SEMINAR: Bioresorbable Zn-based Medical Implants for Orthopaedic and Cardiovascular Applications

Dr. Donhui (Don) Zhu
When Mar 15, 2019
from 10:00 AM to 11:00 AM
Where Shumaker Research Bldg., RM139
Contact Name
Contact Phone 852-7485
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Abstract

Innovations in metallic biomaterials have attracted remarkable attention for their potential as orthopedic implants, cardiovascular interventional devices, and tissue engineering scaffolds, due to their high-strength and toughness compared with polymers and ceramics.  Traditional metallic biomaterials with high corrosion resistance, such as titanium alloys, stainless steels, and cobalt-chromium are generally permanent implants, and may cause chronic deleterious effects.  Thus, a second operation may be necessary to extract the implant, resulting in additional injury and expense.  Biodegradable metals are an alternative approach to the traditional paradigm of corrosion resistant metals.  They can corrode gradually while maintaining mechanical integrity during the critical tissue healing phase, and fully dissolve upon fulfilling their mission. Recently, Zn-based biomaterials have emerged as innovative bioresorbable medical implants, typically for cardiovascular and orthopedic applications.  We focus on the pathophysiological role of Zn2+ in neuronal, vascular, and bone disorders, as well as metallic Zn alloys for stent and bone implant applications.  This project demonstrates metallic Zn's strong potential for bone-related regeneration and cardiovascular stent applications. 

Speaker:  

Dr. Zhu earned his doctorate in Bioengineering at the University of Missouri-Columbia.  His Ph.D. projects aimed at neuro-engineering for treatment of Alzheimer's disease.  Following his doctoral studies, Dr. Zhu trained at the University of Rochester Medical Center for Regenerative Medicine.  He became an Assistant Professor in 2010, with his research focused on biodegradable metallic material for tissue engineering and regeneration.  Dr. Zhu moved to Texas in 2016 as an Associate Professor, and currently has a research interest in biomaterials drug/gene delivery, skeletal/bone disorders, and neurovascular diseases.  He has secured over $3 million total research funding from NIH since 2012, and co-authored more than 50 peer-reviewed journal articles and book chapters.  Dr. Zhu also serves as editor or on editorial boards of several scientific journals and numerous grant proposal review panels, including NIH, NSF, and NASA.

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