Zhong-bin Deng, Ph.D.

Education:

B.S., Yangzhou University, Yangzhou, PR.China, Veterinary Medicine, 1994
M.S., Yangzhou University, Yangzhou, PR.China, Veterinary Medicine, 1997
Ph.D., Soochow University, Suzhou, PR.China, Immunology, 2003
Postdoctoral Fellowship, University of Alabama at Birmingham, 2007
Instructor, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 2010

Curriculum Vitae

Current Positions:

Associate Professor, Department of Surgery, School of Medicine, University of Louisville, Louisville, KY Member, Brown Cancer Center, Louisville, KY

Contact Information:

Clinical Translational Research Building, Room 311
University of Louisville
505 South Hancock St
Louisville, KY 40202, USA
Phone 502-852-8621
Fax 502-852-2123

Email: z0deng01@louisville.edu

Research Description:

My research interest is in understanding the regulation of gut immune cells and microbiota in colitis and its related cancer development, especially colon cancer. IBD is strongly associated with inflammation accompanied by increased infiltration of leukocytes. We are investigating the mechanisms involved in maintaining balance between the good vs bad inflammatory conditions in gut. The complex nature of the human gut microbiota and its relevance to human health and disease is at a very early stage of investigation. It is becoming very clear that changes in the environment, diet and genetic factors greatly influence human microbiota contributing to the modulation of disease progression. Our research also focuses on the role that diet and nutrition play in the prevention and treatment of various cancers such as liver cancer and colon cancer. We put an emphasis on investigating the mechanisms of action of active dietary and nutritional nanoparticles. Our lab uses clinically relevant animal models and an integrated research system to identify effective dietary and nutritional nanoparticles for cancer prevention in vitro and in vivo, evaluate the efficacies of dietary and nutritional regimens, elucidate underlying cellular, molecular, and epigenetic mechanisms of action, identify novel anti-cancer components, and define risk factors of cancer development. We utilize several genetically altered transgenic/compound (knockout/conditional expression of interested genes) pre-clinical mouse models, cellular and molecular models and next generation sequencing methods to understand the IBD and colon cancer progression.

Representative Publications:

