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Doug Lorenz, PhD

Bioinformatics and Biostatistics

Assistant Professor
Room No. 134, 485 E. Gray St.
Louisville, KY 40202
Phone: 502-852-3635

djlore01@louisville.edu

CV


Background

PhD (2011), Applied and Industrial Mathematics, University of Louisville
MSPH (2002), Biostatistics-Decision Science, University of Louisville
MA (2001), Mathematics, University of Louisville
BS (1999), Mathematics, English Minor, University of Louisville

I joined the Department of Bioinformatics and Biostatistics in 2003, as a statistician with the Statistical Consulting Center. I collaborated with over one hundred investigators within and outside the University of Louisville and published numerous collaborative papers. In Fall of 2011, I joined the faculty of the Department of Bioinformatics and Biostatistics as an assistant professor. Currently, I collaborate with Susan Harkema, PhD, Rehabilitation Research Director of the Kentucky Spinal Cord Injury Research Center, Owsley B. Frazier Chair in Neurological Rehabilitation, and Professor in the Department of Neurological Surgery on various projects related neurological rehabilitation of spinal cord injury. I also collaborate with Mary Clyde Pierce, MD of Children’s Memorial Hospital in Chicago in research predicting child abuse in the pediatric emergency setting.

Research

My primary research interest is in survival analysis and in particular multi-state models, an important generalization of survival data and special case of multivariate survival data. I also conduct research in clustered data analysis and problems of informativeness of cluster size and within-cluster covariate distribution. In particular, I have interest in nonparametric methods for clustered data and the development of clustered data analogues of classical procedures from i.i.d. theory. I have a growing interest in Bioinformatics, and in particular the analysis of data from next generation sequencing (NGS).

Teaching

PHST 500-501 – Introduction to Biostatistics I and II
PHST 602 – Biostatistics Seminar Series
PHST 603 – Biostatistics Practicum
PHST 624 – Clinical Trials
PHST 666 – Master's Thesis Research
PHST 681 – Biostatistical Methods II
PHST 683 – Survival Analysis
PHST 726 – Clinical Trials Statistics Laboratory
PHST 762 – Advanced Statistical Inference
PHST 783 – Advanced Survival Analysis
PHPH 697 – Public Health Practicum

Professional Memberships and Certifications

I am a member of the American Statistical Association (ASA), treasurer of the Kentucky Chapter of the ASA, and was acrredited by the ASA in 2010 (PStat®).  I am also a member of the International Biometric Society (IBS), Institute of Mathematical Statistics (IMS), and International Statistical Institute (ISI).

Research Funding

Active
Pierce MC (PI). Clinical Decision Rules to Discriminate Bruising Caused by Physical Child Abuse. Department of Health and Human Services, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development. 1R01HD060997-01A2. 4/2011 through 4/2016. Role: Co-investigator.

Harkema SJ (PI). Development of neural recovery rehab & research centers. Christopher Reeve Paralysis Foundation. RFA7-20-06. Role: Biostatistician.

Behrman A. (PI). Neuromuscular Recovery Scale for Pediatric Spinal Cord Injury. Craig H. Neilsen Foundation.
Role: Biostatistician.

Completed
Ovechkin A. (PI). NIH. R01HL103750-04. Respiratory motor control and blood pressure regulation after spinal cord injury. Department of Health and Human Services, National Institutes of Health. Role: Biostatistician.

Harkema S.J. (PI). Recovery of Cardiovascular Function with Spinal Injury. Craig H. Neilsen Foundation. Role: Biostatistician.

Sisto S.A. (PI). Health Outcomes after Locomotor Training across the NeuroRecovery Network. Craig H. Neilsen Foundation. Role: Biostatistician.

Behrman A. (PI). A New Measure of Neurological and Behavioral Recovery after Spinal Cord Injury. Department of Defense. Role: Biostatistician.

Behrman AL (PI). A New Measure of Neurological and Behavioral Recovery after SCI. Craig H. Nielsen Foundation.  Role: Biostatistical Consultant.

Newton TL (PI). Intimate partner violence and inflammatory processes. National Insititute on Aging, National Institutes of Health: R21 AG0249002-02. Role: Biostatistical consultant.

Ruble LA (PI). Outcomes of Teacher Training on Autism. Department of Health and Human Services, Public Health Service. PAR-03-078. Role: Co-investigator.

Pfieffer MP (PI). A Telehealth Intervention to Improve Symptom Management for Patients with Head and Neck Cancer. National Institutes of Health. RFA-CA-07-013. Role: Biostatistician.

