David J Tollerud, MD
|Environmental and Occupational Health Sciences
Title: Professor & Chair
Office No: 205A
Address: 485 E. Gray St
Student Office Hours: Thursday 3-4pm
David J. Tollerud, M.D., M.P.H. is Professor and Chair of the Department Environmental and Occupational Health Sciences at the University of Louisville School of Public Health and Information Sciences. He received his M.D. degree from Mayo Medical School in 1978 and his M.P.H. degree from the Harvard School of Public Health in 1990. Dr. Tollerud has extensive clinical training, with specialty board certifications in internal medicine, pulmonary and critical care medicine, and environmental and occupational medicine, with a long-standing interest in the health of disadvantaged and underserved populations.
Dr. Tollerud's research interests include the effects of environmental pollution on asthma and other health problems, particularly among children and inner-city disadvantaged populations, nanoparticles, and stem-cell transplants. A second area of research interest is strategies to prevent work-related injury and illness. Dr. Tollerud has published over 60 scientific articles, books and book chapters, is a member of numerous professional and scientific organizations, and sits on a number of local, national and international committees dealing with environmental, occupational, and public health issues.
Ongoing funded research includes:
National Children's Study-Jefferson County Center. This initiative provides critical new information regarding environmental influences on children’s health and develop secondary and tertiary sampling units within Jefferson County over a 25-year period. It is the largest government-funded long-term study of environmental and genetic effects on children’s health to be conducted in the United States.
Center for Environmental Genomics and Integrative Biology. The goal of this grant is to support outstanding basic and translational investigations into the etiology of environmental disease and the development of new approaches to manage these conditions. The Integrated Health Sciences Facility Core’s central goal is to provide Center investigators with services and resources that will facilitate the translation of basic research finding into clinical or public health applications. The
Tolerance Induction for Tissue and Organ Transplants. The goal of this project is to safely establish mixed chimerism and induce tolerance using facilitating cell (FC)-based therapeutic approaches and nonmyeloablative conditioning.
Community outreach and environmental education, particularly to African American and Hispanic communities, is also an important and growing focus of Dr. Tollerud and the Department's activities that include collaboration with other community and state agencies.
Completed research includes:
Health Effects of Occupational Exposures in PGDP Workers. The goal of this study was to carry out a feasibility study and pilot study to evaluate the health impact of occupational exposures on workers at the Paducah, KY Gaseous Diffusion Plant (PGDP) to determine if workers have a mortality rate which exceeds that of the general population, particularly for cancer. This study is an important contribution to our knowledge about the health of a key occupational cohort of workers that contain 6859 individual names from 1953-2003.
Stem Cell Graft Engineering to Treat Sickle Cell Disease (Phase II). The goal of this project is to develop an approach to engineer a bone marrow graft to avoid the major complications of HSCT: graft-versus-host reactivity (GVHD); graft failure; and the need for perfect matching. Our approach is superior to current therapies because it involves a proprietary process that enriches for patented facilitating cells (FC) and stem cells but removes GVHD-producing cells.
Genetic and Environmental Risk Factors for PSP. The goals of this study are to determine if there is an association between progressive supranuclear palsy (PSP) and the H1/H1 genotype, specific H1 sub-haplotypes, alpha-synuclein polymorphisms or parkin gene deficits, or if there are gene-gene interactions; if there is an association between PSP occupational and/or environmental chemical exposures functionally or structurally similar to rotenone/acetogenins; and if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP. Understanding the etiology of PSP may help explain the causes of other tauopathies such as Alzheimer’s disease.
