Yiru Guo, M.D., FAHA

Professor of Medicine

Department of Medicine, Division of Cardiovascular Medicine

E-mail 502-852-5669

Education and Training

  • M.D.Xinjiang Medical University
  • M.Sc.: Peking Union Medical University
  • Postdoctoral Fellowship: University of Louisville, Cardiology

Research Interests

Dr. Guo directs the Murine Physiology Core in the Institute of Molecular Cardiology of the University of Louisville – a state-of-the-art laboratory that performs the most advanced and technically challenging operations in murine models of disease and that serves as the supporting core facility for almost 20 NIH grants. He has developed the first mouse model of early and late phase of ischemic preconditioning with Dr. Roberto Bolli's full support. This model represents a major advance and will be very useful for elucidating the cellular mechanisms of myocardial protection by making it possible to apply molecular biology techniques to intact animal preparations to dissect the precise roles of individual proteins. Using this reliable and physiologically-relevant mouse model, Dr. Guo has identified a specific protein, iNOS, that is responsible for the cardioprotective effects of ischemic preconditioning, one of the most powerful cardioprotective phenomenon discovered thus far. Dr. Guo possesses extensive expertise in the area of cardio-thoracic and vascular surgery, physiology, and pharmacology. His research focuses on: (i) elucidating the mechanisms of ischemic- pharmacologic- and exercise-induced preconditioning by using the ischemia/reperfusion model in genetically engineered animals, (ii) studying protection of ischemic myocardium by using gene and/or cell therapy, and (iii) elucidating adaptations to ischemia/reperfusion injury in the aging heart. Dr. Guo has published more than 70 peer-reviewed papers, three book chapters, and 124 abstracts since 1997. Dr. Guo is currently supported by four NIH grants including one where he serves as PI.

Featured Publications

For a complete listing, please visit: http://www.researcherid.com/rid/L-2618-2015

  • Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation. 2022 Apr 26;145(17):1339-1355. doi: 10.1161/CIRCULATIONAHA.121.057641. Epub 2022 Jan 21. PMID: 35061545; PMCID: PMC9038650.
  • Li Q, Dasari C, Li D, Arshia A, Umer AM, Abouzid MRA, Guo Y, Bolli R. Effects of Heme Oxygenase-1 on c-Kit-Positive Cardiac Cells. Int J Mol Sci. 2021 Dec 15;22(24):13448. doi: 10.3390/ijms222413448. PMID: 34948245; PMCID: PMC8704354.
  • Nong Y, Guo Y, Gumpert A, Li Q, Tomlin A, Zhu X, Bolli R. Single dose of synthetic microRNA-199a or microRNA-149 mimic does not improve cardiac function in a murine model of myocardial infarction. Mol Cell Biochem. 2021 Nov;476(11):4093-4106. doi: 10.1007/s11010-021-04227-w. Epub 2021 Jul 21. PMID: 34287784; PMCID: PMC8478849.
  • Guo Y, Li Q, Xuan YT, Wu WJ, Tan W, Slezak J, Zhu X, Tomlin A, Bolli R. Exercise-induced late preconditioning in mice is triggered by eNOS-dependent generation of nitric oxide and activation of PKCε and is mediated by increased iNOS activity. Int J Cardiol. 2021 Oct 1;340:68-78. doi: 10.1016/j.ijcard.2021.08.021. Epub 2021 Aug 14. PMID: 34400167; PMCID: PMC8453107.
  • Bolli RA, Dasari C, Arshia A, Devadoss D, Guo Y, Ashraf U, Li Q. Physiological Oxygen Tension Enhances Competence and Functional Properties of Murine Cardiac Mesenchymal Cells. Stem Cell Rev Rep. 2021 Jun;17(3):900-910. doi: 10.1007/s12015-020-10106-6. Epub 2021 Jan 3. PMID: 33389682; PMCID: PMC8274526.
  • Bolli RAR, Arshia A, Hassan SA, Dasari C, Nong Y, Guo Y, Tomlin AA, Li Q. Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension Have Superior Therapeutic Efficacy in Heart Failure Caused by Myocardial Infarction. Front Cell Dev Biol. 2021 May 26;9:662415. doi: 10.3389/fcell.2021.662415. PMID: 34124043; PMCID: PMC8189180.
  • Nong Y, Guo Y, Tomlin A, Zhu X, Wysoczynski M, Li Q, Bolli R. Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice. Mol Cell Biochem. 2021 May;476(5):2135-2148. doi: 10.1007/s11010-021-04077-6. Epub 2021 Feb 5. PMID: 33547546; PMCID: PMC8252912.
  • Guo Y, Nong Y, Li Q, Tomlin A, Kahlon A, Gumpert A, Slezak J, Zhu X, Bolli R. Comparison of One and Three Intraventricular Injections of Cardiac Progenitor Cells in a Murine Model of Chronic Ischemic Cardiomyopathy. Stem Cell Rev Rep. 2021 Apr;17(2):604-615. doi: 10.1007/s12015-020-10063-0. Epub 2020 Oct 28. PMID: 33118146; PMCID: PMC8043991.
  • Li Q, Guo Y, Nong Y, Tomlin A, Gumpert A, Zhu X, Hassan SA, Bolli R. Comparison of Repeated Doses of C-kit-Positive Cardiac Cells versus a Single Equivalent Combined Dose in a Murine Model of Chronic Ischemic Cardiomyopathy. Int J Mol Sci. 2021 Mar 19;22(6):3145. doi: 10.3390/ijms22063145. PMID: 33808720; PMCID: PMC8003463.
  • Bolli R, Tang XL, Guo Y, Li Q. After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease. Can J Physiol Pharmacol. 2021 Feb;99(2):129-139. doi: 10.1139/cjpp-2020-0406. Epub 2020 Sep 16. PMID: 32937086; PMCID: PMC8299902.