Publications

Book Chapters

1. Datta, S., Lorenz, D.J., Datta, S. Approximate U-statistics for State Waiting Times Under Right Censoring. In Modern Nonparametric, Robust and Multivariate Methods: Festschrift in Honour of Hannu Oja, Springer International Publishing Switzerland. 2015.

2. Lorenz, D.J., Gill, R.S., Mitra, R., Datta, S. Using RNA-seq Data to Detect Differentially Expressed Genes. In Statistical Analysis of Next Generation Sequence Data, Springer-Verlag. 2014.

Methodological Manuscripts

1. Lorenz, D.J., Datta, S. A nonparametric analysis of waiting times from a multistate model using a novel linear hazards model approach. Electronic Journal of Statistics. 2015; 9: 419-443. DOI: 10.1214/15-EJS1003.

2. Lorenz, D.J., Datta S. Comparing waiting times in a multi-stage model: A log-rank approach. Journal of
Statistical Planning and Inference
. 2012; 142(10): 2832-2843. DOI: 10.1016/j.jspi.2012.04.003.

3. Lorenz, D.J., Datta, S., Harkema S.J. Marginal association measures for clustered data. Statistics in Medicine.
30 Nov. 2011; 30(27): 3181-91. DOI: 10.1002/sim.4368. PMID: 21953204.

Selected Collaborative Manuscripts

1. Alver, S.K., Lorenz, D.J., Marvin, M.R., Brock, G.N. Projected outcomes of six-month delay in exception points vs. an equivalent MELD score for HCC liver transplant candidates. Liver Transplantation. Accepted.

2. Harkema, S.J., Shogren, C., Ardolino, E., Lorenz, D.J.. Assessment of functional improvement without compensation for human spinal cord injury: extending the Neuromuscular Recovery Scale to the upper extremities. Journal of Neurotrauma. DOI: 10.1089/neu.2015.4213. PMID: 27071494

3. Thompson, R., Kaczor, K., Lorenz, D.J., Bennett, B.L., Meyers, G., Pierce, M.C. Is the Use of Physical Discipline
Associated with Aggressive Behaviors in Young Children? Acad Pediatr. DOI: 10.1016/j.acap.2016.02.014.
PMID: 26924534.

4. Magana, J.N., Pierce, M.C., Kaczor, K., Lorenz, D.J., Meyers, G., Bennett, B.L., Kanegaye, J.T. The Prevalence of Bruising Among Infants in Pediatric Emergency Departments. Annals Emerg Med. 2016. 67: 1-8. DOI: 10.1016/j.annemergmed.2015.06.021. PMID: 26233923.

5. Tester, N.J., Lorenz, D.J., Suter, S.P., Beuhner, J., Falanga, D., Watson, E., Velozo C.A., Behrman A.L., Basso M. Responsiveness of the Neuromuscular Recovery Scale during Outpatient Activity-Dependent Rehabilitation for Spinal Cord Injury. Neurorehabilitation and Neural Repair. 2016; 30(27): 528-538. DOI: 10.1177/1545968315605181. PMID: 26359344

6. Behrman, A.L., Velozo, C., Suter, S., Lorenz, D., Basso, D.M. Test-retest reliability of the Neuromuscular Recovery Scale. Arch Phys Med Rehabil. 2015;96:1375-84. DOI: 10.1016/j.apmr.2015.03.022. PMID: 25883038

7. Basso, D.M., Velozo, C., Lorenz, D., Suter, S., Behrman, A.L. Interrater reliability of theNeuromuscular Recovery Scale for spinal cord injury. Arch Phys Med Rehabil. 2015;96:1397-403. DOI: 10.1016/j.apmr.2014.11.026. PMID: 25546720

8. Velozo, C., Moorhouse, M., Ardolino, E., Lorenz, D., Suter, S., Basso, D.M., Behrman, A.L. Validity of the Neuromuscular Recovery Scale: A measurement model approach. Arch Phys Med Rehabil. 2015;96:1385-96. DOI: 10.1016/j.apmr.2015.04.004. PMID: 25912666

9. Khudhair, M., Melloy, P., Lorenz, D.J., Obanor, F., Aitken, E., Datta, S., Luck, J., Fitzgerald, G., and Chakraborty, S. Fusarium crown rot under continuous cropping of susceptible and partially resistant wheat in microcosms at elevated CO2. Plant Pathology. 2014; 63(5): 1033-1043. DOI: 10.1111/ppa.12182

10. Forrest, G.F., Hutchinson, K.J., Lorenz, D.J., VanHiel, L., Basso, M., Sisto, S.A. Are the 10 Meter and 6 Minute Walk Tests Redundant in Patients with Spinal Cord injury? PLOS One. 2014; 9(5):e94108. DOI: 10.1371/journal.pone.0094108. PMID: 24788068.

