My Bibliography

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Hein DW, Salazar-González RA, Doll MA, Zang Y. The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure. Arch Toxicol. 2023 Oct;97(10):2697-2705. doi: 10.1007/s00204-023-03577-2. Epub 2023 Aug 18. PubMed PMID: 37592049; PubMed Central PMCID: PMC10529816.

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Hong KU, Hein DW. N -acetyltransferase 2 haplotype modifies risks for both dyslipidemia and urinary bladder cancer. Pharmacogenet Genomics. 2023 Aug 1;33(6):136-137. doi: 10.1097/FPC.0000000000000500. Epub 2023 May 29. PubMed PMID: 37306342; PubMed Central PMCID: PMC10524719.

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Walls KM, Hong KU, Hein DW. Induction of glucose production by heterocyclic amines is dependent on N-acetyltransferase 2 genetic polymorphism in cryopreserved human hepatocytes. Toxicol Lett. 2023 Jul 1;383:192-195. doi: 10.1016/j.toxlet.2023.07.002. Epub 2023 Jul 7. PubMed PMID: 37423373; PubMed Central PMCID: PMC10528954.

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Hong KU, Tagnedji AH, Doll MA, Walls KM, Hein DW. Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells. J Cancer Res Clin Oncol. 2023 Jul;149(8):5047-5060. doi: 10.1007/s00432-022-04436-w. Epub 2022 Nov 3. PubMed PMID: 36329350; PubMed Central PMCID: PMC10193532.

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Walls KM, Hong KU, Hein DW. Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes. Arch Toxicol. 2023 Jun;97(6):1613-1626. doi: 10.1007/s00204-023-03488-2. Epub 2023 Apr 2. PubMed PMID: 37005939; PubMed Central PMCID: PMC10192068.

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Habil MR, Hein DW. Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity. Arch Toxicol. 2023 Jun;97(6):1765-1772. doi: 10.1007/s00204-023-03497-1. Epub 2023 Apr 25. PubMed PMID: 37097310; PubMed Central PMCID: PMC10192036.

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Habil MR, Salazar-González RA, Doll MA, Hein DW. Effect of N-acetyltransferase 2 genetic polymorphism on 4,4'-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress. Arch Toxicol. 2023 Jun;97(6):1773-1781. doi: 10.1007/s00204-023-03508-1. Epub 2023 May 4. PubMed PMID: 37142755; PubMed Central PMCID: PMC10259506.

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Hong KU, Walls KM, Hein DW. Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders. Front Pharmacol. 2023;14:1091976. doi: 10.3389/fphar.2023.1091976. eCollection 2023. Review. PubMed PMID: 37077812; PubMed Central PMCID: PMC10106703.

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Wise JTF, Yin X, Ma X, Zhang X, Hein DW. Stable Isotope Tracing Reveals an Altered Fate of Glucose in N-Acetyltransferase 1 Knockout Breast Cancer Cells. Genes (Basel). 2023 Mar 31;14(4). doi: 10.3390/genes14040843. PubMed PMID: 37107601; PubMed Central PMCID: PMC10137864.

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Salazar-González RA, Doll MA, Hein DW. N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances. Arch Toxicol. 2023 Jan;97(1):189-199. doi: 10.1007/s00204-022-03383-2. Epub 2022 Sep 23. PubMed PMID: 36138126; PubMed Central PMCID: PMC10187882.

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Oladipupo I, Ali T, Hein DW, Pagidas K, Bohler H, Doll MA, Mann ML, Gentry A, Chiang JL, Pierson RC, Torres S, Reece E, Taylor KC. Association between cigarette smoking and ovarian reserve among women seeking fertility care. PLoS One. 2022;17(12):e0278998. doi: 10.1371/journal.pone.0278998. eCollection 2022. PubMed PMID: 36512605; PubMed Central PMCID: PMC9746951.

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Habil MR, Salazar-González RA, Doll MA, Hein DW. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes. Arch Toxicol. 2022 Dec;96(12):3257-3263. doi: 10.1007/s00204-022-03381-4. Epub 2022 Sep 16. PubMed PMID: 36112171; PubMed Central PMCID: PMC9641657.

