Sandra Wise, Ph.D.

Mechanistic and Translational Toxicology (MTT) Research Interest Group Member


Assistant Professor
Department of Pharmacology and Toxicology
Dr. Wise's research interests include how environmental chemicals, such as hexavalent chromium, depleted uranium and other metals, can transform normal cells into cancer cells. These studies have focused on DNA repair deficiency and its impact on chromosome instability as a driving mechanism to cellular transformation and the development of disease. Currently, she is pursuing how cells exposed to these chemicals induce DNA and chromosomal damage yet are able to survive and evade the normal cell death pathways that should occur in order to protect the organism from disease.

Research Keywords: metal-induced carcinogenesis, hexavalent chromium, DNA repair deficiency, chromosome instability

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