Alfred Bennett Jenson

EDUCATION:

B.A., Texas Christian University, Texas, 1957-61, Chemistry (with honor)
M.S., Baylor University (College of Medicine), Texas, 1964-66, Pathology/Virology
M.D., Baylor College of Medicine, Texas, 1961-66 (with honor)
Internship, Department of Medicine (1966-67), Residency, Department of Pathology,
     (1966-71) Baylor College of Medicine Affiliated Hospital Programs
Research Trainee, U.S. Public Health Service, 1967-71 (Joe Melnick, Ph.D., Mentor)
Postdoctoral Fellow, Scripps Clinic and Research Foundation, La Jolla, California,
     Immunopathology, 1973-75 (Frank Dixon, M.D., Mentor)
Senior Surgeon, Laboratory of Oral Medicine, National Institute for Dental Research, Bethesda, Maryland, 1975-80

Curriculum Vitae

Current Positions:

Senior Scientist and Professor of Vaccinology, JGBCC, UofL
     Associate Member Department of Biochemistry and Molecular Genetics, UofL
     Associate Member of Pharmacology and Toxicology, UofL
Adjunct Senior Research Scientist, Division of Marine Mammal Research and Conservation,
     Harbor Branch Oceanographic Institute, Fort Pierce, Florida

Contact Information:

Clinical Translational Research Building, Room 208
University of Louisville
505 South Hancock St.
Louisville, KY 40202, USA
Phone 502-852-3768
Fax 502-852-7979
Email: abjens01@louisville.edu
          abjenson@yahoo.com

Notable Attributes:

Army Commendation Medal, Vietnam Conflict, 1973
35th Dr. Sobodh Mitra M, Memorial Oration, Chittaranjan National Cancer Institute, Calcutta, 2004.
Mint Jubilee Co-Scientist of Year Award with Shin-je Ghim, Louisville, Kentucky, 2006.
Kentucky Colonel Award, Gov. Fletcher 2007; Gov. Beshear, 2008
Manatee Conservation Award with Shin-je Ghim, Department of Interior, 2008
Distinguished Professor Lectureship, 11th Annual Pathology of Mouse Models of Human Disease,
     The Jackson Laboratory, September 2012
Distinguished Alumni Award, Texas Christian University, April 2014

Licensure:

Licensed in Maryland, and Kentucky
Board Certification in Anatomic Pathology, 1971
Board Eligible in Immunopathology, 1975

Research Description

For 38 years (1980-2018), Dr. Jenson and his translational research laboratories have been working on the role of human papillomavirus (HPV) in benign, premalignant, and malignant squamous lesions of the cervix (100%) oropharynx (60%), anogenital area (80%), oral cavity, and skin. In 1992, Drs. Jenson, Ghim and Schlegel co-invented the HPV vaccine, which was commercialized in 2006 (Gardasil-Merck; Cervarix-GSK) with the potential of saving hundreds of thousands of lives from cancer. Since then the laboratory has focused, in part, on using HPV as a model for studying natural, debilitating PV infections in animals, such as dogs (canine oral papilloma virus: COPV), horses (equine papilloma virus type 1: EqPV-1), cattle (bovine papillomavirus type 1: BPV-1) , the manatee (Trichechus manatus latirostuis: TmPV), dolphin (Tursiops truncates: TtPVs), and snow leopards (Uncus). The work with TmPV was recognized when the laboratory was given the Manatee Conservation Award by the Department of the Interior. It is rare but refreshing to have an animal model for human disease where the animal model benefits as much as humans.

The laboratory (Drs. Jenson, Ghim and Joh) is collaborating with the Department of Medicine (Dr. Rebecca Redman), the School of Dentistry (Dr. Brian Shumway), and School of Public Health (Biostatistics – Dr. Shesh Rai) to study cancers that primarily originate in the base of tongue or tonsils and metastasize to the oropharynx. As part of this study, we plan to test routine blood samples in these patients for biomarkers such as antibodies against viral oncoproteins, differential scanning colorimetry for peptides released by cancer cells, and, possibly exosomes,  techniques that are being developed by investigators in the Health Science Center. The laboratory also has used synthetic peptides and recombinant tobacco-based virus-like particles (VLP) of HPV-16 and EqPV-1 with Dr. Zahin of Dr. Ken Palmer’s laboratory to make a vaccine that is just as effective as Gardasil or Cervarix but is much cheaper than fermentation methods. Most recently, Drs. Jenson and Ghim have been working on a vaccine for human parvovirus B19 infection that causes aplastic crises in patients with congenital and acquired anemias, such as sickle cell disease and transplants for leukemias, respectively.  To accomplish these goals, our laboratory is not restricted to our own expertise – we have developed research collaborations with many other laboratories allowing us to utilize their expertise and the techniques developed by them.

