SEMINAR SERIES : Novel Approaches to Endogenous Heart Repair

Tamer Mohamed, Ph.D.
When Feb 06, 2019
from 12:00 PM to 01:00 PM
Where Shumaker Bldg., RM 139
Contact Name
Contact Phone 852-7485
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Abstract:

After a heart attack the heart loses many muscle cells which leads to the loss of ability to pump blood to the rest of the body. The muscle cells in the adult heart are not able to regenerate themselves which make it difficult to treat such disease. However, in human fetuses, zebrafish, and salamander the heart muscle is able to regenerate. Here we are using cutting edge technologies to understand why the fetuses but not adults are able to regenerate their hearts. This understanding will allow the development of novel therapies to regenerate the dead heart muscle in heart failure patients.
In Mohamed’s lab they are initiating new discovery programs to develop novel heart failure therapies mainly focusing on understanding the cell cycle regulation of cardiomyocyte proliferation and the direct cardiac reprogramming process.
This seminar will report how we could regenerate the heart through gene therapy. The learners will be able to learn about most recent research to treat heart failure. In addition, Dr. Mohamed will explain how transcription factors and cell cycle genes can renew heart muscle.


Speaker: 

Dr. Tamer Mohamed has completed his PhD at the age of 30 years from University of Manchester (UK). He has done his postdoctoral training at the Gladstone Institute, San Francisco, USA. He is currently an assistant professor of cardiology at the University of Louisville, Louisville, USA. He has published more than 25 papers in the field of heart failure and cardiac regeneration in reputed journals with a most recent paper in the renowned journal of Cell. Dr. Mohamed’s patents resulted in 50 million dollar investment from investors to start up Tenaya Therapeutics to develop his discoveries into heart failure therapies.

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