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Rachel Neal, PhD

Rachel Neal

Environmental and Occupational Health Sciences

Associate Professor
Room No. 208 & 209, Medical Dental Research Building
511 S. Floyd St.
Louisville, KY 40202
Office: 502-852-3179 
Lab: 502-852-4703
Fax:  502-852-2276
rachel.neal@louisville.edu

CURRICULUM VITAE

Background

PhD in Chemistry - University of Missouri-Rolla (1999)

Research Interests

-- Fetal basis of adult disease
-- Adverse health effects of maternal smoking
-- Health effects of gut microbiome

My research program utilizes high dimensionality data collection methodologies to probe the impact of adverse fetal environment on offspring health. We utilize metagenomic, proteomic, and metabolomic platforms to delineate the impact, in rodent models, of maternal licit drug use during fetal development on gut-liver-brain axis function.

Current Projects

(1) Survey of tobacco product usage in UofL undergraduates (SPOTS Survey); (2) Impact of gestational cigarette smoke exposure on offspring hepatic SIRT1 mediated metabolic function; (3) Impact of gestational alcohol exposure on offspring heaptic SIRT1 mediated metabolic function; (4) Impact of developmental Pb exposure on immune function in kids; (5) Impact of maternal cigarette smoke consumption and VLBW on infant intestinal microbiome community structure.

Recent Publications

Lutz PM, Kelty EA, Brown TD, Wilson TJ, Brock G, Neal RE.  (2012).  Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children.  Toxicology 291:43-50.

Jagadapillai R, Chen J, Canales L, Birtles T, Pisano MM, Neal RE.  (2012).  Developmental cigarette smoke exposure: kidney proteome profile alterations in low birth weight pups.  Toxicology 299:80-89.

Canales L, Chen J, Kelty E, Musah S, Webb C, Pisano MM, Neal RE.  (2012).  Developmental cigarette smoke exposure: liver proteome profile alterations in low birth weight pups.  Toxicology 300:1-11.

Canales L, Gambrell C, Chen J, Neal RE.  (2013).  Prenatal alcohol exposure alters the cerebral cortex proteome in weanling rats.  Reprod. Toxicol. 39:69-75.

Neal RE, Chen J, Jagadapillai R, Jang H, Abomoelak B, Brock G, Greene RM, Pisano MM.  (2014).  Developmental cigarette smoke exposure: hippocampus proteome and metabolome profiles in low birth weight pups.  Toxicology 317:40-49.

Massey VL, Stocke KS, Schmidt RH, Tan M, Ajami N, Neal RE, Petrosino JF, Barve S, Arteel GE.  (2015).  Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction.  Toxicol. Appl. Pharmacol. 284:304-314.

Neal RE, Chen J, Webb C, Stocke K, Gambrell C, Greene RM, and Pisano MM.  (2016).  Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month old adult offspring.  Reprod. Toxicol. 65:414-424.

Neal RE, Jagadapillai R, Chen J, Webb CL, Stocke K, Gambrell C, Greene RM, Pisano MM.  (2016).  Developmental cigarette smoke exposure II: Kidney proteome profile alterations in 6 month old adult offspring.  Reprod. Toxicol. 65:425-35.

Neal RE, Jagadapillai R, Chen J, Webb C, Stocke K, Greene RM, Pisano MM.  (2016).  Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring.  Reprod. Toxicol. 65:436-447.

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