Other Research Interests
Children's Environmental Health
Community outreach and environmental education
Health Effects of Air Pollution
Minority Environmental Health
Occupational Injuries and Illness
Environmental & Occupational Courses
Environmental Health Sciences Training Program
University of Louisville:
Member, University Environmental Safety & Health Task Force
Member, University Conflict of Interest Task Force
Member, University Committee for Review of Individual Financial Interests in Research
Member, University Scholar Award Committee
Member, Community Farm Alliance, Research Advisory Team
Member, Sustainability Council, Education and Research Committee, Research in Substainability Subcommittee
Teach course segments in the Institute for Public Health Research Environmental Health
Consult with U of L Environmental Health Services on specific issues as requested
School of Public Health and Information Sciences:
Dean's Executive Committee
Council of Chairs and Deans
Chair, Search CommitteeBiostats & Bioinformatics Department Chair
Chair, National Academy of Sciences, Institute of Medicine Committee on the Long-Term Health Consequences of Exposure to Burn Pits in Iraq and Afghanistan
NIH/NIEHS National Children’s Study Publications Committee and liaison for Environmental Sample Challenges Writing Team
Chair, National Academy of Sciences, Institute of Medicine Committee on Epidemiologic Study: SHAD II
Numerous NIH Study Sections
Committee Member, Wet Weather Team Stakeholder Group, Metro Louisville
American College of Chest Physicians
American College of Occupational and Environmental Medicine
American College of Physicians
American College of Preventive Medicine
American Conference of Governmental Industrial Hygienists (ACGIH)
American Industrial Hygiene Association (AIHA)
American Public Health Association
American Society of Hematology
American Thoracic Society
European Respiratory Society
Editorial Board Membership:
American Industrial Hygiene Association (AIHA) Editorial Review Board Member
Journal of Occupational Hearing Loss, Editorial Board Member
Institute of Medicine, Review Coordinator, Gulf War Health, Phase IV
Mentoring several graduate students, T-32 Training post-docs and summer
Honors and Awards
2000-02: Selected to be Chair, Environmental and Occupational Health Assembly Long Range Planning Committee of the American Thoracic Society.
2001: Selected to be a National Associate, National Academies of Science
2001-05: Selected as Member, Board on Health Promotion and Disease Prevention, Institute of Medicine, Washington, DC
2003-05: Elected Chair, Environmental and Occupational Health Assembly, American Thoracic Society
2003-05: Member of the Board of Directors, American Thoracic Society
2005 and 2008: Received Distinguished University Scholar Award from the University of Louisville
Contact Barbara Parker, Administrative Assistant at 502-852-3290
My Support Staff
Barbara Parker, Administrative Assistant
(7 publication(s) displayed.)
"Characterizing Exposure of Veterans to Agent Orange and Other Herbicides Used in Vietnam: Final Report"
Hoel DG, Hammond SK, Koller LD, Loomis DP, Rappaport SM, Smith TJ, Tollerud DJ, Zeise L. National Academy Press, Washington DC
Publication Date: 2003
"Distribution and Administration of Potassium Iodide in the Event of a Nuclear Incident"
Tollerud DJ (Committee Chair), Becker DV, Braverman LE, Keller LR, Langley KS, Maher TJ, Miller K, Reiners CH-J, Russel JJ, Volland RH, Wilds EL, Williams ED, Zeise L. Washington, DC; National Academies Press
Publication Date: 2003
"Herbicide/Doxin Exposure and Type 2 Diabetes"
Tollerud DJ, (Committee Chair). Washington, DC; National Academy Press
Publication Date: 2000
"Veterans and Agent Orange. Update 1998"
Tollerud DJ, (Committee Chair). Washington, DC; National Academy Press
Publication Date: 1998
"Veterans and Agent Orange. Update 1996."
Tollerud DJ, (Committee Chair).. Washington DC; National Academy Press
Publication Date: 1997
"Characterizing Exposure of Veterans to Agent Orange and Other Herbicides Used in Vietnam: Scientific Considerations Regarding a Request for Proposals for Research"
Hoel DG, Hammond SK, Koller LD, Loomis DP, Rappaport SM, Smith TJ, Tollerud DJ, Zeise L. Washington DC; National Academy Press
Publication Date: 1997
"Veterans and Agent Orange"
Fallon H, Tollerud DJ (Committee Vice-Chair), Breslow N, Berlin J, Bolla K, Colditz G, Goetz C, Kaminski N, Kriebel D, Mottet NK, Neugut A, Nicholson W, Olshan A, Rodgers K, Sprince N, Weisel C. Washington DC; National Academy Press
Publication Date: 1993
(5 publication(s) displayed.)
