Sophia M. Sears, Ph.D.

Instructor in Medicine


Education and Training

Ph.D.: University of Louisville, Pharmacology and Toxicology
Postdoctoral Fellowship: University of Louisville, Pharmacology and Toxicology

Featured Publications

  • Kurlawala Z, McMillan JD, Singhal RA, Morehouse J, Burke DA, Sears SM, Duregon E, Beverly LJ, Siskind LJ, Friedland RP. Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS. Sci Rep. 2023 Apr 12;13(1):5945. doi: 10.1038/s41598-023-32594-5. PMID: 37045868; PMCID: PMC10097672.
  • Orwick A, Sears SM, Sharp CN, Doll MA, Shah PP, Beverly LJ, Siskind LJ. Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F287-F300. doi: 10.1152/ajprenal.00317.2022. Epub 2023 Feb 2. PMID: 36727944; PMCID: PMC9988526.
  • Sears SM, Orwick A, Siskind LJ. Modeling Cisplatin-Induced Kidney Injury to Increase Translational Potential. Nephron. 2023;147(1):13-16. doi: 10.1159/000525491. Epub 2022 Jul 6. PMID: 35793615; PMCID: PMC9816344.
  • Sears SM, Feng JL, Orwick A, Vega AA, Krueger AM, Shah PP, Doll MA, Beverly LJ, Siskind LJ. Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury. Am J Physiol Renal Physiol. 2022 Sep 1;323(3):F288-F298. doi: 10.1152/ajprenal.00097.2022. Epub 2022 Jul 7. PMID: 35796459; PMCID: PMC9394729.
  • Sears SM, Vega AA, Kurlawala Z, Oropilla GB, Krueger A, Shah PP, Doll MA, Miller R, Beverly LJ, Siskind LJ. F4/80hi Resident Macrophages Contribute to Cisplatin-Induced Renal Fibrosis. Kidney360. 2022 Feb 10;3(5):818-833. doi: 10.34067/KID.0006442021. PMID: 36128491; PMCID: PMC9438415.
  • Doll MA, Ray AR, Salazar-González RA, Shah PP, Vega AA, Sears SM, Krueger AM, Hong KU, Beverly LJ, Hein DW. Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. Mol Carcinog. 2022 May;61(5):481-493. doi: 10.1002/mc.23392. Epub 2022 Feb 8. PMID: 35133049; PMCID: PMC9018511.
  • Sears SM, Dupre TV, Shah PP, Davis DL, Doll MA, Sharp CN, Vega AA, Megyesi J, Beverly LJ, Snider AJ, Obeid LM, Hannun YA, Siskind LJ. Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury. J Lipid Res. 2022 Mar;63(3):100179. doi: 10.1016/j.jlr.2022.100179. Epub 2022 Feb 10. PMID: 35151662; PMCID: PMC8953688.
  • Sears SM, Siskind LJ. Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis. J Am Soc Nephrol. 2021 Jul;32(7):1559-1567. doi: 10.1681/ASN.2020101455. Epub 2021 May 28. PMID: 34049962; PMCID: PMC8425641.
  • Sears SM, Sharp CN, Krueger A, Oropilla GB, Saforo D, Doll MA, Megyesi J, Beverly LJ, Siskind LJ. C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury. Am J Physiol Renal Physiol. 2020 Oct 1;319(4):F674-F685. doi: 10.1152/ajprenal.00196.2020. Epub 2020 Aug 24. PMID: 32830540; PMCID: PMC7642885.
  • Pal D, Suman S, Kolluru V, Sears S, Das TP, Alatassi H, Ankem MK, Freedman JH, Damodaran C. Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis. Br J Cancer. 2017 Jun 27;117(1):56-64. doi: 10.1038/bjc.2017.143. Epub 2017 Jun 6. PMID: 28588318; PMCID: PMC5520206.