About Dr. Hill

Bradford Hill

Bradford Hill, Ph.D.
Associate Professor of Medicine

Bradford G. Hill, Ph.D., is an Associate Professor in the Department of Medicine and Division of Environmental Medicine, and a University Scholar at the University of Louisville.

Dr. Hill received his Ph.D. in 2007 in Biochemistry and Molecular Biology from the University of Louisville and completed his post-doctoral studies at the University of Alabama-Birmingham, after which he was recruited to the University of Louisville as Faculty in the Diabetes and Obesity Center.

The focus of Dr. Hill's research is to understand how changes in metabolism contribute to cardiometabolic health and disease. In particular, his studies focus on how glucose metabolism and mitochondrial activity influence pathological cardiac remodeling as well as how changes in metabolism underlie adaptations to physiological stressors such as exercise. 

Recent work from Dr. Hill's laboratory shows that exercise-induced periodicity in cardiac glucose utilization regulates physiologic cardiac growth.

His group is also examining how cardiac stromal cell populations are affected by heart failure and metabolic disease. In particular, his group is interested in how diabetes affects the myocardial reparative capacity of cardiac mesenchymal cells, with the goal of increasing their competency for repair in both nondiabetic and diabetic patients.

Dr. Hill serves or has served as a peer reviewer for the National Institutes of Health (NIH), Congressionally Directed Medical Research Program (CDRMP) / Department of Defense (DoD), the American Diabetes Association (ADA), and the American Heart Association (AHA); he has also served as a peer reviewer for numerous international funding agencies. Dr. Hill is currently a member of the Editorial Boards of Circulation ResearchAmerican Journal of Physiology – Heart and Circulatory Physiology, Journal of Molecular and Cellular Cardiology, Free Radical Biology and Medicine, and Redox Biology, among others. He has authored or coauthored over 90 peer-reviewed articles.

Representative Publications:

  • Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, Albeituni S, He L, Hu X, Tieri D, Rouchka EC, Hamada M, Takahashi S, Gibb AA, Kloecker G, Zhang HG, Bousamra M, Hill BG, Zhang X, Yan J. Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. J Clin Invest. 2020 Jan 16. pii: 131335. doi: 10.1172/JCI131335. [Epub ahead of print] PubMed PMID: 31945018.
  • Hill BG, Shiva S, Ballinger S, Zhang J, Darley-Usmar VM. Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine. Biol Chem. 2019 Dec 18;401(1):3-29. doi: 10.1515/hsz-2019-0268. Review. PubMed PMID: 31815377; PubMed Central PMCID: PMC6944318.
  • Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PubMed PMID: 31653685; PubMed Central PMCID: PMC6864295.
  • Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x. PubMed PMID: 31586055; PubMed Central PMCID: PMC6778142.
  • Lorkiewicz PK, Gibb AA, Rood BR, He L, Zheng Y, Clem BF, Zhang X, Hill BG. Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation. Sci Rep. 2019 Sep 23;9(1):13705. doi: 10.1038/s41598-019-50183-3. PubMed PMID: 31548575; PubMed Central PMCID: PMC6757038.
  • Ou Q, Jacobson Z, Abouleisa R, Tang XL, Hindi S, Kumar A, Ivey KN, Giridharan GA, Al-Baz A, Brittian K, Rood B, Lin YH, Watson SA, Perbellini F, McKinsey TA, Hill BG, Jones SP, Terracciano CM, Bolli R, Mohamed TM. A Physiological Biomimetic Culture System for Pig and Human Heart Slices. Circ Res. 2019 Jul 16.doi: 10.1161/CIRCRESAHA.119.314996. [Epub ahead of print] PubMed PMID: 31310161.
  • Mehra P, Guo Y, Nong Y, Lorkiewicz P, Nasr M, Li Q, Muthusamy S, Bradley JA, Bhatnagar A, Wysoczynski M, Bolli R, Hill BG. Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair. Basic Res Cardiol. 2018 Oct 23;113(6):46. doi: 10.1007/s00395-018-0703-0. PubMed PMID: 30353243; PubMed Central PMCID: PMC6314032.
  • Gibb AA, Hill BG. Metabolic Coordination of Physiological and Pathological Cardiac Remodeling. Circ Res. 2018 Jun 22;123(1):107-128. doi:10.1161/CIRCRESAHA.118.312017. Review. PubMed PMID: 29929976; PubMed Central PMCID: PMC6023588.
  • Dassanayaka S, Zheng Y, Gibb AA, Cummins TD, McNally LA, Brittian KR, Jagatheesan G, Audam TN, Long BW, Brainard RE, Jones SP, Hill BG. Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload. Redox Biol. 2018 Jul;17:440-449. doi: 10.1016/j.redox.2018.05.016. Epub 2018 Jun 1. PubMed PMID: 29885625; PubMed Central PMCID: PMC5991908.
  • Osuma EA, Riggs DW, Gibb AA, Hill BG. High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration. Regeneration (Oxf). 2018 Jan 11;5(1):78-86. doi: 10.1002/reg2.95. eCollection 2018 Mar. PubMed PMID: 29721328; PubMed Central PMCID: PMC5911454.
  • Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG. Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth. Circulation. 2017 Nov 28;136(22):2144-2157. doi: 10.1161/CIRCULATIONAHA.117.028274. Epub 2017 Aug 31. PubMed PMID: 28860122; PubMed Central PMCID: PMC5704654.
  • Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. Biochem J. 2017 Aug 7;474(16):2785-2801. doi: 10.1042/BCJ20170474. Erratum in: Biochem J. 2017 Dec 14;474(24):4271-4272. PubMed PMID: 28706006; PubMed Central PMCID: PMC5545928.
  • Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, Hill BG. Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells. J Biol Chem. 2016 Jun 24;291(26):13634-48. doi: 10.1074/jbc.M116.722496. Epub 2016 May 5. PubMed PMID: 27151219; PubMed Central PMCID: PMC4919448.
  • Salabei JK, Lorkiewicz PK, Holden CR, Li Q, Hong KU, Bolli R, Bhatnagar A, Hill BG. Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation. Stem Cells. 2015 Aug;33(8):2613-27. doi: 10.1002/stem.2047. Epub 2015 May 26. PubMed PMID: 25917428; PubMed Central PMCID: PMC4509862.
  • Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E262-77. doi: 10.1152/ajpendo.00271.2013. Epub 2014 Jun 10. PubMed PMID: 24918202; PubMed Central PMCID: PMC4121575.
  • Sansbury BE, Hill BG. Regulation of obesity and insulin resistance by nitric oxide. Free Radic Biol Med. 2014 Aug;73:383-99. doi: 10.1016/j.freeradbiomed.2014.05.016. Epub 2014 May 28. Review. PubMed PMID: 24878261; PubMed Central PMCID: PMC4112002.
  • Sansbury BE, DeMartino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, Hill BG. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail. 2014 Jul;7(4):634-42. doi: 10.1161/CIRCHEARTFAILURE.114.001151. Epub 2014 Apr 24. PubMed PMID: 24762972; PubMed Central PMCID: PMC4102656.
  • Salabei JK, Gibb AA, Hill BG. Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Nat Protoc. 2014 Feb;9(2):421-38. doi: 10.1038/nprot.2014.018. Epub 2014 Jan 23. PubMed PMID: 24457333; PubMed Central PMCID: PMC4063296.
