Qunwei Zhang, MD, MPH, PhD

Qunwei Zhang ImageEpidemiology & Population Health

Professor

Office: Room108F, MDR Building, 511 South Floyd St., Louisville, Kentucky 40202

Lab: Room 205 & 206, MDR Building, 511 South Floyd St., Louisville, Kentucky 40202

Phone: 502-852-7200 (Office); 502-852-2439 (Lab); Fax: 502-852-7246;

Email: qunwei.zhang@louisville.edu

CURRICULUM VITAE

Background

Qunwei Zhang, MD, MPH, PhD, is a Professor at the Department of Epidemiology and Population Health at the University of Louisville School of Public Health and Information Sciences. He was a professor at the Department of Environmental and Occupational Health Sciences before the closure of the department at the end of 2021. Dr. Zhang received his MD degree from Fujian Medical University and his MPH degree from the School of Public Health at Zhejiang University, China. After three years of experimental and clinical studies on the treatment of pneumoconiosis by whole lung lavage, he entered a graduate program at the University of Fukui School of Medicine, Japan, where he earned his PhD degree in 2000 for his study on the mechanisms underlying pulmonary effects induced by metal nanoparticles. His subsequent post-doctoral training was in Dr. Max Costa's (Professor and Chairman) laboratory at New York University School of Medicine, where he studied the molecular mechanisms of metal toxicity and carcinogenesis. He was then recruited to the Institute for Environmental Medicine at the University of Pennsylvania Medical Center as a Research Associate and Institute Associate Investigator under the mentorship of Dr. Aron Fisher (Professor and Director), where he studied on the mechanism of oxidative injury in lung ischemia-reperfusion. Dr. Zhang joined University of Louisville in 2005 as an assistant professor, and was promoted to associate professor in 2011 and professor in 2016. He has published over 90 scientific articles and book chapters, and more than 100 abstracts presented in the national or international conferences.

Support Staff: Robin Newlon (502-852-3294)

Research Interests
Nanotoxicology and pulmonary toxicology;
Metals toxicology, genotoxicology and carcinogenesis;
Lung ischemia and ion channel;
Free radicals and pulmonary diseases;
Gene expression and function;
Shear stress and NADPH oxidase;
Signal transduction involved in tumor promotion, prevention and cellular function.

Current and Past Projects

1.Mechanisms underlying metal nanoparticle-induced lung injury and fibrosis. NHLBI (HL147856). Principal Investigator. June 1, 2019-May 31, 2023

2. Mechanisms of carcinogenic effects of nickel nanoparticles. NIEHS (ES028911). Principal Investigator, Dec.15, 2017-Nov. 30, 2021

3. Mechanisms underlying ambient particulate matter-induced lung cancer. Kentucky Lung Cancer Research Program. Principal Investigator, June.1, 2017-May 30, 2020

4. The role of microRNA miR21 in nickel nanoparticles-induced MMPs production. NIEHS (ES023693). Principal Investigator. Sept. 17, 2014-June 30, 2019

5. Mechanisms underlying ambient particulate matter-induced DNA damage and cell transformation. KSEF-148-502-16-381. Principal Investigator, July 1, 2016-June 30, 2018

6. Develop and evaluate the degradable polymerpoly(troloxester) nanoparticles for  medial application. The Clinical and Translational Science Grant Program at UofL.Principal Investigator, June 1, 2010-May, 31, 2011.

7. Activation of Endothelial cell and gene expression in lungs following exposure to ultrafine particles. Health Effects Institute, Walter A. Rosenblith New Investigator Award (4751-RFA-05-2/06-12).Principal Investigator, Mar.1, 2007-December 31, 2011.

8. KSEF-1686-RED-11.  Oxidative stress and endothelial dysfunction in aminal exposure to ultrafine particles and cigarette smoke. KSEF, Principal Investigator, July 1, 2008-June 30, 2010 (no cost-extension until June 30, 2011).

9. Mechanisms Underlying the Susceptibility of Diabetics to Ultrafine Particles. American Heart Association Great Rivers Affiliate, Principal Investigator, July 1, 2008-June 30, 2010 (no cost-extension until June 30, 2011).

10. Partial-thickness wound healing via topical ATP delivery. NIH/NIAMSD SBIR (2R44AR052984-02). Co-investigator (Dr. Chien, Principal Investigator), Sept.12, 2007-Aug. 31, 2010.

