About Dr. Hill

Bradford Hill

Bradford Hill, Ph.D.
Professor of Medicine

Bradford G. Hill, Ph.D., is a Professor in the Department of Medicine and Division of Environmental Medicine, and a University Scholar at the University of Louisville. The focus of Dr. Hill's research is to understand how changes in metabolism contribute to cardiometabolic health and disease. In particular, his studies focus on how glucose metabolism and mitochondrial activity influence pathological cardiac remodeling as well as how changes in metabolism underlie adaptations to physiological stressors such as exercise. Recent work from Dr. Hill's laboratory shows that exercise-induced periodicity in cardiac glucose utilization regulates physiologic cardiac growth. His group is also examining metabolic mechanisms of cardiomyocyte proliferation and how metabolic changes in cardiac mesenchymal cells (e.g., fibroblasts) influences cardiac repair and remodeling after myocardial infarction. In addition, working with collaborators in the Center, Dr. Hill is examining how exposure to particulate air pollution influences metabolism and cardiometabolic health..

Dr. Hill serves or has served as a peer reviewer for the National Institutes of Health (NIH), Congressionally Directed Medical Research Program (CDRMP) / Department of Defense (DoD), the American Diabetes Association (ADA), and the American Heart Association (AHA); he has also served as a peer reviewer for numerous international funding agencies. Dr. Hill is currently a member of the Editorial Boards of Circulation ResearchAmerican Journal of Physiology – Heart and Circulatory Physiology, Journal of Molecular and Cellular Cardiology, and Redox Biology, among others. He has authored or coauthored over 100 peer-reviewed articles.

Representative Publications:

  • Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, El-Baz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation. 2022 Jan 21. doi: 10.1161/CIRCULATIONAHA.121.057641. Epub ahead of print. PMID: 35061545.
  • Gibb AA, Murray E, Huynh A, Gaspar R, Ploesch T, Lombardi A, Lorkiewicz P, Roy R, Arany Z, Kelly DP, Margulies K, Hill BG, Elrod J. Glutaminolysis is essential for myofibroblast persistence and in vivo targeting reverses fibrosis and cardiac dysfunction in heart failure. Circulation (in press).
  • Mohamed TMA, Abouleisa REE, and Hill BG. Metabolic determinants of cardiomyocyte proliferation. Stem Cells (in press).
  • Fulghum KL, Audam TN, Lorkiewicz PK, Zheng Y, Merchant M, Cummins TD, Dean WL, Cassel TA, Fan TWM, Hill BG. In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium. J Mol Cell Cardiol. 2022 Jan;162:32-42. doi: 10.1016/j.yjmcc.2021.08.013. Epub 2021 Sep 3. PMID: 34487754; PMCID: PMC8766935.
  • Audam TN, Howard CM, Garrett LF, Zheng YW, Bradley JA, Brittian KR, Frank MW, Fulghum KL, Pólos M, Herczeg S, Merkely B, Radovits T, Uchida S, Hill BG, Dassanayaka S, Jackowski S, Jones SP. Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload. Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H784-H797. doi: 10.1152/ajpheart.00411.2021. Epub 2021 Sep 17. PMID: 34533403; PMCID: PMC8794231
  • Abouleisa RRE, McNally L, Salama ABM, Hammad SK, Ou Q, Wells C, Lorkiewicz PK, Bolli R, Mohamed TMA, Hill BG. Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation. Redox Biol. 2021 Oct;46:102094. doi: 10.1016/j.redox.2021.102094. Epub 2021 Aug 5. PMID: 34418597; PMCID: PMC8379496.
  • Hill BG, Rood B, Ribble A, Haberzettl P. Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance. AJP Heart. 2021 Mar 5. doi: 10.1152/ajpheart.00881.2020. PubMed PMID: 33666505.
  • Singh P, O'Toole TE, Conklin DJ, Hill BG, Haberzettl P. Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1440-H1455. doi: 10.1152/ajpheart.00804.2020. Epub 2021 Feb 19. PMID: 33606580; PMCID: PMC8260385.
  • McNally LA, Altamimi TR, Fulghum K, Hill BG. Considerations for using isolated cell systems to understand cardiac metabolism and biology. JMCC. 2020 Dec 20. doi:10.1016/j.yjmcc.2020.12.007. PubMed PMID: 33359038
  • Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, Albeituni S, He L, Hu X, Tieri D, Rouchka EC, Hamada M, Takahashi S, Gibb AA, Kloecker G, Zhang HG, Bousamra M, Hill BG, Zhang X, Yan J. Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. J Clin Invest. 2020 Jan 16. pii: 131335. doi: 10.1172/JCI131335. [Epub ahead of print] PubMed PMID: 31945018.
  • Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PubMed PMID: 31653685; PubMed Central PMCID: PMC6864295.
  • Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x. PubMed PMID: 31586055; PubMed Central PMCID: PMC6778142.
  • Lorkiewicz PK, Gibb AA, Rood BR, He L, Zheng Y, Clem BF, Zhang X, Hill BG. Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation. Sci Rep. 2019 Sep 23;9(1):13705. doi: 10.1038/s41598-019-50183-3. PubMed PMID: 31548575; PubMed Central PMCID: PMC6757038.
  • Fulghum KL, Rood BR, Shang VO, McNally LA, Riggs DW, Zheng YT, Hill BG. Mitochondria-associated lactate dehydrogenase is not a biologically significant contributor to bioenergetic function in murine striated muscle. Redox Biol. 2019 Jun;24:101177. doi: 10.1016/j.redox.2019.101177. Epub 2019 Mar 22. PubMed PMID: 30939431; PubMed Central PMCID: PMC6441728.
  • Fulghum K, Hill BG. Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling. Front Cardiovasc Med. 2018 Sep 11;5:127. doi: 10.3389/fcvm.2018.00127. eCollection 2018. Review. PubMed PMID: 30255026; PubMed Central PMCID: PMC6141631.
  • Gibb AA, Hill BG. Metabolic Coordination of Physiological and Pathological Cardiac Remodeling. Circ Res. 2018 Jun 22;123(1):107-128. doi:10.1161/CIRCRESAHA.118.312017. Review. PubMed PMID: 29929976; PubMed Central PMCID: PMC6023588.
  • Dassanayaka S, Zheng Y, Gibb AA, Cummins TD, McNally LA, Brittian KR, Jagatheesan G, Audam TN, Long BW, Brainard RE, Jones SP, Hill BG. Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload. Redox Biol. 2018 Jul;17:440-449. doi: 10.1016/j.redox.2018.05.016. Epub 2018 Jun 1. PubMed PMID: 29885625; PubMed Central PMCID: PMC5991908.
  • Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill BG, Uchida S, Kumar A. TAK1 regulates skeletal muscle mass and mitochondrial function. JCI Insight. 2018 Feb 8;3(3). pii: 98441. doi: 10.1172/jci.insight.98441. eCollection 2018 Feb 8. PubMed PMID: 29415881; PubMed Central PMCID: PMC5821216.
  • Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG. Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth. Circulation. 2017 Nov 28;136(22):2144-2157. doi: 10.1161/CIRCULATIONAHA.117.028274. Epub 2017 Aug 31. PubMed PMID: 28860122; PubMed Central PMCID: PMC5704654.
  • Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. Biochem J. 2017 Aug 7;474(16):2785-2801. doi: 10.1042/BCJ20170474. Erratum in: Biochem J. 2017 Dec 14;474(24):4271-4272. PubMed PMID: 28706006; PubMed Central PMCID: PMC5545928.