Emerging Therapies for PBC, NASH and ESLD and HCC Seminar Series 2020: Enduring Material

This CME Enduring Material activity will provide updates on the diagnosis and treatment of chronic liver disease with a focus on patient care and symptom management. A national faculty of liver disease experts has come together to deliver state-of-the-art material and true-to-life clinical cases. This course will concentrate on current and emerging diseases of the liver and address the latest diagnosis, treatment, and care management approaches for each. We hope you enjoy the activity and translate its lessons to improve patient outcomes in you practice.


Welcome to On-line version of the Emerging Therapies for PBC, NASH, ESLD and HCC seminar.  The content represents the most up-to-date information on the diagnosis and treatment of chronic liver disease. Your faculty are leading hepatologists from across the country.

The educational content resides on our digital app and you will be provided log-on information and credentials. When you have completed the course work, you will be directed to a site to take the required CME quiz, evaluate the seminar, and request your Continuing Education credits.

Target Audience

The target audience for this activity is Gastroenterologists, Internists, Hepatologists, Family Physicians, Clinical Pharmacists as well as related Advanced-practice Clinicians and Nurse Specialists. 

Joint Provider Statement
 This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Louisville and SC Liver Research Consortia. The University of Louisville is accredited by the ACCME to provide continuing education for physicians.

Designation Statement
 The University of Louisville Office of Continuing Medical Education & Professional Development designates this enduring material for a maximum of 6.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses - This program has been approved by the Kentucky Board of Nursing for 7.3 continuing education credits through University of Louisville Hospital, provider number 4-0068-7-20-1150. The Kentucky Board of Nursing approval of an individual nursing education provider does not constitute endorsement of program content. Completion criteria to obtain CE's: Attend entire session and complete the evaluation.

This online CME activity has been developed by the University of Louisville School of Medicine in joint providership with SC Liver Research Consortia. During the course you will watch and listen to a series of eight video presentations. You will have to register and create a user profile before you are able to download the digital app and view the video material. Once the material has been reviewed, you will take a brief post-activity test followed by a course evaluation, after which you will be able to generate your CME/CE certificate.

As a provider accredited by the ACCME, the Office of CME&PD, School of Medicine, University of Louisville, must ensure balance, independence, objectivity, and scientific rigor in all its sponsored educational activities. All Planners, faculty, reviewers, and other persons that affected the content of this CME activity were required to submit a financial disclosure form from which relevant conflicts of interest were determined.

Paul Pockros, MD - Course Director, Planner, Faculty; Speakers Bureau: Intercept, Gilead, AbbVie; Consulting: Intercept, Gilead, AbbVie, Prometheus; Contracted Research: Gilead, CymbraBay, Intercept.  
Howard J, Horwitz, MPH - Course Coordinator, Planner; has no relevant financial relationships to disclose.
Cathleen Frenette, MD - Planner, Faculty; Speakers Bureau: Bayer, BMS, Squibb, Eisai, Exelixis,  Salix, Gilead, Intercept, AbbVie, Dova, Shionogi; Consulting: Bayer, Gilead, Intercept, Eisai, Wako, Conatus; Contracted Research: Conatus, Genfit, Dova, Eisai, Conatus, Bayer, Mallinckrodt.
Norman Sussman, MD - Planner; Contracted Research: Gilead, Galectin, Intercept
Robert Fontana, MD - Faculty; Consulting: Sanofi; Contracted Research: AbbVie, Gilead, Bristol Myers Squibb.
Shobha Joshi, MD - Faculty; Speakers Bureau: Intercept, AbbVie, Gilead; Contracted Research: Intercept, Enanta.
Mazen Noureddin, MD - Faculty; Contracted Research: Allergan, BMS, Gilead, Galmed, Shire, Zydus; Advisory Board: Gilead, Intercept, Pfizer, Novartis, Echosens, OWL, Roche and Abbott.
Luis Marsano, MD - Content Reviewer; has no relevant financial relationships to disclose.
Demetra Antimisiaris, PharmD - Content Reviewer; has no relevant financial relationships to disclose.
The University of Louisville CME & PD Advisory Board and Office Staff have nothing to disclose with the following Board Member exceptions:   Sathya Krishnasamy, MD -  Novo Nordisk (Grant Funding);  Ashlee Bergin, MD – Merck (Speaking);  Michael Sowell, MD – Amgen (Speaking), Impax (Grant Funding); Rainer Lenhardt, MD - CSL, Behring, Mallinckrodt and Merck (Speaking).