  • Fulghum KL, Rood BR, Shang VO, McNally LA, Riggs DW, Zheng YT, Hill BG. Mitochondria-associated lactate dehydrogenase is not a biologically significant contributor to bioenergetic function in murine striated muscle. Redox Biol. 2019 Jun;24:101177. doi: 10.1016/j.redox.2019.101177. Epub 2019 Mar 22. PubMed PMID: 30939431; PubMed Central PMCID: PMC6441728.
  • Fulghum K, Hill BG. Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling. Front Cardiovasc Med. 2018 Sep 11;5:127. doi:
    10.3389/fcvm.2018.00127. eCollection 2018. Review. PubMed PMID: 30255026; PubMed Central PMCID: PMC6141631.
  • Ghosh Dastidar S, Jagatheesan G, Haberzettl P, Shah J, Hill BG, Bhatnagar A, Conklin DJ. Glutathione S-transferase P deficiency induces glucose intolerance via JNK-dependent enhancement of hepatic gluconeogenesis. Am J Physiol Endocrinol
    Metab. 2018 Nov 1;315(5):E1005-E1018. doi: 10.1152/ajpendo.00345.2017. Epub 2018 Aug 28. PubMed PMID: 30153066; PubMed Central PMCID: PMC6293160.
  • Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill BG, Uchida S, Kumar A. TAK1 regulates skeletal muscle mass and mitochondrial function. JCI Insight. 2018 Feb 8;3(3). pii: 98441. doi: 10.1172/jci.insight.98441. eCollection 2018 Feb 8. PubMed PMID: 29415881; PubMed Central PMCID: PMC5821216.
  • Sultan A, Zheng Y, Trainor PJ, Siow Y, Amraotkar AR, Hill BG, DeFilippis AP. Circulating Prolidase Activity in Patients with Myocardial Infarction. Front Cardiovasc Med. 2017 Jul 31;4:50. doi: 10.3389/fcvm.2017.00050. eCollection 2017. PubMed PMID: 28824924; PubMed Central PMCID: PMC5535509.
  • Gibb AA, McNally LA, Riggs DW, Conklin DJ, Bhatnagar A, Hill BG. FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise. Front Physiol. 2016 Dec 21;7:636. doi: 10.3389/fphys.2016.00636. eCollection 2016. Erratum in: Front Physiol. 2017 Oct 10;8:800. PubMed PMID: 28066267; PubMed Central PMCID: PMC5174104.
  • Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M. CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity. Diabetes. 2016 Aug;65(8):2268-81. doi: 10.2337/db15-1689. Epub 2016 May 3. PubMed PMID: 27207557; PubMed Central PMCID: PMC4955992.
  • Dassanayaka S, Readnower RD, Salabei JK, Long BW, Aird AL, Zheng YT, Muthusamy S, Facundo HT, Hill BG, Jones SP. High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation. Biochem J. 2015 Apr 1;467(1):115-26. doi: 10.1042/BJ20141018. PubMed PMID: 25627821; PubMed Central PMCID: PMC4408906.
  • Salabei JK, Hill BG. Autophagic regulation of smooth muscle cell biology. Redox Biol. 2015;4:97-103. doi: 10.1016/j.redox.2014.12.007. Epub 2014 Dec 18. Review. PubMed PMID: 25544597; PubMed Central PMCID: PMC4309847.
  • Salabei JK, Hill BG. Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation. Redox Biol. 2013 Nov 7;1:542-51. doi: 10.1016/j.redox.2013.10.011. eCollection 2013. PubMed PMID: 24273737; PubMed Central PMCID: PMC3836280.
  • Haberzettl P, b. Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response. Redox Biol. 2013 Jan 26;1:56-64. doi: 10.1016/j.redox.2012.10.003. eCollection 2013. PubMed PMID: 24024137; PubMed Central PMCID: PMC3757667.
  • Salabei JK, Hill BG. Implications of autophagy for vascular smooth muscle cell function and plasticity. Free Radic Biol Med. 2013 Dec;65:693-703. doi: 10.1016/j.freeradbiomed.2013.08.003. Epub 2013 Aug 9. Review. PubMed PMID: 23938401; PubMed Central PMCID: PMC3859773.
  • Sato S, Ogura Y, Mishra V, Shin J, Bhatnagar S, Hill BG, Kumar A. TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity. Skelet Muscle. 2013 Jul 8;3(1):18. doi: 10.1186/2044-5040-3-18. PubMed PMID: 23835416; PubMed Central PMCID: PMC3711790.
  • Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A, Hill BG. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem J. 2013 May 1;451(3):375-88. doi: 10.1042/BJ20121344. PubMed PMID: 23421427; PubMed Central PMCID: PMC4040966.
  • Readnower RD, Brainard RE, Hill BG, Jones SP. Standardized bioenergetic profiling of adult mouse cardiomyocytes. Physiol Genomics. 2012 Dec 18;44(24):1208-13. doi: 10.1152/physiolgenomics.00129.2012. Epub 2012 Oct 23. PubMed PMID: 23092951; PubMed Central PMCID: PMC3544486.
  • Vladykovskaya E, Sithu SD, Haberzettl P, Wickramasinghe NS, Merchant ML, Hill BG, McCracken J, Agarwal A, Dougherty S, Gordon SA, Schuschke DA, Barski OA, O'Toole T, D'Souza SE, Bhatnagar A, Srivastava S. Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem. 2012 Mar 30;287(14):11398-409. doi: 10.1074/jbc.M111.320416. Epub 2012 Jan 6. PubMed PMID: 22228760; PubMed Central PMCID: PMC3322871.
  • Ingram KH, Hill H, Moellering DR, Hill BG, Lara-Castro C, Newcomer B, Brandon LJ, Ingalls CP, Penumetcha M, Rupp JC, Garvey WT. Skeletal muscle lipid peroxidation and insulin resistance in humans. J Clin Endocrinol Metab. 2012 Jul;97(7):E1182-6. doi: 10.1210/jc.2011-2963. Epub 2012 Apr 11. PubMed PMID: 22496506; PubMed Central PMCID: PMC3387404.