Nelleke van Wouwe, Ph.D., M.Sc.

Assistant Professor

Department of Neurosurgery

220 Abraham Flexner Way 502-588-2160

Nelleke C. van Wouwe, Ph.D., M.Sc., joined the research faculty at the University of Louisville School of Medicine in June 2018. She is an Assistant Professor in the Department of Neurosurgery.

At UofL, van Wouwe works on research to understand the function of the basal ganglia in patients with Parkinson's disease, Huntington's disease, Tourette syndrome, and other conditions. The basal ganglia are located at the base of the forebrain and are associated with control of voluntary movements, cognition, emotion, and other functions. She works with Joseph Neimat, M.D., Chair of the Department of Neurological Surgery on experiments conducted in the operating room during Deep Brain Stimulation surgeries. Dr. van Wouwe's NIH-funded research investigates how the basal ganglia affect cognitive functions crucial to navigating daily life situations, such as the ability to stop or change action.

"For example, patients with Parkinson's disease may find it difficult to stop and control voluntary actions. The ability to stop an action can also depend on whether a positive or negative outcome is expected," van Wouwe said. "Generally, dopaminergic medication and deep brain stimulation restore the ability to control actions, but some patients develop impulse control disorders. A better understanding of failures in adaptive behavior in neurologic or neuropsychiatric disorders with altered frontal basal-ganglia circuitry could ultimately help tailor treatment to individual needs."

From 2012 to 2018, van Wouwe researched cognition and movement disorders at Vanderbilt Medical Center in Nashville, Tennessee. She was educated at Leiden University in the Netherlands and conducted research at the Netherlands Organization for Applied Scientific Research in Soesterberg before moving to the United States.

Van Wouwe's research used cognitive behavioral tasks, neurophysiological measurements, neuropsychological instruments and interventions such as medication withdrawal and deep brain stimulation to identify changes in action control and action-outcome learning resulting from neurodegenerative diseases. She investigates the role of the subthalamic nucleus in action control and action-valence learning by means of cognitive testing, deep brain stimulation, and intraoperative recording studies.