Gary W. Hoyle, PhD

Gary Hoyle imageEnvironmental and Occupational Health Sciences
Professor and Acting Chair
485 E. Gray St, Room 205
319 Abraham Flexner Way, Room 701 HSC-A
Louisville, KY 40202
Phone: 502-852-3007; 502-852-7345 
Fax: 502-852-7889

Office hours by appointment.



Dr. Hoyle received a B.A. from Johns Hopkins University in 1982 and a Ph.D. in Biochemistry from Duke University in 1988. He engaged in postdoctoral training at the University of Pennsylvania from 1988-1993 and joined the faculty of Tulane University in the Pulmonary Section of the Department of Medicine in 1993.  Dr. Hoyle joined the department of Environmental and Occupational Health Sciences at the University of Louisville in 2007.  Dr. Hoyle’s research interests are focused on understanding how inhaled agents that are encountered in the environment or in occupational settings injure the lung and how the lung is repaired after injury.  An understanding of mechanisms underlying lung injury and repair has the potential to lead to novel treatments for pulmonary disorders.  Dr. Hoyle has studied mechanisms of lung injury induced by a variety of inhaled agents, including chlorine, ozone, isocyanates, asbestos, silica, bleomycin, allergens, cigarette smoke, and ambient particulate matter.

Recent Grants

9/23/10-8/31/13 National Institutes of Health R21 ES020123 "Repair of airway epithelium following chlorine lung injury"

8/22/11-4/30/17 National Institutes of Health U01 ES015673 “Novel therapies for chlorine-induced lung injury”

9/25/12-6/30/17 National Institutes of Health U01 ES022564 “Countermeasures for chlorine-induced airway fibrosis”

7/1/16-6/30/17 Kentucky Science and Engineering Foundation KSEF-3605-RDE-19 “Macrophages and Airway Fibrosis”

9/30/16-8/31/18 National Institutes of Health R21 ES027391 “Treatment of persistent chlorine-induced small airway disease”

Recent Publications

Musah, S., DeJarnett, N., and Hoyle, G. W. (2012).  Tumor necrosis factor-a mediates interactions between macrophages and epithelial cells underlying proinflammatory gene expression induced by particulate matter.  Toxicol. 299:125-132.

Chang, W., Chen, J., Schlueter, C. F., Rando, R. J., Pathak, Y. V., and Hoyle, G. W. (2012).  Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram.  Toxicol. Appl. Pharmacol. 263:251-258.  PMC3422440.

Musah, S., Chen, J., and Hoyle, G. W. (2012).  Repair of tracheal epithelium by basal cells after chlorine-induced injury.  Respir. Res. 13:107.  PMC3544626.

Mo, Y., Chen, J., Schlueter, C. F., and Hoyle, G. W. (2013).  Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis.  Am. J. Physiol. Lung Cell. Mol. Physiol. 304:L92-L102.  PMC3543638.

Chen, J., Mo, Y., Schlueter, C. F., and Hoyle, G. W. (2013).  Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide.  Toxicol. Appl. Pharmacol. 272:408-413.  PMC4005342.

Mo, Y., Chen, J., Humphrey, D. M. Jr., Fodah, R. A., Warawa, J. M., and Hoyle, G. W.  (2015).  Abnormal epithelial structure and chronic lung inflammation after repair of chlorine-induced airway injury.  Am. J. Physiol. Lung Cell. Mol. Physiol. 308:L168-L178.  PMC4338946.

Satpathy, S. R., Jala, V. R., Bodduluri, S. R., Krishnan, E., Hegde, B., Hoyle, G. W., Fraig, M., Luster, A. D., and Haribabu, B. (2015).  Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumor growth.  Nat. Commun. 6:7064.  PMC4418220.

Hoyle , G. W., Chen, J., Schlueter, C. F., Mo, Y., Humphrey, D. M. Jr., Rawson, G., Niño, J. A., and Carson, K. H.  (2016).  Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation.  Toxicol. Appl. Pharmacol. 298:9-18.  PMC4821717.

Hoyle, G. W., and Svendsen, E. R.  (2016).  Persistent effects of chlorine inhalation on respiratory health.  Ann. N. Y. Acad. Sci. 1378:33-40.

Musah, S., Schlueter, C. F., Humphrey, D. M. Jr., Powell, K. S., Roberts, A. M., and Hoyle G.W.  (2017).  Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation.  Toxicol. Appl. Pharmacol. 315:1-11.

Conklin, D. J., Haberzettl, P., Jagatheesan, G., Kong, M., and Hoyle, G. W.  (2017).  Role of TRPA1 in acute cardioplumonary toxicity of inhaled acrolein.  Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2016.08.028.

Stay connected TwitterFacebookLinkedInYouTubeInstagram