Bioinformatics and Biostatistics Role: Faculty Title: Asst Professor Office No: Rm 137 Address: 485 E. Gray St Phone: (502) 852-3444 Fax: (502) 852-3294 E-mail: guy.brock@louisville.edu

Background

Ph.D. (2003), Statistics, University of New Mexico
M.S. (2000), Statistics, University of New Mexico
B.S. (1996), Biochemistry, University of Colorado

Post-doc in Statistical Genetics, 2003-2005, University of Pittsburgh.

I joined the Department of Bioinformatics and Biostatistics in July 2005 as an Assistant Professor.  Currently, I also serve as the Director of the Statistical Consulting Center (since 01/31/2007).

Research Interests

My primary research interests are in the areas of statistical genetics, bioinformatics, and genomics. Recent projects include developing methods for nonparametric linkage analysis in extended pedigrees, missing value estimation in microarray data, and cluster validation software. I also have collaborative efforts with Epidemiology and Public Health, Pharmacology and Toxicology, Infectious Disease, Surgery, and Molecular, Cellular, and Craniofacial Biology.

Teaching Activities

Fall 2009:

PHST 683 - Survival Analysis
PHST 710 - Advanced Statistical Computing I

Current Projects

Cluster validation software - with fellow faculty members Somnath and Susmita Datta, and graduate student Vasyl Pihur

Empirical evaluation of number of markers required for clustering based on genetic marker data - with Drs. Kathy and Rick Baumgartner (Epidemiology and Population Health)

Collaborative projects with Dr. LaCreis Kidd (Pharmacology and Toxicology), Drs. Robert Greene and Michele Pisano (Molecular, Cellular, and Craniofacial Biology), and Drs. Julio Ramirez and Paula Peyrani Dicastelnuovo (Infectious Disease).

Students Mentored

Jie Fan, MS in Biostatistics, 2007 (joint with Dr. Somnath Datta)
Bart Brown, MS in Decision Science, 2007 (joint with Dr. Somnath Datta)
Oyeyemi Komolafe (Yemi), MPH with Biostatistics concentration, 2007 (Dr. La Creis Kidd, practicum site mentor)
Christina Studts, MS in Biostatistics (expected graduation fall 2009)

Honors and Awards

Student Nominated 2006 Faculty Favorite

Outside Interests

swimming, jazz, guitar, hiking in Louisville's fabulous Metro Parks

Links

My personal webpage

Active Grants

“Molecular Determinants of Developmental Defects” (PI – R.M. Greene)
NIH 2P20-RR017702-06, Center of Biomedical Research Excellence (COBRE)
Role: Co-Investigator/Biostatistician (20% time and effort)
Term: 2007- 2012

"Center for Environmental Genomics and Integrative Biology" (PI - K. Ramos)
NIH/NIEHS P30-ES014443, Bioinformatics, Biostatistics and Computational Biology Core
Role: Co-Investigator/Statistal Consultant (15% time and effort)
Term: 04/01/07 – 03/31/11

“Transcriptional Coactivators and Pregnancy Outcomes” (PI – R.M. Greene)
NIH R01HD053509
Role: Co-Investigator/Biostatistician (8% time and effort)
Term: 2007- 2012

“Nutritional Epigenetics and Orofacial Development” (PI – R.M. Greene)
NIH R01DE018215
Role: Co-Investigator/Biostatistician (9% time and effort)
Term: 2009-2013

Completed Grants

"A Pharmacogenetic Approach to Prostate Cancer Susceptibility" (PI - L. Kidd)
NIH R03CA128028
Role: Co-Investigator (5% time and Effort)
Term: 2007-2009

“Genomic Approach to Predicting Breast Cancer Recurrence” (PI - L. Kidd & J. Wittliff)
Brown Cancer Center Pilot Project
Role: Co-Investigator
Term: 2/1/07-1/31/08

“Combined Genetic Assessment of Angiogenesis Pathway Variants Predictive of Prostate Cancer Risk” (PI - L. Kidd)
Prostate Cancer Foundation - 2006 Competition Awards Program
Role: Co-Investigator (10% time and Effort)
Term: 2/1/07-1/31/08

“Molecular Determinants of Developmental Defects” (PI - R.M. Greene)
NCRR Center for Biomedical Research Excellence (NIH) P20-RR/DE17702
Role: Co-Investigator (15%, from 2/1/07 to 04/01/07)

“The 4-Corners Women’s Health Study” (PI - K. Baumgartner)
NIH R01 CA078762
Role: Co-Investigator (25%, from 04/2006 to 07/2006)

