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Gary W. Hoyle, PhD
| Environmental and Occupational Health Sciences Professor and Acting Chair Office hours by appointment. |
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Background
Dr. Hoyle received a B.A. from Johns Hopkins University in 1982 and a Ph.D. in Biochemistry from Duke University in 1988. He engaged in postdoctoral training at the University of Pennsylvania from 1988-1993 and joined the faculty of Tulane University in the Pulmonary Section of the Department of Medicine in 1993. Dr. Hoyle joined the department of Environmental and Occupational Health Sciences at the University of Louisville in 2007. Dr. Hoyle’s research interests are focused on understanding how inhaled agents that are encountered in the environment or in occupational settings injure the lung and how the lung is repaired after injury. An understanding of mechanisms underlying lung injury and repair has the potential to lead to novel treatments for pulmonary disorders. Dr. Hoyle has studied mechanisms of lung injury induced by a variety of inhaled agents, including chlorine, ozone, isocyanates, asbestos, silica, bleomycin, allergens, cigarette smoke, and ambient particulate matter.
Recent Grants
9/23/10-8/31/13 National Institutes of Health R21 ES020123 "Repair of airway epithelium following chlorine lung injury"
8/22/11-4/30/17 National Institutes of Health U01 ES015673 “Novel therapies for chlorine-induced lung injury”
9/25/12-6/30/17 National Institutes of Health U01 ES022564 “Countermeasures for chlorine-induced airway fibrosis”
7/1/16-6/30/17 Kentucky Science and Engineering Foundation KSEF-3605-RDE-19 “Macrophages and Airway Fibrosis”
9/30/16-8/31/18 National Institutes of Health R21 ES027391 “Treatment of persistent chlorine-induced small airway disease”
Recent Publications
Musah, S., DeJarnett, N., and Hoyle, G. W. (2012). Tumor necrosis factor-a mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter. Toxicol. 299:125-132. http://www.sciencedirect.com/science/article/pii/S0300483X12001709
Chang, W., Chen, J., Schlueter, C. F., Rando, R. J., Pathak, Y. V., and Hoyle, G. W. (2012). Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram. Toxicol. Appl. Pharmacol. 263:251-258. PMC3422440. http://www.sciencedirect.com/science/article/pii/S0041008X12002761
Musah, S., Chen, J., and Hoyle, G. W. (2012). Repair of tracheal epithelium by basal cells after chlorine-induced injury. Respir. Res. 13:107. PMC3544626. http://respiratory-research.com/content/13/1/107
Mo, Y., Chen, J., Schlueter, C. F., and Hoyle, G. W. (2013). Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 304:L92-L102. PMC3543638. http://ajplung.physiology.org/content/304/2/L92.long
Chen, J., Mo, Y., Schlueter, C. F., and Hoyle, G. W. (2013). Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol. Appl. Pharmacol. 272:408-413. PMC4005342. http://www.sciencedirect.com/science/article/pii/S0041008X13002822
Mo, Y., Chen, J., Humphrey, D. M. Jr., Fodah, R. A., Warawa, J. M., and Hoyle, G. W. (2015). Abnormal epithelial structure and chronic lung inflammation after repair of chlorine-induced airway injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 308:L168-L178. PMC4338946. http://ajplung.physiology.org/content/308/2/L168
Satpathy, S. R., Jala, V. R., Bodduluri, S. R., Krishnan, E., Hegde, B., Hoyle, G. W., Fraig, M., Luster, A. D., and Haribabu, B. (2015). Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumor growth. Nat. Commun. 6:7064. PMC4418220. http://www.nature.com/ncomms/2015/150429/ncomms8064/full/ncomms8064.html
Hoyle , G. W., Chen, J., Schlueter, C. F., Mo, Y., Humphrey, D. M. Jr., Rawson, G., Niño, J. A., and Carson, K. H. (2016). Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation. Toxicol. Appl. Pharmacol. 298:9-18. PMC4821717. http://www.sciencedirect.com/science/article/pii/S0041008X16300473
Hoyle, G. W., and Svendsen, E. R. (2016). Persistent effects of chlorine inhalation on respiratory health. Ann. N. Y. Acad. Sci. 1378:33-40. http://onlinelibrary.wiley.com/doi/10.1111/nyas.13139/full
Musah, S., Schlueter, C. F., Humphrey, D. M. Jr., Powell, K. S., Roberts, A. M., and Hoyle G.W. (2017). Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation. Toxicol. Appl. Pharmacol. 315:1-11. http://www.sciencedirect.com/science/article/pii/S0041008X16303726
Conklin, D. J., Haberzettl, P., Jagatheesan, G., Kong, M., and Hoyle, G. W. (2017). Role of TRPA1 in acute cardioplumonary toxicity of inhaled acrolein. Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2016.08.028. http://www.sciencedirect.com/science/article/pii/S0041008X16302514
