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Xiang Zhang

Professor

Director, CREAM Center

Xiang Zhang
Division: Analytical Chemistry
Specialty: Bioanalytical Chemistry & Bioinformatics
Office: Shumaker Research Bld 349
Office Phone: 502-852-8878
Lab Phone: 502-852-3212
Email: xiang.zhang@louisville.edu
Website: Zhang Group Web Page

Education and Research Experience

1989 B.S.   Lanzhou University
1994 M.S.  Institute of Modern Physics, Chinese Academy of Sciences
2001 Ph.D. Purdue University

Research Interests

We are interested in multidisciplinary life sciences research. Our expectation is that the chemistry of biomolecules in living systems can define disease mechanisms. We would like to tell the biological story revealed by these molecules with advanced bioinformatics methodologies and modern analytical techniques. Our bioanalytical research exploits practical and efficient high-throughput technologies for the analyses of complex mixtures derived from living systems. The bioinformatics research in our group develops informatics system that enables mining of high-throughput data for molecular identification, quantification, molecular networks elucidation, and ‘systems level’ knowledge assembly.

Recent Publications

Data dependent peak model-based spectrum deconvolution for analysis of LC-MS data.
Wei, X.; Shi, X.; Kim, S.; S, K.; Patrick, J.S.; Binkley, J.; Kong, M.; McClain, C.; Zhang, X.
Anal. Chem.  2014, 86(4), 2156-2165.

iMatch2: Compound identification using retention index for analysis of gas chromatography-mass spectrometry data.
Koo, I.; Shi, X.; Kim, S.; Zhang, X.
J. Chromatogr. A  2014, 1337, 202-210.

A new method of peak detection for analysis of comprehensive two-dimensional gas chromatography mass spectrometry data.
Kim, S.; Ouyang, M.; Shen, C.; Zhang, X.
Annals of Applied Statistics  2014, in press.

Compound identification in GC-MS by simultaneously evaluating mass spectrum and retention index.
Wei, X.; Koo, I.; Kim, S.; Zhang, X.
Analyst  2014, 139 (10), 2507 - 2514.

Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced fatty liver disease.
Shi, X.; Wei, X.; Koo, I.; Schmidt, R.H.; Yin, X.; Vaughn, A.; Kim, S.H.; McClain, C.J.; Arteel, G.E.; Zhang, X.; Watson, W.H.
J. Proteome Res.  2014, 13, 547−554.

Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma.
Li, Y.; Shi, X.; Zhang, J.; Zhang, X.; Martin, R.
Int. J. Oncol.  2014, 44, 505-513.

MetPP: A computational platform for comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics.
Wei, X.; Shi, X.; Koo, I.; Kim, S.; Schmidt, R.H.; Arteel, G.E.; Watson, W.H.; McClain, C.; Zhang, X.
Bioinformatics  2013, 29, 1786-1792.

Comparative analysis of mass spectral matching-based compound identification in gas chromatography mass spectrometry.
Koo, I.; Kim, S.; Zhang, X.
J. Chromatogr. A  2013, 1298, 132-138.

Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats.
Song, M.; Schuschke, D.A.; Zhou, Z.; Chen, T.; Shi, X.; Zhang, J.; Zhang, X.; Pierce, W.M.; Johnson, T.W.; Vos, M.B.; McClain, C.
Obesity  2013, DOI: 10.1002/oby.20380.

Chronic alcohol exposure disturbs lipid homeostasis at the adipose-liver axis: analysis of triacylglycerols using high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling.
Wei, X.; Shi, X.; Tang, Y.; Sun, W.; Yin, X.; Sun, X.; Bogdanov, B.; Kim, S.; McClain, C.; Zhou, Z.; Zhang, X.
Plos One  2013, 8(2):e55382.

An efficient post-hoc integration method improving peak alignment of metabolomics data from GC×GC/TOF-MS.
Jeong, J.; Zhang, X.; Shi, X.; Kim, S.; Shen, C.
BMC Bioinformatics  2013, 14:123.

Olanzapine activates hepatic mammalian target of rapamycin (mTOR): new mechanistic insight into metabolic dysregulation with a typical antipsychotic drugs.
Schmidt, R.H.; Jokinen, J.D.; Massey, V.L.; Falkner, K.C.; Shi, X.; Yin, X.; Zhang, X.; Beier, J.I.; Arteel, G.E.
J. Pharmacol. Exp. Ther.  2013, accepted on Aug. 5.

Detection of volatile biomarkers of therapeutic radiation in breath.
Phillips, M.; Byrnes, R.; Cataneo, R.N.; Chaturvedi, A.; Kaplan, P.; Libardoni, M.; Mehta, V.; Mundada, M.; Patel, U.; Ramakrishna, N.; Schiff, P.; Zhang, X.
J. Breath Res.  2013, 7:036002.

A method of aligning peak lists generated by gas chromatography high-resolution mass spectrometry.
Wei, X.; Shi, X.; Merrick, M.; Willis, P.; Alonso, D.; Zhang, X.
Analyst  2013, DOI: 10.1039/C3AN00667K.

Electron ionization–induced release of coded isotopic reporter ions in an m/z zone of minimal interference for quantifiable, multiplexed GC-MS analyses.
Laulhé, S.; Geers, T.E.; Shi, X.; Zhang, X.; Nantz, M.H.
Anal. Methods  2013, DOI:10.1039/C3AY41124A.
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