Publications

Journal Articles

1. Arnold, F.W., LaJoie, A.S., Brock, G.N., Peyrani, P., Rello, J., Menéndez, R., Lopardo, G., Torres, T., Rossi, P., Ramirez, J.A., and the CAPO investigators.  “Improving Outcomes in Elderly Patients with Community-Acquired Pneumonia by Adhering to National Guidelines: Community-Acquired Pneumonia Organization International Cohort Study Results” Archives of Internal Medicine (in press)
2. Woodall, C.E., Brock, G.N., Byam, J.A., Scoggins, C.R., McMasters, K.M., and Martin, R.C.  “An evaluation of 2,537 gastrointestinal stromal tumors for a proposed clinical staging system” Archives of Surgery (in press).
3. Brock, G.N., Beavis, W., and Salter, L. “Fuzzy logic and alternate methods for detecting gene regulatory Networks,” Information Fusion 2009 July;10(3):250-259.
4. Marvin M.R., Brock, G.N., Kwarteng, K., Nagubandi, R., Ravindra, K.V., Eng, M. and Buell, J.F. “Increasing utilization of human T-cell lymphotropic virus(+) donors in liver transplantation: is it safe?” Transplantation 2009 87(8):1180-1190.
5. Xu, P., Brock, G.N., and Parrish, R.S. “Modified linear discriminant analysis approaches for classification of high-dimensional microarray data” Computational Statistics and Data Analysis 2009 53(5):1674-1687.
6. Landry, C.S., Brock, G., Scoggins, C.R., McMasters, K.M., and Martin, R.C.  “A Proposed Staging System for Gastric Carcinoid Tumors Based on an Analysis of 1,543 Patients,” Annals of Surgical Oncology 2009 Jan;16(1):51-60.
7. Landry, C.S., Brock, G., Scoggins, C.R., McMasters, K.M., and Martin, R.C.  “A proposed staging system for colon carcinoid tumors based on an analysis of 2,459 patients,” Journal of the American College of Surgeons 2008 Dec;207(6):874-81.
8. Landry, C.S., Brock, G., Scoggins, C.R., McMasters, K.M., and Martin, R.C.  “A Proposed Staging System for Small Bowel Carcinoid Tumors Based on an Analysis of 6,380 Patients,” American Journal of Surgery 2008 Dec;196(6):896-903.
9. Buell, J.F., and Brock, G., “Risk of cancer in liver transplant recipients: A look into the mirror,” Liver Transplantation 2008 Nov; 14(11):1561-3.
10. Buell, J.F., Thomas, M.T., Rudich, S., Marvin, M., Nagubandi, R., Ravindra, K.V., Brock, G., and McMasters, K.M.  “Experience with more than 500 minimally invasive hepatic procedures” Annals of Surgery 2008 Sep; 248(3):475-86.
11. Landry, C.S., Brock, G., Scoggins, C.R., McMasters, K.M., and Martin, R.C.  “A proposed staging system for rectal carcinoid tumors based on an analysis of 4701 patients” Surgery 2008; 144(3):460-6.
12. Bordon, J., Peyrani, P., Brock, G., Blassi, F., Rello, J., File, T., Ramirez, J.A., and  the CAPO Study Group. “The care of hospitalized patients with community-acquired pneumonia should not be altered by the presence of pneumococcal bacteremia: Results from the community-acquired pneumonia organization (CAPO) international cohort study.” CHEST  2008; 133(3):618-24
13. Bhattacharjee, S., Kuo, C-L., Mukhopadhyay, N., Brock, G., Weeks, D.E., and Feingold, F. “Robust score statistics for QTL linkage analysis” The American Journal of Human Genetics 2008; 82(3):567-82.
14. Brock, G.N., Pihur, V., Datta, S., and Datta, S. “clValid, an R package for cluster  validation” Journal of Statistical Software Vol. 25, Issue 4, Mar 2008.
15. Brock, G.N., Shaffer, J.R., Blakesley-Ball, R.E., Lotz, M.J., and Tseng, G.C. “Which missing value imputation method to use in expression profiles: a comparative study and two selection schemes” BMC Bioinformatics 2008; 9(1):12.
16. Brock, G.N., Weeks, D.E., Sobel, E. and Feingold, E. “A novel method for estimating significance levels in NPL scores for large pedigrees” Genetic Epidemiology 2007; 31(5):417-430.
17. Brock, G.N., Maher, B.S., Goldstein, T.H., Cooper, M.E., and Marazita, M.L. “Methods for detecting gene-gene interaction in multiplex extended pedigrees” BMC Genetics 2005; 6 Suppl 1:S144
18. Maher, B.S., and Brock, G.N. “Approaches to detecting epistasis in the genetic analysis workshop 14 Pedigrees” Genetic Epidemiology 2005; 29 Suppl 1:S116-9.

Peer-Reviewed Book Chapters

1. Pihur, V., Brock, G.N., Datta, S. and Datta, S. “Cluster validation for microarray data: An appraisal”. In Indian Statistical Institute Platinum Jubilee Series, Statistical Science and Interdisciplinary Research - Vol. 4, Advances in Multivariate Statistical Methods (A. SenGupta, Ed), World Scientific Press, 2009.
2. Brock, G.N., Pihur, V., Kubatko, L. “Detecting gene regulatory networks from microarray data using fuzzy logic” In Fuzzy Systems in Bioinformatics, Bioengineering and Computational Biology (Studies in Fuzziness and Soft Computing) (Jin, Y. and Wang, L., Ed), Springer-Verlag, Berlin Heidelberg, 2009.