"Committee on the Disposition of the Air Force Health Study" National Acadamies, Institute of Medicine Report: Tollerud, DJ (Committee Chair) National Academies Press, Washington, DC Publication Date: 2006
"Small Clinical Experiments Translational and Experimental Clinical Research" Weinrich M, Tollerud DJ, Hornung C, Ildstad S Lippincott, Williams & Wilkins Publication Date: 2005
"Outdoor Air Pollution"
Occupational, Industrial, and Environmental Toxicology
McDow S, Tollerud DJ. Michael Greenberg; St. Louis, MO: Mosby;
Publication Date: 2003 / 2005
"A Practical Approach to Occupational and Environment Medicine"
Tollerud DJ, Emmett EA.. Robert McCunney; Wilkins, PA: Lippencott Williams;
Publication Date: 2003
"Foundries and Steelmaking"
"Occupational and Environmental Respiratory Disease"
Muldoon SR, Tollerud DJ. Harper P, Balmes J, Schenker M; St. Louis, MO: Mosby;
Publication Date: 1994
(56 publication(s) displayed.)
Tollerud DJ, Weiss ST, Elting EH, Speizer FE, Ferris BG, Jr. The relationship of respiratory symptoms in tunnel and turnpike workers to cigarette smoking and automobile exhaust. Arch Environ Health 1983; 38:334-340.
Tollerud DJ, Blattner WA, Fraser MC, Brown LM, Pottern L, Shapiro E, Kirkemo A, Shawker TH, Javadpour N, O'Connell K, Stutzman RE, Fraumeni JF. Familial testicular cancer and urogenital developmental anomalies. Cancer 1985; 55:1849-1854.
Tollerud DJ, Brinton LA, Stone BJ, Tobacman JK, Blattner WA. Mortality from multiple myeloma in North Carolina furniture workers. JNCI 1985; 74:799-801.
Ildstad ST, Tollerud DJ, Bigelow ME, Remensnyder JP. Squamous cell carcinoma of the head and neck at the Massachusetts General Hospital: a comparison of biologic characteristics in men and women. Surgery 1986:99:7-13.
Ildstad ST, Tollerud DJ, Bigelow ME, Remensnyder JP. Early Recognition of oral cancers in the elderly. Geriatric Med Today 1986; 5(12):33-38.
Newman MJ, Light BA, Weston A, Tollerud DJ, Clark JW, Mann DL, Blackman JP, Harris CC. Detection and characterization of human serum antibodies to polycyclic aromatic hydrocarbon diol-epoxide DNA adducts. J Clin Investigation 1988; 82:145-153.
Ildstad ST, Tollerud DJ, Weiss RG, Ryan DP, McGowan MA, Martin LW. Duplications of the alimentary tract: clinical characteristics, preferred treatment, and associated malformations. Ann Surgery 1988; 208:184-189.
Tollerud DJ, Clark JW, Brown LM, Neuland CY, Mann DL, Pankiw-Trost LK, Blattner WA, Hoover RN. Association of cigarette smoking with decreased numbers of circulating natural killer cells. Am Rev Resp Dis. 1989; 139-194-198.
Tollerud DJ, Wesseler TA, Kim CK, Baughman RP. Use of a rapid differential stain for identifying pneumocystis carinii in bronchoalveolar lavage fluid. Chest 1989; 95-494-497.
Ildstad ST, Tollerud DJ, Bigelow ME, Remensnyder JP. A multivariate analysis of determinants of survival for patients with squamous cell carcinoma of the head and neck. Ann Surg. 1989; 209:237-241.
Tollerud DJ, Clark JW, Brown LM, Neuland CY, Mann DL, Pankiw-Trost, LK, Blattner WA, Hoover RN. The effects of cigarette smoking on T-cell subsets: a population-based survey of healthy caucasians. Am Rev Resp Dis 1989; 139:1446-1451.
Brown LM, Tollerud DJ, Pottern LM, Clark JW, Kase R, Blattner WA, Hoover RN. Biochemical epidemiology in community-based studies: practical lesions from a study of T-cell subsets. J Clin Epidemiology 1989;42:561-568.
Tollerud DJ, Clark JW, Brown LM, Neuland CY, Pankiw-Trost LK, Blattner WA, Hooker RN. The influence of age, race, and gender on peripheral blood mononuclear cell subsets in healthy nonsmokers. J Clin Immunology 1989; 9:214-222.
