You are here: Home Faculty & Staff Directory Dongfeng Wu, PhD

Dongfeng Wu, PhD


Bioinformatics and Biostatistics

Role: Faculty
Title: Associate Professor
Office No: 122
Address: 485 E. Gray St.
Phone: 502/852-1888
Fax: 502/852-3294


B.S., 1990, Probability and Statistics, Peking University, P.R. China.
M.S., 1993, Probability and Statistics, Peking University, P.R. China.
M.S., 1999, Computer Science, University of California, Santa Barbara.
Ph.D.,1999, Statistics, University of California, Santa Barbara.

I joined the Department of Bioinformatics and Biostatistics in September 2007 as an Associate Professor. Before that, I was an Assistant Professor at Mississippi State University (tenured and promoted to associate prof in Spring 2007).

Research Interests

My main research area is in probability modeling and statistical inferences in periodic cancer screening. Besides that, I am interested in Bayesian inference, statistical decision theory, time series, smoothing spline, wavelet regression and all kinds of statistical problems in medical research.

Current Projects

a. When to schedule the next mamogram for an asymptomatic woman with her screening history?
b. How to evaluate long-term benefit due to regular cancer screening?


Teaching Activities

a. Probability---PHST 661.
b. Mathematical Statistics---PHST 662.
c. Bayesian Inference---PHST 691.
d. Advanced Nonparametric Statistics---PHST 780.


Students Mentored

1. At Mississippi State University (2001-2007).

Xuhong Liu. December 2002. Project title: Periodic Screening for Breast Cancer.

Jixiang Wu. May 2003. Project title: Complex Trait Analyses by Mixed Linear Model Approach: Methodology and Application. Currently an assistant professor at South Dakota State University.

Wen-hsiung Chou. May 2003. Project title: Discrete Choice Modeling: Multinomial Logit Model.

Dongyu Ying. May 2004. Project title: Statistical Inference for the Breast Cancer Control Data.

Justin H Shows. July 2004. Project title: Lead Time Estimation in Cancer Screening. Currently an assistant professor at Mississippi State University.

Xiaoying Tan. December 2006. Project title: Applications in Periodic Cancer Screening Model -- MLE, MCMC Simulations and Bootstrap Sampling.

Changshun Li. August 2007. Project title: A Review of Colorectal Cancer Screening with Fecal Occult Blood Test.

2. At University of Louisville (2007- ).

Yinlu Chen. Project title: Breast Cancer Screening Model – Application to the Canadian Study. August 2009. Currently working at UofL.

Rona J. Roberts. Dept. of Psychiatry, School of Medicine, and SPHIS CREST program. Project title: Effect of long acting naltrexone on adherence to recommendation for treatment. April 2010.

Chengxin Li. Project title: The statistical effects on measuring myocyte with different image zoom rates. August 2010.

Xinyuan Duan. Project title: Evaluating Fiberoptic Intubation Simulator Training in Reaching Proficiency of Skills. December 2010.

Muhammad Babar. SPHIS CREST program. Project title: Effect of remote telemedicine intersive care unit monitoring program on clinical outcomes. December 2011.

Dianhong Luo. Project title: The trend and disparities in the diagnosis of breast cancer by mobile mammography at a comprehensive cancer center. August 2012.

Vikranth Shetty. Co-Chair Dr. Shesh Rai. Project title: Statistical methods to find miRNA related to aging in mice. August 2012.

Jiying Ling. Project title: Evaluating nutrition and physical activity trend in middle school students at four underserved regions in Kentucky. May 2013 (expected).


Editorial Board Member, Journal of Biometrics and Biostatistics.
Editorial Board Member, Journal of Cancer Science and Therapy.


Outside Interests

a. Listening:
Turning Point,
Wadley's preaching
Yu Hongjie's preaching;
Attending the BSF class;
b. Reading--favorite
Timothy Keller: The Prodigal God; Countfeit Gods; The Reason for God.
Kyle Idleman: Not a Fan.
James I. Packer: Knowing God.
Oswald Chambers: My Utmost for His Highest.
Rick Warren: Purpose Driven Life.
Tedd Tripp: Shepherding a Child's Heart.
Larry Fowler: Raising a Modern Day Joseph.
James Dobson: The New Dare to Discipline.
Stormie Omartian: The Power of a Praying Parent.
Dutch Sheets: Intercessory Prayer.
Neil T. Anderson: Victory Over the Darkness.
C.S. Lewis,
A.B. Simpson: Himself.
c. Training my kids, going to their swim meets as a family;
d. Gardening: planting/caring fruit trees.
e. Quote: "Above all else, guard your heart, for it is the wellspring of life." - Proverbs 4:23.

Completed Grant

NIH/NCI grant: R03CA115012. Role: Principal Investigator.
Project Title: Statistical inference for lead time in cancer screening.

Selected Peer-Reviewed Publications

Book Chapters

Wu D and Perez A (2011). "Probability Modeling and Inference in Screening: exemplification with the fecal occult blood test." in "Colorectal Cancer/Book 1." InTech. October, 2011. ISBN: 978-953-307-707-9.

Wu D and Rosner GL (2010). "Probability modeling and statistical inference in periodic cancer screening." in "Frontiers in Computational and System Biology." Springer. June, 2010. ISBN: 978-1-84996-195-0.

