Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

  • Professor of Medicine, Pharmacology and Toxicology, Biochemistry and Molecular Genetics
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Hepatology; Nutrition; Liver Transplantation


Board Certifications

  • American Board of Internal Medicine -
    Gastroenterology / Transplant Hepatology

Education and Training

  • Medical School: University of Kentucky
  • Residency: Washington University Barnes-Jewish Hospital
  • Fellowship: University of Louisville

Get To Know Dr. Cave


Featured Publications

  • Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015. Epub 2022 Apr 5. PMID: 35395240; PMCID: PMC9124454.
  • Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol. 2022 May;199:115012. doi: 10.1016/j.bcp.2022.115012. Epub 2022 Apr 5. PMID: 35393120; PMCID: PMC9050949.
  • Young JL, Cave MC, Xu Q, Kong M, Xu J, Lin Q, Tan Y, Cai L. Whole life exposure to low dose cadmium alters diet-induced NAFLD. Toxicol Appl Pharmacol. 2022 Feb 1;436:115855. doi: 10.1016/j.taap.2021.115855. Epub 2022 Jan 3. PMID: 34990729; PMCID: PMC8796138.
  • Zelko IN, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol. 2022 Feb;37(2):245-255. doi: 10.1002/tox.23394. Epub 2021 Oct 30. PMID: 34717031; PMCID: PMC8724461.
  • Cave MC, Pinkston CM, Rai SN, Wahlang B, Pavuk M, Head KZ, Carswell GK, Nelson GM, Klinge CM, Bell DA, Birnbaum LS, Chorley BN. Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey. Environ Health Perspect. 2022 Jan;130(1):17003. doi: 10.1289/EHP9467. Epub 2022 Jan 6. PMID: 34989596; PMCID: PMC8734566.
  • Petriello MC, Mottaleb MA, Serio TC, Balyan B, Cave MC, Pavuk M, Birnbaum LS, Morris AJ. Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II). Environ Int. 2022 Jan;158:106907. doi: 10.1016/j.envint.2021.106907. Epub 2021 Nov 8. PMID: 34763231; PMCID: PMC9131314.
  • Das S, Rai A, Merchant ML, Cave MC, Rai SN. A Comprehensive Survey of Statistical Approaches for Differential Expression Analysis in Single-Cell RNA Sequencing Studies. Genes (Basel). 2021 Dec 2;12(12):1947. doi: 10.3390/genes12121947. PMID: 34946896; PMCID: PMC8701051.
  • Jin J, Wahlang B, Thapa M, Head KZ, Hardesty JE, Srivastava S, Merchant ML, Rai SN, Prough RA, Cave MC. Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver. Acta Pharm Sin B. 2021 Dec;11(12):3806-3819. doi: 10.1016/j.apsb.2021.10.014. Epub 2021 Oct 21. PMID: 35024308; PMCID: PMC8727924.
  • Heckroth MA, Eisa M, Cave M. Resolution of Autoimmune Hepatitis Following Total Colectomy in Severe Ulcerative Colitis: A Rare Presentation Associated With Leaky Gut. Cureus. 2021 Nov 5;13(11):e19276. doi: 10.7759/cureus.19276. PMID: 34900465; PMCID: PMC8648171.
  • Klinge CM, Piell KM, Petri BJ, He L, Zhang X, Pan J, Rai SN, Andreeva K, Rouchka EC, Wahlang B, Beier JI, Cave MC. Combined exposure to polychlorinated biphenyls and high-fat diet modifies the global epitranscriptomic landscape in mouse liver. Environ Epigenet. 2021 Sep 17;7(1):dvab008. doi: 10.1093/eep/dvab008. PMID: 34548932; PMCID: PMC8448424.