Joseph B. Moore IV, Ph.D.

Associate Professor of Medicine

502-852-2036 E-Mail

Education and Training

Ph.D.: University of Louisville, Biochemistry and Molecular Biology
Postdoctoral Fellowship: Johns Hopkins University, Pediatric Oncology

Research Interests

Dr. Moore’s laboratory focuses on the use of biochemical and developmental programming strategies to investigate the genetic and molecular mechanisms modulating the survival and cardiac reparative properties of adult cardiac progenitor populations (CPCs) residing in the adult mammalian heart. The long term goal of such work is to identify molecular pathways that could be exploited, through genetic modification or pharmacological pretreatment, to enhance the therapeutic efficacy of various autologous cardiac progenitor populations in patients with ischemic cardiac injury.

Specific interests include:

  1. Pathophysiological and etiological mechanisms of heart failure
  2. Molecular mechanisms underlying cell therapy-mediated cardiac repair
  3. Methods to enhance the cardiac reparative capacity of donor cell populations for cell therapy
  4. Genetic and molecular signaling pathways directing cardiovascular cell lineage commitment and specification

Featured Publications

Find all papers and citations via ResearchGate

  • Moore JB 4th, Uchida S. Functional characterization of long noncoding RNAs. Curr Opin Cardiol. 2020 Feb 14. doi: 10.1097/HCO.0000000000000725. [Epub ahead of print] PubMed PMID: 32068613.
  • Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB 4th, Provencher S, Zhang L, Uchida S. Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases. Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C1-C28. doi: 10.1152/ajpcell.00078.2019. Epub 2019 Sep 4. PubMed PMID: 31483703; PubMed Central PMCID: PMC6985837.
  • Moore JB 4th, Merchant ML, Uchida S. Circular RNAs as diagnostic tool for renal transplant patients with acute rejection. Ann Transl Med. 2019 Dec;7(Suppl 8):S302. doi: 10.21037/atm.2019.11.08. PubMed PMID: 32016021; PubMed Central PMCID: PMC6976506.
  • Moradi S, Mahdizadeh H, Šarić T, Kim J, Harati J, Shahsavarani H, Greber B, Moore JB 4th. Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations. Stem Cell Res Ther. 2019 Nov 21;10(1):341. doi: 10.1186/s13287-019-1455-y. Review. PubMed PMID: 31753034; PubMed Central PMCID: PMC6873767.
  • Wysoczynski M, Pathan A, Moore JB 4th, Farid T, Kim J, Nasr M, Kang Y, Li H, Bolli R. Pro-Angiogenic Actions of CMC-Derived Extracellular Vesicles Rely on Selective Packaging of Angiopoietin 1 and 2, but Not FGF-2 and VEGF. Stem Cell Rev Rep. 2019 Aug;15(4):530-542. doi: 10.1007/s12015-019-09891-6. PubMed PMID: 31102187; PubMed Central PMCID: PMC6941436.
  • Wysoczynski M, Moore JB 4th, Uchida S. A novel macrophage subtype directs hematopoietic stem cell homing and retention. Ann Transl Med. 2019 Jul;7(Suppl 3):S79. doi: 10.21037/atm.2019.04.11. PubMed PMID: 31576288; PubMed Central PMCID: PMC6685852.
  • Moore JB 4th, Tang XL, Zhao J, Fischer AG, Wu WJ, Uchida S, Gumpert AM, Stowers H, Wysoczynski M, Bolli R. Epigenetically modified cardiac mesenchymal stromal cells limit myocardial fibrosis and promote functional recovery in a model of chronic ischemic cardiomyopathy. Basic Res Cardiol. 2018 Nov 16;114(1):3. doi: 10.1007/s00395-018-0710-1. PubMed PMID: 30446837; PubMed Central PMCID: PMC6335654.
  • Hosen MR, Militello G, Weirick T, Ponomareva Y, Dassanayaka S, Moore JB 4th, Döring C, Wysoczynski M, Jones SP, Dimmeler S, Uchida S. Airn Regulates Igf2bp2 Translation in Cardiomyocytes. Circ Res. 2018 May 11;122(10):1347-1353. doi: 10.1161/CIRCRESAHA.117.312215. Epub 2018 Feb 26. PubMed PMID: 29483092; PubMed Central PMCID: PMC5948151.
  • Amraotkar AR, Song DD, Otero D, Trainor PJ, Ismail I, Kothari V, Singh A, Moore JB 4th, Rai SN, DeFilippis AP. Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction. Clin Appl Thromb Hemost. 2017 Nov;23(8):1052-1059. doi: 10.1177/1076029616683804. Epub 2016 Dec 21. PubMed PMID: 28294633; PubMed Central PMCID: PMC5572529.
  • Moore JB 4th, Zhao J, Fischer AG, Keith MCL, Hagan D, Wysoczynski M, Bolli R. Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion. J Am Heart Assoc. 2017 Jul 5;6(7). pii: e006183. doi: 10.1161/JAHA.117.006183. PubMed PMID: 28679560; PubMed Central PMCID: PMC5586316.