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David A. Scott

 Name: David A. Scott

Titles: (1) Associate Professor, Oral Health and Rehabilitation, Division of Oral Health and Systemic Disease; (2) Associate Professor, Microbiology and Immunology; (3) Associate Professor, Pharmacology and Toxicology; (4) Faculty Member, James Graham Brown Cancer Centre.

Phone: +1-502-852-8905 (Office, 260B); +1-502-852-5531(Lab, 260)

E-mail:
dascot07@louisville.edu

Background

Dr. Scott completed his B.Sc. degree in Microbiology at Heriot-Watt University, Edinburgh Scotland in 1987 and, as a N.A.T.O. Fellow, obtained his Ph.D. in Microbiology and Immunology from McGill University, Montréal, Québec in 1997. He subsequently was a Research Fellow in the Department of Dental Clinical Research at King’s College London under the supervision of Drs. Richard Palmer and Ron Wilson. David moved to the University of Louisville after 4 years as an Associate Professor in the oldest Oral Biology department in the world at the University of Manitoba. He is a member of the editorial board of Tobacco Induced Diseases, Journal of Clinical Periodontology and the Journal of Clinical and Cellular Immunology, and is a frequent reviewer for multiple international scientific journals and several funding bodies, including NIH, AIBS, and CIHR. Dr. Scott is also an Honorary Member of the Delphi Society and the Omicron Kappa Upsilon Society.

Research Interests and Current Projects

  • Dr. Scott’s is funded by NIH (R01DE019826 and R01DE017680) and is pursuing the following projects;
  • Tobacco-induced alterations to microbial-associated molecular patterns of Porphyromonas gingivalis
  • Tobacco-induced alterations to innate-pathogen interactions
  • Tobacco alkaloid amplification of endogenous anti-inflammatory pathways
  • Identification of gingivitis- and periodontitis-specific infrared molecular signatures

 

Teaching Activities

  • Undergraduate
  • SUHD 800-01: Correlated Sciences (Course Director)
  •  OBIO 606 Oral Biology Seminar and Communication Skills (Co-Director)


Graduate

  • OBIO 606: Seminars in Oral Biology (Course Director)
  • OBIO 600: Introduction to Oral Immunology (Lecturer)
  • OBIO 619: Oral Biology Research (Course Director, titular)
  • OBIO 620: Oral Biology Thesis (Course Director, titular)
  • One Ph.D student
  • Four M.Sc. student
  • One Post-doctoral fellow


Continuing Education

  • The role of the dental professional in smoking cessation,  ULSD CME/CDE/CNE course
  • Tobacco smoking and oral health in men, Kentucky State Legislature CE program


Service
National and International

  • International Society for the Prevention of Tobacco Induced Diseases (Executive Committee Member, Secretary, Past President)
  • The Tobacco Control Research and Policy Unit, Hong Kong University (Advisor)
  • U.S. Surgeon General’s Report: Mechanisms of tobacco-induced pathologies – how cigarettes cause disease (Senior Reviewer).


University of Louisville

  • School of Interdisciplinary and Graduate Studies, Faculty  Council
  • School of Interdisciplinary and Graduate Studies, Dean’s Advisory Council
  • School of Interdisciplinary and Graduate Studies, Academic Affairs Committee
  • Provostial International Affairs Advisory Board


School of Dentistry

  • Post-graduate Academic Affairs Committee
  • Research Committee
  • Oral Biology Admissions and Curriculum Committee


Memberships

  • International Society for the Prevention of Tobacco Induced Diseases (Secretary; www.isptid.globalink.org)
  • International Association for Dental Research (Member; www.iadr.com)
  • Society for Anaerobic Microbiology (Member; www.clostridia.net/SAM/index.htm)
  • Society for Leukocyte Biology (Member; www.leukocytebiology.org)



Publications

Books
“Molecular mechanisms of tobacco smoke-induced diseases”, Scott DA*, Wang XL, editors. Publisher: Nova Science Inc., 2006; ISBN 1-59454-514-6.