11. Carcinogenesis of nickel nanoparticles. Pilot project from the NIESH Center for Environmental Genomics and Integrative Biology (CEGIB) at the University of Louisville,  Principal Investigator, April 1, 2008-March 31, 2009

12. Center for Environmental Genomics and Integrative Biology (1P30ES01443-01A1). NIH/NIESH. Dr. Ramos (Principal Investigator), Dr. Zhang is a Career Development Program recipient, April 1, 2007-March 31, 2008

13. Endothelial generation of reactive oxygen species in lung exposure to ultrafine particles. National American Lung Association (RG-872-N), Principal Investigator. July 2004-Dec 2006.

14. Genotoxic effects of transition metal nanoparticles. University of Louisville Intramural Research Incentive Grant,    Principal Investigator,      June 1, 2006-May 31, 2007

Honors and Awards

2008 Winner, Scientific Importance, Research!Louisville

2006 Walter A. Rosenblith New Investigator Award, Health Effects Institute

2006 First Place of the Scientific Importance, Research!Louisville

2004-2006 National American Lung Association research grant award (Independent Investigator Award)

2002 Mechanism of Toxicity Gordon Research Conference travel grant award

2000-2002 Japan Society for the Promotion of Science (JSPS) post-doc fellowship for foreign researcher (about $100,000.00) - returned fellowship due to accepting the research associate scientist position in New York University, USA.

1998 Third British Epidemiology and Public Health Course travel grant award

1997 9th International Conference on Occupational Respiratory Diseases travel grant award

1995-2000 Japanese Ministry of Education, Sciences and Culture scholarship award (Japanese Government Scholarship)

1995 25th International Congress on Occupational Health travel grant award

Post-doc Fellow Received Awards Under the Mentor of Dr. Zhang

2018    First Place:  Basic Research in Public Health, Research! Louisville (Awardee: Dr. Yiqun Mo)

2017    First Place:  Basic Research in Public Health, Research! Louisville (Awardee: Dr. Yiqun Mo)

2015    First Place:  Basic Research in Public Health, Research! Louisville (Awardee: Dr. Yiqun Mo

2010   The post-doc award, Nanotoxicology Specialty Section, 49 th Annual Meeting of Society of Toxicology at Salt Lake City, March 7-11, 2010. (Awardee: Dr. Rong Wan)

2009   Best Abstract by a post-doc, Inhalation and Respiratory Specialty Section, Annual Meeting of Society of Toxicology at Baltimore, March 15-19, 2009. (Awardee:Dr. Yiqun Mo)

2009  Travel Award for Trainees, Wound Biotechnology Foundation,   Wound Healing Society, 19 th Annual Meeting and Exhibition, Dallas, Texas,  April 26-29, 2009. (Awardee:Dr. Yiqun Mo)


Publications

Book

1.    Qunwei Zhang (Editor). Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular  Biology,                  Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). DOI: 10.1007/978-1-4939-8916-4; Hardcover ISBN: 978-1-4939-8915-7; eBook ISBN: 978-1-4939-8916-4.   https://www.springer.com/us/book/9781493989157

