SEMINAR: Big Data and Systems Biology Approaches to Explore Transcriptome and RNA Regulatory Networks

Dr. Juw Won Park, Asst. Prof., CECS Department, University of Louisville
When Jan 29, 2016
from 03:30 PM to 04:30 PM
Where Duthie Center for Engineering, Room 117
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The seminar is free and open to the public. A reception and social time begins at 3:00 p.m., Seminar at 3:30 p.m.

Abstract: The high-throughput RNA sequencing (RNA-seq) has provided a powerful tool for transcriptome analysis. Due to the dramatic decrease in cost, it became quite common to generate millions and billions of sequence reads from a given RNA sample to identify/quantify the abundance of mRNA isoforms across the entire transcriptome. Large consortium projects also started generating massive RNA-seq data on tens of thousands of samples along with various other genomic/phenotypic measurements. However, the extraordinary potentials embedded in these large, complex datasets cannot be fully recognized without the development of proper methods for analyzing these big transcriptome and genome datasets. In this presentation, I will discuss my recent efforts in developing computational and statistical methods for the analysis of transcriptome isoform complexity and RNA regulatory networks using RNA-seq datasets.

Bio: Juw Won Park worked as a postdoctoral fellow in the Department of Microbiology, Immunology, & Molecular Genetics  at UCLA. He has written many research papers about the analysis of alternative mRNA splicing and its regulation in eukaryotic cells using high-throughput RNA sequencing and related genomic technologies, including their applications in biology. He is also coauthor of the rMATS software for alternative splicing analysis. Juw Won received NIH Institutional T32 Training Grant in Molecular & Cellular Biology of the Lung in 2009 through 2012. Juw Won received his B.S. in computer science from Korea University in 1995 and received his M.S. in computer science from the University of Iowa in 1999. He has a Ph.D. in computer science from the University of Iowa in 2009.