11. Helm, C.W., Lorenz, D.J., Meyer, N.J., Rising, W.R., Wilff, J.L. Retinoids for preventing the progression of cervical intra-epithelial neoplasia. Cochrane Database Syst Rev, 2013 Jun 6; (6):CD003296. DOI:10.1002/14651858.CD003296.pub3. PMID: 23740788

12. Hymel, K.P., Wilson, D.F., Boos, S.C., Pullin, D.A., Homa, K., Lorenz, D.J., Herman, B.E., Graf, J.M., Isaac, R., Narang, S.K., Armijo-Garcia, V. Derivation of a clinical prediction rule for pediatric abusive head trauma. Pediatr Crit Care Med. 2013 Feb;14(2):210-20. DOI: 10.1097/PCC.0b013e3182712b09. PMID: 23314183.

13. Lorenz, D.J., Datta, S., Harkema, S.J. Longitudinal patterns of functional recovery in patients with incomplete spinal cord injury receiving activity-based rehabilitation. Arch Phys Med Rehabil. Sep. 2012; 93(9): 1541-1552. DOI: 10.1016/j.apmr.2012.01.027. PMID: 22920451.

14. Datta, S., Lorenz, D.J, Harkema, S.J. A dynamic longitudinal evaluation of the utility of the Berg Balance Scale in patients with motor incomplete spinal cord injury. Arch Phys Med Rehabil. Sep. 2012; 93(9): 1565-1573. DOI: 10.1016/j.apmr.2012.01.026. PMID: 22920453.

15. Forrest, G.F., Lorenz, D.J., Hutchinson, K., Van Hiel, L., Basso, D.M., Datta, S., Sisto, S.A., Harkema, S.J. Ambulation and balance outcomes measure different aspects of recovery in individuals with chronic incomplete spinal cord injury. Arch Phys Med Rehabil. Sep. 2012; 93(9): 1553-1564. DOI: 10.1016/j.apmr.2011.08.051.PMID: 22920452.

16. Behrman, A.L., Ardolino, E., VanHiel, L., Kern, M., Arkinson, D., Lorenz, D., Harkema, S. Assessment of functional improvement without compensation reduces variability of outcome measures after human spinal cord injury. Arch Phys Med Rehabil. Sep. 2012; 93(9): 1518-1529. DOI: 10.1016/j.apmr.2011.04.027. PMID:22920449.

17. Harkema, S.J., Schmidt-Read, M., Lorenz, D., Edgerton, V.R., Behrman, A. Balance and ambulation improvements
in individuals with chronic incomplete spinal cord injury using locomotor training-based rehabilitation. Arch Phys Med Rehabil. Sep. 2012; 93(9): 1508-1517. DOI: 10.1016/j.apmr.2011.01.024. PMID:21777905.

18. Sisto, S.A., Lorenz, D., Hutchinson, K., Wenzel, L., Harkema, S., Krassioukov, A. Cardiovascular status of individuals with incomplete spinal cord injury from 7 Neurorecovery Network rehabilitation centers. Arch Phys Med Rehabil. Sep. 2012; 93(9): 1578-1587. DOI: 10.1016/j.apmr.2012.04.03. PMID: 22920455.

19. Newton, T.L., Fernandez-Botran, R., Miller, J.J., Lorenz, D.J., Burns, V.E., Fleming, K.N. Markers of Inflammation in MidlifeWomen with Intimate Partner Violence Histories. JWomens Health (Larchmt). 2011 Dec;20(12):1871-80. DOI: 10.1089/jwh.2011.2788. PMID: 22044065.

20. Condra, C.S., Parbhu, D., Lorenz, D., Herr, S.M. Charges and complications associated with the medical evaluation of febrile infants. Pediatr Emerg Care. 2010 Mar; 26(3): 186-91. DOI: 10.1097/PEC.0b013e3181d1e180. PMID: 20179660.

21. Pierce, M.C., Kaczor, K., Aldridge, S., O’Flynn, J., Lorenz, D.. Bruising Characteristics Discriminate Physical Child Abuse From Accidental Trauma in Young Children. Pediatrics. 2010 Jan; 125(1):67-74. 10.1542/peds.2008-3632. PMID: 19969620.

