Jonathan Kopechek

Assistant Professor, Bioengineering


Jonathan A. Kopechek, Ph.D., is an Assistant Professor in the Department of Bioengineering at the University of Louisville. Prior to joining UofL he was a Ruth L. Kirschstein NRSA Postdoctoral Fellow (NIH/F32) at the University of Pittsburgh. He was also previously a postdoctoral fellow in the Cross-Disciplinary Training in Nanotechnology for Cancer program (NIH/R25) at Boston University. He has received honors and awards for his work from the American Heart Association, the Focused Ultrasound Surgery Foundation, and the University of Pittsburgh School of Medicine. Dr. Kopechek has over 10 years of experience in image-guided therapy research and published 18 peer-reviewed journal articles as of 2016. He established the Theranostic Ultrasound Laboratory at the University of Louisville in 2016.

Research Experience

Dr. Kopechek’s research interests focus on the development of image-guided molecular therapy platforms utilizing ultrasound-responsive drug and gene carriers for treatment of cancer and cardiovascular diseases. These include gas-filled microbubbles and liquid perfluorocarbon nanodroplets, which can be activated with focused ultrasound pulses to spatially and temporally control the delivery of therapeutic agents. These formulations are in development for targeted delivery of therapeutic nucleic acids, such as miRNAs, or other therapeutic molecules in order to repair and regenerate injured cardiac muscle or suppress tumor growth. The long-term goal is to develop targeted, non-invasive therapeutic delivery platforms with far-reaching clinical impact on the treatment of many diseases.

Theranostic Ultrasound Lab Website

Google Scholar Profile