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What is kidney transplantation?
Kidney transplantation is a procedure offered to patients whose kidneys have failed in their normal function. Normally, kidneys function by regulating fluid volume, balancing chemicals in your blood, producing hormones that regulate your blood pressure and producing urine to filter wastes from your body. When one or more of these systems fail it can lead to a dangerous situation, which can in turn affect other organ systems. Some patients with kidney failure are candidates for a kidney transplant. Receiving a new kidney, whether it is from a living or cadaveric donor, can correct these problems and restore the functions that have failed.
Bone Marrow Transplantation for Kidney Tolerance
Bone marrow transplantation combined with kidney transplantation is an approach to avoid the need for long-term anti-rejection drug therapy. The bone marrow is specially processed to select certain types of cells that may give you a better chance of having tolerance the new donor kidney, thereby decreasing your chance of rejection. The hope is that you may require fewer drugs and reduced dosages of anti-rejection drugs.
Clinical Research Trial for Kidney Tolerance
The purpose of this clinical trial will be to try and stimulate your body to produce a tolerance to your new kidney. This tolerance would allow you to see the transplanted kidney as part of yourself and not try and reject it. You would also maintain your own immunity to diseases and infections.
Principal Investigator - Joseph Leventhal, M.D.