Book Chapters

  1. Mo Y, Zhang Y, Zhang Q. Evaluation of Pulmonary Toxicity of Nanoparticles by Bronchoalveolar Lavage Method. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:313-322. doi: 10.1007/978-1-4939-8916-4_18. PMID:30547469
  2. Zhang Y, Wan R, Zhang Q, Mo Y. Application of gelatin zymography in nanotoxicity research. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:133-143. doi: 10.1007/978-1-4939-8916-4_8. PMID:30547459
  3. Wan R, Mo Y, Tong R, Gao M, Zhang Q. Determination of Phosphorylated Histone H2AX in Nanoparticle-Induced Genotoxic Studies. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:145-159. doi: 10.1007/978-1-4939-8916-4_9. PMID:30547460
  4. Long G, Mo Y, Zhang Q, Jiang M. Analysis of Nanomaterial Toxicity by Western Blot.. Nanotoxicity: Methods and Protocols. In the series: Methods in Molecular Biology, edited by Qunwei Zhang, Springer Protocol. (www.SpringerProtocols.com). Humana Press (2019). Methods Mol Biol. 2019;1894:161-169. doi: 10.1007/978-1-4939-8916-4_10. PMID:30547461
  5. Mo Y, Gu A, Tollerud DJ, Zhang Q. Nanoparticle toxicity and environmental impact. Oxidative stress and biomaterial. Editors: Thomas Dziubla and D. Allan Butterfield. Elsevier Ltd. (2016). ISBN: 978-0-12-803269-5, page 117-143.
  6. Mo Y, Wan R, Tollerud DJ, Zhang Q. Nanomaterials.  Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspect. Editors: Yusuke Hiraku, Shosuke Kawanishi, Hiroshi Ohshima. John Wiley & Sons, Inc. (2014).  ISBN: 978-1-118-16030-5, page 235-249.
  7. Mo Y, Wan R, Zhang Q.  Application of reverse transcription-PCR and real-time PCR in nanotoxicity research. Nanotoxicity: Method and Protocols. In the series: Methods in Molecular Biology (Vol. 926). Editor: Reineke, Joshua. Springer Protocols (www.SpringerProtocols.com).  Humana Press (2012) Methods Mol. Biol. 2012; 926: 99-112.  PMID: 22975959.
  8. Fisher AB, Zhang Q.  NADPH and NADPH oxidase. Encyclopedia of Respiratory Medicine. Editors: Geoffrey J. Laurent and Steven D. Shapiro. C2006 Elsevier Ltd, ISBN: 0-12 438360-2, 2006; Vol 3: 77-83.
  9. Zhang Q, Kusaka Y, Sato K, Donaldson K.  Differences in the inflammogenicity of standard and ultrafine metals: the role of nitric oxide. Advances in the Prevention of Occupational Respiratory Diseases. Editors: Chiyotani K, Hosoda Y, Aizawa Y. Elsevier Sciences B.V. 1998: 866-872.
  10. Zhang Z, Zhang Q, Yang D, Ding X, Luo J, He L Zhong H, Chen F. Luo J, Hong C.  The therapeutic effect of whole lung lavage with polyvinypyridine-N-Oxide solution in pneumoconiosis patients.  Advances in the Prevention of Occupational Respiratory Diseases. Editors: Chiyotani K, Hosoda Y, Aizawa Y. Elsevier Sciences B.V. 1998: 838-844.
  11. Kusaka Y, Zhang Q, Sato K, Kyono H, Kohyama N.  Which is more immunotoxic to the respiratory system, ionic or metallic cobalt? Metal Ions in Biology Medicine. Editors: Collery PH, Corbella J, Domingo JL, Etienne JC, Liobet JM. John Liibbey Eurotext, Pairs, 1996, Vol 4: 661-613.
  12. Sato K, Kusaka Y, Zhang Q, Okada K, Nakakuki K, Muraoka R.  Effect of cadmium on citrate uptake by isolated rats renal brush border membrane vesicles. Metal Ions in Biology Medicine. Editors: Collery PH, Corbella J, Domingo JL, Etienne JC, Liobet JM.  John Liibbey Eurotext, Pairs, 1996, Vol 4: 238-240.

