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Researchers recognized for work that can lead to commercialization

by UofL Today last modified Nov 06, 2009 03:34 PM

One of the reasons the University of Louisville is seen as an important economic development engine in Louisville is the work of university researchers that leads to patents, licenses and options.

Researchers recognized for work that can lead to commercialization

Bill Pierce, pharmacology, and interim vice president for research, was among the honorees.

At the Fall 2009 Celebration of Faculty Excellence Nov. 5, President James Ramsey, Provost Shirley Willihnganz and other administrators recognized 28 researchers for their work that has resulted in receipt of a patent license or option over the past year. Such work can lead to commercialization, high-tech business development and high-paying jobs within the region. About half of were recognized for work done at the James Graham Brown Cancer Center.

Ramsey commended the recipients for their commitment to making research and new innovations happen at UofL.

"All of you have one thing in common ... you have set high standards of excellence - your work enhances the prestige and respect of our university," he said. "You have distinguished yourselves among your colleagues and your personal dedication to excellence is an inspiration to all of us."


William M. Pierce Jr. and Leonard C. Waite, School of Medicine

Title: Bone Targeting Compounds for Delivering Agents to Bone for Interaction Therewith

Description: Osteoporosis affects a multitude of people, and this patent is for an innovative compound that "targets" the bone in order to "carry" other compounds that could diagnose, treat or prevent this or many other bone diseases.

Suzanne Ildstad, School of Medicine

Title: Methods of Screening for Compounds That Improve Engraftment

Description: Bone marrow transplantation offers great promise for the treatment of a number of chronic disease states. This technology provides for methods for screening for compounds that improve engraftment by expanding facilitating cell numbers and enhancing their functionality.

Mahendra Sunkara, J.B. Speed School of Engineering. 

Title: Formation of Metal Oxide Nanowire Networks (Nanowebs of Low-Melting Metals)

Description: The invention provides a method for producing nanowires that intersect to form crystalline networks of nanowebs, which have potential applications in electronics, optoelectronics and catalysis. Before these structures can be used in next-generation devices, however, a reliable and repeatable process for creating nanostructures in a controlled manner  - such as the one invented - is needed, so this process holds great promise.

Ben Jensen, School of Medicine, and Shin-je Ghim, School of Medicine

Title: Diagnosing and Protecting against Tursiops Truncatus Papillomavirus

Description: While the dire effects of Human Papillomavirus - HPV - are well known, it is relatively unknown that these viruses also affect many animals. This technology describes a papillomavirus vaccine for bottlenose dolphins.  

Don Miller, Paula Bates, and John Trent, School of Medicine; and Bo Xu, College of Arts and Sciences

Title: Method for the Diagnosis and Prognosis of Malignant Diseases

Description: A hallmark of a cancer cell is uncontrolled proliferation.  A common way to identify a cancer cell is to detect abnormally expressed proteins as "markers" which distinguish the cancer cells from healthy ones, and this technology describes methods to detect and find pre-cancerous conditions and later-stage malignant diseases and disorders.


Ayman El-Baz and Aly Farag, J.B. Speed School of Engineering

Title: Fast and Accurate Lung Segmentation Framework, Automatic Analysis of 3D Low-Dose CT Images for Early Diagnosis of Lung Cancer, and a Framework for Automatic Detection of Lung Nodules in Low-Dose Chest CT Scans: New Template Modeling and Evaluation for Cad System Design. (The first two parts are solely the result of El-Baz's work and the third is the result of his collaboration with Farag)

Company: Clarity Imaging Solutions

Description: The option is for a non-invasive imaging method and software for detecting small lung nodules and tracking their growth over time, providing a predictive model for early stage lung cancer.

Michael Voor, School of Medicine

Title: Device and Method to Prevent Hip Fractures and Device to Prevent and Pretreat Hip or Proximal Femoral Fractures

Company: Vivorte

Description: It is a small orthopedic medical device that, when implanted in the hip via a simple surgical procedure, increases bone strength and in turn decreases the likelihood of bone fracture.


