News
Emcees, red carpet interviewer announced by The Julep Ball
Movie and television actress Josie Davis joins “Voice of the Cards” Sean Moth and WHAS11 morning anchor Brooke Katz in emceeing The Julep Ball.
Katz will interview celebrities as they make their red carpet entrances, while Davis and Moth will keep the evening moving as emcees.
The premier Derby Eve Party with a Purpose, The Julep Ball is held annually on the evening before the Kentucky Derby and supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.
An Official Event of the 140th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets to The Julep Ball sell out early each year. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.
About Josie Davis
Josie Davis is best remembered as a series regular on the hit television series Charles in Charge opposite Scott Baio, which she began when she was 12 years old. After the show wrapped, Josie transitioned into series regular roles on Beverly Hills 90210 and then the television series Titans with Victoria Principal.
Davis’ feature film credits include a lead role in Nicholas Cage’s directorial debut Sonny, opposite James Franco and Scott Caan. She also starred in Carolina Moon, opposite Claire Forlani and Oliver Hudson, The Perfect Assistant, Seduced by Lies, and The Perfect Student, Blind Injustice, Past Obsessions, and Dirty Teacher, all for Lifetime.
Davis next can be seen in the indie film Mantervention, coming to theatres in Summer 2014, and also in Stealing Roses opposite John Heard and Wizardream opposite Malcolm McDowell.
Her television credits include a recurring role on CSI: NY and guest starring roles on Two and a Half Men, The Mentalist, Chuck, Bones, Rules of Engagement, Navy NCIS, Burn Notice,Breakout Kings and many more. Josie is a lifetime member of The Actors Studio being run by Martin Landau and Mark Rydell. For more information, visit: www.JosieDavis.com.
About Brooke Katz
Brooke Katz came to WHAS11 and Louisville from her hometown of Charleston, S.C. She anchors the 4:30 a.m. edition of Good Morning Kentuckiana as well as the noon newscast. She also does traffic reports for the 5 a.m. and 6 a.m. shows.
Brooke started her career in journalism at Charleston’s WCBD-TV in 2008, working as a reporter and a producer. On the streets, she covered a wide range of stories from hard news to special health and fitness segments. Since coming to Louisville, Brooke has worked as a multimedia journalist, a general assignments reporter and a feature reporter.
In her spare time, Brooke is an exercise enthusiast. She’s been teaching aerobics classes since her senior year in high school. Brooke received her degree in journalism and media studies and a certificate in criminology from Rutgers University in New Jersey.
About Sean Moth
Enjoying his 15th season at the University of Louisville, Moth has been the “Voice of the Cardinals Athletic Department” during that span as the arena and stadium announcer for the football, volleyball and men’s and women’s basketball teams. In addition, he has been the radio voice of the Louisville Cardinals baseball team for the past 12 seasons.
As associate director of creative services, he works with video and social media and has emceed banquets and events at UofL and around the City of Louisville. The teams he works with have carried him on their coattails to 12 bowl games, five Final Fours and two College World Series.
Moth lives in Louisville with his wife of 20 years, Angie and their 16-year-old son Erik who attends Youth Performing Arts School. When Moth “used to have spare time,” as he phrases it, he enjoyed cooking, good music, fly-fishing and photography.
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About the James Graham Brown Cancer Center:
The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.
The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.
Petrino to walk the red carpet at The Julep Ball
Most often seen walking the sidelines, University of Louisville Head Football Coach Bobby Petrino will be walking the red carpet instead on May 2.
Petrino and wife Becky will be celebrity guests at The Julep Ball, the premier Derby Eve Party with a Purpose. Held annually on the evening before the Kentucky Derby, The Julep Ball supports the work of the James Graham Brown Cancer Center at the University of Louisville. The event on May 2 at the KFC Yum! Center kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m.
An Official Event of the 140th Kentucky Derby®, The Julep Ball provides a celebrity-studded night to remember with a multi-course seated dinner, a knock-your-socks-off auction, multiple open specialty bars, complimentary valet parking, and dancing until the wee hours of Derby morning. Tickets to The Julep Ball sell out in advance each year. The full evening’s entertainment is $600 per person, $5,000 for a table of 10, and $100 per person for dance-only tickets. For further information and to buy tickets, go to The Julep Ball website, julepball.org.
About Bobby Petrino
One of the nation's best offensive minds returned home to Louisville in January when UofL Vice President/Director of Athletics Tom Jurich announced Petrino as the Cardinals' football coach. The Cardinals’ head coach from 2003-06, Petrino led UofL to an unprecedented 41-9 record in four seasons on the sidelines and currently boasts an 83-30 record at the collegiate level.
During his time at Louisville, Petrino directed the program to a bowl game each year, but more significantly, guided the school to its first BCS victory – a 24-13 win over Wake Forest in the FedEx Orange Bowl. The 41 wins over that four-year span are the most in school history and featured an average margin of victory of 26.0.
He also showed the ability to develop players, as Petrino had 14 selected in the NFL Draft, including Amobi Okoye, who was the 10th overall selection in 2007 by the Houston Texans. Eric Wood, who was recruited by Petrino, was the 28th selection by the Buffalo Bills in 2009. Michael Bush, a fourth-round pick by the Oakland Raiders, amassed 2,514 rushing yards in three-plus seasons with the Cardinals.
Coupling his success at Louisville and Arkansas, Petrino has led his teams to seven bowl games in nine years, including both Louisville’s and Arkansas’ first BCS bowl games. His programs have achieved four 10-win seasons along with top-10 finishes nationally three times. His 2006 Louisville squad and 2011 Arkansas team concluded with No. 5 rankings in the Associated Press polls.
During Petrino’s time at Louisville, he coached the Bronko Nagurski and Ted Hendricks Award winner Elvis Dumervil, who led the nation in sacks (20) and forced fumbles (10) on his way to earning All-America honors in 2006. During that same season, Bush scored 24 touchdowns and became the school's first 1,000-yard rusher since 1999.
While the head coach of three different programs, Petrino’s offenses have compiled a 100-yard rusher on 99 occasions and a 300-yard passer 66 times over the last 15 seasons.
Prior to returning to Louisville, Petrino spent one season as head coach at Western Kentucky, where he helped WKU finish the regular season with an FBS school record eight wins while closing the season on a four-game winning streak. The team also set a new school record for total offense (5,502 yards) and passing first downs (141) in a season.
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About the James Graham Brown Cancer Center:
The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.
The Julep Ball is sponsored in part by Advanced Cancer Therapeutics, Ashton Advertising, Bob Montgomery Dixie Honda, Boutique Serendipity, The Dahlem Company, Dillards, Enterprise, Headz Salon, Heaven Hill, Hubbuch & Co., InGrid Design, Jaust Consulting Partners, Jefferson County Sheriff’s Office, KentuckyOne Health, Kroger, Louisville Magazine, Maker’s Mark, Millennium: The Takeda Oncology Company, Morgan Stanley, MPI Printing, Nfocus, Old 502 Winery, Power Creative, Tito’s Handmade Vodka, WAKY and WHAS11.
3D model of child’s heart helps surgeons save life
See video interviews with the faculty who made it happen here.
A 14-month-old boy in need of life-saving heart surgery is the beneficiary of a collaboration among University of Louisville engineers, physicians and Kosair Children’s Hospital.
Roland Lian Cung Bawi of Owensboro was born with four congenital heart defects and his doctors were looking for greater insights into his condition prior to a Feb. 10 operation.
Dr. Philip Dydynski, chief of radiology at Kosair Children’s Hospital, recently had toured the Rapid Prototyping Center at the University of Louisville’s J.B. Speed School of Engineering and became impressed with the 3D printing capabilities available there.
He asked the center’s operations manager, Tim Gornet, if a 3D model of the child’s heart could be constructed using a template created by images from a CT scan to allow doctors to better plan and prepare for his surgery. No problem, Gornet said.
The result of the Rapid Prototyping Center’s work was a model heart 1.5 times the size of the child’s. It was built in three pieces using a flexible filament and required about 20 machine hours – and only about $600 -- to make, Gornet said.