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Hong KU, Gardner JQ, Doll MA, Stepp MW, Wilkey DW, Benz FW, Cai J, Merchant ML, Hein DW. Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells. Data Brief. 2022 Dec;45:108634. doi: 10.1016/j.dib.2022.108634. eCollection 2022 Dec. PubMed PMID: 36426076; PubMed Central PMCID: PMC9679541.

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Hong KU, Salazar-González RA, Walls KM, Hein DW. Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines. Toxicol Sci. 2022 Nov 23;190(2):158-172. doi: 10.1093/toxsci/kfac103. PubMed PMID: 36156098; PubMed Central PMCID: PMC9702998.

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Habil MR, Salazar-González RA, Doll MA, Hein DW. Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. Arch Toxicol. 2022 Nov;96(11):2999-3012. doi: 10.1007/s00204-022-03367-2. Epub 2022 Aug 30. PubMed PMID: 36040704; PubMed Central PMCID: PMC10187863.

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Habil MR, Doll MA, Hein DW. Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant. Front Pharmacol. 2022;13:931323. doi: 10.3389/fphar.2022.931323. eCollection 2022. PubMed PMID: 36386142; PubMed Central PMCID: PMC9650386.

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Wise JTF, Salazar-González RA, Walls KM, Doll MA, Habil MR, Hein DW. Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116095. doi: 10.1016/j.taap.2022.116095. Epub 2022 Jun 2. PubMed PMID: 35662664; PubMed Central PMCID: PMC9382885.

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Hong KU, Gardner JQ, Doll MA, Stepp MW, Wilkey DW, Benz FW, Cai J, Merchant ML, Hein DW. Proteomic analysis of arylamine N-acetyltransferase 1 knockout breast cancer cells: Implications in immune evasion and mitochondrial biogenesis. Toxicol Rep. 2022;9:1566-1573. doi: 10.1016/j.toxrep.2022.07.010. eCollection 2022. PubMed PMID: 36158865; PubMed Central PMCID: PMC9500399.

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Doll MA, Ray AR, Salazar-González RA, Shah PP, Vega AA, Sears SM, Krueger AM, Hong KU, Beverly LJ, Hein DW. Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. Mol Carcinog. 2022 May;61(5):481-493. doi: 10.1002/mc.23392. Epub 2022 Feb 8. PubMed PMID: 35133049; PubMed Central PMCID: PMC9018511.

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Wise JTF, Salazar-González RA, Habil MR, Doll MA, Hein DW. Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells. Toxicol Appl Pharmacol. 2022 May 1;442:115993. doi: 10.1016/j.taap.2022.115993. Epub 2022 Mar 27. PubMed PMID: 35353990; PubMed Central PMCID: PMC9112076.

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Hein DW, Doll MA, Habil MR. Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens. Front Pharmacol. 2022;13:821133. doi: 10.3389/fphar.2022.821133. eCollection 2022. PubMed PMID: 35281898; PubMed Central PMCID: PMC8914035.

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Doll MA, Hein DW. 560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment. Front Pharmacol. 2022;13:820082. doi: 10.3389/fphar.2022.820082. eCollection 2022. PubMed PMID: 35273499; PubMed Central PMCID: PMC8902414.

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Leggett CS, Doll MA, Salazar-González RA, Habil MR, Trent JO, Hein DW. Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1. Arch Toxicol. 2022 Feb;96(2):511-524. doi: 10.1007/s00204-021-03194-x. Epub 2021 Nov 16. PubMed PMID: 34783865; PubMed Central PMCID: PMC8837702.

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Salazar-González RA, Doll MA, Hein DW. Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status. Front Pharmacol. 2022;13:797469. doi: 10.3389/fphar.2022.797469. eCollection 2022. PubMed PMID: 35153780; PubMed Central PMCID: PMC8828969.

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Carlisle SM, Trainor PJ, Doll MA, Hein DW. Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2. Front Pharmacol. 2021;12:803254. doi: 10.3389/fphar.2021.803254. eCollection 2021. PubMed PMID: 35046826; PubMed Central PMCID: PMC8762260.

