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Coulter Translational Research Partnership

 

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About the Coulter Translational Partnership

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blankspacer_25 blankspacer_25 MissionW. H. Coulter |  Project Awards |  Proposal Process |  Application Requirements |  Committee Members |  Team |  Contact

 





The Partnership Mission




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The mission of the Coulter Translational Partnership (CTP) in Bioengineering at the University of Louisville is to promote translation of research through successful collaboration between engineers and clinicians, supporting promising technologies.  The Coulter Translational Partnership funds promising projects in order to move innovative technologies to clinical application through commercialization.  The ultimate goal of this partnership is to concentrate on outcomes which will accelerate the introduction of new technologies to improve the treatment and diagnosis of disease or reduce healthcare costs.

In 2005 the Coulter Foundation created a pioneering program consisting of 10 universities, now known as TP1, to begin their commitment to translational research.  The success of the first program was the basis for establishing a second.

The $5 Million grant program was awarded to the University of Louisville Department of Bioengineering in 2011 by the Wallace H. Coulter Foundation.  The University was honored to receive the Coulter Translational Partnership Award which placed U of L in the “Sweet 16” of the US Institutions in the area of Translational Research along with:

Boston University

Case Western Reserve University

Drexel University

Duke University

Georgia Tech/Emory University

Stanford University

University of Michigan

University of Virginia

University of Washington

Columbia University

Johns Hopkins University

University of Louisville

University of Missouri

University of Pittsburgh

University of Southern California

University of Wisconsin

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Wallace H. Coulter

Engineer       Inventor       Entrepreneur      Visionary





Wallace Coulter was co-founder and Chairman of Coulter® Corporation, a worldwide medical diagnostics company. His two great passions in life were applying engineering principles to scientific research and embracing the diversity of world cultures.  Wallace Coulter was the inventor of the Coulter Principle, which is a method for using electronic impedance to count and size microscopic particles suspended in a fluid.  The first application of this principle was the Coulter Counter- a diagnostic device for counting red blood cells.  The Coulter Principle is responsible for the practice of hematology and the complete blood count or “CBC” is the most common diagnostic medical test worldwide.

Under Wallace Coulter’s leadership at the Coulter Corporation, the company became a worldwide leader in hematology, flow cytometry, industrial fine particle analysis and other laboratory diagnostics.  Wallace Coulter was the inventor on 82 patents, many of the inventions coming in the later part of his life.

The Coulter® Corporation was acquired by Beckman Instruments, Inc. in 1997 and the company is now known as Beckman Coulter, Inc.

Following his death, the Wallace H. Coulter Foundation was established to support translational research in biomedical engineering with the goal of accelerating the introduction of new technologies into patient care.  The Foundation works with universities, colleges and professional associations that share his values of endless curiosity, continuous learning, teamwork, consideration and respect for the individual.  The highest level of ethics and integrity are the cornerstone values of the Wallace H. Coulter Foundation.

Wallace Coulter’s legacy of achievements includes critical advancements in diagnosis and treatment of disease, a dynamic corporation that will continue to innovate in healthcare, as well as colleagues, associates, friends and family who were inspired by his influence.  His fame and accomplishments continue to be recognized.  In 2004, Wallace Coulter was posthumously inducted into the National Inventor’s Hall of Fame.

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2013 Project Awards





Congratulations to the 2013 Coulter Translational Partnership Award Recipients.  On average, the teams were awarded $101,000 for one year!

 

Shape Adaptive Therapy to Treat Tumors

Warren Boling, M.D., Neurosurgery

Chin Ng, Ph.D., Radiology

Robert Cohn, Ph.D., Electrical & Computer Engineering

 

Treatment of Cervical Pathologies by Curcumin Delivered Locally by a Polymeric Device

Lynn Parker Petty, M.D., Obstetrics & Gynecology

Ramesh Gupta, Ph.D., Pharmacology

Martin O’Toole, Ph.D., Bioengineering

 

Preclinical Validation of a Novel Multiple Sample Biopsy Device

Gerald W. Dryden, M.D., Medicine

William Hnat, Ph.D., Mechanical Engineering

 

Novel Suture-Less Trocar Site Closure & Herniation Prevention Device

Daniel Metzinger, M.D., Obstetrics & Gynecology

Scott Cambron, M.S., Bioengineering

 

The following teams received a competitive renewal for a second year of funding:

 

A Novel Image Based Diagnostic System for Accurate Diagnosis of Autism

Manuel Casanova, M.D., Psychiatry

Ayman El-Baz, Ph.D., Bioengineering

 

Left Atrial Appendage Closure Device for Stroke Prevention

Matthew Williams, M.D., Surgery (Cardiothoracic Surgery)

Guruprasad Giridharan, Ph.D., Bioengineering

 

Engineering an End to Cataracts

Tongalp Tezel, M.D., Ophthalmology

Martin O’Toole, Ph.D., Bioengineering














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2012 Project Awards






Congratulations to the 2012 Coulter Translational Partnership Award Recipients.  On average, the teams were awarded $88,000 for one year!