Once the model was built, Dr. Erle Austin III, cardiothoracic surgeon with University of Louisville Physicians, was able to develop a surgical plan and complete the heart repair with only one operation.
“I found the model to be a game changer in planning to do surgery on a complex congenital heart defect,” he said.
Roland was released from Kosair Children’s Hospital Feb. 14 and returned Feb. 21 for checkups with his doctors. His prognosis is good.
That’s good news for Gornet, whose work at the Rapid Prototyping Center routinely benefits manufacturers and heavy industry. Helping surgeons save a life was new territory for him.
“Knowing we can make somebody’s life better is exciting,” he said.
UofL geriatrician named finalist for national award
Patrick J. Murphy Jr., M.D., director of the University of Louisville Home Call Program and professor of geriatrics in the Department of Family and Geriatric Medicine, has been named one of six finalists for a national award recognizing leadership in long-term care.
Murphy has been nominated for the 2014 Medical Director of the Year award, presented by AMDA-Dedicated to Long Term Care. Formerly called the American Medical Directors Association, AMDA is a professional association of medical directors, attending physicians and other professionals practicing in long-term care and provides education, advocacy, information and professional development to promote the delivery of quality long-term care medicine.
The award will be presented Feb. 28 at the AMDA annual meeting in Nashville, Tenn.
Murphy is the only award nominee who is board-certified as a fellow of the American Academy of Family Practice and the only nominee on the faculty of an academic health center. He also has earned certification from AMDA as a medical director.
Murphy founded the UofL Home Care Program, which allows elderly patients to have better accessibility to and coordination of their health care. He also instituted the Palliative Care Committee and the Behavioral Committee at area nursing homes to improve coordination of palliative care, behavioral management and overall quality of care.
As a member of the Greater Louisville Medical Society’s Transitions of Care Committee, Murphy worked with local emergency department physicians to improve the documentation of patient transfers and led an effort to implement a standardized form for nursing home care transfers.
He has instituted changes in medical student and resident training as well to better prepare future physicians in caring for geriatric patients. He regularly brings medical students with him on home care visits to augment their learning. He also began a program at UofL where medical residents follow three nursing home patients for two years and conduct monthly rounds with him.
Murphy practices with University of Louisville Physicians-Geriatrics.
The remaining five nominees for the award are David Barthold, M.D., Bessemer, Ala.; Gregory James, D.O., Oldsmar, Fla.; David LeVine, M.D., St. Petersburg, Fla.; S. Liliana Oakes, M.D., San Antonio; and Neelofer Sohall, M.D., Lancaster, Penn.
Kentucky Area Health Education Centers celebrating 40th anniversary in 2014
It seems logical now but it was quite the novel idea back in 1974: Provide funding to bring health care education services, providers and students to rural and other medically underserved areas of the Commonwealth. The program would give people of those areas access to health care they might otherwise not have, while students would receive medical training they might otherwise not receive.
These principles have been the foundation of the Kentucky Area Health Education Centers program since its predecessor program began in 1974. As the program reaches its 40th anniversary, KY AHEC, as it is known, continues to serve a vital role in all corners of the state.
“AHEC has impacted many lives and will continue to do so for many more years,” said former state AHEC director and now UofL Assistant Vice President for Health Affairs V. Faye Jones, M.D., Ph.D. “The need is there for AHEC. Kentucky communities know AHECs provide vital health education and clinical services.”
UofL Senior Associate Dean for State Initiatives and Outreach Kelli Dunn, M.D., was named KY AHEC director this month. She stresses the role AHEC plays in access to health training and health care delivery across the commonwealth. “In addition to training medical students” Dunn said, “our AHEC sites train a variety of other health care professionals, including nursing and nurse practitioner students as well as emergency medical technicians and others. The AHECs also provide critical educational services and outreach within our communities.”
Program began nationwide in 1971, in Kentucky in 1974
KY AHEC is part of a national AHEC program. Funded by the Kentucky Legislature, along with foundations and other sources, KY AHEC is jointly administered by the University of Louisville and the University of Kentucky.
The national AHEC program began in 1971. Kentucky did not qualify for the initial program, but in 1974, the state formed the Kentucky Area Health Education System (AHES) to support health-student rotations throughout the state.
Severe challenges to the state budget in the late 1970s forced the closure of many AHES centers, however. The uncertainty of the AHES program led UofL and UK to partner on a new federal AHEC grant application, originally awarded in 1985 to the state with funding distributed to the two universities to administer the program.
The funding has continued uninterrupted since that time, providing continuity of community education, training and care through eight AHEC regions in Kentucky. UofL oversees the four AHEC regions in the western half of the state while UK oversees the other four regions in the eastern half.
KY AHEC fulfills triple mission
KY AHEC focuses on three goals. First, its mission is to help train health professions students in underserved health care settings. Second, AHEC partners with communities statewide to provide health care and career education. Third, and perhaps most importantly, AHEC encourages medical, dental, nursing, allied health and other health professions students to practice in underserved areas in Kentucky after graduation.
Judging by the UofL School of Medicine Class of 2013, the program is working: 31 percent of class members said they plan to practice in an underserved area, and 83 percent will volunteer in free clinics for the underserved.
The program also reaches out to the future health professions workforce. In the Purchase Area AHEC alone, for example, almost 2,700 middle and high school students received hands-on health careers programming in their schools. And in the West AHEC region, Outbreak Camp is a week-long program for middle and high school students, taught by area math and science teachers to connect their students to future health careers.
Community education also is a cornerstone of KY AHEC. The Northwest AHEC region provides the GRACE Project, a training program for faith communities to become well-informed lay health workers for their congregations, as well as the Veterans Behavioral/Mental Health for Veterans/Service Members and Families Project to educate civilian health care providers on issues affecting veterans returning from Iraq and Afghanistan. The South Central AHEC provides Child Passenger Safety Technician Training, a 30-hour program from the National Highway Traffic Safety Administration to train people in the community how to travel safely with everyone properly buckled up.
The economic impact of the UofL AHEC program also shows the program’s impact: Faculty, students and residents in the four AHEC regions served by UofL provided almost $3.48 million in donated health care services last year.
Physicians, patients show program’s effect
Amelia Kiser, M.D., was a member of UofL’s medical class of 1996 who was born and raised in the Glasgow, Ky., area and credits her AHEC rotation as one reason she returned to southern Kentucky to practice. Today, she sees patients and mentors trainees and AHEC students at UofL’s Glasgow/Barren County Family Medicine Residency program
“The AHEC rotations were the best, because if you’re in the city, it’s a completely different atmosphere,” Kiser said. “You don’t approach things in the city the way you do here. I could be in an urban setting; I just choose to be in a rural setting.”
Kiser contends that practicing in an underserved area actually furthers a physician’s career. “Regardless (of where you train), you understand and can solve medical issues, but here, you are friend and counselor also,” she said. “Your job does not stop when you leave here. You run into people at Walmart, at the ball game, at church. And they will pull you aside and say, ‘Dr. Kiser, I just need to ask you one thing… .’ But, I love it, I wouldn’t practice anywhere else.”
Another UofL alumnus, R. Brent Wright, M.D., had his pick of metropolitan locations to establish his medical career. The 1998 School of Medicine graduate was his high school’s valedictorian and a top medical school student at UofL. But, instead of heading toward large hospital environments or bustling cities, he chose Glasgow.
Wright, the current Glasgow/Barren County Family Medicine Residency Director and UofL associate dean for Rural Health Innovation, came to Glasgow as part of the first class of residents there in 1998. He was recruited to stay on as an educator and fell in love with the area.
As a student, Wright’s AHEC rotation was in Munfordville, Ky. “(I was) with the quintessential, colorful, old country doctor,” Wright said. “Every day with that practice was just fun. I saw myself being in a similar community. I knew I’d return to a smaller city to practice medicine.”
Years later, the student has become the professor. Wright’s energy is focused now not only on his patients, but also on his residents and AHEC students. “You see young students come in and how they progress over three years is amazing,” he said. “It’s a great deal of pride for me, because you become so close to the residents and see how much they contribute to these patients.”
