Bioinformatics and Biostatistics Role: Faculty Title: Professor Office No: 4026, K-wing Address: 555 S. Floyd Street Phone: 502 852 6376 Fax: 502 852 3294 E-mail: somnath.dattaATlouisvilleDOTedu www.louisville.edu/~s0datt03

Background

Ph. D. (1988), Statistics and Probability, Michigan State University, East Lansing.
M. Stat. (1985), Mathematical Statistics and Probability, Indian Statistical Institute, Calcutta.
B. Stat. (1983), Statistics, Indian Statistical Institute, Calcutta.

I joined the Department of Bioinformatics & Biostatistics as a tenured full professor in July of 2005. Prior to that, I was in the Statistics department at the University of Georgia where I started my academic career as an assistant professor in 1988 and moved through the ranks attaining full professorship in 1998. Over the years I have written over seventy research papers in various peer reviewed Statistics & Biostatistics journals. For the last several years I have been collaborating with Dr. Glen Satten and other statisticians and scientists at the Centers for Disease Control and Prevention in Atlanta. Currently, I am collaborating with Susan Harkema  at U of L on Spinal Cord Injury Research.  I am also conducting research in statistical methodologies that is supported by the National Science Foundation and the National Security Agency.

Research Interests

My research interests include various topics in Statistics and Biostatistics such as Bioinformatics, Bootstrap Methods, Compound Decision Problems, Empirical Bayes Methods, Nonparametric Function Estimation, Statistical Genetics, Survival Data Analysis, Time Series Analysis etc. At present, I am working on multistage data that are an important special case of multivariate survival or event time data. I am interested in nonparametric and semiparametric inference procedures for such multistage models. I am also interested in nonparametric inference procedures for marginal effects in clustered data, such as those arise in longitudinal studies. In the area of Bioinformatics, I am interested in developing novel statistical methods for gene expression and proteomic data.

Teaching Activities

I am scheduled to teach "Advanced Statistical Inference" in the Fall of 2007. It is a core course designed for the Biostatistics concentration PhD program.

Current Projects

Biostatistics Projects:
Nonparametric Inference in Censored Data Problems funded by National Security Agency, Mathematical Science Grant.
Theory and Applications of U-statistics for Multistate Models under Censoring funded by National Science Foundation, Statistics program.

Bioinformatics Projects:
Validation and ranking of clustering algorithms for gene expression data; better clustering algorithms using existing annotations. Genetic network via statistical/computation means from microarray data.

Collaborative project:
Multivariate Analysis of Spinal Cord Injury Recovery Data. Funded by Christopher Reeve Foundation  and NIH (PI: S. Harkema).

Service

Co-Editor-in-Chief,  Statistics & Probability Letters,  (from July 1, 2007).

Associate Editor, The American Statistician, current
Co-Editor, Sankhya, current.

Associate Editor, Communications in Statistics, current.

Editorial Board Member of International Journal of Statistics and Systems (IJSS) , current

Guest Associate Editor, Statistics and Probability Letters; Journal of Statistical Planning and Inference.

Panel member: Integrated Cancer Biology, National Institute of Health (NIH), 2004.

Reviewer for Mathematical Reviews; National Science Foundation; Springer.

Mentoring Activities

Current and past graduate student thesis/dissertation supervision

PhD
Michael R. Allen, Inference and Bootstrap for Some Linear Time Series Models. Completed: Summer 1997. Currently at Department of Mathematics, Tennessee Technological University, Cookeville, TN 38505.

S. Kim (jointly with I. V. Basawa), Inference for Nonlinear Time Series Models via Estimating Functions. Completed: Spring 1998.

HaiTao Zheng (jointly with I. V. Basawa), Inference for Time Series Models for Count Data. Completed: Summer 2005. Currently at Department of Mathematics & Statistics, San Diego State University, San Diego, CA 92182.

Dipankar Bandopadhyay, Novel Nonparametric Methods for Event Time Data. Completed: Spring 2006. Currently at Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425.

DeSale Habtzghi (jointly with M. Meyer), Maximum Likelihood Based Estimation of Hazard Function under Shape Restrictions and Related Statistical Inference. Completed: Spring 2006. Currently at Department of Mathematics, Georgia College and State University, Milledgeville, GA 31061.

Lan Ling, Inference for Multistate Models expected completion: Summer 2008.

MS
Cathleen Gillespie, Intra-Individual Variation in Serum Vitamin A Measures Among Participants in the Third National Health and Nutrition Examination Survey, 1988-1994, completed: Spring 2002.

Yang Fan, A New Bivariate Survival Function Estimator under Random Right Censoring. Completed: Spring 2005.

Vasyl Pihur, expected completion: Spring 2007.

Honors and Awards

2007: Listed in Who's Who in America, 61st Edition.
2006: Fellow of the American Statistical Association.

