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Dr. Palaniappan Sethu



Associate Professor

Department of Bioengineering,

2100 S. Brook St., SRB 357
University of Louisville,
Louisville, KY 40292
Ph: (502) 8520351
Fax: (502) 852 1577


Ph.D. in Biomedical Engineering, University of Michigan, Ann Arbor, 2002
M.S. in Biomedical Engineering, University of Michigan, Ann Arbor, 2002
M.S. in Industrial Engineering, University of Michigan, Ann Arbor, 2000
B.E. in Mechanical Engineering, PSG College of Technology, Coimbatore, India, 1998

Lab Website: Microscale Biotechnology Lab

Other Lab Website (Note:this link leaves the UofL site):  P.Sethu's other Microscale Biotechnology Lab website

Research Interests:

My laboratory uses engineering approaches and micro/nano- scale technologies to address a host of problems in biology and medicine. We focus on translational research to ensure that technologies developed in our laboratory find practical application in the research or clinical setting. Current research projects target a diverse range of applications ranging from molecular analysis to in vitro cell culture models and can be broadly classified into three focus areas:

(A) Physiologically relevant models of cardiac and vascular tissue

(B) Microfluidic cell separations

(C) Nanotechnology based approaches to study sub-cellular signaling


  • National Science Foundation CAREER Award, 2012

  • Center for Environmental Genomics and Integrative Biology, Early Career Award, 2010

  • Wallace H. Coulter Foundation Early Career Award for Translational Research in Biomedical Engineering 2006

  • Postdoctoral Fellowship, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital, Boston, MA

  • Graduate Student Research Fellowship, Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI

  • Best Outgoing Student, Class of 1998, Mechanical Engineering, PSG College of Technology, Coimbatore, India


Selected Publications:

1.        Spencer L. York, Ahmad R. Arida, Karan S. Shah, Palaniappan Sethu and Marnie M. Saunders, “Osteocyte Characterization on Polydimethylsiloxane Substrates for Microsystems Applications”, (In Press: Journal of Biomimetics, Biomaterials, and Tissue Engineering, Impact Factor: 1)

2.        Heng Wu, Arkady Uryash, Jorge Bassuk, Paul Kurlansky, Guruprasad Giridharan, Mostafa Shakeri, Rosendo Estrada, Palaniappan Sethu and Jose Adams, “Mechanisms of Periodic Acceleration Induced endothelial Nitric Oxide Synthase (eNOS) Expression and Upregulation Using an In-Vitro Human Aortic Endothelial Cell Model”, (In Press: Cardiovascular Engineering and Technology, Impact Factor: 1.2, Citations: N/A)

3.        Vahidreza Parichehreh and Palaniappan Sethu, “Inertial lift enhanced phase partitioning for continuous microfluidic charge based sorting of particles and cells”, Lab Chip. 2012 Mar 7;12(7):1296-301. Epub 2012 Feb 16. (Impact Factor 6.3, Citations: N/A)

4.        John Kirtley,  Eric C. Rouchka, Richard M. Flight, Palaniappan Sethu, John W. Eaton, Robert S. Keynton, “Meta-analysis of gene expression changes in response to radiation exposure”, BMC Bioinformatics, Volume: 12, Supplement: 7, Article Number: A20,  2011. (Impact Factor: 3.43, Citations: N/A)

5.        Balaji Panchapakesan, Palaniappan Sethu, Benjamin King, Brittany Book, Madhusuduna Rao and Joseph Irudayraj, “Gold Nanoprobes for Theranogstics”, Invited Review, Nanomedicine (Lond). 2011 Dec;6(10):1787-811. (Impact Factor: 6.14, Citations: N/A)

6.        Lorelei D. Shoemaker, Achal S. Achrol, Palaniappan Sethu, Gary K. Steinberg and Steven D. Chang, “Clinical Neuroproteomics and Biomarkers: From Basic Research to Clinical Decision-making”, Neurosurgery. 2012 Mar;70(3):518-25. (Impact Factor: 3.23, Citations: N/A) [Editor’s Choice]

7.        Rosendo Estrada, Guruprasad Giridharan, Mai-Dung Nguyen, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Endothelial Cell Culture Model to Replicate Disturbed Flow Conditions Seen in Atherosclerosis Susceptible Regions”, Biomicrofluidics, 5, 032006, 2011 (Impact Factor: 3.9, Citations: N/A) [Also featured in: Vir. J. Bio. Phys. Res. / Volume 22 / Issue 7 / Multicellular Phenomena]

8.        Krishnakiran Medepalli, Bruce Alphenaar, Ashok Raj and Palaniappan Sethu, “Evaluation of the Direct and Indirect Response of Blood Leukocytes to Carbon Nanotubes (CNTs)”, Nanomedicine. 2011 Dec;7(6):983-91. Epub 2011 May 4. (Impact Factor: 6.692, Citations: N/A)

9.        Rosendo Estrada, Guruprasad A. Giridharan, Mai-Dung Nguyen, Thomas J. Roussel, Mostafa Shakeri, Vahidreza Parichehreh, Sumanth D. Prabhu and Palaniappan Sethu, “Endothelial Cell Culture Model (ECCM) for Replication of Physiological Profiles of Pressure, Flow, Strain and Shear Stress In-Vitro”, Anal Chem. 2011 Apr 15;83(8):3170-7., (Impact Factor: 5.712, Citations: N/A)

10.     Vahidreza Parichehreh, Kranthi Kumar Bhavanam, Vinay Raj, Ashok Raj and Palaniappan Sethu, “Osmosis as a basis for Differential Blood Cell Sorting”, Biomed Microdevices 2011 Jun;13(3):453-62. (Impact Factor: 3.323, Citations: N/A)

11. Ayman El-Baz, Palaniappan Sethu, Georgy Gimel’farb, Fahmi Khalifa, Robert Falk, Mohamed Abo El-Ghar, “Validation of A Novel Imaged-Based Approach for Accurate Measuring the Growth Rate of Detected Lung nodules Using Elastic Phantoms Generated By State-of-the-Art Microfluidics Technology”, Biotechnol J. 2011 Feb;6(2):195-203. (Impact Factor: 2.100, Citations: N/A)

12. Balaji Panchapakesan,  Robert Caprara, Vanessa Velasco, James Loomis,  Ben King, Peng Xu, Tom Burkhead, Palaniappan Sethu, Lindsey J. Stallons, William G. McGregor, Shesh N. Rai,  Goetz Kloecker and Eric Wickstrom, “Micro- and nanotechnology approaches for capturing circulating tumor cells”, Cancer Nanotechnology, Volume 1, Numbers 1-6, Pages 3-11, 2011 (Impact Factor: 1.58,  Citations: N/A)


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Updated 11/16/2012

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