009-1017.

Other Experience and Professional Memberships:

1997- Member, American Statistical Association.

2000- Member, International Biometric Society.

2010- Member, International Chinese Statistical Association.

2001- Journal reviewer: Annals of Applied Statistics; Statistics in Medicine; Information
Sciences; Quality of Life Research; Cancers; Statistical Methodology;
Computational Statistics and Data Analysis; Diagnostics; Journal of
Epidemiology and Global Health; Breast Cancer: Targets and Therapy; Statistics
and Its Interface, etc.

2002- Book reviewer: Pearson/Prentice Hall; W.H. Freeman and Company.

2009- NIH scientific review ZRG1 PSE-C (58) R and ZRG1 PSE-J (58) R, mail
reviewer. NIH Challenge Grants in Health and Science Research, RC1.

2010- Editor-in-Chief, Journal of Biometrics and Biostatistics.

2010- Editorial board, Journal of Cancer Science and Therapy.

2011- Editor-in-Chief, Open Access Medical Statistics.

2013- Editorial board, Annals of Biometrics and Biostatistics.

2012 NIH scientific review panel: ZRG1 BDCN M-70/PCORI 11.

2013 NIH scientific review panel: ZRG1 PSE-D(90)A-AREA R15.

2014 NIH scientific review panel: ZRG1 PSEQ 80-AREA R15, ZRG1 PSE-R (80)-
AREA R15.

2015 Patient-Centered Outcome Research Institute (PCORI), scientific review panel:
Pure Analytics.

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