Journal Articles

  1. Mo Y, Mo L, Zhang Y, Zhang YB, Yuan J, Zhang Q. High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages. Particle Fibre Toxicology. 2023 Nov 2;20(1):41. https://doi.org/10.1186/s12989-023-00552-8. PMID: 37919797
    1. Zhang YB, Mo Y, Zhang Y, Yuan J, Zhang Q. MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts. Particle and Fibre Toxicology 2023 May 22;20(1):22. doi: 10.1186/s12989-023-00532-y. PMID: 37217992 
    2. Yuan J, Mo Y, Zhang Y, Zhang YB, Zhang Q. Nickel nanoparticles induce autophagy and apoptosis via HIF-1α/mTOR signaling in human bronchial epithelial cells. Environmental  Pollution 2023 Jul 15;329:121670. doi: 10.1016/j.envpol.2023.121670. PMID: 37080518
    3. Yuan J, Mo Y, Zhang YB, Zhang Y, Zhang Q. Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1α/HDAC3 pathway. Nanotoxicology. 2022; 16 (NOS. 6–8): 695–712. doi: 10.1080/17435390.2022.2142169.  PMID: 36345150
    4. Zhang Y, Du L, Yan J, Bai Q, Niu Q, Mo Y, Zhang Q, Nie J. Prenatal Benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation, Ecotoxicology and Environmental Safety. 2022 Nov;246:114180. doi: 10.1016/j.ecoenv.2022.114180. PMID: 36265406
    5. Feng S, Xu Z, Zhang Z, Mo Y, Deng Y, Li L, Fei S, Wu J, Wang K, Zhang Q, Song J, Zhou R. RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. Toxicology, 2022 Nov;481:153354. doi: 10.1016/j.tox.2022.153354. PMID: 36265525
    6. Yuan J, Mo L, Mo Y, Zhang YB, Zhang Y, Zhang Q. A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells. Toxicology. 2022 Jul;477:153271. doi: 10.1016/j.tox.2022.153271. Epub 2022 Jul 22. PMID: 35872226
    7. Huang R, Zhang Q, Zhou P. Editorial: Epigenetic and Related Signaling Pathways in Response to Ionizing Radiation and Nanoparticles. Front Cell Dev Biol. 2022 May 27;10:932757. doi: 10.3389/fcell.2022.932757. eCollection 2022. PMID: 35712664
    8. Yuan J, Wang T, Wang L, Li P, Shen H, Mo Y, Zhang Q, Ni C. Transcriptome-wide association study identifies PSMB9 as a susceptibility gene for coal workers’ pneumoconiosis. Environmental Toxicology 2022;37(8):2103-2114. PMID: 35506645
    9. Karagas MR, Wang A, Dorman DC, Hall AL, Pi J, Sergi CM, Symanski E, Ward EM, Arrandale VH, Azuma K, Brambila E, Calaf GM, Fritz JM, Fukushima S, Gaitens JM, Grimsrud TK, Guo L, Lynge E, Marinho-Reis AP, McDiarmid MA, Middleton DRS, Ong TP, Polya DA, Quintanilla-Vega B, Roberts GK, Santonen T, Sauni R, Silva MJ, Wild P, Zhang CW, Zhang Q, Grosse Y, Benbrahim-Tallaa L, de Conti A, DeBono NL, El Ghissassi F, Madia F, Reisfeld B, Stayner LT, Suonio E, Viegas S, Wedekind R, Ahmadi S, Mattock H, Gwinn WM, Schubauer-Berigan MK. Carcinogenicity of cobalt, antimony compounds, and weapons-grade tungsten alloy. Lancet Oncology. 2022; 23 (5):577-578.   Apr 7:S1470-2045(22)00219-4.  https://doi.org/10.1016/S1470-2045(22)00219-4. PMID: 35397803
    10. Nie J, Zhang Y, Ning L, Yan Z, Duan L, Xi H, Niu Q, Zhang Q.  Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis.  Environmental Toxicology 2022 Jan; 37(1): 17-27. doi: 10.1002/tox.23374.  PMID: 34529316
    11. Zhang Y, Mo Y, Yuan J, Zhang Y, Mo L, Zhang Q. MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells. Nanotoxicology. 2021; 15 (10): 1380-1402. https://doi.org/10.1080/17435390.2022.2030822   PMID: 35108494
    12. Mo Y, Zhang Y, Zhang YB, Yuan J, Mo L, Zhang Q.  Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway.  Journal of Nanobiotechnology 2021 Nov 17; 19(1): 370. https://doi.org/10.1186/s12951-021-01117-7.  PMID: 34789290
    13. Yuan J, Li P, Pan H, Xu Q, Xu T, Li Y, Wei D, Mo Y, Zhang Q, Chen J, Ni C.  miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1. Ecotoxicology and Environmental Safety 2021; 20: 112375. https://doi.org/10.1016/j.ecoenv.2021.112372. PMID: 34082245
    14. Sarojini H, Bajorek A, Wan R, Wang J, Zhang Q, Billeter AT, Chien S.  Enhanced skin incisional wound healing with intracellular ATP delivery via macrophage proliferation and direct collagen production. Frontiers in Pharmacology 2021; 12: 594586. https://doi.org/10.3389/fphar.2021.594586.  PMID: 34220491