Ildstad ST, Tollerud DJ, Noseworthy J, Ryckman F, Sheldan CA, McEnery PT, Martin LW. Renal transplantation in pediatric recipients. Transplantation Proceedings 1989; 21:1936-7.
Ildstad ST, Tollerud DJ, Weiss RG, Cox JA, Martin LW. Cardiac contusion in pediatric patients with blunt thoracic trauma. J Ped Surg 1990; 25:287-289.
Tollerud DJ, Brown LM, Blattner WA, Hoover RN. The influence of race on T-cell subset distributions. Mechanisms of B Cell Neoplasia. Springer-Verlag. New York, 1990.
Ildstad ST, Tollerud DJ, Noseworthy J, Ryckman F, Sheldon CA, Martin LW. The influence of donor age on graft survival in renal transplantation. J Ped Surg 1990; 25:134-139.
Tollerud DJ, Ildstad ST, Brown LM, Clark JW, Blattner WA, Mann DL, Neuland CY, Pankiw-Trost L, Hoover RN. T-cell subsets in healthy teenagers: the transition to the adult phenotype. Clin Imm Immunopathol 1990; 56:88-96.
Caporaso NE, Tucker MA, Hoover RN, Hayes RB, Pickle LW, Issaq HJ, Muschik GM, Green-Gallo L, Buivys D, Aisner S, Resau JH, Trump BF, Tollerud DJ, Weston A, Harris CC. Lung cancer and the debrisoquine metabolic phenotype. J Natl Cancer Inst 1990; 82:1264-1272.
Boggs SS, Patrene KD, Austin CA, Vecchini F, Tollerud DJ. Latent deficiency of the hematopoietic microenvironment of aged mice as revealed in W/Wv mice given +/+ cells. Experimental Hematology 1991.
Tollerud DJ, O'Connor GT, Sparrow D, Weiss ST. Asthma, hay fever, and phlegm production are associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE level: The normative aging study. Am Rev Resp Dis 1991; 144:776-781.
Tollerud DJ, Brown LM, Clark JW, Neuland CY, Mann DL, Pankiw-Trost L, Blattner WA. Cryopreservation and long-term liquid nitrogen storage of peripheral blood mononuclear cells for flow cytometry analysis: Effects on cell subset proportions and fluorescence intensity. J Clin Lab Analysis 1991; 5:255-261.
Tollerud DJ, Brown LM, Blattner WA, Mann DL, Pankiw-Trost L, Hoover RA. T-cell subsets in healthy black smokers and nonsmokers. Evidence for ethnic group as an important response modifier. Am Rev Resp Dis 1991; 144:612-616.
Tollerud DJ, Weiss ST, Leung DYM. Elevated soluble interleukin-2 receptors in young healthy cigarette smokers. Int Arch Allergy Appl Immunol 1992; 97:25-30.
Baughman R, Lower EE, Flessa H, Tollerud DJ. Thrombocytopenia in the Intensive Care Unit. Chest 1993;1234-7.
Sherman CB, Tollerud DJ, Heffner LJ, Speizer FE, Weiss ST. Airways Responsiveness in Young Black and White Women. Am Rev Resp Dis 1993; 148:98-102.
Tollerud DJ, Kurman CC, Morris-Brown L, Nelson DL, Blattner WA. Racial Variation in Serum Soluble Interleukin-2 Receptor Levels: A Population-based Study of Healthy Smokers and Nonsmokers. J Immunol Immunopathol 1994; Vol.70, No.3, March, 274-279.
Karol MH, Tollerud DJ, Campbell TP, Fabbri L, Maestrelli P, Saetta M, Mapp Ce. The Predictive Value of Airways Hyperresponsiveness and Circulating IgE for Identifying Types of Responses to Toluene Diisocyanate Inhalation Challenge. Am Rev Resp Dis 1994; 149:611-615.
Diamondstone LS, Tollerud DJ, Fuchs D, Wachter H, Brown LM, Maloney E, Kurman CC, Nelson DL, Blattner WA. Factors Influencing Serum Neopterin and 2-Microglobulin Levels in a Healthy Diverse Population. J Clin Immunol 1994; Vol 14, No.6:368-374.
