Bioinformatics and Biostatistics Role:    Faculty Title:    Associate Professor Office No:    132 Address:    485 E. Gray St Phone:    502 852 3988 Fax:    502 852 3294 Email:  maiying.kong@louisville.edu

 







Background
B.S., Computational Mathematics, Xian Jiaotong University, Shaanxi, China.
M.S., Computational Mathematics, Xian Jiaotong University, Shaanxi, China.
Ph.D., Statistics, 2004, Indiana University, Bloomington, Indiana. (Advisor: Rabi Bhattacharya)
Post-doc in Biostatistics, 2004-2006, University of Texas, M. D. Anderson Cancer Center (Mentor: J. Jack Lee)
Assistant Professor, July 2006- June 2012, Department of Bioinformatics and Biostatistics, SPHIS, University of Louisville                                                 
Associate Professor, July 2012-Current, Department of Bioinformatics and Biostatistics, SPHIS, University of Louisville

Research Interests
My primary research interests are developing biostatistics methods and applying them to basic/clinical/translational research. I have developed statistical methods on dose-response study, combination drug study, preclinical experimental designs, and longitudinal studies. Currently, I am working on longitudinal study and high-dimensional data analyses. 

Students Mentored
Ming Wang, MS in Biostatistics, 2008 (joint with Dr. Somnath Datta)
Lin Sun, MS in Biostatistics, 2010
Hyejeong Jang, MS in Biostatistics, 2011
Lei Zhou, MS in Biostatistics, December 2012
Sheng Xu , MS in Biostatistics, expected in Spring 2013 (joint with Dr. Somnath Datta)
Yubing Wan, Ph.D. candidate in Biostatistics (joint with Dr. Susmita Datta)

Teaching Activities
I have taught one master level course and three doctoral level courses.
PHST 680:   Biostatistical Method I
PHCI 624-01: Clinical Trials I: Planning and Design
PHST 781:   Advanced Linear Model
PHST 782:   Generalized Linear Model
PHST 704:   Mixed Effect Models and Longitudinal Data Analyses

Honors and Awards
Trainee Excellence Award Winner, M.D. Anderson Alumni and Faculty Association, March 2006
Starr Fellowship, International Program, Indiana University, 2003-2004
William B. Wilcox Mathematics Award, Indiana University, May 2002 

Active Grants
Protection of ischemic myocardium.
PI: R. Bolli
NIH/ NHLBI
Role: Co-Investigator 
Term: 7/1/2011-6/31/2016

Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR)
PI: R. Bolli
NIH/ NHLBI  U24 HL094373
Role: Director of the Biostatistics Core
Term: 8/1/2010-7/31/2015
 
Center of Excellence in Diabetes and Obesity Research
PI: A. Bhatnagar
NIH/ NCRR 1 P20 RR024489
Role: Biostatistician
Term: 10/01/2008 – 09/30/2013   

Effects of diesel emissions on vascular Inflammation and thrombosis
PI: D. Conklin
HEI ACES 
Role: Co-Investigator
Term: 2/1/2010-1/30/2012 

Completed Grants
Development of Statistical Analyses for Longitudinal Study
PI: M. Kong
University of Louisville: Intramural Research Incentive Grants 
Term: 7/1/2008-6/30/2009

Longitudinal prospective study of PSP
PI: I. Litvan
CurePSP
Role: Biostatistician
Term: 7/1/2007-6/30/2009 

Publications

Journal Articles

Jang H, Conklin DJ, Kong M.  Piecewise nonlinear mixed-effects models for modeling cardiac function and assessing treatment effects. Computer Methods and Programs in Biomedicine. (in press). PMID 23253450

Kong M, Yan J (2011). Modeling and testing treated tumor growth using cubic smoothing splines. Biometrical Journal 53, 595-613. [doi: 10.1002/bimj.201000098] [PMID 21604288] 