    15. Yuan J, Zhang Y, Zhang Y, Mo Y, Zhang Q.  Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes.  Particle and Fibre Toxicology 2021 Mar 19; 18(1): 13. https://doi.org/10.1186/s12989-021-00405-2.  PMID: 33740985  
    16. Mo Y, Zhang Y, Wan R, Jiang M, Xu Y, Zhang Q.  miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis.  Nanotoxicology 2020; 14(9): 1175–1197. https://doi.org/10.1080/17435390.2020.1808727.  PMID: 32924694 
    17. Mo Y, Zhang Y, Mo L, Wan R, Jiang M, Zhang Q.  The role of miR-21 in nickel nanoparticle-induced MMP-2 and MMP-9 production in mouse primary monocytes: in vitro and in vivo studies.  Environmental Pollution 2020 Dec; 267: 115597. https://doi.org/10.1016/j.envpol.2020.115597.  PMID:  33254626      
    18. Zhang Feng S, Zhang Z, Mo Y, Tong R, Zhang Z, Chen Z. He D, Wan R, Gao M, Mo Y. Zhang Q, Huang Y.  Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: the role of oxidative stress.  Toxicology in Vitro 2020; 69: 10496769. https://doi.org/10.1016/j.tiv.2020.104967.  PMID: 32805375
    19. Zhang X, He Y, Lin Q, Hung L, Zhang Q, Xu Y.  Adverse effects of sub-chronic exposure to cooking oil fumes on the gonads and the GPR30-mediated signaling pathway in female rats.  Molecular and Cellular Toxicology 2020; 16(1): 13-24.
    20. Mo Y, Sarojini H, Wan R, Zhang Q, Wang J, Eichenberger SE, Kotwal G, Chien S.  Intracellular ATP delivery causes rapid tissue regeneration via upregulation of cytokines, chemokines, and stem cells.  Frontiers in Pharmacology2020 Jan 16; 10: 1502.doi: 10.3389/fphar.2019.01502. eCollection 2019. PMID: 32009945
    21. Huang Y, Zhu J, Li H, Wang W, Li Y, Yang X, Zheng N, Liu Q, Zhang Q, Zhang W, Liu J.  Cadmium exposure during prenatal development causes testosterone disruption in multigeneration via SF-1 signaling in rats.  Food and Chemical Toxicology 2020; 135:110897. https://doi.org/10.1016/j.fct.2019.110897.  PMID: 31654709
    22. Cai Z, Zheng F, Ding Y, Zhan Y, Gong R, Li J, Aschner M, Zhang Q, Wu S, Li H.  Nrf2-regulated miR-380-3p blocks the translation of Sp3 protein and its mediation of paraquat-induced toxicity in mouse neuroblastoma N2a cells.  Toxicology Sciences 2019; 171(2): 515–529.  PMID: 31368498
    23. Zheng F, Luo Z, Zheng C, Li J, Zeng J, Yang H, Chen J, Jin Y, Aschnere M, Wu S, Zhang Q, Li H. Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats. Toxicology and Applied Pharmacology 2019; 369: 90-99.  PMID: 30849457
    24. Mo Y, Jiang M, Zhang Y, Wan R, Li J, Zhong CJ, Li H, Tang S, Zhang Q.  Comparative mouse lung injury by nickel nanoparticles with differential surface modification.  Journal of Nanobiotechnology 2019; 17: 2. https://doi.org/10.1186/s12951-018-0436-0.  PMID:30616599
    25. Wang L, Yang H, Wang Q, Zhang Q, Wang Z, Zhang Q, Wu S, Li H.  Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2.  Toxicology Letter 2018; 291: 11-28.  PMID: 29627306
    26. Wang Q, Zhan Y, Ren N, Wang Z, Zhang Q, Wu S, Li H.  Paraquat and MPTP alter microRNA expression profiles, and down-regulated expression of miR-17-5p contributes to PQ-induced dopaminergic neurodegeneration.  Journal Applied Toxicology 2018; 38(5): 665-667.  PMID: 29250806
    27. Guo Z, Zhang Z, Wang Q, Wang L. Zhang J, Zhang Q, Li H, Wu S.  Manganese chloride induces histone acetylation changes in neuronal cells: its role in manganese-induced damage.  Neurotoxicology 2018; 65: 255–263.  PMID: 29155171
    28. Wang Q, Ren N, Cai Z, Lin Q, Wang Z, Zhang Q, Wu S, Li H.  Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2.  NPJ Parkinson’s Dis 2017 Oct 20; 3: 31. doi: 10.1038/s41531-017-0033-1. eCollection 2017. PMID: 29071302
    29. Wan R*, Mo Y*, Zhang Z*, Jiang M, Tang S, Zhang Q.  Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice.  Particle and Fibre Toxicology 2017 Sep 18; 14(1): 38.                             https://doi.org/10.1186/s12989-017-0219-z (*co-first author).  PMID: 28923112