Two of those patients are Ray and Joyce Pennington. They drive more than an hour from their home in Summershade, Ky., to the Glasgow clinic. “We’ve been coming here 13 years, and it’s worth the drive to get here,” the elderly Pennington said. “We’re real thankful to have doctors who we know care about us personally. We’re older and need someone to watch out for us. These folks are like a part of our family.”
Continuing the program for all Kentuckians
Kelli Dunn and Faye Jones know that it is people such as the Penningtons that need AHEC to continue for the next 40 years – and beyond. “The funding for KY AHEC connects us with our communities,” Dunn said. “Without the funding, the program, education and activities tailored to these communities simply would not exist.”
“AHEC has served and continues to serve such a vital need,” added Jones. “The communities rely on AHEC for their community health education needs. As a university, we rely on the AHEC to provide the educational experiences for our professional students. It’s so simple and so important to continue the work and grow it.
“Our focus is on the reality that drives us every day: We are here to improve the health care status of Kentucky.”
UofL opens pediatric and dental offices at Sam Swope Kosair Charities Centre
LOUISVILLE, Ky. –The University of Louisville and Kosair Charities have entered a new partnership, opening general pediatrics and pediatric dentistry practices at the Sam Swope Kosair Charities Centre, where children with disabilities and chronic health conditions and children from the community can get expert care from UofL pediatricians and pediatric dentists.
“In 2011 we opened the UofL Autism Center here on the Kosair Charities campus. Now their clients will have easy access to pediatricians and pediatric dentists practicing in offices designed for children with sensory problems and physical challenges,” said James Ramsey, president of the University of Louisville. “We are so grateful to Kosair Charities for helping us create a medical/dental home that is welcoming to all children—from the toddler whose autism makes dental care a challenge, to the teen who needs a sports physical to play volleyball at a neighborhood school.”
Kosair Charities has donated the rent amount over a five-year period, providing a combined 12,500 square feet of renovated space in the Kosair Charities headquarters building for the two clinics: University of Louisville Department of Pediatrics at Kosair Charities and University of Louisville School of Dentistry at Kosair Charities. The university may opt to renew the lease for two additional five-year terms, bringing the estimated value of this agreement to $3.7 million over 15 years.
“This year Kosair Charities celebrates 90 years of caring for children. Since 1923, the University of Louisville has been a primary partner in meeting the health and wellness needs of Kosair Kids®. This new collaborative project builds on 90 years of working together and positions UofL and Kosair Charities for decades of service to future generations of Kosair Kids®,” said Jerry Ward, chairman of the board for Kosair Charities.
The patient mix for both practices will include children receiving services elsewhere on the Kosair Charities campus, children from surrounding neighborhoods, children whose families participate in the Family Scholar House program and children who are uninsured or under-insured.
The UofL Department of Pediatrics at Kosair Charities office has nine exam rooms, a laboratory and separate sick- and well-child reception areas. Pediatrician Erica Labar, MD, began seeing patients in the Eastern Parkway office on July 1. A second physician will join Labar in 2014. Medical students and pediatric residents will also rotate through the clinic.
“What could be more fitting than to provide a medical/dental home on the grounds of the former Kosair Crippled Children Hospital, where thousands of children were once treated for disabling diseases such as polio and smallpox,” said Gerard Rabalais, MD, MHA, chairman, UofL Department of Pediatrics. “I’m confident that Dr. Labar and her team will continue the tradition of compassion and excellence long associated with this historic location.”
The UofL School of Dentistry at Kosair Charities pediatric office will open in the fall, under the leadership of Ann Greenwell, DMD, MSD. The clinical space will be outfitted with six dental chairs and equipped to meet the special needs of autistic and physically-challenged children.
“We know good oral health is integral to overall health and wellness. Coordination of care is the future of health care in this country, and we are removing many of the logistical barriers for the children of the community,” said John Sauk, DDS, MS, dean of the UofL School of Dentistry.
The dental clinic will provide comprehensive dental care– including routine exams, fillings, treatment for trauma, mouth guards for athletes and orthodontic care.
About Kosair Charities:
Since 1923 Kosair Charities has had one primary mission – helping children in need.Kosair Charities knows that the quality of a child’s tomorrow depends largely on the quality of health, medical treatment, and support a child receives today.That’s why over the years Kosair Charities has given more than $335 million to serve thousands of children and provide them a second chance at life. Kosair Charities is also the largest private benefactor to Kosair Children's Hospital.For more information please visit http://kosair.org or call 502.637.7696.
Going bald, by choice
University of Louisville School of Medicine students shaved their heads in 2013 to raise funds for pediatric cancer research. They will do so again on Feb. 13, 2014, at the St. Baldrick’s event.
Primping for a date with that special someone on Valentine’s Day usually doesn’t include choosing to go bald.
Yet that is what 13 University of Louisville School of Medicine students will do the day before, on Feb. 13, to show their support for kids with cancer and raise funds for pediatric cancer research.
The students will hold a St. Baldrick’s head-shaving event Thursday, Feb. 13, at noon in the Health Sciences Center Auditorium, located on Preston Street between East Chestnut Street and East Muhammad Ali Boulevard. This is the third year that UofL medical students have hosted a St. Baldrick’s event.
In exchange for donations, the students will have their heads shaved completely or will cut their ponytails to donate hair to make wigs for children who have lost their hair as a result of cancer treatment. The foundation has matched each participant with a child battling cancer to honor at the event.
The students hope to raise at least $10,000 and are currently taking donations for the event on their website, http://www.stbaldricks.org/events/ULSOM2014.
Other giveaways are planned as well. The students are raffling off gift cards and other prizes donated by area merchants. Drawings for each prize will be held at the Feb. 13th event and winners do not need to be present to win.
Donating items to the raffle are A Reader's Corner, Bardstown Road Bicycle Co., Baxter's 942 Bar and Grill, Belle of Louisville, Bluegrass Burgers, Buffalo Wild Wings, Carrabba's, Day's Espresso & Coffee, Gordon Biersch, Guestroom Records, Hard Rock Café, Highland Cleaners, Jack Fry's, LIFEbar, Molly Malone's-Baxter Avenue, Molly Malone's-Shelbyville Road, Palermo Viejo, Parkside Bikes, Potbelly Sandwich Shop, Salsarita's, Seviche, Sol Azteca's Grill & Cantina, The Sport and Social Club, Tin Roof, Vic's Classic Bikes, Vincenzo's, Wild and Woolly Video and Za's Pizza Pub.
“We are grateful to our raffle sponsors for their support,” said Tony Simms, assistant director for medical student affairs at UofL who is assisting the students in holding the St. Baldrick’s event. “Our students are passionate about the cause and want to make a difference, and with everyone’s help, we will do just that.”
The effort is organized nationally each year by the St. Baldrick’s Foundation, founded by three reinsurance industry executives, Tim Kenny, John Bender and Enda McDonnell, in New York. The first St. Baldrick’s event in a Manhattan pub was timed with St. Patrick’s Day 2000 and generated $104,000 in donations.
Today, St. Baldrick’s is believed to be the largest volunteer fundraiser for childhood cancer research and second only to the federal government in the amount of funding provided to pediatric cancer researchers. Since 2005, St. Baldrick’s donors and volunteers have enabled the foundation to provide more than $127 million to grant recipients.
UofL scientists uncover how grapefruits provide a secret weapon in medical drug delivery
Lipids (right panel first three tubes) derived from grapefruit. GNVs can efficiently deliver a variety of therapeutic agents, including DNA, RNA (DIR-GNVs), proteins and anti-cancer drugs (GNVs-Drugs) as demonstrated in this study.
Grapefruits have long been known for their health benefits, and the subtropical fruit may revolutionize how medical therapies like anti-cancer drugs are delivered to specific tumor cells.