Li C, Kong M, Wu D (2011). The statistical effects of measuring myocytes with different image zoom rates. Open Access Medical Statistics 1, 3-12. [doi: http://dx.doi.org/10.2147/OAMS.S20303] 

Wang M, Kong M, Datta S (2011). Inference for marginal linear models with clustered longitudinal data for potentially informative cluster sizes. Statistical Methods in Medical Research 20, 347-367. [PMID: 20223781]

Godfrey GJ, Lockwood W, Kong M, Bertolone S, Raj A (2010). Antibody development in pediatric Sickle Cell patients undergoing erythrocytapheresis: an 11-year review. Pediatric Blood & Cancer 55(6), 1134-1137. [PMID: 20979172]

Fujimoto J, Kong M, Lee JJ, Hong WK, and Lotan R (2010). Validation of a novel statistical model for assessing the synergy of combined agents in cancer chemoprevention. Cancer Prevention Research 3, 917-928. (co-first author; front cover) [PMID: 20663979]

Kong M, Zhang M, Gopalakrishnan V, and Wolff J (2010). Dose-time-effect modeling for in vitro experiments. Statistics in Biopharmaceutical Research 2(1), 84-96. [doi:10.1198/sbr.2009.0050]

Lee JJ, Lin HY, Liu DD, and Kong M (2010). Applying Emax model and interaction index for assessing drug interaction in combination studies. Frontiers in Bioscience (E2), 582-601. [PMID: 20036904; PMCID: PMC2974574]

Kong M, Lee JJ (2010). Applying Emax model and bivariate thin plate splines to assessing drug interactions. Frontiers in Bioscience (E2), 279-292. [PMID: 20036878]

Kajiwara Y, Panchabhai S, Liu DD, Kong M, Lee JJ, and Levin VA (2009). Melding a new 3-dimensional agarose colony assay with the Emax model to determine the effects of drug combinations on cancer cells. Technology in Cancer Research & Treatment 8(2), 163-172. [PMID: 19334798]

Lee JJ, Kong M (2009). Confidence intervals of interaction index for assessing multiple drug interaction. Statistics in Biopharmaceutical Research 1, 4-17. [PMID: 2003766; PMCID: PMC2796809]

Kong M, Lee JJ (2008). A semiparametric model for assessing drug interaction. Biometrics 64, 396-405. [PMID: 17900314]

Salvador C, Li B, Hansen R, Cramer DE, Kong M, Yan J (2008). Yeast-derived b-Glucan augments the therapeutic efficacy mediated by anti-vascular Endothelial Growth Factor monoclonal antibody in human carcinoma xenograft models. Clinical Cancer Research 14, 1239-1247. [PMID: 18281559; PMCID: PMC2394864]

Lee JJ, Kong M, Ayers GD, Lotan R (2007). Interaction index and different methods for determining drug interaction in combination therapy. Journal of Biopharmaceutical Statistics 17, 461-480. [PMID: 17479394]

Bhattacharya R, Kong M (2007). Consistency and asymptotic normal property of estimated effective doses in bioassay. Journal of Statistical Planning and Inference 137, 643-658. [doi:10.1016/j.jspi.2006.06.027]

Kong M, Lee JJ (2006). A generalized response surface model with varying relative potency for assessing drug interaction.  Biometrics 62 (4), 986–995. [PMID: 17156272]

Kong M, Eubank R (2006). Monotone smoothing with application to dose-response curves. Communication in Statistics—Computation and Simulation 35, 991-1004. [doi: 10.1080/03610910600880492]

Kong M, Bhattacharya R, James C, Basu A (2005). A statistical approach to estimate the 3D size distribution of spheres from 2D size distributions. Geological Society of America Bulletin 117, 244-249. [doi: 10.1130/B25000.1]

 Letter to Editor

J. Lee, M. Kong (2011). Response to Comment re: Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Research (in press).

J. Lee, M. Kong (2011). Rebuttal to the Response of Chou. Cancer Research (in press)