    30. Liu Q, Xu C, Ji G, Liu H, Mo Y, Tollerud DJ, Gu A, Zhang Q.  Sublethal effects of zinc oxide nanoparticles on male reproductive cells.  Toxicology in Vitro 2016; 35: 131-138.  PMID: 27247145
    31. Zhang Y, Mo Y, Gu A, Wan R, Zhang Q, Tollerud DJ.  Effects of urban particulate matter with high glucose on human monocytes U937.  Journal of Applied Toxicology 2016; 36: 586–595. PMID: 26179980
    32. Xu Y, Zhang X, Chen Y, Ren N, Lin W, Zhang Q.  Health effects of electromagnetic fields on reproductive-age female operators of plastic welding machines in Fuzhou, China.  Journal of Occupational and Environmental Medicine 2016; 58(2): 148-153.  PMID: 26849258
    33. Zou H, Zhang Q, Xing M, Gao X, Zhou Li, Tollerud DJ, Tang S, Zhang M.  Evaluation of appropriate exposure metrics for nanoparticles in workplaces.  Environmental Science: Processes & Impacts 2015; 17(8): 1470-1481.  PMID: 26166442
    34. Xu C, Liu Q, Liu H, Zhang Q, Héroux P, Jiang ZY, Gu A.  Low serum testosterone levels are associated with elevated urinary mandelic acid, tungsten, and strontium levels in adult men according to the US 2011-2012 National Health and Nutrition Examination Survey.  PLoS One 2015 May 21; 10(5): e0127451. PMID: 25996772
    35. Xu C, Liu Q, Zhang Q, Jiang Z, Gu A.  Urinary enterolactone associated with liver enzyme levels in U.S. adults: NHANES survey.  British Journal of Nutrition 2015; 114: 91-97.  PMID: 25990984
    36. Yang X, Shao H, Liu W, Gu W, Shu X, Mo Y, Chen X, Zhang Q, Jiang M.  Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity.  Toxicology Letters 2015; 234: 40-49.  PMID: 25680694
    37. Xu C, Liu Q, Zhang Q, Jiang Z, Gu A.  Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-2010.  British Journal of Nutrition 2015; 113: 683-690.  PMID: 25634494
    38. Feng L, Zhang Y, Jiang M, Mo Y, Wan R, Jia Z, Tollerud DJ, Zhang X, Zhang Q.  Up-regulation of Gadd45a after exposure to metal nanoparticles: the role of hypoxia inducible factor 1a.  Environmental Toxicology 2015; 30 (4): 490-499.  PMID: 24277352
    39. Skeete Z, Cheng H, Crew E, Shan S, Zhao W, Cronk H, Luo J, Zhang Q, Zhong CJ.  Design of functional nanoparticles and assemblies for theranostic applications.  ACS Applied Materials & Interfaces 2014; 6 (24): 21752-21768.  PMID: 25111087
    40. Wan R, Mo Y, Feng L, Chien S, Tollerud DJ, Zhang Q.  DNA damage caused by metal nanoparticles: the involvement of oxidative stress and activation of ATM.  Chemical Research in Toxicology 2012; 25: 1402-1411. (Highlighting in this issue; 2012; 25(7):1283).  PMID:22559321
    41. Mo Y, Wan R, Feng L, Chien S, Tollerud DJ, Zhang Q.  Combination effects of Cigarette smoke extract and ambient ultrafine particles on endothelial cells.  Toxicology in Vitro 2012; 26: 295-303.  PMID: 22178768
    42. Wan R, Mo Y, Chien S, Li Y, Li Y, Tollerud DJ, and Zhang Q.  The role of hypoxia inducible factor-1α in MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles.  Nanotoxicology 2011; 5(4): 568-582.  PMID: 21401309
    43. Pushpakumar SB, Perez-Abadia G, Soni C, Wan R, Todnem N, Patibandla P, Fenster T, Zhang Q, Barker JH, Maldonado C.  Enhancing complement control on endothelial barrier reduced renal post-ischemia dysfunction.  Journal of Surgery Research 2011, 170: e263-e270.  PMID: 21816416
    44. Wang J, Wan R, Mo Y, Zhang Q, Sherwood L, Chien S.  Creating a long-term diabetic rabbit model. Experimental Diabetes Research 2010, Article ID 289614, 10 pages, doi: 10.1155/2010/289614.  PMID: 21234414
    45. Wang L, Zhang J, Zheng Y, Yang J, Zhang Q, Zhu X.  Bioeffects of CdTe quantum dots on human umbilical vein endothelial cells.  Journal of Nanoscience Nanotechnology 2010; 10: 8591-8596.  PMID: 21121370
    46. Yu M, Mo Y, Wan R, Chien S, Zhang X, and Zhang Q.  Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles.  Toxicology Letters 2010; 195: 82-89. PMID: 20171267
    47. Wang J, Wan R, Mo Y, Li M, Zhang Q, Chien S.  Intracellular delivery of ATP enhanced healing process in full thickness skin wounds in diabetic animals.  The American Journal of Surgery 2010; 199: 823-832. PMID: 20609726
