Anna M. Gumpert, Ph.D.

Assistant Professor of Medicine

Department of Medicine, Division of Cardiovascular Medicine

E-mail 502-852-2084

Education and Training

Ph.D.: Lehigh University, Cell and Molecular Biology
Postdoctoral Fellowship: Temple University Center for Translational Medicine, Stem Cell Therapy Program


Research Interests

  • Investigating adrenergic signaling and its contributions to stem cell based regenerative response both on the systemic level and during cardiac muscle injury and repair.
  • Exploring changes in cellular signaling in a developing and regenerating myocardium.
  • Elucidating the contribution of exosomes and extracellular vesicles on maintenance and repair of vasculature.


Featured Publications

For a complete list, please visit

  • Tang XL, Wysoczynski M, Gumpert AM, Li Y, Wu WJ, Li H, Stowers H, Bolli R. Effect of intravenous cell therapy in rats with old myocardial infarction. Mol Cell Biochem. 2022 Feb;477(2):431-444. doi: 10.1007/s11010-021-04283-2. Epub 2021 Nov 16. PMID: 34783963; PMCID: PMC8896398
  • Nong Y, Guo Y, Gumpert A, Li Q, Tomlin A, Zhu X, Bolli R. Single dose of synthetic microRNA-199a or microRNA-149 mimic does not improve cardiac function in a murine model of myocardial infarction. Mol Cell Biochem. 2021 Nov;476(11):4093-4106. doi: 10.1007/s11010-021-04227-w. Epub 2021 Jul 21. PMID: 34287784; PMCID: PMC8478849.
  • Guo Y, Nong Y, Li Q, Tomlin A, Kahlon A, Gumpert A, Slezak J, Zhu X, Bolli R. Comparison of One and Three Intraventricular Injections of Cardiac Progenitor Cells in a Murine Model of Chronic Ischemic Cardiomyopathy. Stem Cell Rev Rep. 2021 Apr;17(2):604-615. doi: 10.1007/s12015-020-10063-0. Epub 2020 Oct 28. PMID: 33118146; PMCID: PMC8043991.
  • Li Q, Guo Y, Nong Y, Tomlin A, Gumpert A, Zhu X, Hassan SA, Bolli R. Comparison of Repeated Doses of C-kit-Positive Cardiac Cells versus a Single Equivalent Combined Dose in a Murine Model of Chronic Ischemic Cardiomyopathy. Int J Mol Sci. 2021 Mar 19;22(6):3145. doi: 10.3390/ijms22063145. PMID: 33808720; PMCID: PMC8003463.
  • Dassanayaka S, Brittian KR, Long BW, Higgins LA, Bradley JA, Audam TN, Jurkovic A, Gumpert AM, Harrison LT, Hartyánszky I, Perge P, Merkely B, Radovits T, Hanover JA, Jones SP. Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction. PLoS One. 2020 Nov 30;15(11):e0242250. doi: 10.1371/journal.pone.0242250. PMID: 33253217; PMCID: PMC7703924.
  • Moore JB 4th, Sadri G, Fischer AG, Weirick T, Militello G, Wysoczynski M, Gumpert AM, Braun T, Uchida S. The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development. Circ Res. 2020 Jul 31;127(4):550-552. doi: 10.1161/CIRCRESAHA.120.316932. Epub 2020 May 4. PMID: 32362246; PMCID: PMC7415551.
  • Audam TN, Nong Y, Tomlin A, Jurkovic A, Li H, Zhu X, Long BW, Zheng YW, Weirick T, Brittian KR, Riggs DW, Gumpert A, Uchida S, Guo Y, Wysoczynski M, Jones SP. Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H109-H122. doi: 10.1152/ajpheart.00114.2020. Epub 2020 May 22. PMID: 32442025; PMCID: PMC7474443.
  • Dassanayaka S, Brittian KR, Jurkovic A, Higgins LA, Audam TN, Long BW, Harrison LT, Militello G, Riggs DW, Chitre MG, Uchida S, Muthusamy S, Gumpert AM, Jones SP. E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation. Basic Res Cardiol. 2019 May 31;114(4):28. doi: 10.1007/s00395-019-0737-y. PMID: 31152247; PMCID: PMC7278029.
  • Moore JB 4th, Tang XL, Zhao J, Fischer AG, Wu WJ, Uchida S, Gumpert AM, Stowers H, Wysoczynski M, Bolli R. Epigenetically modified cardiac mesenchymal stromal cells limit myocardial fibrosis and promote functional recovery in a model of chronic ischemic cardiomyopathy. Basic Res Cardiol. 2018 Nov 16;114(1):3. doi: 10.1007/s00395-018-0710-1. PMID: 30446837; PMCID: PMC6335654.
  • Tang XL, Nakamura S, Li Q, Wysoczynski M, Gumpert AM, Wu WJ, Hunt G, Stowers H, Ou Q, Bolli R. Repeated Administrations of Cardiac Progenitor Cells Are Superior to a Single Administration of an Equivalent Cumulative Dose. J Am Heart Assoc. 2018 Feb 13;7(4):e007400. doi: 10.1161/JAHA.117.007400. PMID: 29440036; PMCID: PMC5850187.