SEMINAR: Current cellular methods to improve cardiac and microvascular function in aging

Amanda Jo LeBlanc, Ph.D.
When Feb 27, 2019
from 12:00 PM to 01:30 PM
Where Shumaker, RM139
Contact Name
Contact Phone 5028527485
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Abstract:

While coronary artery disease (CAD) occurs in both older men and women, coronary microvascular dysfunction (CMD) is more often present in older women, who often exhibit signs and symptoms of CAD in the absence of obstructive coronary arteries. Treatment with adipose-derived Stromal Vascular Fraction (SVF) 3-D epicardial patch has been previously shown to increase microvessel perfusion in an infarcted young heart. But more recently, our laboratory has demonstrated that intravenous delivery of SVF results in improved cardiac and coronary perfusion in a model of aging, with demonstrated vascular incorporation of SVF cells. The primary purpose of this presentation is to describe our recent studies of utilizing adipose-derived SVF in the effort to reverse perfusion deficits caused by aging, and also to highlight other seminal studies which use autologous or allogeneic cells to improve cardiac and microvascular function.

Speaker:  Amanda Jo LeBlanc, Ph.D.

Amanda Jo LeBlanc, Ph.D., is an Associate Professor in the Department of Physiology and the Cardiovascular Innovation Institute at the University of Louisville. Dr. LeBlanc received her Ph.D. in Exercise Physiology from West Virginia University in 2008. She pursued initial postdoctoral training with Dr. Timothy Nurkiewicz at WVU and then received additional training under Drs. Stuart K. Williams and James Hoying at the Cardiovascular Innovation Institute before joining the faculty in 2012.
Dr. LeBlanc’s primary research areas include developing cell-based therapies designed to improve coronary perfusion in aging hearts and investigating the dynamic relationship between vasoreactivity and reactive oxygen species. Her recent work has shown the promise of an autologous cell therapy derived from adipose tissue in resetting vascular tone in peripheral vessels via a macrophage-specific cell type. She has extended those findings by demonstrating a reversal of age-related coronary microvascular dysfunction and diastolic dysfunction following an intravenous administration of the cell therapy. Dr. LeBlanc’s earlier work investigated the sex- and estrogen-related differences in nitric oxide-dependent coronary microvascular reactivity with advancing age. These studies not only discovered novel regulation of coronary perfusion in aging, but also provide a new therapeutic intervention to improve age-related vascular and cardiac dysfunction.

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