University of Louisville researchers have uncovered how to create nanoparticles using natural lipids derived from grapefruit, and have discovered how to use them as drug delivery vehicles. UofL scientists Huang-Ge Zhang, D.V.M., Ph.D., Qilong Wang, Ph.D., and their team today (May 21, 2013), published their findings in Nature Communications.
“These nanoparticles, which we’ve named grapefruit-derived nanovectors (GNVs), are derived from an edible plant, and we believe they are less toxic for patients, result in less biohazardous waste for the environment, and are much cheaper to produce at large scale than nanoparticles made from synthetic materials,” Zhang said.
The researchers demonstrated that GNVs can transport various therapeutic agents, including anti-cancer drugs, DNA/RNA and proteins such as antibodies. Treatment of animals with GNVs seemed to cause less adverse effects than treatment with drugs encapsulated in synthetic lipids.
“Our GNVs can be modified to target specific cells – we can use them like missiles to carry a variety of therapeutic agents for the purpose of destroying diseased cells,” he said. “Furthermore, we can do this at an affordable price.”
The therapeutic potential of grapefruit derived nanoparticles was further validated through a Phase 1 clinical trial for treatment of colon cancer patients. So far, researchers have observed no toxicity in the patients who orally took the anti-inflammatory agent curcumin encapsulated in grapefruit nanoparticles.
The UofL scientists also plan to test whether this technology can be applied in the treatment of inflammation related autoimmune diseases like rheumatoid arthritis.
A Common Sense Approach
Zhang said he began this research by considering how our ancestors selected food to eat.
“The fruits and vegetables we buy from the grocery today were passed down from generation to generation as favorable and nutritious for the human body. On the flip side, outcomes were not favorable for our ancestors who ate poisonous mushrooms, for example,” he said. “It made sense for us to consider eatable plants as a mechanism to create medical nanoparticles as a potential non-toxic therapeutic delivery vehicle.”
In addition to grapefruit, Zhang and his team analyzed the nanoparticles from tomatoes and grapes. Grapefruits were chosen for further exploration because a larger quantity of lipids can be derived from this fruit.
Here’s a chance for an autographed ball from your NCAA National Champion Cardinals
Don’t have enough University of Louisville Cardinal NCAA National Championship memorabilia yet? Here’s your chance for more. A basketball signed by the players of the NCAA National Champion Cardinals will be among the items auctioned this Friday at Bluegrass Brewing Company East in St. Matthews, 3929 Shelbyville Rd.
Proceeds will help fund medical mission trips this summer to Kenya and Ecuador by medical students of the University of Louisville School of Medicine. The live and silent auction events get underway at 6 p.m., and first-year medical student Ahmed Farag said a variety of items will be available to bidders. “We’ll auction off tickets for several individual Cardinal football games next season, gift baskets from a number of area vendors, gift cards from companies such as Best Buy and more, and a lot of other items,” Farag said.
“We worked to get as much variety as possible in the auction items so we could appeal to all tastes. “But, speaking as both a current student and UofL alum” – Farag earned bachelor’s and master’s degrees in engineering from UofL – “I believe the autographed basketball will be the top draw of the auction.” Funds raised by the auction will help pay for medications and supplies that UofL students will need to treat patients while on mission trips to Kenya and Ecuador in the summer.
Each year, UofL medical students volunteer their time – and pay their own way – to medically underserved nations to provide care under the supervision of a volunteer physician and other professionals. No tax dollars are utilized for these trips; all other expenses associated with the trips are covered by the organizations that sponsor them along with donations and gifts. During the trips, the students will see upwards of 1,000 patients, many of whom travel a great distance to receive the care they provide.
Most of the diseases and conditions they encounter are easily preventable in the United States, but because of poverty and lack of access to medical care, many people in these regions die from diarrhea, malaria, untreated wounds, upper respiratory tract infections and more. In many cases, the care provided by the UofL medical student team is the only health care patients receive, making it crucial for those who receive it. In return, students say they get valuable clinical experience and a new perspective on and compassion for patients. “I know I will have a chance to get first-hand experience in treating conditions there that I won’t see here (in Louisville),” Farag said.
Tickets to the family-friendly event are $5 in advance and $6 at the door. Live music and food and drink specials also will be featured. Auction items and cash donations are still being accepted, Farag said; to donate items, contact Shannon Hallinan at 937-609-4542 or schall05@louisville.edu; to donate cash to the mission trip effort, visit the group’s PayPal link at https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=MPC77Z3SD4DA4.
Sony recording artist, 'The Voice' star Angie Johnson to open The Julep Ball
Sony Music Nashville recording artist and songwriter Angie Johnson will bring her powerful voice and country sounds to Louisville's Derby Eve Party with a Purpose, The Julep Ball, Friday, May 3, at the KFC Yum! Center.
The evening kicks off with a 6:30 p.m. cocktail reception, followed by dinner and a live auction at 8 p.m. Johnson will then open the evening's entertainment at 9 p.m., followed by the World's Greatest Party Band, the B-52s. Dancing to deejay music follows.
The event supports the work of the James Graham Brown Cancer Center at the University of Louisville.
A Missouri native who performed at the Kentucky Derby in 2012, Johnson has ties to Kentucky, describing herself as "‘Kentuckanese' – my father's from Kentucky and met my mother while stationed in Okinawa, Japan," she said. She's no stranger to active military service herself, having served as an intelligence analyst and Air Force Band vocalist with the U.S. Air Force in Afghanistan. She continues that service today, serving one weekend each month with the Air National Guard.
A YouTube video of Johnson singing Adele's "Rolling in the Deep" during a performance for active-duty troops launched her civilian singing career. Now viewed more than 3 million times, the video was seen by the host of NBC-TV's "The Voice," Carson Daly. He Tweeted Johnson, encouraging her to audition for "The Voice" while she was still stationed in the Middle East.
"When I first read Carson Daly's Tweet inviting me to audition for ‘The Voice,' I instantly felt like there was some huge shift in the cosmos," she said. "There I was, sitting in a tent in Afghanistan, and I was communicating with Carson Daly on the other side of the planet…THE Carson Daly. I couldn't wrap my head around it for days."
Johnson was chosen by then-judge CeeLo Green for his team on "The Voice," and his guidance has proven invaluable, she said. "The most important thing I learned from CeeLo is to know who you are and be confident in that. Another great thing I learned from him is to always keep educating yourself about music. (And) he taught me that you really have to love what you do. The moment you stop loving it, or stop being passionate about it, is the moment your creativity starts to die. I never want to be like that."
Since her stint on "The Voice," Johnson has toured throughout the country and signed with Sony Music Nashville. "I'm working on a recording project. I want to write, write, write until my fingers fall off. I'm performing all over the country, (and) I plan on continuing my service in the Air National Guard as long as I can."
Most tickets for The Julep Ball's full evening of entertainment are now sold out, but some are still available as are plenty of dance-only tickets. The full evening's entertainment is $500 per person while dance-only tickets are $150 per person. For further information and to buy tickets, go to The Julep Ball website, julepball.org.
At The Julep Ball, party-goers can mingle with local and national business leaders, horse industry professionals and celebrities from sports, music, cinema and television while enjoying the entertainment provided by Johnson and the B-52s. A celebrity emcee for the evening will be CBS Sports Radio broadcaster and former NFL great Tiki Barber. The crowd can watch celebrities make their entrance on the red carpet and dance until the wee hours of Saturday morning. Special moments of The Julep Ball again will come when Brown Cancer Center scientists, physicians and patients are honored and saluted for their efforts.
The Julep Ball is sponsored in part by Brown-Forman, Republic National Distribution Company of Kentucky, Power Creative, Kroger, LG&E, The Event Company, Ingrid Design, Raymond E. and Eleanor H. Loyd, Blue Grass Motorsport, Hilliard Lyons, KentuckyOne Health, Tafel Motors, Jefferson County Sheriff's Office, Advanced Electrical Systems, Montgomery Chevrolet, AT&T Kentucky, BKD, Millennium Pharmaceuticals, Republic Bank, Stites & Harbison, Heuser Clinic and Publishers Printing. Media partners are Louisville Magazine, NFocus, the Voice-Tribune, WHAS11 and 102.3 The Max.
