SEMINAR: Nano Materials for Medical Diagnosis and Treatment

Dr. Donglu Shi, The Materials Science and Engineering Program University of Cincinnati
When Mar 03, 2017
from 01:00 PM to 02:00 PM
Where Ernst Hall, Room 310
Contact Name
Contact Phone (502) 852-6347
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Abstract:

In this presentation, current nanotechnologies will be reviewed for biomedical applications. Several important strategies will be presented on cell targeting, optical imaging, drag delivery, and photonically activated cancer therapy. One of the typical designs involves conjugating of quantum dots on magnetic nano particle with electrical charges for imaging, cell targeting, and photothermal tumor treatment. Cell targeting in cancer therapy has been a great challenge due to the heterogeneities of cancer biomarkers. The key, therefore, is to develop a new targeting strategy that does not rely on biomarkers. In this study, cancer cells are targeted by using the surface-charged, fluorescent, superparamagnetic Fe3O4-nanocomposite.  The positively charged Fe3O4 nanocomposite binds predominantly to cancer cells due to their negative surface charge. Once the nanoscale composite is bound to cancer cells, irradiation by an 808 nm laser induces a photothermal effect that kills the cancer cells. Negatively charged nanocomposites do not bind to cancer cells. This simple strategy provides a new path for effective cancer cell targeting and treatment without relying on biochemical markers.

About the Speaker:

Donglu Shi, Ph.D
Professor and Chair of the Materials Science and Engineering Program, College of Engineering, University of Cincinnati

Donglu Shi received his Ph. D. in Engineering in 1986 from the University of Massachusetts at Amherst. He was a Staff Scientist at the Materials Science Division of Argonne National Laboratory for 8 years. In 1995, Donglu Shi joined the faculty in the Department of Materials Science and Engineering at University of Cincinnati.

Donglu Shi has so far published 270 refereed SCI journal publications including Physical Review Letters, Nature, Advanced Materials, Biomaterials, and ACS Nano. He has edited 10 books in superconductivity, functional thin films, nanomaterials, biomaterials, tissue engineering, and nano biomedicine. He is currently the Editor-in-Chief of Nano LIFE, and Associate Editor of Materials Science & Engineering: C, and J. of Nanomaterials. He is a UC Graduate Fellow, and won SIGMA XI Research Recognition Award, Excellent Research Award, and Neil Wandmecher Teaching Award.
The most recent works on nano-biomedicine pioneer some novel approaches in developing multifunctional nano carrier systems for early cancer diagnosis and therapy. Based on new designs of nanostructures, these methods have enabled successful cell targeting for tumor therapy, optical imaging by quantum dots, photothermal ablation of cancer cells, and drug delivery by intelligent triggering mechanisms.