Left Atrial Appendage Closure Device for Stroke Prevention

Matthew Williams, M.D., Surgery (Cardiothoracic Surgery)

Guruprasad Giridharan, Ph.D., Bioengineering

A Novel Image Based Diagnostic System for Accurate Diagnosis of Autism

Manuel Casanova, M.D., Psychiatry

Ayman El-Baz, Ph.D., Bioengineering

Development of a Novel, Open-jaw Polypectomy Snare Device

Gerald W. Dryden, M.D., Medicine

John Naber, Ph.D., Electrical/Bioengineering

SIVIC for Establishing Secure Endoscopic Access to the Gastrointestinal Tract

Gerald W. Dryden, M.D., Medicine

William Hnat, Ph.D., Mechanical

Engineering an End to Cataracts

Tongalp Tezel, M.D., Ophthalmology

Martin O’Toole, Ph.D., Bioengineering

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Proposal Process





Criteria:

Each proposal must have co-investigators, at least one whose primary or secondary appointment is in the Department of Bioengineering at the University of Louisville and at least one physician/clinical investigator (MD, DDS, PT, RN). The research must relate directly to applications in health care, and the objectives of the project should include an outcome that will benefit patients. Evaluation of each proposal will be made on the basis of scientific merit, potential health care impact and significance, experience of the investigators, the potential for commercialization, and the likelihood of successfully obtaining follow-on funding.

Duration:

Grants will be for a one-year period, and may be submitted for renewal upon successful achievement of milestones.  Any renewal applications will be evaluated on a competitive basis with new applications.

Budgets:

Grant budgets are approximately $100,000 (direct cost only) for a one-year period. Funds may be used for salary support (no tuition) for graduate students, students and other research staff but may not be used for general staff or administrative support or faculty salaries. Supplies, prototyping expenses, imaging time and travel directly associated with the research activity are examples of eligible budget items.

Important Dates:

Pre-Proposal Deadline:                        Extended to November 22, 2013 by 12 Noon.

Full Proposal Deadline:                       March 7, 2014

Oral Presentation Dates:                     May, 2014

Funding Start Date:                              July 1, 2014

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Application Requirements





Pre-Proposal:

The pre-proposal is designed to address a series of questions focusing on objectives and methods that provide introductory information to the selection committee.  The pre-proposal format (2 page limit, 12 point font, with 1 inch margins) will address the following:

  1. Describe the product/idea you are proposing for this Coulter Award.  Does it address an unmet clinical need?
  2. Who are the co-PIs (engineer and clinician) for this new idea/development?  Describe the collaborative relationship.
  3. Describe the market for this product and any competitive products currently in use.  What is the gold standard?
  4. How is your product unique and is it patentable?  If not patentable is other proprietary protection likely?
  5. List current funding and pending proposals for each co-investigator relative to this product/idea.

For the pre-proposal to be considered, a Research Disclosure Form must be filed with the Office of Technology Transfer.

For questions, please contact Jessica Sharon at (502) 852-4143 or by email at address below.

Applicants should complete the two-page PRE-PROPOSAL and deliver it to the Coulter Program office in Lutz Hall, Room 433 or you may email submission documents to Jessica Sharon at jessica.sharon@louisville.edu by November 22, 2013 by 12 Noon.  Projects invited for full proposal submission will be notified by December 23, 2013.

 

Full Proposal:

Those projects invited to submit a full proposal will be due on March 7, 2014.

 

Oral Presentations:

The Coulter Oversight Committee will select final candidates from those submitting full proposals.   If your proposal is selected, your team is required to give a brief oral presentation to the Coulter Oversight Committee in May, 2014 (TBA).   The Committee will select awardees from this final group.

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Oversight Committee Members





Venture Capital and Entrepreneur

Steven Gailar –  Kentucky Seed Capital Fund

Carter McNabb – River City Capital Fund

Paul Spence, MD – SCR Development Group

University of Louisville School of Medicine Members/Clinical

Henry Kaplan, MD – Evans Professor of Ophthalmology, Chairman, Department of Ophthalmology and Visual Sciences, Director, Kentucky Lions Eye Center

Craig McClain, MD, PhD – Professor of Medicine, Pharmacology and Toxicology, Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition, Associate Vice President for Translational Research

Donald Miller, MD, PhD – Professor of Medicine and Pharmacology, Chief, Division of Medical Oncology and Hematology, Director, James Graham Brown Cancer Center, James Graham Brown Foundation Chair

Mark Slaughter, MD – Professor and Chief, Division of Thoracic and Cardiovascular Surgery

Office of Technology Transfer

Holly Clark, PhD – OTT

Melea East, JD – OTT

Coulter Principle Investigator

Robert Keynton, PhD – Chair, Professor and Lutz Endowed Chair of Biomechanical Devices, Department of Bioengineering

Coulter Foundation Member

Stephen Snowdy, PhD

 

*Additional members (Ad Hoc) may be added to gain their knowledge and expertise in a specialized field, as needed for review of a submitted proposal.

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Coulter Team





Bioengineering Principle Investigator

Robert Keynton, PhD

Chair, Professor and Lutz Endowed Chair of Biomechanical Devices, Department of Bioengineering, Speed School of Engineering

rob.keynton@louisville.edu

School of Medicine Co-Principle Investigator

Mark Slaughter, MD

Professor and Chief, Division of Thoracic and Cardiovascular Surgery, University of Louisville School of Medicine

UofL Office of Technology Transfer (OTT)

Holly Symonds Clark, PhD

Acting Co-Director

Melea East, JD

Acting Co-Director

Coulter Program Office

Jessica Sharon

Coulter Project Director

Rick D'Augustine

CPD Senior Advisor

Tammy Hillerich

Coulter Program Assistant

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Coulter Contact

Jessica Sharon--Coulter Project Director

jessica.sharon@louisville.edu

502 852-4143

Tammy Hillerich--Coulter Program Assistant

tammy.hillerich@louisville.edu

502 852-4142

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