Statewide campaign pushes for early detection of autism, related disorders
The University of Louisville's Autism Center at Kosair Charities will kick off a statewide program April 1 to help parents, teachers and caregivers recognize the early signs of autism.
The ongoing campaign, "Learn the Signs. Act Early In Kentucky," steps up outreach efforts during April's National Autism Awareness Month with free, public workshops, webinars and print materials that can be downloaded from a website.
"We want our message to reach anyone and everyone who spends time with children," said Scott Tomchek, co-clinical director for UofL's autism center and Kentucky ambassador for the Centers for Disease Control and Prevention's Act Early program.
Autism is a complex developmental disability that typically appears during the first three years of life and affects a person's ability to communicate and interact with others. Autism is defined by a certain set of behaviors and is what is known as a "spectrum disorder," meaning that it affects individuals differently and to varying degrees.
According to the Autism Society, 1 percent of all children in the United States ages 3-17 have an autism spectrum disorder. It is estimated that 1 of every 88 babies born will develop an autism spectrum disorder, and that up to 1.5 million Americans are currently living with the condition.
The campaign is a partnership that includes the autism center, University of Kentucky Human Development Institute, the Kentucky Department of Education, the Kentucky Cabinet for Health and Family Services and autism support groups.
Harold Kleinert, executive director of UK's Human Development Institute, said the statewide push to increase the public's understanding of autism and related disorders can have a big impact.
"Doctors rely, in part, on a parent's observations when it comes to assessing a child's developmental progress," Kleinert said. "So educating the public helps the doctor who, in turn, can find ways to help children who aren't reaching developmental milestones when they should."
To learn more about the campaign or download materials, see louisville.edu/education/kyautismtraining/actearly or contact Rebecca Grau, assistant director of UofL's Autism Center at Kosair Charities, at 502-852-7799.
Oral health fair for adults with diabetes in tri-county region set for March 19
Improving oral health literacy is one goal of a University of Louisville health fair aimed at serving residents of Bullitt, Henry and Shelby Counties who are at-risk for diabetes or have been diagnosed with the disease.
The oral health fair will be held Tuesday, March 19, from 10 a.m.-noon at the UofL School of Dentistry, 501 S. Preston St. University of Louisville dental and nursing school faculty and students will provide oral exams, blood pressure screenings, diabetes risk assessments and oral health education.
Dental care is one of the most unmet health needs in the United States. Oral disease can affect general health, and it can be easy to overlook the implications of poor oral health. Diabetes, for example, can increase the incidence and progression of gum disease; likewise gum disease can affect glucose control in people with diabestes.
UofL is a partner of the Kentuckiana Regional Planning and Development Agency (KIPDA) Diabetes Coalition, which serves residents of Bullitt, Henry and Shelby Counties who are over age 50 and at-risk for Type 2 diabetes.
The tri-county region has been identified as having high incidence of diabetes. The coalition effort is aimed at reducing diabetes-related inequalities in vulnerable populations such as older adults, minorities and low-income residents.
In 2011, the Centers for Disease Control and Prevention awarded KIPDA and UofL a five-year grant to help reduce the prevalence of the disease within the three counties.
Exclusive auction items at The Julep Ball offer fine spirits
Two exclusive auction packages guaranteed to appeal to the connoisseur of fine spirits will be offered this year at The Julep Ball, set for Derby Eve, May 3, at the KFC Yum! Center.
Woodford Reserve Distiller's Select bourbon and Jack Daniel's Single Barrel whiskey are each providing a barrel of their product in personalized, individually labeled bottles bearing the winning bidder's name. The winning bidder also receives a personalized barrel head, distillery tour and other exclusive benefits.
"We are excited to offer these two auction packages exclusively to our guests as part of the full evening of entertainment at The Julep Ball. Both are designed for the person who understands and appreciates the nuances of small-batch distilling and wants a unique experience," said Michael Neumann, director of The Julep Ball and major gifts officer at the University of Louisville. The Julep Ball supports the James Graham Brown Cancer Center at UofL.
Woodford Reserve, billed as the Official Bourbon of the Kentucky Derby(R), is offering the "Personal Selection Experience." The package provides 180 one-liter bottles of Woodford Reserve Distiller's Select bourbon in bottles labeled with the winning bidder's name. The winning bidder will consult with Woodford Reserve craftsmen to select his or her own barrels. Also included are a personalized barrel head; one used Woodford Reserve barrel; a private tour of the Woodford Reserve distillery in Versailles, Ky.; lunch for up to six people in the tasting group; and the winning bidder's name engraved on a permanent plaque at the distillery.
Jack Daniel's wants bidders to know, "Your barrel is waiting." This package offers 42 cases or 252 bottles of Jack Daniel's Single Barrel whiskey and personalized medallions, barrel head, nameplate and brick with the winning bidder's name on display in the Single Barrel Society Room at the Jack Daniel's Distillery. The package includes whiskey selection at the distillery in Lynchburg, Tenn., two coach air tickets and two nights' hotel accommodation in Nashville, transportation to and from the distillery and lunch for two at Miss Mary Bobo's in Lynchburg.
Three-quarters of the available tickets for the full evening's entertainment, which includes the opportunity to bid on these exclusive auction packages, are now sold out, but plenty of dance-only tickets are still available. The full evening's entertainment is $500 per person while dance-only tickets are $150 per person. For further information and to buy tickets, go to The Julep Ball website, julepball.org.
At The Julep Ball, party-goers can mingle with local and national business leaders, horse industry professionals and celebrities from sports, music, cinema and television and enjoy entertainment provided by the World's Greatest Party Band, the B-52s. A celebrity emcee for the evening will be CBS Sports Radio broadcaster and former NFL great Tiki Barber. The crowd can watch celebrities make their entrance on the red carpet entrance and dance until the wee hours of Saturday morning following the B-52s concert. Special moments of The Julep Ball again will come when the scientists, physicians and patients at the forefront of cancer treatment and delivery are honored and saluted for their efforts.
The Julep Ball is a 21-and-older event, and the winning bidders and their guests taking part in the small-batch packages' activities must be age 21 or older as well. Woodford Reserve and Jack Daniel's join with The Julep Ball in advocating for responsible drinking.
The Julep Ball is sponsored in part by Brown-Forman, Republic National Distribution Company of Kentucky, Power Creative, Kroger, LG&E, The Event Company, Ingrid Design, Raymond E. and Eleanor H. Loyd, Hilliard Lyons, KentuckyOne Health, Tafel Motors, Jefferson County Sheriff's Office, Advanced Electrical Systems, Montgomery Chevrolet, AT&T Kentucky, BKD, Millennium Pharmaceuticals, Republic Bank, Stites & Harbison, Heuser Clinic and Publishers Printing. Media partners are Louisville Magazine, NFocus, the Voice-Tribune, WHAS11 and 102.3 The Max.
Darrell Griffith encouraging Cardinal fans to Dress in Blue for "Blue of L Day"
One day each year, Cardinal fans can shed their red for a worthy cause.
On Friday, March 1, the Kentucky Cancer Program at the University of Louisville will again sponsor Dress In Blue Day for colon cancer screening awareness.
This year's celebration, dubbed "Blue of L Day," will feature UofL basketball legend Darrell Griffith along with Madeline Abramson, honorary chair of Dress in Blue Day for Kentucky and wife of Lt. Gov. Jerry Abramson. The event will be held at the Kentucky Science Center, 727 W. Main St., from 10 a.m. to 4 p.m.
A highlight of the day's activities will be Abramson and Griffith's appearance from noon to 1 p.m. They will meet participants and discuss the importance of colon cancer screening.
Participants also will see the "Incredible Colon," a 20-foot long, 10-foot tall, walk-through replica of the human colon that provides images to educate the public about colorectal cancer. The first 200 participants wearing blue who tour the Incredible Colon between noon and 1 p.m. will receive free Dress in Blue t-shirts.
