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You are here: Home Faculty Bioengineering Full-Time Faculty Dr. Palanaippan Sethu Dr. Palaniappan Sethu

Dr. Palaniappan Sethu





Assistant Professor

Department of Bioengineering,

2100 S. Brook St., SRB 357
University of Louisville,
Louisville, KY 40292
Ph: (502) 8520351
Fax: (502) 852 1577


Ph.D. in Biomedical Engineering, University of Michigan, Ann Arbor, 2002
M.S. in Biomedical Engineering, University of Michigan, Ann Arbor, 2002
M.S. in Industrial Engineering, University of Michigan, Ann Arbor, 2000
B.E. in Mechanical Engineering, PSG College of Technology, Coimbatore, India, 1998

Lab Website: Microscale Biotechnology Lab

Research Interests:

My laboratory uses engineering approaches and Micro/Nano- scale technologies to develop new and enabling technologies to address a host of problems in Biology and Medicine. We focus on translational research to address critical needs in the research and clinical setting. Active research projects target a diverse range of applications ranging from molecular analysis to in vitro cell culture models and can be broadly classified into three focus areas:


A. Microfluidic Cellular and Molecular Analysis

B. Physiologically Relevant Cell Culture Models

C. Periodic Linear Acceleration (pGz) based Therapeutics


  • Center for Environmental Genomics and Integrative Biology, Early Career Award, 2010
  • Wallace H. Coulter Foundation Early Career Award for Translational Research in Biomedical Engineering 2006
  • Postdoctoral Fellowship, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital, Boston, MA
  • Graduate Student Research Fellowship, Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI
  • Best Outgoing Student, Class of 1998, Mechanical Engineering, PSG College of Technology, Coimbatore, India
  • 1st Place (Undergraduate Division, Bioengineering) and 1st Place Overall, Thanh Huong T Luong, Mai-Dung Nguyen, Guruprasad Giridharan and Palaniappan Sethu, Engineering Expo 2010, Louisville, KY.
  • 2nd Place, Bobby L. Gibbons II, Mai-Dung Nguyen, Guruprasad Giridharan, Mohammed Ishmahil, Sumant D. Prabhu and Palaniappan Sethu, Research Louisville 2008.
  • 1st Place Undergraduate Division, William N. White and Palaniappan Sethu, University of Louisville, Engineering Expo 2007.


Selected Publications (2011):

  • Lorelei D. Shoemaker, Achal S. Achrol, Palaniappan Sethu, Gary K. Steinberg and Steven D. Chang, “Clinical Neuroproteomics and Biomarkers: From Basic Research to Clinical Decision-making”, Neurosurgery. 2011 Aug 19. [Epub ahead of print] (Neurosurgery)
  • Rosendo Estrada, Guruprasad Giridharan, Mai-Dung Nguyen, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Endothelial Cell Culture Model to Replicate Disturbed Flow Conditions Seen in Atherosclerosis Susceptible Regions”, Biomicrofluidics, 5, 032006, 2011  [Also featured in: Vir. J. Bio. Phys. Res. / Volume 22 / Issue 7 / Multicellular Phenomena]
  • Krishnakiran Medepalli, Bruce Alphenaar, Ashok Raj and Palaniappan Sethu, “Evaluation of the Direct and Indirect Response of Blood Leukocytes to Carbon Nanotubes (CNTs)”, Nanomedicine. 2011 May 4, [Epub ahead of print]
  • Rosendo Estrada, Guruprasad A. Giridharan, Mai-Dung Nguyen, Thomas J. Roussel, Mostafa Shakeri, Vahidreza Parichehreh, Sumanth D. Prabhu and Palaniappan Sethu, “Endothelial Cell Culture Model (ECCM) for Replication of Physiological Profiles of Pressure, Flow, Strain and Shear Stress In-Vitro”, Anal Chem. 2011 Apr 15;83(8):3170-7.
  • Vahidreza Parichehreh, Kranthi Kumar Bhavanam, Vinay Raj, Ashok Raj and Palaniappan Sethu, “Osmosis as a basis for Differential Blood Cell Sorting”, Biomed Microdevices, Biomed Microdevices 2011 Jun;13(3):453-62.
  • Ayman El-Baz, Palaniappan Sethu, Georgy Gimel’farb, Fahmi Khalifa, Robert Falk, Mohamed Abo El-Ghar, “Validation of A Novel Imaged-Based Approach for Accurate Measuring the Growth Rate of Detected Lung nodules Using Elastic Phantoms Generated By State-of-the-Art Microfluidics Technology”, Biotechnol J. 2011 Feb;6(2):195-203.
  • Balaji Panchapakesan,  Robert Caprara, Vanessa Velasco, James Loomis,  Ben King, Peng Xu, Tom Burkhead, Palaniappan Sethu, Lindsey J. Stallons, William G. McGregor, Shesh N. Rai,  Goetz Kloecker and Eric Wickstrom, “Micro- and nanotechnology approaches for capturing circulating tumor cells”, Cancer Nanotechnology, Volume 1, Numbers 1-6, Pages 3-11, 2011
  • Guruprasad Giridharan, Mai-Dung Nguyen, Vahidreza Parichehreh, Rosendo Estrada, Tariq Hamid, Mohammed Ismahil, Sumanth D. Prabhu and Palaniappan Sethu, “Microfluidic Cardiac Cell Culture Model”, Anal Chem. 2010 Sep 15;82(18):7581-7



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Updated 11/03/2011

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