About
Professor
Department of Pharmacology and Toxicology
University Scholar
Wise Laboratory of Environmental and Genetic Toxicology
Dr. John Pierce Wise, Sr. conducts basic and translation research studying how environmental chemicals transform normal cells into tumor cells focusing on chromosomes and how chemicals alter the number and structure of chromosomes leading to chromosome instability and cancer. Research projects in the laboratory include understanding DNA damage, DNA repair, mitosis, centrosome biology, cell-cell communication, chromatin folding, the fourth dimensional genome; all in a one environmental health context.
Research Keywords: DNA damage, DNA repair, carcinogenesis, chromosomal instability, one environmental health