Also on display at the Kentucky Science Center is the Body Worlds Vital exhibit that includes whole-body plastinates, a large arrangement of individual organs, organ and arterial configurations and translucent slices that give a complete picture of how the human body works. The exhibit shows how to best fight, manage and prevent life-threatening diseases – such as cancer, diabetes, and heart ailments – through healthy choices and life style changes.
Early diagnosis and treatment is the goal of Dress in Blue Day, said Dr. Donald Miller, director of the James Graham Brown Cancer Center at UofL. "Colon cancer screening can save lives. Most colon cancers can be prevented or cured if detected early," he said.
"I've been screened for colon cancer twice," UofL President James R. Ramsey said, "and I join Dr. Miller in encouraging everyone age 50 and over to schedule a screening appointment – and to go blue for colon cancer on March 1."
The Kentucky Capitol Dome in Frankfort will be lit in blue for colon cancer awareness beginning March 1 through March 10, also. The Kentucky Cancer Program will sponsor a colon cancer display in the Capital Annex Hall March 4-8 for legislators and visitors to learn about the importance of colon cancer screening.
Admission to the event varies with several options for the Body Worlds Vital exhibition available; for details, visit the Kentucky Science Center web site at kysciencecenter.org. The first 100 UofL employees attending the event can receive a $5 discount with their UofL ID.
UofL honors Kosair Charities support
For decades the University of Louisville and Kosair Charities have partnered to help meet the health care needs of children throughout the state. What may surprise some people is that these efforts go beyond the delivery of care and research of new treatments to include advocacy efforts for children.
For more than five years, Kosair Charities has helped support the UofL Department of Pediatrics' child abuse pediatricians. In recognition of that support and the ongoing commitment to ensure that children are free of abuse and neglect, the child abuse prevention program now will be known as the Kosair Charities Division of Pediatric Forensic Medicine.
"The professionals in this program fight every day to end child abuse and neglect," said Gerard Rabalais, M.D., chair of the UofL Department of Pediatrics. "Through partnerships with community organizations, law enforcement agencies, health care providers, Child Protective Services and the Department of Justice, suspected cases of abuse and/or neglect are aggressively investigated so that the tragedy of child abuse is eliminated from Kentucky."
"More than five years ago, Dr. Rabalais brought forward the idea of a partnership with Kosair Charities to create a program designed to eliminate child abuse and neglect," said Jerry Ward, chairman of the board of Kosair Charities. "With a mission of protecting the health and well-being of children in Kentucky and Southern Indiana, we immediately agreed. The importance of this program cannot be understated and all of us at Kosair Charities are honored that the University of Louisville would recognize our contribution to the cause in such a significant manner."
The Kosair Charities Division of Pediatric Forensic Medicine is the state's only physical abuse and neglect assessment program. The formal consultation service provides medical expertise on the diagnosis, documentation and follow-up of suspected cases of child physical abuse and neglect.
The division director, Melissa Currie, M.D., is nationally recognized for her expertise in the field. She serves on Gov. Steve Beshear's review panel that investigates fatalities and near-fatalities found to be the result of abuse or neglect. Currie was among the first group of pediatricians nationwide to be board-certified in child abuse pediatrics and Kentucky's first board-certified child abuse pediatrician.
"Without understanding the underlying signs that point toward abuse or neglect, there are cases that can go undetected," Currie said. "Our partnership with Kosair Charities allows us to have the resources we need to see that doesn't happen. It is such an honor to be affiliated with a group with such a strong commitment to the well-being of children.
"In addition to their support for our program and many others, Kosair Charities has recently assembled a coalition of community leaders who are working on a multi-faceted, comprehensive effort to address child abuse. Their vision is that by 2023 all children in Kentucky will be free from abuse and neglect. Great things happen when we all work together, and particularly when we have the unwavering support of a Kosair Charities—a fixture in Louisville for 90 years."
"Our combined efforts to fight child abuse and neglect again demonstrate the strength of the alliance between Kosair Charities and the University of Louisville as we work to enhance the health and well-being of children," said David L. Dunn, M.D., Ph.D., UofL executive vice president for health affairs.
Tiki Barber selected ‘Official Celebrity Emcee of the 2013 Julep Ball’
NFL great Tiki Barber has been selected as an Official Celebrity Emcee of the 2013 Julep Ball, set for Derby Eve, May 3, at the KFC Yum! Center.
Barber co-hosts the daily national morning show "TBD In The AM" on the CBS Sports Radio network. He spent a decade with the New York Football Giants and holds almost every Giants' rushing record – first in total yards, rushing yards and rushing attempts and second in rushing touchdowns.
"I am thrilled to be part of The Julep Ball and lend my support to the fight against cancer being waged in Kentucky at the James Graham Brown Cancer Center," Barber said. "I am looking forward to a great ‘party with a purpose' as The Julep Ball is known."
Fulfilling that purpose is carried out every day at the Brown Cancer Center at the University of Louisville. The mission of the cancer center is to generate new knowledge relating to the nature of cancer, and to create new and more effective approaches to prevention, diagnosis and therapy, while delivering medical advances with compassion and respect to cancer patients throughout the state and region.
In addition to participating with The Julep Ball, Barber also is scheduled to attend the Kentucky Oaks Pink Friday on Friday, May 3 and the 139th Kentucky Derby on Saturday, May 4.
At The Julep Ball, Barber will join other local and national business leaders, horse industry professionals and celebrities from sports, music, cinema and television. Entertainment will be provided by the World's Greatest Party Band, the B-52s. The celebrity red carpet entrance will return, as will dancing until the wee hours of Saturday morning following the B-52s concert. Special moments of The Julep Ball again will come when the scientists and patients at the forefront of cancer treatment and delivery are honored and saluted for their efforts.
The event is already more than halfway sold out so party-goers should get their tickets now. The full evening's entertainment is $500 per person while dance-only tickets are $150 per person. For further information and to buy tickets, go to The Julep Ball website, julepball.org.
The Julep Ball is sponsored in part by Brown-Forman, Republic National Distribution Company of Kentucky, Power Creative, Kroger, LG&E, Ingrid Design, Raymond E. and Eleanor H. Loyd, Hilliard Lyons, KentuckyOne Health, Tafel Motors, Jefferson County Sheriff's Office, Advanced Electrical Systems, Montgomery Chevrolet, AT&T Kentucky, BKD, Republic Bank, Stites & Harbison, Heuser Clinic and Publishers Printing. Media partners are Louisville Magazine, NFocus, the Voice-Tribune, WHAS11 and 102.3 The Max.
About Tiki Barber
Barber joins Marshall Faulk and Marcus Allen as the only players in NFL history with at least 10,000 yards rushing and 5,000 yards receiving in a career. He retired ranking third all-time in yards per carry with 4.7 and 10th all-time in total yards from scrimmage with 15,632.
Prior to being drafted by the Giants in 1997, Barber excelled both academically and athletically at the University of Virginia. He graduated in from UVa's McIntire School of Commerce with a concentration in management information systems and was named to the Phi Eta Sigma Honor Society. On the football field, Barber left the Cavaliers as their all-time leading rusher. UVa retired his jersey, No. 21, in 2007.
Barber has been active in media and journalism for most of his professional life. In 1999, he began his broadcasting career working for WFAN radio, which led to stints at WCBS-TV, Sirius Satellite Radio, the YES Network, Fox News, NBC News and Sports and MSNBC. In January 2013, he began his latest media endeavor as co-host of CBS Sports Radio's new national morning show, "TBD In The AM," available on more than 250 stations across the country with in excess of 10 million listeners.
Barber is also an entrepreneur, co-founding Thuzio.com, an e-commerce marketplace that facilitates transactions between local athletes, and other public individuals, with consumers looking to book various experiences.
Active in the community, Barber is a board member of the Fresh Air Fund, the Federal Law Enforcement Foundation, the Advisory Board for the Hospital for Special Surgery and the Board of Managers of the University of Virginia Alumni Association. He also is a member of the Leadership Council for the Robin Hood Foundation.
