Childhood Asthma in Urban Settings - Clinical Research Centers (U01 Clinical Trial Optional)

(See related solicitation:  RFA-A1-19-074)

Brief Synopsis from Sponsor: The CAUSE Clinical Research Network will conduct observational studies and clinical trials to further improve our understanding of asthma and to develop effective interventions and asthma prevention approaches tailored to children of low-income families living in urban communities.

Research supported by this FOA will involve a) children of families living in census tracts within US Office of Management and Budget-defined Metropolitan Statistical Areas (MSAs) where ≥10% of families have income below the poverty level and b) children of families who have publicly-funded health insurance, but live in MSA census tracts where <10% of families have income below the poverty level.

Specifically, research areas to be pursued in center-specific projects by the CAUSE-CRC investigators may include, but are not limited to:

  • Mechanisms of immune tolerance to allergens;
  • Understanding the role of early environmental exposures in the pathogenesis of asthma;
  • The role of the respiratory epithelium in asthma;
  • Investigations into the pathogenesis and mechanisms of non-atopic asthma;
  • Development or early-stage evaluation of allergen immunotherapy or other immunomodulatory modalities to mitigate and/or prevent the effects of relevant allergens on asthma.

Other areas of interest include studies that fall under the general objective of elucidating the pathogenesis of asthma or improving the management of asthma in children living in low-income, urban communities and focus on the immune system.

Please read full opportunity linked above before submitting your proposal.

Maximum Award Amount:  Application budgets are limited to $300,000 in direct costs and need to reflect the actual needs of the proposed projects. The proposed project period must be 7 years.

Be aware: Only one application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed. UofL will decide which to submit via an internal application process determined by peer review.

Anyone interested in submitting for this program must first submit an internal application to with the opportunity title in the subject line and copying the applicable research dean, by 5 p.m. on the date listed above, including the following materials:

  • A summary of the proposal (maximum two pages);
  • A paragraph describing why you would be the most competitive candidate for this program;
  • Your current curriculum vitae;
  • A cover page that contains:
    • The name of this funding opportunity and title of your proposal;
    • Your name, position, and UofL office contact information;
    • Collaborator names, positions, and institutions (if applicable).

Reviewers will judge proposals as they would in any peer review process, so PIs are urged to put forward competitive internal proposals. Along with typical criteria, reviewers will evaluate internal proposals based on their fit with the sponsor’s articulated goals and criteria as well as the UofL strategic goals.

The above internal application materials should be submitted via email as a single .PDF file to by the internal deadline listed above. 

If you have any questions, please
Research Development & Strategic Initiatives
Office of the EVP – Research & Innovation
2301 South 3rd Street, Jouett Hall | Louisville, KY 40292
(Office) 502-852-1708 | (Cell) 502-777-3784