    48. Wattamwar PP, Mo Y, Wan R, Palli R, Zhang Q, Dziubla TD.  Antioxidant activity of degradable polymer poly(trolox) to suppress oxidative stress injury in cells.  Advanced Functional Materials 2010; 20: 147-154.
    49. Mo Y, Wan R, Wang J, Chien S, Tollerud DJ, Zhang Q.  Diabetes is associated with increased sensitivity of alveolar macrophages to urban particulate matter exposure.  Toxicology 2009; 262: 130-137.  PMID: 19505525
    50. Mo Y, Wan R, Chien S, Tollerud, DJ, Zhang Q.  Activation of endothelial cells after exposure to ambient ultrafine particles: the role of NADPH oxidase.  Toxicology and Applied Pharmacology 2009; 236: 183-193.  PMID: 19371610
    51. Wang J, Zhang Q, Wan R, Mo Y, Li M, Tseng M, Chien S.  Intracellular ATP enhanced skin wound healing in rabbits.  Annals of Plastic Surgery 2009; 64(2): 180-186.  PMID: 19158531
    52. Wan R, Mo Y, Zhang X, Chien S, Tollerud DJ, Zhang Q.  Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: the role of oxidative stress and protein tyrosine kinase activation.  Toxicology and Applied Pharmacology 2008; 233: 276-285.  PMID: 18835569
    53. Mo Y, Zhu X, Hu X, Tollerud DJ, Zhang Q.  Cytokine and NO release from peripheral blood neutrophils after exposure to metal nanoparticles: in vitro and ex vivo studies.  Nanotoxicology 2008; 2(2): 79-87.
    54. Zhang Q, Chatterjee S, Wei Z, Liu W, Fisher AB.  Rac and PI3 kinase mediate endothelial cell reactive oxygen species generation during normoxic lung ischemia.  Antioxidants & Redox Signaling 2008; 10(4): 679-690 (Journal cover).  PMID: 18162054
    55. Zhang Q, Matsuzaki I, Chatterjee S, Fisher AB.  Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent.  American Journal Physiology Lung Cellular Molecular Physiology 2005; 289: L954-L961.  PMID: 16280460
    56. Matsuzaki I, Chatterjee S, Manevich Y, DeBolt K, Zhang Q, Fisher AB.  Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction. American Journal Physiology Heart Circulatory Physiology 2005; 288: H336-343.  PMID: 15331375
    57. Zhao J, Chen H, Davison T, Kluz T, Zhang Q, Costa M.  Nickel-induced 1,4-alpha-glucan branching enzyme 1 upregulation via the hypoxic signaling pathway.  Toxicology and Applied Pharmacology 2004; 196: 404-409.  PMID: 15094311
    58. Davidson T, Kluz T, Burns F, Rossman T, Zhang Q, Uddin A, Nadas A, Costa M.  Exposure to chromium (VI) in the drinking water increased susceptibility to UV-induced skin tumors in hairless mice.  Toxicology and Applied Pharmacology 2004; 196: 431-437.  PMID: 15094314
    59. Mo Y, Feinstein SI, Manevich Y, Zhang Q, Lu L, Ho YS, Fisher AB.  Mouse 1-Cys peroxiredoxin highly related intronless gene is an expressed pseudogene.  FEBS Letter 2003; 555(2): 192-198.  PMID: 14644414
    60. Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M.  Inhibition and reversal of nickel-induced transformation by histone deacetylase inhibitor trichostatin A.  Toxicology and Applied Pharmacology 2003; 192: 201-211.  PMID: 14575637
    61. Salnikow K, Davision T, Zhang Q, Chen L, Su W, Costa M.  The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis.  Cancer Research 2003; 63: 3524-3530.  PMID: 12839937
    62. Zhang Q, Kusaka Y, Zhu X, Sato K, Mo Y, Kluz T, Donaldson K.  Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation.  Journal of Occupational Health 2003, 45: 20-32.  PMID: 14605425
    63. Costa M, Salnikow K, Sutherland JE, Broday L, Peng W, Zhang Q, Kluz T.  The role of oxidative stress in nickel and chromate genotoxicity.  Molecular Cellular Biochemistry 2002, 234/235: 265-275.  PMID: 12162442
    64. Cangul H, Broday L, Salnikow K, Sutherland J, Peng W, Zhang Q, Poltaratsky V, Zoroddu MA.  Molecular mechanism of nickel carcinogenesis.  Toxicology Letter 2002, 127: 69-75.  PMID: 12052643
    65. Zhang Q, Kluz T, Salnikow K, Costa M.  Comparison of the cytotoxicity, cellular uptake and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell line derived from three different individuals.  Biological Trace Element Research 2002, 86: 11-22.  PMID: 12002656