Barber has long been an advocate for the underserved and is a staunch supporter of literacy campaigns. He released his memoir, "Tiki: My Life in the Game and Beyond," in September 2007. He also has co-authored, with his twin brother, Ronde, three successful children's books and six young-adult novels.
About the James Graham Brown Cancer Center:
The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region's leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is affiliated with the Kentucky Cancer Program and the University of Louisville Hospital. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.
Amid the merriment, a moment devoted to medicine
At The Julep Ball each year, a moment comes when the fun and excitement of the party retreat to the wings, allowing the reason the event exists to take center stage. This year, that moment will again come as the James Graham Brown Cancer Center’s Scientist and Physician of the Year are introduced.
Today, the Brown Cancer Center at the University of Louisville, a proud partner of KentuckyOne Health, announced that Jonathan "Brad" Chaires is Scientist of the Year and Jeffrey "Jeff" Bumpous is Physician of the Year. The two will be honored at the ball on Friday, May 3, at the KFC Yum! Center.
Known as the "Derby Eve Party with a Purpose," The Julep Ball supports the work of the Brown Cancer Center and its researchers and physicians such as Chaires and Bumpous.
"One of the main goals of the Brown Cancer Center is to have on our faculty excellent physicians like Jeff Bumpous and scientists like Brad Chaires," said Donald Miller, M.D., director of the cancer center. "This allows us to provide the most advanced cancer treatment available anywhere in the world. Jeff and Brad are prime representatives of all the scientists and physicians at the Brown Cancer Center who work every day to make life better for cancer patients in our region."
Both Chaires and Bumpous are "Bucks for Brains" faculty at UofL: Chaires is the James Graham Brown Endowed Chair of Biophysics and professor in the Department of Medicine; and Bumpous is the J. Samuel Bumgardner Professor of Otolaryngologic Surgery and chief of the Division of Otolaryngology in the Department of Surgery. Kentucky’s Research Challenge Trust Fund – created in 1997 and commonly known as Bucks for Brains – matches state funds with private donations providing strategic investment in university scholarship and research.
"Kentucky is a beautiful state, a wonderful state, but we still have a major problem with cancer in Kentucky," Miller said. "Supporters of The Julep Ball help us advance the war on cancer and better meet the needs of our patients and their families. We cannot thank our volunteers and supporters enough for what they help make possible."
At The Julep Ball, local and national business leaders, horse industry professionals and celebrities from sports, music, cinema and television again will be on hand. Entertainment will be provided by the World’s Greatest Party Band, the B-52s, and a celebrity emcee for the evening will be CBS Sports Radio broadcaster and former NFL great Tiki Barber. The celebrity red carpet entrance will return, as will dancing until the wee hours of Saturday morning following the B-52s concert. Special moments of The Julep Ball again will come when the scientists, physicians and patients at the forefront of cancer treatment and delivery are honored and saluted for their efforts.
Three-quarters of the available tickets for the full evening’s entertainment are now sold out, but plenty of dance-only tickets are still available. The full evening’s entertainment is $500 per person while dance-only tickets are $150 per person. For further information and to buy tickets, go to The Julep Ball website, julepball.org.
The Julep Ball is sponsored in part by Brown-Forman, Republic National Distribution Company of Kentucky, Power Creative, Kroger, LG&E, Ingrid Design, Raymond E. and Eleanor H. Loyd, Hilliard Lyons, KentuckyOne Health, Tafel Motors, Jefferson County Sheriff’s Office, Advanced Electrical Systems, Montgomery Chevrolet, AT&T Kentucky, BKD, Republic Bank, Stites & Harbison, Heuser Clinic and Publishers Printing. Media partners are Louisville Magazine, NFocus, the Voice-Tribune, WHAS11 and 102.3 The Max.
About Brad Chaires, Ph.D., Scientist of the Year
Chaires came to UofL in 2004. In his work, he collaborates closely with other Brown Cancer Center faculty members, and it is this type of collaboration that drew him to Louisville from the University of Mississippi Medical Center. "What the Brown Cancer Center and Don Miller have done in creating a strong structural biology program gave me an instant team for collaborative efforts. This collaborative approach is unique among cancer centers throughout the country," he said.
Chaires’ current research focuses on drug discovery at the basic research level, examining new compounds that interact with nucleic acid structures. "We believe there are specific nucleic acid structures that we can target to shut off the production of proteins early in the development of cancer," he said.
Earlier in his tenure at UofL, Chaires and his research team pioneered the use of calorimetry for characterizing the human plasma proteome as a new tool for the rapid diagnosis of disease. Calorimetry is the technique used to measure the heat produced by chemical reactions or physical changes that occur in organisms. Chaires and his team used differential scanning calorimetry, which enables the collection of data from a very small amount of material, to create a visual map of how blood proteins behave when heated, providing clues to specific diseases.
"It turns out that these maps look pretty much the same for people who are healthy," Chaires said. "However, they look different for people with various diseases. In fact, our research showed that diseases leave a distinctive ‘fingerprint’ on the test result," making a simple blood test a possible new way to spot disease more quickly.
Chaires earned a bachelor’s degree in biology from the University of California, Santa Cruz, a Ph.D. in biophysics from the University of Connecticut and was a National Institutes of Health Postdoctoral Fellow at Yale University. He was on the faculty of the University of Mississippi from 1982 to 2004; during that time, he spent a year on sabbatical as a Visiting Professor at the prestigious Max Planck Institute for Biophysical Chemistry
Chaires is co-holder of three U.S. patents for technology developed from his research, and even as federal funding for research has diminished over the past decade, he has won competitive grant funding continuously since 1984 from the National Cancer Institute, other National Institutes of Health agencies, the National Science Foundation and a variety of other agencies and foundations. He has published prolifically in scientific and medical journals as the lead or co-author of more than 150 articles.
About Jeff Bumpous, M.D., Physician of the Year
Bumpous has been at UofL since 1994 and leads a multidisciplinary team of health care providers in treating cancers of the head and neck. These include cancers of the mouth, larynx (voice box), pharynx (throat), nasal cavity, sinuses, salivary glands and thyroid gland.
Kentucky has one of the highest rates of head and neck cancer in the United States, making the work of surgeons such as Bumpous crucial. "In Kentucky, we see a high rate of patients with oropharyngeal cancers, and at the Brown Cancer Center, our patients number in the hundreds each year," he said. The oropharynx is the middle section of the pharynx.
As might be expected, the high rate of oropharyngeal cancers is attributed to Kentucky’s higher-than-average rate of smoking, Bumpous said, but, "we also have seen over the past decade an increase in oropharyngeal ragged cancer that is HPV-related." HPV is the human papillomavirus; in January, the American Cancer Society reported that it has passed tobacco as the most common cause of oral cancer in the United States.
To treat cancer, Bumpous said, an inclusive approach is paramount. "I am a big believer in the multidisciplinary approach, and am proud that our clinic was one of the first multidisciplinary clinics at the Brown Cancer Center," he said. Multidisciplinary care involves a complete treatment team of medical oncologists, radiation oncologists, surgeons and other medical professionals along with support staff such as social workers, palliative care providers and other caregivers.
"We put the patient first and the cancer second," Bumpous said. "The entire team develops the plan with the patient, and my fundamental role is to serve the patient through the best evidence-based medicine we can provide."
Bumpous earned his bachelor’s degree from Morehead State University and his medical degree from UofL. He completed his internship and residency in general surgery, otolaryngology and head and neck surgery at Saint Louis University and a post-graduate fellowship in advanced head and neck and cranial base surgery at the University of Pittsburgh. He is board-certified in otolaryngology and is lead or co-author of more than 60 journal articles and scientific book chapters.
University of Louisville researchers sign global licensing agreement
Suzanne Ildstad, M.D., is shown with research coordinator Thomas Miller in her Institute for Cellular Therapeutics lab.
The University of Louisville today announced that researcher Dr. Suzanne Ildstad, representing Regenerex LLC, has entered into a license and research collaboration agreement with Novartis to provide access to stem cell technology that has the potential to help transplant patients avoid taking anti-rejection medicine for life and could serve as a platform for treatment of other diseases.