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Hein DW, Millner LM. Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review. Expert Opin Drug Metab Toxicol. 2021 Jan;17(1):9-21. doi: 10.1080/17425255.2021.1840551. Epub 2020 Nov 3. Review. PubMed PMID: 33094670; PubMed Central PMCID: PMC7790970.

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Leggett CS, Doll MA, States JC, Hein DW. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol. 2021 Jan;95(1):311-319. doi: 10.1007/s00204-020-02901-4. Epub 2020 Nov 2. PubMed PMID: 33136180; PubMed Central PMCID: PMC7855884.

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Hong KU, Doll MA, Lykoudi A, Salazar-González RA, Habil MR, Walls KM, Bakr AF, Ghare SS, Barve SS, Arteel GE, Hein DW. Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2. Toxicol Rep. 2020;7:1319-1330. doi: 10.1016/j.toxrep.2020.09.011. eCollection 2020. PubMed PMID: 33083237; PubMed Central PMCID: PMC7553889.

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Carlisle SM, Trainor PJ, Hong KU, Doll MA, Hein DW. CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804. doi: 10.1038/s41598-020-66863-4. PubMed PMID: 32555504; PubMed Central PMCID: PMC7299936.

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Salazar-González RA, Doll MA, Hein DW. Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes. Sci Rep. 2020 May 5;10(1):7566. doi: 10.1038/s41598-020-64508-0. PubMed PMID: 32372066; PubMed Central PMCID: PMC7200704.

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Habil MR, Doll MA, Hein DW. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes. Pharmacogenet Genomics. 2020 Apr;30(3):61-65. doi: 10.1097/FPC.0000000000000394. PubMed PMID: 31895247; PubMed Central PMCID: PMC7060095.

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Baldauf KJ, Salazar-González RA, Doll MA, Pierce WM Jr, States JC, Hein DW. Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay. Environ Mol Mutagen. 2020 Feb;61(2):235-245. doi: 10.1002/em.22331. Epub 2019 Sep 30. PubMed PMID: 31490564; PubMed Central PMCID: PMC7017392.

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Stepp MW, Salazar-González RA, Hong KU, Doll MA, Hein DW. N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines. J Oncol. 2019;2019:3860426. doi: 10.1155/2019/3860426. eCollection 2019. PubMed PMID: 31531019; PubMed Central PMCID: PMC6720663.

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Salazar-González RA, Zhang X, Doll MA, Lykoudi A, Hein DW. Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline. Arch Toxicol. 2019 Aug;93(8):2237-2246. doi: 10.1007/s00204-019-02516-4. Epub 2019 Jul 10. PubMed PMID: 31292670; PubMed Central PMCID: PMC6713601.

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Carlisle SM, Trainor PJ, Doll MA, Stepp MW, Klinge CM, Hein DW. Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity. Mol Carcinog. 2018 Nov;57(11):1458-1466. doi: 10.1002/mc.22869. Epub 2018 Jul 18. PubMed PMID: 29964355; PubMed Central PMCID: PMC6353662.

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Hein DW, Fakis G, Boukouvala S. Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review. Pharmacogenet Genomics. 2018 Oct;28(10):238-244. doi: 10.1097/FPC.0000000000000350. Review. PubMed PMID: 30222709; PubMed Central PMCID: PMC6208141.

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Salazar-González RA, Turiján-Espinoza E, Hein DW, Milán-Segovia RC, Uresti-Rivera EE, Portales-Pérez DP. Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1. Biochem Pharmacol. 2018 Oct;156:340-347. doi: 10.1016/j.bcp.2018.08.034. Epub 2018 Aug 25. PubMed PMID: 30149019; PubMed Central PMCID: PMC6350916.

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Carlisle SM, Hein DW. Retrospective analysis of estrogen receptor 1 and N‑acetyltransferase gene expression in normal breast tissue, primary breast tumors, and established breast cancer cell lines. Int J Oncol. 2018 Aug;53(2):694-702. doi: 10.3892/ijo.2018.4436. Epub 2018 Jun 11. PubMed PMID: 29901116; PubMed Central PMCID: PMC6017241.