22. Padmanabhan, P., Berkenbosch, J.W., Lorenz, D.J., Pierce, M.C. Evaluation of Cerebral Oxygenation during Procedural Sedation in Children using Near Infrared Spectroscopy. Ann Emerg Med. Aug 2009; 54(2). DOI:10.1016/j.annemergmed.2009.02.009. PMID: 19285362.

23. Datta, S., Lorenz, D.J., Morrison, S., Ardolino, E., Harkema, S.J. A Multivariate Examination of Temporal Changes in Berg Balance Scale Items for Patients with ASIA Impairment Scale C and D Spinal Cord Injuries. Arch Phys Med Rehabili. 2009 Jul; 90(7): 1208-17. DOI: 10.1016/j.apmr.2008.09.577. PMID: 19577035.

24. Fortu, J.M., Kim, I.K., Cooper, A., Condra, C., Lorenz, D.J., Pierce, M.C. Psychiatric patients in the pediatric emergency department undergoing routine urine toxicology screens for medical clearance: results and use. Pediatr Emerg Care. 2009 Jun; 25(6): 387-92. DOI: 10.1097/PEC.0b013e3181a79305. PMID:19458561.

25. Spiller, H., Lorenz, D.J.. Trends in Volatile Substance Abuse. J Addict Dis. 2009;28(2):164-70. DOI:10.1080/10550880902772894. PMID: 19340679.

26. Spiller, H., Lorenz, D.J., Bailey, E.J., Dart, R.C. Epidemiological trends in abuse and misuse of prescription opioids. J Addict Dis. 2009;28(2):130-6. DOI: 10.1080/10550880902772431. PMID: 19340675.

27. Ruble, L.I., McDuffie, A.S., King, A.S., Lorenz, D.J.. Caregiver responsiveness and social interaction behaviors of young children with autism. Topics in Early Childhood Special Education. Nov 2008; 28: 158-70. DOI:10.1177/0271121408323009.

28. Warkentine, F., Pierce, M.C., Kim, I.K., Lorenz, D.J., Paul, R.I. The anatomic relationship of femoral vein to femoral artery in euvolemic pediatric patients by ultrasonography: implications for pediatric femoral central venous access. Acad Emerg Med. 2008 May 15; 15(5):426-30. DOI: 10.1111/j.1553-2712.2008.00087.x. PMID:18439197.

29. Koller, D.M., Myers, A.B., Lorenz, D., Godambe, S.A. Effectiveness of Oxycodone, Ibuprofen, or the Combination in the Initial Management of Orthopedic Injury-Related Pain in Children. Ped Emerg Care. Sep 2007; 23(9). PMID: 17876251.

Honors and Awards

University of Louisville "Top 4" Faculty Favorite, 2014

University of Louisville Faculty Favorite, 2015

Elected member, Delta Omega, Beta Pi Chapter

Graduate Dean’s Citation, University of Louisville, 2011, 2002

Hohman Fellowship, Department of Mathematics, University of Louisville, 2006

Professional Service

Editorial Board Member
Annals of Biometrics & Biostatistics (2013 – ), Journal of Medical Statistics and Informatics (2013 – ), International Journal of Statistics and Probability (2012 – )

Referee
Journal of Statistical Computation and Simulation (2016), Statistics in Medicine (2015), Journal of Agricultural,
Biological, and Environmental Statistics
(2015), Pediatrics (2015, 2010), Statistics and Its Interface (2012-2013),
Statistics and Probability Letters (2012), BMC Bioinformatics (2012), Bioinformatics (2012), Archives of Physical
Medicine and Rehabilitation
(2012), Physical Therapy (2012)

University Service
Department of Bioinformatics and Biostatistics
Director, Statistical Consulting Center (2016 – )
Graduate committee (admissions and curriculum, 2012 – )
Student recruitment committee (chair, 2012 – )
Student grievance committee (2011 – )
Curator of department website (2011 – )
Dual Degree coordinator (2011 – )
Faculty hiring committees (2008, 2011, 2013 – )
System backup committee (2004 – 2006)

School of Public Health and Information Science, University of Louisville
Student academic grievance committee (2013 – )
MPH Practicum mentoring committee (2013 – )
MPH Advisory committee (2013 – 2015)
Student affairs advisory council (2011 – 2013)

University of Louisville
Ideas to Action (i2a) Leadership Committee (2014)
Poster judge for Research! Louisville (2013, 2014)

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