    66. Sutherland JE, Peng W, Zhang Q, Costa M.  The histone acetylase inhibitor trichostatin A reduce nickel-induced gene silicening in yeast and mammalian cells.  Mutation Research (Fundamental and Molecular mechanisms of Mutagenesis), 2001; 497: 225-233.  PMID: 11470494
    67. Huang C, Zhang Q, Li J, Ding M, ShiX, CastranovaV, Ji G, Costa M, Dong Z.  Involvement of Erks activation in cadmium-induced AP-1 transactivation in vivo and in vitro.  Molecular Cellular Biochemistry 2001, 222: 141-147.  PMID: 11678596
    68. Zhang Q, Mo Y, Lou J, Zhu X, He L, Zhong H.  Determination the platelet activating factor in silicotic patients and its effect on the fibroblast cells.  Environmental Health and Preventive Medicine 2001, 5(4): 134-137.  PMID: 21432401
    69. Sato K, Kusaka Y, Zhang Q, Zhu X, Okada K.  Effect of platinum complex (PtCx) on citrate uptake by rat renal brush border membrane vesicles (BBMV): direct effects of cisplatin.  Industrial Health 2000; 38(3): 327-329.  PMID: 10943082
    70. Zhang Q, Kusaka Y, Donaldson K.  Comparative rat pulmonary responses caused by exposure to standard cobalt and ultrafine cobalt.  Journal Occupational Health 2000; 42: 179-184.
    71. Zhang Q, Kusaka Y, Donaldson K.  Comparative injurious and pro-inflammatory effects of three ultrafine metals in macrophages from young and old rats.  Inhalation Toxicology 2000; 12 (Suppl 3): 267-273. PMID: 26368625.
    72. Wang D, Kato N, Inaba Y, Tango T, Yoshida Y, Kusaka Y, Deguchi Y, Tomita F and Zhang Q.  Physical and personality traits of preschool children in Fuzhou, China: only child vs. sibling.  Child: Care, Health and Development 2000; 26(1): 49-60.  PMID: 10696518
    73. Zhu X, Sato K, Kusaka Y, Zhang Q.  The endocrine disruptive effects of mercury.  Environmental Health and Preventive Medicine 2000; 4: 174-183.  PMID: 21432482
    74. Zhang Q, Kusaka Y, Sato K, Wang D, Donaldson K.  Tumor necrosis factor-alpha release from rat pulmonary leukocytes exposed to ultrafine cobalt: in vivo and in vitro studies.  Environmental Health and Preventive Medicine 1999; 4: 87-91.  PMID: 21432178
    75. Zhang Q, Kusaka Y, Sato K, Mo Y, Fukuda M, Donaldson K.  Toxicity of ultrafine nickel particle in lung after intratracheal instillation.  Journal of Occupational Health 1998; 40: 171-176.
    76. Zhang Q, Kusaka Y, Sato K, Nakakuki K, Koyama N, Donaldson K.  Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radical.  Journal of Toxicology and Environmental Health 1998; 53: 423-438.  PMID: 9537280
    77. Sato K, Kusaka Y, Zhang Q, Deguchi Y, Li B, Okada K, Nakakuki K, Muraoka R.  Direct effect of inorganic mercury on citrate uptake by isolated rat renal brush border membrane vesicles.  Industrial Health 1997; 35: 456-460.  PMID: 9348716
    78. Sato K, Kusaka Y, Zhang Q, Yanagihara M, Ueda K.  An epidemiological study on mercury sensitization.  Allergy International 1997; 46: 201-206.
    79. Sato K, Kusaka Y, Zhang Q, Deguchi Y, Li B, Okada K, Nakakuki K, Muraoka R.  Citrate uptake by isolated rat renal brush border membrane vesicles in cadmium-intoxicated rats.  Industrial Health 1997; 35: 388-393.  PMID: 9104787
    80. Kusaka Y, Sato K, Zhang Q, Morita A, Kasahara T, Yanagihara Y.  Association of natural killer cell activity with serum Ig E.  International Arch Allergy and Immunology 1997; 112: 331-335.  PMID: 9104787
    81. Zhang Q, Kusaka Y, Zhang QF, He L, Zhang Z, Sato K.  Dynamic changes of constituents in bronchoalveolar fluid in experimental silicotic rats.  Industrial Health 1996; 34: 379-388. (Correspondence author).  PMID: 8908848
    82. Sato K, Kusaka Y, Zhang Q, Yanagihara M, Ueda K, Morihiro H and Ishii Y.  Investigation of the association between mercury sensitization and HLA-DR6.  Contact Dermatitis (Environmental and Occupational Dermatitis) 1996; 34: 295.  PMID: 8730172


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