Hardware & Software Requirements
High speed internet connection
Browser: Google Chrome is recommended

Original Release & Termination Dates
Course Originally Released On: 7/16/ 2020
Date of Most Recent Review: 7/16/2020
Course Termination Date: 7/19/2023

Special Services
If you need special accommodations due to a disability, or for an alternative form of course materials, please contact Howard Horwitz. Continuing Medical Education & Professional Development fully complies with the legal requirements of the ADA and the rules and regulations thereof.

Provider Contact Information
If you need technical support or have questions about the course, please e-mail us at cmepd@louisville.edu

Privacy Policy
The University of Louisville's Continuing Medical Education and Professional Development office respects your privacy. Personal information collected from participants of our medical educational activities will not, unless required by law, be shared with any third party. The primary reason we collect your personal information is for accountability and documentation of your continuing education activities in compliance with Accreditation Council for Continuing Medical Education (ACCME) regulations. We do not distribute unsolicited e-mails, nor, unless required by law, do we share the names of our subscribers with any third party.

The University of Louisville has obtained permission to use the content in this educational activity.

Commercial Support
This Internet Activity Enduring Material is Supported by educational grants from Eisai.

Course Learning Objectives
As a result of participating in this activity, participants should be able to:

1. Summarize the causes of chronic liver disease and hepatic encephalopathy and promising treatments.
2. Describe the complexities of organ transplant procedures and waitlists.
3. Perform the appropriate diagnostic tests required to ensure early diagnosis of hepatocellular carcinoma (HCC).
4. Integrate newer treatment options for HCC as well as approaches to reduce tumor size and number.
5. Appraise the current therapies for PBC and clinical approaches for PSC.
6. Model the importance of liver biopsy for assessment of PSC and NASH as well as emerging, non-invasive diagnostic tools and procedures.
7. Identify diagnostic tests for NASH that may become in daily use soon.
8. Translate approaches and findings from the 2019 EASL and AASLD key presentations to your setting.
9. Discover why Immunotherapy is the new Method of Action for Hepatocellular Carcinoma.
10. Evaluate treatment options for thrombocytopenia; including therapeutic alternatives to platelet transfusion.
11. Employ the progression pathways of Fatty Liver Disease to NASH to Liver Cancer to improve patient management.
12. Utilize current clinical cases to improve diagnostic and treatment skills.
13. Apply new knowledge of treatments for liver diseases using evidence-based approaches.


1. Physicians and Clinical Pharmacists - $95
2. Nurses, Nurse Practitioners and PAs - $70
3. Medical Residents & Fellows - $60
4. All Others - $95

After you complete registration an email confirmation will be sent with a "Click Here for App instructions" link leading to instructions to download the digital app and view the presentation material. Be sure to save the email and password you develop when you register and pay for this course. After watching the presentations you will have to login again to complete the post-test, evaluation, and generate your CME certificate.

Content Questions and Comments
All participants are invited to submit their questions or comments about the content or cases in the presentations to
Questions will be routed one of the faculty experts for reply and each will be answered within 48 hours of receipt.

Attendee Cancellation, Substitution, Refund Policy
The course tuition is refundable, minus a $20 processing fee, if your cancellation is received prior to accessing the course content in the digital app. No refunds or credits will be given after the course materials are accessed.