Education and Training

M.S.: Jagiellonian University, Immunology and Microbiology
Ph.D.: Pomeranian Medical University, Hematology
Postdoctoral Research: University of Louisville, Molecular Cardiology

Research Interests

The focus of my research is to understand how the immune system governs the pathophysiology of heart failure. Integrated themes of the ongoing projects in my laboratory include:

• Immunomodulatory mechanisms of infarct healing after myocardial infarction;
• Mechanisms controlling the initiation and resolution of inflammation in the heart;
• The impact of heart failure on medullary and extramedullary hematopoiesis; and
• The effects of cardiovascular risk factors on immune homeostasis.

Featured Publications

Find all papers and citations via ResearchGate

• Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, Moore JB 4th. Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function. Matrix Biol. 2022 May;109:49-69. doi: 10.1016/j.matbio.2022.03.007. Epub 2022 Mar 26. PMID: 35346795; PMCID: PMC9161575.
• Wysoczynski M, Stephan J, Uchida S. Glucosamine regulates macrophage function in heart failure. Clin Transl Med. 2022 Apr;12(4):e819. doi: 10.1002/ctm2.819. PMID: 35452185; PMCID: PMC9028091.
• Tang XL, Wysoczynski M, Gumpert AM, Li Y, Wu WJ, Li H, Stowers H, Bolli R. Effect of intravenous cell therapy in rats with old myocardial infarction. Mol Cell Biochem. 2022 Feb;477(2):431-444. doi: 10.1007/s11010-021-04283-2. Epub 2021 Nov 16. PMID: 34783963; PMCID: PMC8896398.
• Petri BJ, Piell KM, South Whitt GC, Wilt AE, Poulton CC, Lehman NL, Clem BF, Nystoriak MA, Wysoczynski M, Klinge CM. HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer Lett. 2021 Oct 10;518:152-168. doi: 10.1016/j.canlet.2021.07.015. Epub 2021 Jul 14. PMID: 34273466; PMCID: PMC8358706.
• Solanki M, Dobson L, Alwair H, Ghafghazi S, Wysoczynski M, Slaughter MS, Trivedi JR. Association of temporal trends in neutrophil lymphocyte ratio on left ventricular assist device patient outcomes. Artif Organs. 2021 Jul;45(7):742-747. doi: 10.1111/aor.13911. Epub 2021 Feb 20. PMID: 33434359.
• Nong Y, Guo Y, Tomlin A, Zhu X, Wysoczynski M, Li Q, Bolli R. Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice. Mol Cell Biochem. 2021 May;476(5):2135-2148. doi: 10.1007/s11010-021-04077-6. Epub 2021 Feb 5. PMID: 33547546; PMCID: PMC8252912.
• Moore JB, Wysoczynski M. Immunomodulatory Effects of Cell Therapy after Myocardial Infarction. J Cell Immunol. 2021;3(2):85-90. doi: 10.33696/immunology.3.082. PMID: 33959728; PMCID: PMC8098722.
• Kang Y, Nasr M, Guo Y, Uchida S, Weirick T, Li H, Kim J, Moore JB 4th, Muthusamy S, Bolli R, Wysoczynski M. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci Rep. 2020 Sep 8;10(1):14754. doi: 10.1038/s41598-020-71580-z. PMID: 32901075; PMCID: PMC7479609.
• Moore JB 4th, Sadri G, Fischer AG, Weirick T, Militello G, Wysoczynski M, Gumpert AM, Braun T, Uchida S. The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development. Circ Res. 2020 Jul 31;127(4):550-552. doi: 10.1161/CIRCRESAHA.120.316932. Epub 2020 May 4. PMID: 32362246; PMCID: PMC7415551.
• Wysoczynski M, Kim J, Moore JB 4th, Uchida S. Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease. Noncoding RNA. 2020 Jul 11;6(3):28. doi: 10.3390/ncrna6030028. PMID: 32664594; PMCID: PMC7549353.