Journal Articles

Kim S, Erwin D, and Wu D. (2012). Efficacy of dual lung cancer screening by chest x-ray and sputum cytology using Johns Hopkins lung project data. Journal of Biometrics and Biostatistics. 3:139. doi:10.4172/2155-6180.1000139.

Wu D, Kafadar, K, Rosner GL, Broemeling LD. (2012). The lead time distribution when lifetime is subject to competing risks in cancer screening. The International Journal of Biostatistics. Volume 8: Issue 1, Article 6, ISSN: 1557-4679, DOI: 10.1515/1557-4679.1363, April 2012.

Luo D, Cambon AC, Wu D.(2012). Evaluating long term effect of FOBT in colon cancer screening. Cancer Epidemiology. 36 (2012), e54-e60. DOI: 10.1016/j.canep.2011.09.011.

Duan X, Wu D, Bautista AF, Akca O, Carter MB, Latif RK. (2011). Assessment of reaching to proficiency in procedural skills: fiberoptic airway simulator training in novices. Open Access Medical Statistics. 2011: 1, 45-50. DOI:10.2147/OAMS.S24625.

Wu D, Erwin D, and Kim S. (2011). Projection of long-term outcomes using X-rays and Pooled cytology in Lung Cancer Screening. Open Access Medical Statistics. 2011: 1 13-19. DOI:10.2147/OAMS. S22987.

Li C, Kong M and Wu D(2011). The statistical effects on measuring myocyte with different image zoom rates. Open Access Medical Statistics. 2011:1 3-12. DOI: 10.2147/OAMS.S20303.

Wu D and Perez A(2011). A limited Review of Over-Diagnosis Methods and Long Term Effects in Breast Cancer Screening. Oncology Review. DOI: 10.1007/s12156-011-0077-0.

Shows J and Wu D(2011). Inferences for the Lead Time in Breast Cancer Screening Trials Under a Stable Disease Model. Cancers 2011, 3(2), 2131-2140; DOI:10.3390/cancers3022131

Wu D, Erwin D, and Rosner GL(2011). Sojourn time and lead time projection in lung cancer screening. Lung Cancer.72(2011):322-326. DOI: 10.1016/j.lungcan.2010.10.010

Chen Y, Brock G, and Wu D.(2010). Estimating Key Parameters in Periodic Breast Cancer Screening - Application to the Canadian National Breast Screening Study data. Cancer Epidemiology. 34, 429-433. DOI:10.1016/j.canep.2010.04.001

Wu D., Erwin D, and Rosner GL.(2009). A projection of benefits due to fecal occult blood test for colorectal cancer. Cancer Epidemiology. 33. 212-215.

Wu D., Erwin D, and Rosner GL.(2009). Estimating key parameters in FOBT screening for colorectal cancer. Cancer Causes and Control. 20: 41-46.

Shi, Q. and Wu, D.(2009). Modeling Moisture Absorption Process of Wood-Based Composites Under Over-Saturated Moisture Conditions Using Two-Part Equations. Wood Science and Technology. 43, 143-150. DOI: 10.1007/s00226-008-0201-x.

Wu, D, Carino RL, and Wu, X(2008). When sensitivity is a function of age and time spent in the preclinical state in periodic cancer screening. Journal of Modern Applied Statistical Methods. Vol. 7, No. 1, 297-303.

Wu, D., Rosner, G. L., and Broemeling, L. D.(2007). Bayesian inference for the lead time in periodic cancer screening. Biometrics. Vol. 63, No. 3, 873–880.

Zhang, Y. and Wu, D.(2006). Methodologies to Predict Service Lives of Pavement Marking Materials. Journal of the Transportation Research Forum. Vol. 45, 5-18.

Wu, J., Wu, D., Jenkins, J. N., and McCarty, J.C.(2006). A Recursive Approach to Detect Multivariable Conditional Variance Components And Conditional Random Effects. Computational Statistics and Data Analysis. 50, 285-300.

Wu, J., Jenkins, J. N., McCarty, J. C. and Wu, D.(2006).Variance Component Estimation Using the ADAA Model When Genotypes Vary Across Environments. Crop Science. Vol.46, 174-179.

Wu, D., Rosner, G. L., and Broemeling, L. D.(2005). MLE and Bayesian inference of age-dependent sensitivity and transition probability in periodic screening. Biometrics. Vol.61, No.4, 1056-1063.

Wu, D., Wu, X., Banicescu, I. and Carino, R. (2005). Simulation Procedure in Periodic Cancer Screening Trials. Journal of Modern Applied Statistical Methods. Vol.4, No.2, 522-527.

Broemeling, L. D. and Wu, D.(2005). Power functions for Bayesian tests with application to the design of clinical trials: the fixed-sample case. Journal of Modern Applied Statistical Methods. Vol. 4, No. 1, 163-171.

Wu, D.(2004). A Visually Adaptive Bayesian Model in Wavelet Regression. Journal of Modern Applied Statistical Methods. Vol. 3, No. 1, 200-212.

Wu, D.(2002). NORM thresholding method in wavelet regression. Journal of Statistical Computation and Simulation. Vol. 72, 233-246.

Shen, Y., Wu, D., and Zelen, M.(2001). Testing the independence of two diagnostic tests, Biometrics. Vol. 57, 1009-1017.

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