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Hein DW, Hollenberg PF, McQueen CA, Glowinski IB. In Memoriam: Wendell W. Weber, PhD, MD (1925-2018). Pharmacogenet Genomics. 2018 July; 28(7):177-178. NIHMSID: NIHMS966857.doi: 10.1097/FPC.0000000000000340.

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Stepp MW, Doll MA, Carlisle SM, States JC, Hein DW. Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231. Mol Carcinog. 2018 Apr;57(4):549-558. doi: 10.1002/mc.22779. Epub 2018 Feb 3. PubMed PMID: 29315819; PubMed Central PMCID: PMC5832614.

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Hein DW, Kidd CR. Design and Success of a 21st Century Cancer Education Program at the University of Louisville. J Cancer Educ. 2018 Apr;33(2):298-308. doi: 10.1007/s13187-016-1083-5. PubMed PMID: 27474114; PubMed Central PMCID: PMC5280580.

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Zhang X, Carlisle SM, Doll MA, Martin RCG, States JC, Klinge CM, Hein DW. High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5α-androstane-3β,17β-Diol, or Dihydrotestosterone in Breast Cancer Cells. J Pharmacol Exp Ther. 2018 Apr;365(1):84-93. doi: 10.1124/jpet.117.247031. Epub 2018 Jan 16. PubMed PMID: 29339455; PubMed Central PMCID: PMC5830641.

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Salazar-González RA, Turiján-Espinoza E, Hein DW, Niño-Moreno PC, Romano-Moreno S, Milán-Segovia RC, Portales-Pérez DP. Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype. Arch Toxicol. 2018 Feb;92(2):661-668. doi: 10.1007/s00204-017-2082-y. Epub 2017 Oct 17. PubMed PMID: 29043425.

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Hein DW, Zhang X, Doll MA. Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation. Toxicol Lett. 2018 Feb;283:100-105. doi: 10.1016/j.toxlet.2017.11.028. Epub 2017 Nov 24. PubMed PMID: 29180287; PubMed Central PMCID: PMC5745265.

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Fathzadeh M, Hein DW, Knowles JW. The human arylamine N-acetyltransferase type 2 gene: Genomics and cardiometabolic risk. In: Laurieri N, Sim E, editors. Arylamine N-Acetyltransferases in Health and Disease [Internet] Singapore: World Scientific Publishing; 2018. Chapter 1.2; p.43-67. Available from: https://www.worldscientific.com/doi/10.1142/9789813232013_0002.

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Hein DW. N-acetyltransferase 2 polymorphism and human urinary bladder and breast cancer risks. In: Laurieri N, Sim E, editors. Arylamine N-Acetyltransferases in Health and Disease [Internet] Singapore: World Scientific Publishing; 2018. Chapter 4.1; p.327-349. Available from: https://www.worldscientific.com/doi/abs/10.1142/9789813232013_0013.

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Allen CE, Doll MA, Hein DW. N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281. doi: 10.1124/dmd.117.078543. Epub 2017 Oct 10. PubMed PMID: 29018032; PubMed Central PMCID: PMC5706087.

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Hein DW, Doll MA. Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens. Arch Toxicol. 2017 Sep;91(9):3185-3188. doi: 10.1007/s00204-017-1997-7. Epub 2017 May 23. PubMed PMID: 28536864; PubMed Central PMCID: PMC5700865.

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Hein DW, Doll MA. Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype. Arch Toxicol. 2017 Aug;91(8):2827-2835. doi: 10.1007/s00204-017-1989-7. Epub 2017 May 18. PubMed PMID: 28523442; PubMed Central PMCID: PMC5710007.

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Doll MA, Hein DW. Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes. Arch Toxicol. 2017 Jul;91(7):2655-2661. doi: 10.1007/s00204-017-1988-8. Epub 2017 May 17. PubMed PMID: 28516247; PubMed Central PMCID: PMC5713641.