Francis  Zamborini, College of Arts and Sciences ; Abdelilah Safir, Brigitte H. Totten, Robert Cohn, Mehdi Yazdanpanah and Santosh Pabba,  J.B. Speed School of Engineering

Title: Metallic Nanoneedle Tips, Devices and Systems: Fabrication and Application

Company: NaugaNeedles

Description: The technology involves the development of constant diameter, silver-gallium nanoneedles-or very small needles. Applications of the nanoneedles include scanning electrochemical microscopy, cell probing, ultra sensitive measurements, mass detections and liquid property measurements.

Ted Kalbfleisch, School of Medicine

Titles: Drag and Deep Drop, and A Software System to Facilitate World Wide Life Sciences Interoperable Research

Company: Intrepid Bioinformatics Solutions, Inc., a Metacyte company

Description: With this exclusive license agreement, Intrepid Bioinformatics Solutions, Inc., a Metacyte company, plans to launch a web-based data repository. This dynamic system will allow researchers to securely manage their own proprietary data, as well as that of collaborators and existing public data currently available online.

Gerald Hammond, College of Arts and Sciences; and Paula Bates, School of Medicine

Title: Synthesis of a Novel and Selective Difluoro Anticancer Compound

Company: Transmed Oncology

Description: This novel class of compounds with anti-cancer activities can regulate multiple cell growth pathways and demonstrate anti-cancer activity with low toxicity to normal cells using.  Phase I clinical trials with this technology will be initiated in early 2010. 

John Trent, Sucheta Telang, Jason Chesney and Brian Clem, School of Medicine

Title: Small Molecule Inhibition of Choline Kinase Suppresses Tumor Growth

Company: Advanced Cancer Therapeutics

Description: Choline metabolism is altered in a wide variety of cancers including those of the lungs, breast, ovaries, brain and prostate. Choline Kinase is over expressed in most solid tumors, and, therefore, has a vital role in cell proliferation. This technology has identified a class of small molecule inhibitors of choline kinase. 

Brad Chaires, Nichola Garbett and Ben Jenson, School of Medicine

Title: A Thermal Denaturation Method for Quantitative Analysis of the Plasma and Serum

Company: Louisville Bioscience

Description: This powerful diagnostic technology can be used as a sensitive and reliable indicator of particular disease states and can accurately identify and distinguish between different stages of numerous difficult-to-diagnose diseases, including cancer. The company intends to develop it as a form of personalized medicine that should alter treatment paradigms, improve patient outcomes and reduce the cost of patient care.

Ben Jenson, Shin-je Ghim, Donald Miller, Kenneth Palmer and Amanda Lasnik, School of Medicine

Title: Canine Oral Papillomavirus-L2 Antigen (COPV-L2)

Company: Advanced Cancer Therapeutics

Description: Human Papillomavirus (HPV) is a leading cause of cervical cancer. About 20 million people are infected with this sexually transmitted disease (STD). This new form of the HPV vaccine can be produced in genetically-modified tobacco plants. It should provide broader immune protection at a lower cost than the currently available HPV vaccine. Development plans include providing cost-effective, broad immunity for people at risk of contracting HPV in both developed and developing nations.

Donald Miller, Kara Sedoris and Sheila Thomas, School of Medicine 

Title: Cancer Cell Death Induced by Oncogene Promoter Sequences

Company: Advanced Cancer Therapeutics

Description: This naturally occurring, genomic DNA sequence has the ability to form four-stranded DNA. The researchers have demonstrated that this sequence inhibits the growth of cancer cells but has no effect on non-cancer cells, and stops the growth of a wide variety of tumor types.

Lung-Tsiong Yam, School of Medicine

Title: Monoclonal Antibody (9C5) to Tartrate-Resistant Acid Phosphatase (TRACP)

Description: A research tool that can be used to monitor the expression of a protein known to be increased in some pathological conditions, including but not limited to osteoporosis and metabolic bone diseases.

Shonna Riedell, James Graham Brown Cancer Center, and Kenneth Palmer, School of Medicine

Title: New Strategy for Development of Human Papillomavirus L2 Vaccine Contruct

Description not available

Mehdi M. Yazdanpanah and Robert W. Cohn, J.B. Speed School of Engineering

Title: Pulling Nanolithography

Description not available

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