Neas LM, Dockery DW, Koutrakis P, Tollerud DJ, Speizer FE. The association of ambient ir pollution with twice daily peak expiratory flow rate measurements in children. Am J Epidem 1995; 141:111-22.
Tollerud DJ, Brown LM, Blattner WA, Weiss ST, Maloney EM, Kurman CC, Nelson DL, Hoover RN. Racial Differences in Serum Immunoglobulin Levels: Relationship to Cigarette Smoking, T-cell Subsets and Soluble Interleukin-2 Receptors. J Clin Lab Analysis 1995;9:37-41.
Satoh S, Kramarik JA, Tollerud DJ, Karol MH. A Model for Assessing the Respiratory Hypersensitivity Potential of Chemical Allergens. Toxicology Letters 1995;78:57-66.
Satoh T, Tollerud DJ, Guevarra L, Rake Y, Nakadate T, Kagawa J. Chemiluminescence assays for cytokines in serum: influence of age, smoking, and race in health subjects. Japanese J of Allergology 1995;44(7):661-9.
Shvedova AA, Satoh T, Tollerud DJ, Guevarra L, Karol MH. Elevated Levels of IL-6, INF-, and TNF- in Mice in Response to Cotton Dust are Modulated by ANTI-TNF- Antiserum. Experimental Lung Research 1996;22:149-161.
Krasnow JS, Tollerud DJ, Naus G, DeLoia JA. Endometrial Th2 cytokine expression throughout the menstrual cycle and early pregnancy. Human Reproduction 1996; 11 (8):1747-54.
Moyna NM, Acker GR, Fulton JR, Weber K, Goss FL, Robertson RJ, Tollerud DJ, Rabin BS. Lymphocyte function and cytokine production during incremental exercise in active and sedentary males and females. Int J Sports Med 1996; 17(8):585-591.
Newton-Nash DK, Tollerud DJ, Guevarra L, Gill JC. Interferon- Secretion Defects in Hemophilia A Patients Receiving Highly Purified Plasma-Derived or Recombinant Factor VIII. Br J of Hematology 1996 Dec; 95(3):554-560.
Maloney E, Brown LM, Diamondstone L, Blattner WA, Fuchs D, Wachter H, Tollerud DJ. Longitudinal Changes in Cellular & Soluble Immune Parameters in Healthy Adults. J Clin Lab Anal 1997;11(4):190-195.
Keman S, Willemse B, Tollerud DJ, Guevarra L, Schins RP, Borm PJA. Blood Interleukin-8 Production in Chemical Workers with Bronchitic Symptoms. Am J Ind Med 1997 Dec; 32(6):670-673.
Satoh T, Brown LM, Maloney E, Blattner WA, Tollerud DJ. Soluble Interleukin-2 Receptors, Beta-2 Microglobulin, and Neopterin Levels in Healthy Teenagers: Relationship to Age, Gender, Race and T-cell Subsets. Clin Immunol Immunopathol 1998; 88 (2):176-182.
Hacken N, Oosterhoff Y, Kauffman H, Guevarra L, Satoh T, Tollerud DJ, Dirkje P. Elevated Levels of Serum Interferon- in Subjects with Atopic Asthma Correlate with Increased airway Responsiveness and 16-04 h PEF-variation. Eur Resp J 1998; 11(2):312-316.
Woodin MA, Hauser R, Siegel PD, Tollerud DJ, Lewis DM, Liu Y, Smith T, Christiani DC. Nasal Lavage Inflammatory Mediators as Biomarkers of Upper Airway Exposure to Fuel Oil Ash. Am J Resp Crit Care Med 1998; 158(1):182-187.
Peele P, Tollerud DJ. Managed Care in Workers’ Compensation Plans. Ann Rev Public Health 2001; 22:1-14.
Rodricks JV, Collins JJ, Farland WH, Tollerud DJ. Contrasting Roles of Epidemiology in Dioxin-Related Policy: Lessons Learned. Amer Journal of Epidemiology 2001 Dec 15; 154(12 Suppl):S43-9.
Litonjua A, Sparrow D, Guevarra L, O’Connor G, Weiss ST, Tollerud DJ. Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study. Ann Allergy, Asthma & Immunology 2003; 90:422-428 .
