Kira C. Taylor, Ph.D., M.S.
|Epidemiology and Population Health
Title: Asst Professor
Office No: 232
Address: 485 E. Gray St
Office Hours: By Appointment
B.A., Biology, Rice University
M.S., Biological Sciences, Stanford University
Research focus: human and molecular genetics
M.A.Ed., Science Education, Wake Forest University
Ph.D., Epidemiology, Emory University
Dissertation research: genetic and environmental influences on reproductive traits.
Genetic epidemiology of cardiovascular disease-related traits
Examination of genetic influences across populations
In my research, I interrogate associations between genetic variants and disease, with particular attention to gene-environment interactions and heterogeneity of genetic effects across populations. By learning how genes, pathways, and proteins interact with their environment and influence disease, we can better understand the underpinnings of the disease process, which will ultimately lead to improved prevention and treatment.
I am currently participating in genome-wide association studies, large-scale sequencing studies, and candidate gene-environment interaction studies as applied to cardiovascular disease, including anthropometric and hemostasis-related traits, with a focus on women and on diverse populations. Studies include: the Women's Health Initiative; the Candidate Gene Association Resource (CARe) consortium; the Population Architecture and Genomics using Epidemiology (PAGE) consortium; the Exome Sequencing Project(ESP-GO); and the Atherosclerosis Risk In Communities (ARIC) study.
Honors and Awards
National Research Service Award (Postdoctoral) from the National Heart, Lung, and Blood Institute
Environmental Protection Agency STAR Fellow
Woodrow Wilson Teaching Fellow
National Science Foundation Predoctoral Fellowship
Sherman, Stephanie L., Kira C. Taylor, and Emily G. Allen. (2006). FMR1 Premutation: a leading cause of inherited ovarian dysfunction. In: Fragile Sites: New discoveries and changing perspectives. (2006). Eds: Arrieta, I, Penagarikano,O, Telez, M. Nova Science Publishers, Inc, Hauppauge, NY., pp. 299-320.
Publications: Journal Articles
Liu, Ching-Ti*, Keri L. Monda*, Kira C. Taylor*, Leslie Lange, Ellen Demerath, Kari E. North†, and Caroline S. Fox†, for the central adiposity IBC consortium. 2013."Genome-wide Association of Body Fat Distribution in African Ancestry Populations Reveals Evidence for New Loci.” PLoS Genetics, in press. Full list of authors available upon request.
*Co-first authors. †Joint oversight.
Kira C Taylor, Cara L Carty, Logan Dumitrescu, Petra Buzkova, Shelley A Cole, Lucia Hindorff, Fred R Schumacher, Lynne R Wilkens, Ralph V Shohet, P Miguel Quibrera, Karen C Johnson, Brian E Henderson, Jeff Haessler, Nora Franceschini, Charles B Eaton, David J Duggan, Barbara Cochran, Iona Cheng, Chris S Carlson, Kristin Brown-Gentry, Garnet Anderson, Jose Luis Ambite, Christopher Haiman, Loic Le Marchand, Charles Kooperberg, Dana C Crawford, Steven Buyske, Kari E North and Myriam Fornage. (2013). Discovery and replication of gene-by-sex interactions for lipid traits in diverse populations from the Population Architecture using Genomics and Epidemiology Study. BMC Genetics, 14:33 (1 May 2013).
Monda, Keri L.*, Gary Chen*, Kira C. Taylor*, Cameron Palmer*, Todd Edwards*, Kari E. North†, and Chris Haiman†, for the African-American BMI GWAS consortium. 2013. Three Novel Loci Associated with Body Mass Index Identified in a Large Genome-wide Association Study of Men and Women of African Ancestry. Nature Genetics, published online April 14 2013. doi:10.1038/ng.2608. Full list of authors available upon request.
*Co-first authors; †Corresponding senior authors.
Guo, Yiran*, Matthew Lanktree*, Kira C. Taylor*, Hakon Hakonsarson†, Leslie Lange†, Brendan Keating†, for the BMI IBC consortium (2013). Gene-centric meta-analyses of 108,912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, Jan 1;22(1):184-201. Full list of authors available upon request.
*Co-first authors; †Corresponding senior authors.
Agrawal, Arpana, Neal D. Freedman, Yu-Ching Cheng*, Peng Lin*, John R. Shaffer*, Qi Sun*, Kira Taylor*, Brian Yaspan*, John Cole, Marilyn Cornelis, Rebecca S. DeSensi, Annette Fitzpatrick, Gerardo Heiss, Jae H. Kang, Jeffrey O’Connell, Siiri Bennett, Ebony Bookman, Kathleen K. Bucholz, Neil Caporaso, Richard Crout, Danielle M. Dick, Howard J. Edenberg, Alison Goate, Victor Hesselbrock, Steven Kittner, John Kramer, John I. Nurnberger Jr, Lu Qi, John P. Rice, Marc Schuckit, Rob M. van Dam, Eric Boerwinkle%, Frank Hu%, Steven Levy%, Mary Marazita%, Braxton Mitchell%, Louis R. Pasquale% & Laura J. Bierut for the GENEVA Consortium (2012). Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. American Journal of Clinical Nutrition, 95:539-47.
*These authors, arranged alphabetically, made equal contributions.
Taylor KC, Small CM, Dominguez CE, Murray LE, Tang W, et al. (2011) Alcohol, Smoking, and Caffeine in Relation to Fecundability, With Effect Modification by NAT2. Annals of Epidemiology (published online first).
Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, et al. (2011) A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Human Molecular Genetics 20: 3525-3534.
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, … Taylor KC… et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics 88: 6-18.
Dumitrescu L, Carty CL, Taylor K, Schumacher FR, Hindorff LA, et al. (2011) Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genetics 7: e1002138.
Wassel CL, Lange LA, Keating BJ, Taylor KC, Johnson AD, et al. (2011) Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). Blood 117: 268-275.
Taylor KC, Small CM, Epstein MP, Sherman SL, Tang W, et al. (2010) Associations of progesterone receptor polymorphisms with age at menarche and menstrual cycle length. Hormone Research in Paediatrics 74: 421-427.
Taylor KC, Small CM, Epstein MP, Terrell ML, Marcus M (2009) Heritability of age at menarche and menstrual cycle length in a population exposed to a brominated flame retardant. International Journal of Child and Adolescent Health 2: 383-394.
Taylor KC, Jackson LW, Lynch CD, Kostyniak PJ, Buck Louis GM (2007) Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio. Environmental Research 103: 99-105.
Allen EG, Sullivan AK, Marcus M, Small C, Dominguez C, Epstein MP, Charen K, He W, Taylor KC, and Sherman SL. (2007) Examination of reproductive aging milestones among women who carry the FMR1 premutation. Human Reproduction 22: 2142-2152.