Chapters

  • Scott DA* and Bagaitkar J. Tobacco smoke and susceptibility to infectious bacterial diseases. In: “Cigarette Smoke Toxicity” David Bernhard, Editor. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2010.
  • SCOTT DA*, WANG XL. “Mechanisms of Cigarette Smoking Induced Pathogenesis – An Overview” In: Molecular mechanisms of tobacco smoke-induced diseases. Scott DA and Wang XL, editors. Publisher: Nova Science Inc., 2006.
  • LIU K-Z, SOWA M, SCOTT DA*. “Infrared spectroscopy: A novel molecular tool for the quantification of tobacco smoke exposure and the early diagnosis of tobacco-induced diseases.” In: Molecular mechanisms of tobacco smoke-induced diseases. Scott DA and Wang XL, editors. Publisher: Nova Science Inc., 2006.
  • PALMER RM, WILSON RF, SCOTT DA*. “Periodontitis and tobacco smoking” In: Molecular mechanisms of tobacco smoke-induced diseases. Scott DA and Wang XL, editors. Publisher: Nova Science Inc., 2006.



Selected Recent Journal Articles

  • ADAMOWICZ K, WANG H, ZELLER I, POTEMPA J, MARTIN M, SCOTT DA*. Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice. Molecular Medicine 2012, 18: 1190-6.

  • BAGAITKAR J, ZELLER I, RENAUD DE, SCOTT DA*. Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells. Tobacco Induced Diseases 2012,10:e18.

  • KRAUSS JL, SCOTT DA*. Neutrophils in periodontal inflammation. Frontiers in Oral Biology 2012, 15:56-83.

  • POTEMPA J, SCOTT DA*. Cigarette smoke-exposed neutrophils die unconventionally but are effectively phagocytosed. Cell Death and Disease 2011, 2:e131.

  • BAGAITKAR J, PATEL C, RENAUD DE, DAEP CA, DEMUTH DR, SCOTT DA*. Tobacco smoke augments oral (P. gingivalis – S. gordonii) biofilm formation. PLOS One 2011, 6:e27386.

  • BUDUNELI N, LARSSON L, BIYIKOĞLU B, BAGAITKAR J,  RENAUD DE, SCOTT DA*. Lipid A-derived C12 and C14 3-OH fatty acids are decreased in relation to C13 3-OH fatty acid in smokers with chronic periodontitis. Journal of Dental Research 2011, 90:47-52.

  • BAGAITKAR J, DEMUTH DR, DAEP C, PIERCE DL, RENAUD DE, SCOTT DA*. Tobacco-regulated changes to P. gingivalis fimbrial proteins and capsule polysaccharides induce TLR2 hyposensitivity. PLOS One 2010;5:e9323.

     

  • BAGAITKAR J, WILLIAMS LR, RENAUD DE, BEMAKANAKERE MR, SCOTT DA*, DEMUTH DR. Tobacco-induced alterations to Porphyromonas gingivalis gene activity and host-pathogen interactions. Environmental Microbiology 2009; 11:1242-1253.

  • REHANI K, MARTIN M, RENAUD DE, HAMZA H, WILLIAMS LR, SCOTT DA*. Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells. Biochimica et Biophysica Acta: Molecular Cell Research 2008; 1783: 378-385.

     
  •  BAGAITKAR J, SCOTT DA*. Tobacco use and susceptibility to bacterial infection. Tobacco Induced diseases 2009; 4:12.

  •  XU M, SCOTT JE, BISHOP HR, LIU K-Z, RENAUD DE, SOUSSI-GOUNNI A, SCOTT DA*. The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release. Cell Biology 2008;9:19.


Patents


Patents

 


Patents

  • K.Z. Liu, DA Scott*, DL Singer and MG Sowa. A Means and Method for the Diagnosis of Periodontitis by Infrared Spectroscopy. U.S. Provisional Patent Application 60/780,060, (March 8) 2006.
  • D.A. Scott*, M. Martin. Therapeutic Cotinine Compositions. U.S. Patent Application 60/890,954 (February 21 2007).
  • D.A. Scott*, M. Martin. Therapeutic Cotinine Compositions. U.S. Patent Application PCT/US2008/054569 (February 21 2008).
  • D.A. Scott*, K.-Z. Liu. Molecular Signatures Of Diabetes In Saliva. U.S. Patent Application 61/139,263 (12/19/2008)

 

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