Literature Cited:

  1. Jenson AB, Rosenthal JD, Olson C, Pass F, Lancaster WD, Shah K. Immunologic-relatedness of papillomaviruses from different species.  J Natl Cancer Inst 1980 Mar;64:495-500. PMID: 6153407.
  2. Jenson AB, Sommer S, Payling-Wright C, Pass F, Link CC Jr, Lancaster WD.  Human papillomavirus.  Frequency and distribution in plantar and common warts.  Lab Invest 1982 Nov;47:491-7. PMID: 6290785.
  3.   Cowsert LM, Lake P, Jenson AB.  Topographical and conformational epitopes of bovine papillomavirus type 1 defined by monoclonal antibodies.  J Natl Cancer Inst 1987 Nov;79:1053-57. PMID: 2446044.
  4. Jenson AB, Lim LY, Singer E.  Comparison of human papillomavirus type serotyping by monoclonal antibodies with genotyping by in situ hybridization of plantar warts.  J Cutan Pathol 1989 Apr;16:54-9. PMID: 2547854.
  5.   Ghim S, Christensen ND, Kreider JW, Jenson AB.  Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenografts.  Int J Cancer 1991 Sep 9;49(2):285-89. PMID: 1715330.
  6.   Ghim SJ, Jenson AB, Schlegel R.  HPV-1 L1 protein expressed in cos cells displays conformational epitopes found on intact virions.  Virology 1992 Sep;190:548-52. PMID: 1382345.
  7.   Lorincz AT, Reid R, Jenson AB, Greenberg MD, Lancaster W, Kurman RJ.  Human papillomavirus infection of the cervix:  Relative risk associations of 15 common anogenital types.  Obstet Gynecol 1992 Mar;79:328-37. PMID: 1310805.
  8. Jenson AB, Jenson MC, Cowsert L, Ghim SJ, Sundberg JP.  Multiplicity of uses of monoclonal antibodies that define papillomavirus linear immunodominant epitopes.  Immunol Res 1997 Feb;16:115-9. PMID: 9048212.
  9.   Suzich JA, Ghim SJ, Palmer-Hill FJ, White WI, Tamura JK, Bell JA, Newsome JA, Jenson AB, Schlegel R.  Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas.  Proc Natl Acad Sci USA 1995 Dec 5;92(5):11553-57. PMID: 8524802.
  10. Ghim SJ, Young R, Jenson AB.  Antigenicity of bovine papillomavirus type 1 (BPV1) L1 virus-like particles compared with that of intact BPV-1 virions.  J Gen Virol 1996 Feb;77:183-88. PMID: 8627221.
  11. Ghim, S, Basu, PS, Jenson, AB.  Cervical cancer, etiology, pathogenesis treatment and future vaccines.  Asian Pacific Journal of Cancer Prevention 2002 3(3):207-14. PMID: 12718577.
  12. Rehtanz M, Bossart GD, Doescher B, Rector A, Van Ranst M, Fair PA, Jenson AB, Ghim SJ.  Bottlenose dolphins (Tursiops truncates) papillomavirus.  Vet Microbiol 2009 Jan 1;133:43-53, doi: 10.1016/j.vetmic.2008.06.017. Epub 208 Jul 4. PMID: 17686105.
  13. Donà MG, Rehtanz M, Adimey NM, Bossart GD, Jenson AB, Bonde RK, Ghim SJ.  Seroepidemiology of TmPV1 infection in captive and wild Florida manatees (Trichechus manatus latirostris).  J Wildl Dis 2011 Jul;47(3):673-84. PMID: 21719832.
  14. Garbett NC, Merchant ML, Helm CW, Jenson AB, Klein JB, Chaires JB. Detection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry.  PLoS One 2014 Jan 8;9(1):e84710. PMID: 24416269.
  15. Khanal S, Joh J, Kwon AM, Zahin M, Perez CA, Dunlap NE, Silverman CL, Tennant PA, Potts KL, Kloecker GH, Bumpous JM, Ghim SJ, Jenson AB, Redman RA.  Human papillomavirus E7 serology and association with p16.  Exp Mol Pathol 2015 Oct;99(2):335-40. PMID:26116154.
  16. Khanal S, Ferraris ED, Zahin M, Joh J, Ghim SJ, Jenson AB.  Targeting synthetic Human Papillomavirus (HPV) L2 disulfide-induced N-terminus conformational epitopes for pan-HPV vaccine development.  Exp Mol Pathol 2015 Oct;99(2):330-4. PMID: 26134615.
  17. Zahin M, Joh J, Khanal S, Husk A, Mason H, Warzecha H, Ghim SJ, Miller DM, Matoba N, Jenson AB.  Scalable production of HPV16 L1 protein and VLPs from tobacco leaves.PLoS One 2016 Aug 12;11(8):e0160995. doi: 10.1371/journal.pone.0160995. eCollection 2016, PMID: 27518899.
  18. Khanal S, Trainor PJ, Zahin M, Ghim SJ, Joh J, Rai SN, Jenson AB, Shumway BS.  Histologic variation in high grade oral epithelial dysplasia when associated with high-risk human papillomavirus.Oral Surg Oral Med Oral Pathol Oral Radiol 2017 May;123(5):566-85.  doi: 10.1016/j.oooo.2017.01.008. Epub 2017 Jan 24.  PMID: 28407985.
  19. Joh J, Chilton PM, Wilcher SA, Zahin M, Park J, Proctor ML, Ghim SJ, Jenson AB.  T cell-mediated antitumor immune response eliminates skin tumors induced by mouse papillomavirus, MmuPV1.Exp Mol Pathol 2017 Sep 20;103(2):181-90. doi: 10.1016/j.yexmp.2017.09.003, PMID: 28939161.
  20. Zahin M, Dean WL, Ghim SJ, Joh J, Gray RD, Khanal S, Bossart GD, Mignucci-Giannoni AA, Rouchka EC, Jenson AB, Trent JO, Chaires JB, Chariker JH.  Identification of G-quadruplex forming sequences in three manatee Papillomaviruses.  PLoS One 2018 Apr 9;13(4):0195625. doi: 0.1371/journal.pone.0195625. eCollection 2018. PMID: 29630682.

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