About Dr. Hill

Bradford Hill

Bradford Hill, Ph.D.
Associate Professor of Medicine

Bradford G. Hill, Ph.D.is an Associate Professor in the Department of Medicine and Division of Cardiovascular Medicine, and a University Scholar at the University of Louisville.

Dr. Hill received his Ph.D. in 2007 in Biochemistry and Molecular Biology from the University of Louisville and completed his post-doctoral studies at the University of Alabama-Birmingham, after which he was recruited to the University of Louisville as Faculty in the Institute of Molecular Cardiology and the Diabetes and Obesity Center.

The focus of Dr. Hill's research is to understand how changes in metabolism contribute to cardiometabolic health and disease. In particular, his studies focus on how glucose metabolism and mitochondrial activity influence pathological cardiac remodeling as well as how changes in metabolism underlie adaptations to physiological stressors such as exercise. 

Recent work from Dr. Hill's laboratory shows that exercise-induced periodicity in cardiac glucose utilization regulates physiologic cardiac growth.

His group is also examining how cardiac stromal cell populations are affected by heart failure and metabolic disease. In particular, his group is interested in how diabetes affects the myocardial reparative capacity of cardiac mesenchymal cells, with the goal of increasing their competency for repair in both nondiabetic and diabetic patients.

Dr. Hill has served as an ad hoc peer reviewer for the Congressionally Directed Medical Research Program (CDRMP) / Department of Defense (DoD) and the American Heart Association (AHA); he has also served as a peer reviewer for numerous international funding agencies.

Dr. Hill is currently a member of the Editorial Boards of Circulation Research, Free Radical Biology and Medicine, and Redox Biology, among others. He has authored or coauthored over 70 peer-reviewed articles.

Representative Publications:

  • Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill BG, Uchida S, Kumar A. TAK1 regulates skeletal muscle mass and mitochondrial function. JCI Insight. 2018 Feb 8;3(3). pii: 98441. doi: 10.1172/jci.insight.98441. [Epub ahead of print] PubMed PMID: 29415881.
  • Osuma EA, Riggs DW, Gibb AA, Hill BG. High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration. Regeneration. 2017;1–9.
  • Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor PJ, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG. Exercise-Induced Changes in Glucose Metabolism Promote Physiologic Cardiac Growth. Circulation. 2017 Aug 31. pii: CIRCULATIONAHA.117.028274. doi: 10.1161/CIRCULATIONAHA.117.028274. [Epub ahead of print] PubMed PMID: 28860122.
  • Sultan A, Zheng Y, Trainor PJ, Siow Y, Amraotkar AR, Hill BG*, DeFilippis AP*. Circulating Prolidase Activity in Patients with Myocardial Infarction. Front Cardiovasc Med. 2017 Jul 31;4:50. doi: 10.3389/fcvm.2017.00050. eCollection 2017. PubMed PMID: 28824924; PubMed Central PMCID: PMC5535509. *co-corresponding authors
  • Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. Biochem J. 2017 Aug 7;474(16):2785-2801. doi: 10.1042/BCJ20170474. PubMed PMID: 28706006; PubMed Central PMCID: PMC5545928.
  • Gibb AA, McNally LA, Riggs DW, Conklin DJ, Bhatnagar A, Hill BG. FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise. Front Physiol. 2016 Dec 21;7:636. doi: 10.3389/fphys.2016.00636. eCollection 2016. PubMed PMID: 28066267; PubMed Central PMCID: PMC5174104.
  • Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, Hill BG. Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells. J Biol Chem. 2016 Jun 24;291(26):13634-48. doi: 10.1074/jbc.M116.722496. Epub 2016 May 5. PubMed PMID: 27151219; PubMed Central PMCID: PMC4919448.
  • Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M. CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity. Diabetes. 2016 Aug;65(8):2268-81. doi: 10.2337/db15-1689. Epub 2016 May 3. PubMed PMID: 27207557; PubMed Central PMCID: PMC4955992.
  • Salabei JK, Lorkiewicz PK, Holden CR, Li Q, Hong KU, Bolli R, Bhatnagar A, Hill BG. Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation. Stem Cells. 2015 Aug;33(8):2613-27. doi: 10.1002/stem.2047. Epub 2015 May 26. PubMed PMID: 25917428; PubMed Central PMCID: PMC4509862.
  • Dassanayaka S, Readnower RD, Salabei JK, Long BW, Aird AL, Zheng YT, Muthusamy S, Facundo HT, Hill BG*, Jones SP*. High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation. Biochem J. 2015 Apr 1;467(1):115-26. doi: 10.1042/BJ20141018. PubMed PMID: 25627821; PubMed Central PMCID: PMC4408906. *co-corresponding authors
  • Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E262-77. doi: 10.1152/ajpendo.00271.2013. Epub 2014 Jun 10. PubMed PMID: 24918202; PubMed Central PMCID: PMC4121575.
  • Sansbury BE, Hill BG. Regulation of obesity and insulin resistance by nitric oxide. Free Radic Biol Med. 2014 Aug;73:383-99. doi: 10.1016/j.freeradbiomed.2014.05.016. Epub 2014 May 28. Review. PubMed PMID: 24878261; PubMed Central PMCID: PMC4112002.
  • Sansbury BE, DeMartino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, Hill BG. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail. 2014 Jul;7(4):634-42. doi: 10.1161/CIRCHEARTFAILURE.114.001151. Epub 2014 Apr 24. PubMed PMID: 24762972; PubMed Central PMCID: PMC4102656.
  • Salabei JK, Gibb AA, Hill BG. Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Nat Protoc. 2014 Feb;9(2):421-38. doi: 10.1038/nprot.2014.018. Epub 2014 Jan 23. PubMed PMID: 24457333; PubMed Central PMCID: PMC4063296.
  • Salabei JK, Hill BG. Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation. Redox Biol. 2013 Nov 7;1:542-51. doi: 10.1016/j.redox.2013.10.011. eCollection 2013. PubMed PMID: 24273737; PubMed Central PMCID: PMC3836280.
  • Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite M, Bhatnagar A, Hill BG. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res. 2012 Oct 12;111(9):1176-89. doi: 10.1161/CIRCRESAHA.112.266395. Epub 2012 Aug 14. PubMed PMID: 22896587; PubMed Central PMCID: PMC3707504.