SEMINAR: Cancer Immunotherapy-Challenges and Solutions to Improve Clinical Benefit

Kavitha Yaddanapudi, Ph.D.
When Mar 06, 2019
from 12:00 PM to 01:00 PM
Where Shumaker Research Bldg., RM 139
Contact Name
Contact Phone 852-7485
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Abstract:  Cancer immunotherapy—treatments that enhance the power of the immune system to fight cancer—represents the most promising cancer therapeutic approach since the development of the first chemotherapies in the 1940s. While some patients experience potent and durable clinical responses to these breakthrough immunotherapies, response rates are highly variable. Critical questions at present include deciphering why some cancer patients respond while others do not, as well as why certain cancers respond while others like pancreatic cancer do not. Therapeutic resistance in late-stage cancer patients is linked to the abilities of the tumors to foster an immunosuppressive environment that actively antagonizes anti-tumor immune responses. Our current research efforts are focused on characterizing the immunobiology of these suppressive mechanisms and on developing therapeutic approaches aimed at relieving the tumor-induced immune suppression in late-stage cancer patients, allowing for enhanced response to immunotherapeutic agents.

Speaker:  Dr. Kavitha Yaddanapudi is an Assistant Professor of Medicine, School of Medicine, University of Louisville. Dr. Yaddanapudi is a member of the Immune-Oncology group at the JG Brown Cancer Center, UofL and an associate faculty member of the Department of Microbiology and Immunology, UofL. She completed her post-doctoral studies at Columbia University, New York. The primary focus of Dr. Yaddanapudi’s research program is the development of novel immune-based strategies for the treatment of cancer. A secondary focus is towards understanding the role of tumor microenvironment in the regulation of immune responses in cancer, particularly in the context of myeloid cells.

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