  1. Lei C#, Sun R#, Xu G, Feng W, Yi, Tan, McClain CJ, Deng Z. Enteric VIP neuron maintains gut microbiota homeostasis through regulating epithelium fucosylation. Cell Host& Microbe. 2022 Sep 13; S1931-3128(22). # Co-First Author.
  2. Sun R, Gu X, Chen L, Lei C, Chu S, Xu G, Doll M, Feng W, Siskind L, McClain CJ, Deng Z. Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection. Cell Reports. 2022. March 29; 38 (13).
  3. Sun R, Lei C, Chen L, He L, Guo H, Zhang X, Feng W, Yan J, McClain CJ, Deng Z. Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma. Oncogene.2022 Mar 4. PMCID: PMC901861.
  1. Sriwastva M#, Deng Z#, Wang B, Teng Y, Kumar A, Sundaram K, Mu J, Lei C, Dryden GW, Xu F, Zhang L, Yan J, Zhang X, Park JW, Merchant M, Egilmez NK, Zhang HG. (2022)Mulberry exosomes-like nanoparticles prevent DSS-induced colitis via AhR/COPS8 signalling pathway. EMBO Reports. Feb 3;23(3): e53365. PMCID: PMC8892346. # Co-First Author.
  2. Chu S, Sun R, Gu X, Chen L, Liu M, Guo H, Ju S, Vatsalya V, Feng W, McClain CJ, Deng Z. (2021). Inhibition of sphingosine-1-phosphate-induced Th17 Cells ameliorates alcoholic steatohepatitis in mice. Hepatology. Mar;73(3):952-967. PMCID: PMC8009334.
  3. Jiang M, Li F, Liu Y, Gu Z, Zhang L, Lee J, He L, Vatsalya V, Zhang HG, Deng Z, Zhang X, Chen SY, Guo GL, Barve S, McClain CJ, Feng W. Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation. Hepatology. 2022 Jun 11. Online ahead of print. PMID: 35689610
  4. Teng, Ren Y, Sayed M, Hu X, Lei C, Kumar A, Hutchins E, Mu J, Deng Z, Luo C, Sundaram K, Sriwastva MK, Zhang L, Hsieh M, Reiman R, Haribabu B, Yan J, Jala VR, Miller DM, Van Keuren-Jensen K, Merchant ML, McClain CJ, Park JW, Egilmez NK, Zhang HG. (2018). Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota.Cell Host Microbe, 24(5):637-652. PMCID: PMC6746408.
  1. Gu X, Sun R, Chen L, Chu S, Liu M, Dol M, Li X, Feng W, Siskind L, McClain CJ, Deng Z. (2021).  Neutral ceramidase mediates nonalcoholic steatohepatitis by regulating monounsaturated fatty acids and gut IgA+ B cells. Hepatology. Mar;73(3):901-919. PMCID: PMC8943690.  (EditorialCommentary: Ceramide Salvage, Gut Mucosal Immunoglobulin A Signaling, and Diet-Induced NASH)
  1. Deng Z*, Rong Y, Teng Y, Zhuang X, Samykutty A, Mu J, Zhang L, Cao P, Yan J, Miller D, Zhang HG.  Exosomes miR-126a released from MDSCs induced by DOX treatment promotes lung metastasis.  Oncogene 2017 Feb 2;36(5):639-51. PMID: 27345402. (*: Corresponding author).
  2. Deng Z, Rong Y, Teng Y, Mu J, Zhuang X,Tseng M, Samykutty A, Zhang L, Yan J, Miller D, Suttles J,and Zhang HG.  Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.  Molecular Therapy2017 Jul 5;25(7):1641-1654. PMID:28274798.
  3. Teng Y, Ren Y, Xu X, Mu J, Samykutty A, Zhuang X, Deng Z, Zhang L, Merchant M, Yan J, Miller D,  Kumar A, Zhang HG.  Major vault protein (MVP) dependent sorting tumor suppressor miR-193a into tumor exosomes promotes colon cancer progression.  Nature Communications 2017 Feb 17;8:14448. PMID: 28211508.
  4. Wang Q, Ren Y, Mu J, Egilmez NK, Zhuang X, Deng Z, Zhang L, Yan J, Miller D, Zhang HG. Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.  Cancer Research 2015 Apr 16;75(12):2520-9. [Epub ahead of print]. PMID: 25883092.
  5. Deng Z*,  Mu J, Tseng M, Wattenberg B, Zhuang X, Egilmez NK , Wang Q, Zhang L, Norris J, Guo H, Yan J , Bodduluri H, Miller D, Zhang HG*. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.  Nature Communications 2015 Apr 24;6:6928.PMID: 25907800.PMCID: PMC4410277.(*: Corresponding author).
  6. Zhuang X, Deng ZB, Mu J, Zhang L, Yan J, Miller D, Feng W, McClain CJ, Zhang HG.  Ginger-derived nanoparticles protect against alcohol-induced liver damage.  J Extracell Vesicles 2015 Nov 25;4:28713. doi: 10.3402/jev.v4.28713. eCollection 2015. PMID: 26610593.
  7. DengZB*, Zhuang X, Ju S, Xiang X, Mu J, Wang Q, Hong J, Zhang L, Kronenberg M, Yan J, Miller D, Zhang HG*.  Intestinal mucus-derived nanoparticles mediate activation of Wnt/β-catenin signaling plays a role in induction of liver NKT cell anergy in mice.  Hepatology 2013 Mar;57(3):1250-61. PMID: 22991247. PMCID: PMC4414328.(*: Corresponding author).
  8. DengZB*, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG*.  Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.  J Immunol 2013 Apr 1;190(7):3579-89. PMID: 23467936. PMCID: PMC4396634. (*: Corresponding author).
  9. DengZ, Cheng Z, Xiang X, Yan J, Zhuang X, Liu C, Jiang H, Ju S, Zhang L, Grizzle W, Mobley J, Roman J, Miller D, Zhang HG.  Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression.  American Journal of Pathology 2012 Jan;180(1):390-8. PMID: 22067905.
  10. DengZ*, Pardi R, Cheadle W, Xiang X, Grizzle W, Miller D, Mountz J, Zhang HG*.  Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages. Blood 2011 May 5;117(18):4796-804. PMID: 21403132.  (*: Corresponding author).
  11. DengZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S, Zhuang X, Shah SV, Sun D, Michalek S, Grizzle WE, Garvey T, Mobley J, Zhang HG.  Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance.  Diabetes 2009 Nov;58(11):2498-505. PMID: 19675137. PMC2768161.
  12. DengZB, Liu Y, Liu C, Xiang X, Wang J, Cheng Z, Shah SV, Zhang S, Zhang L, Zhuang X, Michalek S, Grizzle WE, Zhang HG.  Immature myeloid cells induced by a high fat diet contribute to liver inflammation.  Hepatology, 2009 Nov; 50(5):1412-20. PMID: 19708080.PMCID: PMC2852608.

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