"CDC ATSDR 2005 Statistical Science Award: Best Application Paper", Standardization and denoising algorithms for mass spectra to classify whole-organism bacterial specimens, Satten, G. A., Datta, S., Moura, H., Woolfitt, A., Carvalho, G., De, B. K, Pavlopoulos, A., Carlone, G. M., and Barr, J. : Bioinformatics, 20, 3128-3136 (2004).

"CDC ATSDR 2004 Statistical Science Award: Best Theoretical Paper", Marginal analyses of clustered data when cluster size is informative, Williamson, J. M., Datta, S. and Satten, G. A.: Biometrics, 59, 36-42 (2003).

Snedecor Award nomination, 2003 for the paper Estimation of integrated transition hazards and stage occupation probabilities for non-Markov systems under stage dependent censoring by Datta, S. and Satten, G. A.. Biometrics, 58, 792-802 (2002).

"CDC ATSDR 2001 Statistical Science Award: Best Theoretical Paper", A simulate-update algorithm for missing data problems, Satten, G. A. and Datta, S.: Computational Statistics, 15, 243-277 (2000).

"CDC ATSDR 1999 Statistical Science Award: Best Theoretical Paper", A semiparametric approach to the proportional hazards model for interval censored data, Satten, G. A. and Datta, S. and Williamson, J. M.: Journal of the American Statistical Association, 93, 318-327 (1998).

Outside Interests

Photography, Digital Editing, Sound Recording, Stamp Collecting.

Just for Fun

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Links

My Other Web-site

Publications

Journal Articles
(17 publication(s) displayed.)
"Nonparametric marginal estimation in a multistage model using current status data"
Datta, S. and Sundaram, R.. Biometrics; ():
Publication Date: 2006

 
"Methods for evaluating clustering algorithms for gene expression data using a reference set of functional classes"
Datta, S. and Datta, S.. BMC Bioinformatics; 7(): 397
Publication Date: 2006

 
"Empirical Bayes screening of many p-values with applications to microarray studies"
Datta, Susmita and Datta, Somnath. Bioinformatics; 21(9): 1987-1994
Publication Date: 2005

 
"Rank-sum tests for clustered data"
Datta, Somnath & Satten, Glen A.. Journal of the American Statistical Association; 100(September): 908-915
Publication Date: 2005

 
"Standardization and denoising algorithms for mass spectra to classify whole-organism bacterial specimens"
Satten, G. A., Datta, S., Moura, H., Woolfitt, A., Carvalho, G., De, B. K, Pavlopoulos, A., Carlone, G. M., and Barr, J.. Bioinformatics; 20(17): 3128-3136
Publication Date: 2004

 
"An empirical Bayes adjustment to increase the sensitivity of detecting differentially expressed genes in microarray experiments"
Datta, Susmita, Satten, G. A., Benos, D. J., Xia, J., Heslin, M., and Datta, Somnath. Bioinformatics; 20(2): 235-242
Publication Date: 2004

 
"How will plant pathogens adapt to host plant resistance at elevated CO2 under a changing climate?"
Chakraborty, S. and Datta, S.. New Phytologist; 159(10): 733-742
Publication Date: 2003

 
"Comparisons and validation of statistical clustering techniques for microarray gene expression data"
Datta, Susmita and Datta, Somnath. Bioinformatics; 19(4): 459-466
Publication Date: 2003

 
"Marginal analyses of clustered data when cluster size is informative"
Williamson, J., Datta, S., and Satten, G. A.. Biometrics; 59(): 36-42
Publication Date: 2003

 
"Estimation of integrated transition hazards and stage occupation probabilities for non-Markov systems under stage dependent censoring"
Datta, S. and Satten, G. A.. Biometrics; 58(): 792-802
Publication Date: 2002

 
"Marginal estimation for Multistage models: waiting time distributions and competing risk analyses"
Satten, G. A. and Datta, S.. Statistics in Medicine; 21(): 3-19
Publication Date: 2002

 
"An estimator for the survival function when data are subject to dependent censoring"
Satten, G. A., Datta, S. and Robins, J. M.. Statistics & Probability Letters; 54(): 397-403
Publication Date: 2001

 
"The Kaplan-Meier Estimator as an inverse-probability-of-censoring weighted average"
Satten, G. A. and Datta, S.. American Statistician; 55(): 207-210
Publication Date: 2001

 
"Analysis of dynamic cohort data"
Williamson, J. M., Satten, G. A., Hanson, J. A., Weinstock, H., and Datta, S.. American Journal of Epidemiology; 154(): 366-372
Publication Date: 2001

 
"A simulate-update algorithm for missing data problems"
Satten, G. A. and Datta, S.. Computational Statistics; 15(): 243-277
Publication Date: 2000

 
"Nonparametric estimation for the three-stage irreversible illness-death model"
Datta, Somnath, Satten, G. A. and Datta, Susmita. Biometrics; 56(): 841-847
Publication Date: 2000

 
"Validating marker-based incidence estimates in repeatedly screened population"
Satten, G. A., Janssen, R., Busch, M. P., and Datta, S.. Biometrics; 55(): 1224-1227
Publication Date: 1999