The University of Louisville and Regenerex LLC announced the research collaboration agreement which will significantly enhance the university’s Institute for Cellular Therapeutics’ ability to carry out cutting edge research related to the Facilitating Cell, a novel cell discovered by Ildstad, a professor of surgery and director of the institute at UofL as well as CEO of Regenerex. Underpinning this collaboration is an exclusive global licensing and research collaboration agreement between Regenerex and Novartis.
Ildstad published results in a March 2012 Science Translational Medicine demonstrating the efficacy of this process, known as Facilitating Cell Therapy, or FCRx which is currently undergoing Phase II trials. Five of eight kidney transplant patients were able to stop taking about a dozen pills a day to suppress their immune systems. It was the first study of its kind where the donor and recipient did not have to be biologically related and did not have to be immunologically matched.
In a standard kidney transplant, the donor agrees to donate a kidney. In the approach being studied, the individual is asked to donate part of their immune system as well. The process begins about one month before the kidney transplant, when bone marrow stem cells are collected from the blood of the kidney donor using a process called apheresis. The donor cells are then processed, where they are enriched for developing “facilitating cells” believed to help transplants succeed. During the same time period, the recipient undergoes pre-transplant “conditioning,” which includes radiation and chemotherapy to suppress the bone marrow so the donor’s stem cells have more space to grow in the recipient’s body.
One day after the kidney is transplanted into the recipient, the donor stem cells engraft in the marrow of the recipient and give rise to other specialized blood cells, like immune cells. The goal is to create an environment where two bone marrow systems co-exist and function in one person. Following transplantation, the recipient takes anti-rejection drugs which are decreased over time with the goal to stop a year after the transplant.
In 1998, Ildstad was one of the first recruits to the University of Louisville under the Commonwealth’s Bucks for Brains initiative, advanced by former Gov. Paul Patton. As the Jewish Hospital Distinguished Chair in Transplantation Research, Ildstad brought a team of 25 families from Philadelphia to join the University of Louisville. In the following years the team has continued to examine the facilitating cell (FCRx) platform technology for the treatment of kidney transplant recipients as well as considering its potential for the treatment of red blood cell disorders, inherited metabolic storage disorders of childhood, and autoimmune disorders.
“Being a transplant recipient is not easy. In order to prevent rejection, current transplant recipients must take multiple pills a day for the rest of their lives. These immunosuppressive medications come with serious side effects with prolonged use including high blood pressure, diabetes, infection, heart disease and cancer, as well as direct damaging effects to the organ transplant,” Ildstad said. “This new approach would potentially offer a better quality of life and fewer health risks for transplant recipients.”
“In 1997, the University of Louisville was given a mandate to become a premier metropolitan research university that transforms the lives of the people of Kentucky and beyond,” said Dr. James Ramsey, president of UofL. “Dr. Ildstad was among the first faculty members hired utilizing seed funds from the state to help us attract highly talented researchers through the Bucks for Brains program. Regenerex demonstrates the potential for that vision to be realized bringing new jobs to the city, adding to the revenue from the Tax Increment Financing district and providing funding to UofL in support of our academic mission.”
The collaboration provides for investments in research, as well as milestones and royalty payments from Regenerex to the University of Louisville in connection with commercialization of the FCRx technology. The therapeutic potential for the technology is wide ranging. The collaboration also involves a sponsored research agreement to support a multi-year collaboration between Regenerex, UofL and the Novartis Institutes for BioMedical Research to pioneer new applications of the technology.
“The ‘holy grail’ of transplantation is immune tolerance, that is making the body recognize a transplanted organ as ‘self’ and not reject it as foreign tissue, but without the need for immunosuppressive drugs with their numerous serious side effects,” said Dr. David L. Dunn, executive vice president for health affairs at UofL. “Dr. Ildstad and her team may well have solved this puzzle.”
Ramsey noted that in addition to the supreme efforts of the research team, it would not have been possible for the work to move forward without the support of the state, the National Institutes of Health, the Department of Defense, Jewish Hospital Foundation, Kentucky Science and Technology Corporation and the National Stem Cell Foundation.
“It is immensely rewarding for our donors to know they helped move potentially life-changing therapies closer to being available for people in need worldwide,” said Paula Grisanti, chair of the National Stem Cell Foundation.
Dead Man Walking
<p align="left">Physicians have a fundamental responsibility to treat people in need, to educate their patients about health care reforms and to work with their professional organizations to demand health care for everyone, regardless of their ability to pay.</p>
<p align="left">That is the thrust two University of Louisville physicians, Michael Stillman, M.D., and Monalisa Tailor, M.D., put forth in a “Perspective” for the <i>New England Journal of Medicine.</i> Their article, “<a href="http://www.nejm.org/doi/full/10.1056/NEJMp1312793?query=featured_home">Dead Man Walking</a>,” will be published in an upcoming print issue of the publication and was posted online Oct. 23.</p>
<p align="left">The two <a href="http://www.louisville.edu/medschool/medicine">Department of Medicine</a> faculty tell the story of a man they call “Tommy Davis” who was chronically uninsured despite being employed full-time. Davis spent a year experiencing severe abdominal pain and constipation. Only when the pain was at its most severe did he come to the emergency room for relief.</p>
<p align="left">The diagnosis? Metastatic colon cancer. Davis will die too soon because he was uninsured.</p>
<p align="left">“If we’d found it sooner,” Davis said to the physicians, “it would have made a difference. But now I’m just a dead man walking.”</p>
<p align="left">Stillman and Tailor say this patient’s circumstances are not unique. “For many of our patients, poverty alone limits access to care,” they write. “… a fair number of our patients – the medical ‘have-nots’ – are denied basic services simply because they lack insurance, and our country’s response to this problem has, at times, seemed toothless.”</p>
<p align="left">While the physicians cite elected officials for bearing the brunt of the blame for the “appalling vulnerability of the 22 percent of American adults who currently lack insurance,” they also point to each physician’s responsibility for improving conditions for the un- and under-insured.</p>
<p align="left">“In discussing and grieving over what has happened to Mr. Davis and our many clinic patients (like him) we have considered our own obligations. First, we can honor our fundamental professional duty to help. … the Hippocratic Oath compels us to treat the sick according to our ability and judgment … .</p>
<p align="left">“Second, we can familiarize ourselves with legislative details and educate our patients” so they can receive the fullest possible benefits due them.</p>
<p align="left">“Finally, we can pressure our professional organizations to demand health care for all. … Lack of insurance can be lethal, and we believe our professional community should treat inaccessible coverage as a public health catastrophe and stand behind people who are at risk.</p>
<p align="left">“We find it terribly and tragically inhumane that Mr. Davis and tens of thousands of other citizens of this wealthy country will die this year for lack of insurance.”</p>
‘Spike It to Cancer’ sand volleyball event benefits cancer center at UofL, Oct. 19
<p align="left">Benefactors of a fund to support patients at the <a href="http://browncancercenter.org">James Graham Brown Cancer Center at the University of Louisville</a> are sponsoring a sand volleyball event to raise money for the fund.</p>
<p align="left">Earlier this year, Alex and Tommy Gift established the Mary Jane Gift Quality of Life Fund at the cancer center in honor of their late mother to help patients enjoy life while facing a cancer diagnosis. To benefit the fund, the Gifts are sponsoring “Spike It to Cancer,” a sand volleyball event at Baxter Jack’s sand volleyball complex, 427 Baxter Ave, from noon to 6 p.m. on Saturday, Oct. 19.</p>
<p align="left">Admission is $20 per person and includes appetizers, snacks and soft drinks. Payment by cash, check or credit card will be accepted at the door.</p>
<p>“All proceeds from this event go to the Mary Jane Gift Quality of Life Fund that pays for extras provided to patients and caregivers, such as theater tickets or a night out on the town,” Michael Neumann, executive director of development, said. “We invite everyone to get a team together, sponsor a team or come watch the fun while they support a worthy cause.”</p>
<p>For additional details, contact Neumann at 502-562-4642.</p>