Tsunoda M, Litonjua A, Kuniak MP, Weiss ST, Satoh S, Tollerud DJ. Serum cytokine levels, cigarette smoking and airway responsiveness among pregnant women. Int Arch Allergy and Immunol 2003; 130:158-164.
Tsunoda M, Tsunoda H, Guevarra L, Tollerud DJ. The relationship between serum cytokine levels and common laboratory tests in healthy Japanese men. Env Health and Prev Med 2003; 8:6-12.
Peele PB, Tollerud DJ. Depression and Occupational Injury: Results of a pilot investigation. Journal of Occupational and Environmental Medicine 2005, Apr;47(4):424-7.
Min Li, McDow SR, Tollerud DJ, Mazurek MA. Quantitation, Detection and Measurement Precision of Organic Molecular Markers in Urban Particulate Matter from Philadelphia, PA. Journal of Air & Waste Management Association, Proceedings from 98th Annual Conference and Exhibition, June 2005.
Min L, McDow SR, Tollerud DJ, Mazurek MA. Seasonal abundance of organic molecular markers in urban particulate matter from Philadelphia, PA. Atmospheric Environment Vol 40, Issue 13, April 2006, Pages 2260-2273.
Hughes TS, Muldoon SB, Tollerud DJ. Underestimation of mortality due to chronic obstructive pulmonary disease (COPD) in Kentucky. Journal of the Kentucky Medical Assoc 104(8):331-9, August 2006.
Rice C, Brewer D, Hornung R, Ho M, Tollerud DJ. When 4/2 Does Not Equal 2: Approaches To Extending A Categorical Exposure Rank to a Quantitative Exposure Range. Compendium publication of Collegium Ramazzini meeting, Carpi, Italy. October 2007.
Mo Y, Zhu X, Hu X, Tollerud DJ, Zhang Q. Cytokine and NO release from peripheral blood neutrophils after exposure to metal nanoparticles: in vitro and in vivo studies. Nanotoxicology. June 2008; 2(2): 79-87
Wan R, Mo Y, Zhang X, Chien S, Tollerud DJ, Zhang Q. Matrix metalloproteinase 2 and 9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tryosine kinase activation. Toxicology and Applied Pharmacology 2008; 233:276-285.
Mo Y, Wan R, Chien S, Tollerud, DJ, Zhang Q. Activation of endothelial cells after exposure to ambient ultrafine particles: the role of NADPH oxidase. Toxicology and Applied Pharmacology 2009; 236:183-193
Bahr D, Hughes T, Silver K, Aldrich T, Brion G, Tollerud DJ. Occupational Cohort Follow-up: The Twenty-First Century Procedures (accepted for publication in the Journal of Registry Management 2009)
Adams KJ, DeBeliso M, Sevene-Adams P, Berning J, Miller T, Tollerud DJ. “Physiological and Psychophysical Comparison Between a Lifting Task with Identical Weight but Different Coupling Factors.” Journal of Strength and Conditioning Research, Feb 2010, Vol 24, 2:307-312.
Chan MC, Hughes TS, Muldoon S, Aldrich T, Rice C, Hornung R, Brion G, Tollerud D, and The Paducah Gaseous Diffusion Plant Project Team. “All Cause Mortality Among Paducah Gaseous Diffusion Plant (PGDP) Workers.” JOEM, Jul 2010, 52(7):725-732.
Aldrich TE, Seidu D, Bahr D, Freitas S, Brion GM, Tollerud D, and The Paducah Gaseous Diffusion Plant Project Team. “Time-Period Mortality Patterns in a Gaseous Diffusion Plant Workforce.” IJOMEH, 2010; 23(2): 145-151.
Bahr DE, Aldrich TE, Seidu D, Brion GM, Tollerud DJ, and the Paducah Gaseous Diffusion Plant Project Team. “Occupational Exposure to Trichloroethylene in Paducah Gaseous Diffusion Plant Workers.” [IJOMEH, 2011;24(1):1 – 11; DOI 10.2478/s13382-011-0007-1]
Wan R, Mo Y, Yu M, Chien S, Tollerud DJ, Zhang Q. The role of hypoxia-inducible factor in MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. Nanotoxicology [2011 in press]