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School of Dentistry

Jixiang Ding, Ph.D.

DingJixiang Ding, Ph.D.
Associate Professor
Department of Molecular, Cellular & Craniofacial Biology

Research Narrative
The research in Dr. Ding’s laboratory is aiming to elucidate the molecular basis of congenital diseases through understanding the molecular pathways and genetic programs that control fundamental embryonic processes such as axis formation, cardiac development, craniofacial morphogenesis and patterning. On going studies address TGF-s and Nodal signaling pathways during holoprosencephaly (HPE) and other craniofacial malformation such as cleft palate using genetically manipulated mouse models. We have also addressed the formation of the first and second heart fields and dynamic relationship between the two heart fields during mouse cardiac morphogenesis. The results from these studies will provide significant insights into the mechanisms underlying facial abnormality and congenital heart diseases, two extremely common birth defects in US and world wide. 

dna.jpgGrants Funded
Role:     Principal Investigator
Title:    Mechanism of mammalian embryonic heart formation
Funding Agency: KSEF
Total Direct cost requested: $72,000
Period: 07/01/2010-06/30/2012

Role: Principal Investigator
Title: Regulation of Nodal signaling in holoprosencephaly
Funding Agency: National Institutes of Health
Type: R01
Total Direct Costs: $1,125,000
Period: In no cost extension

Role: Principal Investigator
Title: Regulation of Nodal signaling in holoprosencephaly
Funding Agency: National Institutes of Health
Type: K02 career development award
Total Direct Costs: $482,958
Period: ended in June 2010.

Peer Reviewed Publications

Jin JZ, Tan M, Warner DR, Darling DS, Higashi Y, Gridley T and Ding J. (2010) Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn 239, 2110-7.


External Professional Activities
Manuscript reviewer for Developmental Biology; Cell, Tissue & Organ; Mechanisms of Development.


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